The Renaissance began in Italy in the late Middle Ages and spread throughout Europe by the 16th century. It was a period of cultural, artistic, political, and economic "rebirth" following the Middle Ages. In Italy, the Renaissance was led by wealthy merchant families in city-states like Florence, Milan, and Venice. Artists and scholars looked to ancient Greek and Roman culture for inspiration and focused on human potential and achievements, rather than religion. This led to developments in fields like art, literature, science, and philosophy that emphasized realism, secular themes, and a human-centered worldview.