The document summarizes several major events and developments between 1000-1600 CE: 1) The Crusades led to increased trade between Europe and Asia but also religious tensions between Christianity and Islam over territory in the Holy Land. 2) The Black Death pandemic in the 14th century killed over 25 million people in Europe and led to the decline of feudalism and growth of urban trade centers. 3) The Age of Exploration beginning in the 1400s saw Europeans like Columbus explore the world which began the era of European domination and global exchange of goods, ideas, and peoples through events like the Columbian Exchange and Triangular Trade. 4) Developments in Europe included the Printing Press which spread knowledge and ideas