Acute diarrhea is caused by infections spread through the fecal-oral route. It affects over 1.7 billion people globally each year and causes 760,000 deaths in children under 5. The key to management is fluid replacement to prevent dehydration through oral rehydration solutions. Antimicrobial treatment is usually not needed for acute infectious diarrhea but may be used for invasive bacteria like Shigella or Salmonella to prevent systemic complications. Proper hygiene and sanitation can help limit the spread of diarrhea-causing illnesses.
Ulcerative colitis is a chronic, or
long-lasting, disease that causes inflammation and sores, called ulcers, in the
inner lining of the large intestine, which includes the colon and the
rectum—the end part of the colon.
UC is one of the two main forms of chronic
inflammatory disease of the gastrointestinal tract, called inflammatory bowel
disease (IBD). The other form is called Crohn’s disease.
Normally, the large intestine absorbs water
from stool and changes it from a liquid to a solid. In UC, the inflammation
causes loss of the lining of the colon, leading to bleeding, production of pus,
diarrhea, and abdominal discomfort.
Ulcerative colitis is a chronic, or
long-lasting, disease that causes inflammation and sores, called ulcers, in the
inner lining of the large intestine, which includes the colon and the
rectum—the end part of the colon.
UC is one of the two main forms of chronic
inflammatory disease of the gastrointestinal tract, called inflammatory bowel
disease (IBD). The other form is called Crohn’s disease.
Normally, the large intestine absorbs water
from stool and changes it from a liquid to a solid. In UC, the inflammation
causes loss of the lining of the colon, leading to bleeding, production of pus,
diarrhea, and abdominal discomfort.
Image result for ulcerative colitis
Ulcerative colitis (UL-sur-uh-tiv koe-LIE-tis) is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in your digestive tract. Ulcerative colitis affects the innermost lining of your large intestine (colon) and rectum. Symptoms usually develop over time, rather than suddenly.
Image result for ulcerative colitis
Ulcerative colitis (UL-sur-uh-tiv koe-LIE-tis) is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in your digestive tract. Ulcerative colitis affects the innermost lining of your large intestine (colon) and rectum. Symptoms usually develop over time, rather than suddenly.
Defined as inflammation of the mucous membrane of stomach and intestine usually causing nausea ,vomiting and diarrhea.
Gastro-intestinal infections represent a major public health and clinical problem worldwide. Many species of bacteria, viruses and protozoa cause gastro-intestinal infection.
Acute infectious diarrhea
Seminar Prepared by :-
Mohammed Musa
Mohammed Saadi
Hussein Jassam
Mahmoud Ahmed
Meran Salih
Internal Medicine
College of Medicine - University of Kirkuk
A bunch of topic were selected for our subject Communicable Diseases, surprisingly I picked up "Cholera El tor"...
I have done enough research regarding this topic from Brunner and Suddarths MedSurg books and other resources. I collated the ideas and came up to this presentation...
Hope it will be able to help my colleagues, students and those people who needs to know the what, why's, and how of Cholera!
xoxo ^___^
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
2. Acute diarrhea:
Sometimes with vomiting, is the predominant symptom in infective GEitis.
Acute diarrhoea also a symptom of other infs&non-infectious diseases.
Stress, whether psychological or physical, can also produce loose stools.
> 1.7 billion acute diarrhoea annually globally, with 760 000 deaths < 5.
In developed countries, diarrhoea remains an important problem, with the
elderly being most vulnerable.
The majority of episodes are due to infections spread by the faecal–oral
route transmitted either on fomites, on contaminated hands, food or water.
Measures as the provision of clean drinking water, appropriate disposal of
human/ animal sewage& the application of simple principles of food
hygiene can all limit gastroenteritis.
The clinical features of food-borne gastroenteritis vary.
Some organisms (Bacillus cereus, Staph. Aureus& Vibrio cholerae) elute
exotoxins that cause vomiting&/or so-called ‘secretory’ diarrhoea (watery
diarrhoea without blood or faecal leucocytes reflecting SB dysfunction).
3. Acute diarrhea:
In general, the time from ingestion to the onset of symptoms is short&
other than dehydration, little systemic upset occurs.
Other organisms,as Shigella spp., Campylobacter spp&EHEC, may
directly invade the mucosa of the small bowel or produce cytotoxins that
cause mucosal ulceration, typically affecting the terminal SB& colon.
The incubation period is longer& more systemic upset occurs, with
prolonged bloody diarrhoea.
Salmonella spp. are capable of invading enterocytes& of causing both a
secretory response&invasive disease with systemic features, seen with
Salmonella Typhi& Salmonella Paratyphi (enteric fever), but may
occasionally be seen with other non-typhoidal Salmonella spp., particularly
in the immunocompromised host& the elderly.
4. Acute diarrhea:clin evaluation
The history should address foods ingested, duration& frequency of
diarrhoea, presence of blood or steatorrhoea, abdominal pain& tenesmus,
&whether other people have been affected.
Fever&bloody diarrhoea suggest an invasive, colitic, dysenteric process.
An incubation period of < 18 hours suggests toxin-mediated food
poisoning,>5 days suggests diarrhoea caused by protozoa or helminths.
Person-to-person spread suggests certain infections, as shigellosis or
cholera.
Examination includes assessment of the degree of dehydration.
Assessment for early signs of hypotension, such as thirst,headache, altered
skin turgor, dry mucous membranes&postural hypotension, is important,
particularly in tropical regions where dehydration progresses rapidly.
Signs of more marked dehydration include supine hypotension &
tachycardia,decreased urinary output, delirium& sunken eyes.
The blood pressure, pulse rate, urine output& ongoing stool losses should
be monitored closely
5. Acute diarrhea:clin evaluation
The severity of diarrhoea may be assessed by reference to the Bristol stool
form scale (Bristol stool chart), which allows an objective assessment of
stool consistency by providing a verbal/ visual reference scale.
The Bristol stool form scale was developed monitor patients with irritable
bowel syndrome, but its main use is to monitor hospital inpatients with
loose stool to assist in decisions on stool sampling& infection prevention
precautions, especially in relation to C. difficile.
6. Acute diarrhea:Investigations
These include stool inspection for blood/ microscopy for leucocytes, ova,
cysts,parasites if the history indicates residence or travel to areas where
these infections are prevalent.
Stool culture should be performed &C. difficile toxin sought.
FBC/ serum electrolytes indicate the degree of inflammation&
dehydration.
Where cholera is prevalent, examination of a wet film with dark-field
microscopy for darting motility may provide a diagnosis.
In a malarious area, a blood film for malaria parasites should be obtained.
Blood/urine cultures& a chest X-ray may identify alternative sites of
infection, particularly if the clinical features suggest a syndrome other than
gastroenteritis.
7. Acute diarrhea:Management
All patients with acute, potentially infective diarrhoea should be
appropriately isolated to minimise person-to-person spread of infection.
If the history suggests a food-borne source, public health measures must be
implemented to identify the source& to establish whether other linked
cases exist.
8. Acute diarrhea:Management
Fluid replacement:
Replacement of fluid losses in diarrhoeal illness is crucial& life-saving.
Although normal daily fluid intake in an adult is only 1–2 L, there is
considerable additional fluid movement in/ out of the gut in secretions.
Altered gut resorption with diarrhoea can result in substantial fluid loss;
for example, 10–20 L of fluid may be lost in 24 hours in cholera.
The fluid lost in diarrhoea is isotonic, so both water/ electrolytes need to be
replaced.
Absorption of electrolytes from gut is active process requiring energy.
Infected mucosa is capable of very rapid fluid/ electrolyte transport if
carbohydrate is available as an energy source.
9. Acute diarrhea:Management
Oral rehydration solutions (ORS)
Contain sugars, water& electrolytes
ORS can be just as effective as IV replacement fluid, even in the
management of cholera.
In mild to moderate GEitis, adults should be encouraged to drink fluids, if
possible, continue normal dietary food intake.
If this is impossible – due to vomiting, for example – IVF will be required.
In very sick patients or those with cardiac or renal disease, monitoring of
UO&CVP may be necessary.
The volume of fluid replacement required should be estimated based on
the following considerations:
Replacement of established deficit:After 48 hs of moderate diarrhoea (6–10
stools/24 hrs), the average adult will be 2–4 L depleted from diarrhoea
alone &associated vomiting will compound this.
10. Acute diarrhea:Management
Adults with this symptomatology should therefore be given rapid
replacement of 1–1.5 L, either orally ORS or by IV infusion (normal
saline), within the first 2–4 hours of presentation.
Longer symptomatology or more persistent/severe diarrhoea rapidly
produces fluid losses comparable to diabetic ketoacidosis& a metabolic
emergency requiring active intervention.
Replacement of ongoing losses.
The average adult’s diarrhoeal stool accounts for a loss of 200 mL of
isotonic fluid.
Stool losses should be carefully charted&estimate of ongoing replacement
fluid calculated.
Commercially available rehydration sachets are conveniently produced to
provide 200 mL of ORS; one sachet per diarrhoea stool is an appropriate
estimate of supplementary replacement requirements.
Replacement of normal daily req:The average adult has a daily 1–1.5 L of
fluid+ calculations above, increased substantially in fever or a hot envir.
11. Acute diarrhea:Management
Antimicrobials: non-specific gastroenteritis, routine use of antimicrobials
does not improve outcome& lead to antimicrobial resistance or side-effects.
They are usually used where there is systemic involvement, a host with
immunocompromise or significant comorbidity.
Evidence suggests that, in EHEC infections, the use of antibiotics may
make the complication of HUS more likely due to increased toxin release.
Conversely, antibiotics are indicated in Shigella dysenteriae infection& in
invasive salmonellosis – in particular, typhoid fever.
Antibiotics may also be advantageous in cholera epidemics, reducing
infectivity& controlling the spread of infection.
12. Acute diarrhea:Management
Antimicrobial-associated diarrhoea (AAD) is a common complication of
antimicrobial therapy, especially with broad spectrum agents.
It is most common in the elderly but can occur at all ages.
Although the specific mechanism is unknown in most cases of AAD, C.
difficile is implicated in 20–25% of cases& is the most common cause
among patients with evidence of colitis.
C. perfringens is a rarer cause that usually remains undiagnosed&
Klebsiella oxytoca may also cause antibiotic-associated haemorrhagic
colitis.