The U.S. Subcommittee on Disaster Reduction aims to enhance disaster resilience through a ten-year science and technology agenda focused on reducing loss from natural and technological disasters. The document outlines six grand challenges that prioritize federal investments in hazard information, understanding natural processes, developing mitigation strategies, reducing infrastructure vulnerability, assessing resilience, and promoting risk-wise behavior. An implementation strategy for these challenges will be detailed in subsequent documents addressing major hazards and critical topics.