Regulation of temperature of Human bodyRanadhi Das
Homoeothermic (WARM blooded)- Humans capable of maintaining their body temperatures within narrow limits inspite of wide variations in environmental (ambient) temperature.
Poikilothermic- (Cold blooded) eg.-fish, reptiles
Neutral zone temperature/ Comfortable temperature/Critical / ambient temperature- at which there is no active heat loss and heat gain mechanism operated by body.
So it is the lowest ambient temperature at which mammals can maintain its body temperature at the basal metabolic rate.
Normally it is 27 ± 2º C
Living tissues can function optimally only within a very narrow range of temperature. Therefore accurate regulation of body temperature is a great boon: it enables the animal to be physically active all round the year, and in different geographical locations.
We have discuss Definition of homeostasis which is state of balance .then The scope of human physiology in homeostasis means the feature and characteristics of homeostasis control system and feedback system. Negative and positive feedback when and where it place . Also components of homeostasis control system which include reflex arc, local homeostatic response . And intercellular chemical messengers .
Cells and its components(Anatomy) Easy explanationSwatilekha Das
Cells and its components,discussion on cell membrane, cytoplasm, nucleus with pictures....
easy explanation of anatomy topic for 1 st year GNM & B.Sc nursing students...
Comment to get explanation on your required topics.....
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Temperature practical cum theory part by Pandian M, From DYPMCKOP. This PPT f...Pandian M
INTRODUCTION
HOMEOTHERMIC ANIMALS
POIKILOTHERMIC ANIMALS
BODY TEMPERATURE
Normal Body Temperatures
VARIATIONS OF BODY TEMPERATURE
Pathological Variations
HEAT GAIN OR HEAT PRODUCTIONIN THE BODY
HEAT LOSS FROM THE BODY
Regulation of Body Temperature
Hypothalamus has two centers which regulate the body temperature:
Applied
Body temperature by Pandian M, Tutor Dept of Physiology, DYPMCKOP, this PPT f...Pandian M
BODY TEMPERATURE
HEAT BALANCE
Mechanisms of heat gain
Mechanisms of heat loss
VARIATIONS OF BODY TEMPERATURE
REGULATION OF BODY TEMPERATURE
Thermoreceptors
Hypothalamus: the thermostat
Thermoregulatory effector mechanisms
ABNORMALITIES OF BODY TEMPERATURE
Regulation of temperature of Human bodyRanadhi Das
Homoeothermic (WARM blooded)- Humans capable of maintaining their body temperatures within narrow limits inspite of wide variations in environmental (ambient) temperature.
Poikilothermic- (Cold blooded) eg.-fish, reptiles
Neutral zone temperature/ Comfortable temperature/Critical / ambient temperature- at which there is no active heat loss and heat gain mechanism operated by body.
So it is the lowest ambient temperature at which mammals can maintain its body temperature at the basal metabolic rate.
Normally it is 27 ± 2º C
Living tissues can function optimally only within a very narrow range of temperature. Therefore accurate regulation of body temperature is a great boon: it enables the animal to be physically active all round the year, and in different geographical locations.
We have discuss Definition of homeostasis which is state of balance .then The scope of human physiology in homeostasis means the feature and characteristics of homeostasis control system and feedback system. Negative and positive feedback when and where it place . Also components of homeostasis control system which include reflex arc, local homeostatic response . And intercellular chemical messengers .
Cells and its components(Anatomy) Easy explanationSwatilekha Das
Cells and its components,discussion on cell membrane, cytoplasm, nucleus with pictures....
easy explanation of anatomy topic for 1 st year GNM & B.Sc nursing students...
Comment to get explanation on your required topics.....
please like and share and follow.....
Temperature practical cum theory part by Pandian M, From DYPMCKOP. This PPT f...Pandian M
INTRODUCTION
HOMEOTHERMIC ANIMALS
POIKILOTHERMIC ANIMALS
BODY TEMPERATURE
Normal Body Temperatures
VARIATIONS OF BODY TEMPERATURE
Pathological Variations
HEAT GAIN OR HEAT PRODUCTIONIN THE BODY
HEAT LOSS FROM THE BODY
Regulation of Body Temperature
Hypothalamus has two centers which regulate the body temperature:
Applied
Body temperature by Pandian M, Tutor Dept of Physiology, DYPMCKOP, this PPT f...Pandian M
BODY TEMPERATURE
HEAT BALANCE
Mechanisms of heat gain
Mechanisms of heat loss
VARIATIONS OF BODY TEMPERATURE
REGULATION OF BODY TEMPERATURE
Thermoreceptors
Hypothalamus: the thermostat
Thermoregulatory effector mechanisms
ABNORMALITIES OF BODY TEMPERATURE
Role of hypothalamus in regulation of body temperatureSaad Salih
Thermoregulation is a process that allows your body to maintain its core internal temperature. All thermoregulation mechanisms are designed to return your body to homeostasis. This is a state of equilibrium.
A healthy internal body temperature falls within a narrow window. The average person has a baseline temperature between 98°F (37°C) and 100°F (37.8°C). Your body has some flexibility with temperature. However, if you get to the extremes of body temperature, it can affect your body’s ability to function. For example, if your body temperature falls to 95°F (35°C) or lower, you have “hypothermia.” This condition can potentially lead to cardiac arrest, brain damage, or even death. If your body temperature rises as high as 107.6°F (42 °C), you can suffer brain damage or even death.
Many factors can affect your body’s temperature, such as spending time in cold or hot weather conditions.
Factors that can raise your internal temperature include:
fever
exercise
digestion
Factors that can lower your internal temperature include:
drug use
alcohol use
metabolic conditions, such as an under-functioning thyroid gland
Your hypothalamus is a section of your brain that controls thermoregulation. When it senses your internal temperature becoming too low or high, it sends signals to your muscles, organs, glands, and nervous system. They respond in a variety of ways to help return your temperature to normal.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Introduction
• Anatomy of the skin
Epidermis
Dermis
Color of the skin
• Pigmentation of the skin
• Hemoglobin in the blood
Glands of the skin
Sebaceous gland
Sweat gland
Murugavel.R.MSc Nursing, Associate
professor.
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3. Function of the skin:
Protective function
Protection from Bacteria and toxic substances
Protection from mechanical blow
Protection from ultraviolet rays
Sensory function (touch, pain, pressure, temp)
Storage function(fat, H2O, chloride, sugar)
Synthetic function (vit D3)
Regulation of body temperature
Regulation of water and electrolyte balance(sweat)
Excretory function (urea, salt, fatty substances)
Absorptive function(ointment, fat)
Secretory function(sweat & sebum)Murugavel.R.MSc Nursing, Associate
professor.
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5. Introduction
• 2 types of organism:
Homeothermic animals
Animals which maintain constant Body temp e.g birds
mammals. Also called warm blooded animals.
Poikilothermic animals
Animals which doesn’t maintain constant body temp. e.g
Amphibians and reptiles. Also called cold blooded animals
Murugavel.R.MSc Nursing, Associate
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6. Body temperature
• Oral temp.
• Axilla temp.
• Rectum temp.
• Over the skin ( surface temp).
Normal body temp 37°C or 98.6°F
Varies between 35.8 37.3C or 98.4 - 99.1.
Temp varies in site e.g axilla, rectum, oral
Core temp is the average temp of structures
present in deeper part if the body. Normal Core
temp 37.8°C or 100°F
Murugavel.R.MSc Nursing, Associate
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7. Variation of body temperature
Physiological variations
Age
Sex
Diurnal variation(early morning 1°C less)
After meals (0.5°C)
Exercise
Sleep
Emotion
menstrual cycle.
Pathological variation.
Hyperthermia, fever, hypothermia
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8. Heat balance
Heat gain or heat production in the body
Metabolic activity
Muscular activity
Role of hormones
Radiation of heat from the environment
shivering
Heat loss from the body
Conduction
Radiation
Convection
Evaporation – insensible perspiration
panting
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9. Metabolic activity
• Metabolism of food stuff produce heat
• About 9 calories of heat is produced during
metabolism of fat, when 1 L of O2 is utilized.
• For CHO 4.7 calories
Murugavel.R.MSc Nursing, Associate
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10. Muscular activity
• Heat is produced in the muscle both at rest
and during activity
• 80% of heat is produced by musculoskeletal
activity.
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11. Role of hormones
• Thyroxine and adrenaline increase the heat by
accelerating the metabolic activity.
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12. Radiation of heat from the environment
• Body gain heat by radiation. Especially when
environment temp increases.
Murugavel.R.MSc Nursing, Associate
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13. shivering
• It means rapid involuntary contraction or
twitching of the muscle during exposure to
cold.
• It is a compensatory mechanism in the body,
during which enormous heat is produce.
Murugavel.R.MSc Nursing, Associate
professor.
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14. Heat loss of the body
• Maximum heat is lost from the body through skin and
small amount through respiration, kidney, and GI.
• When environment temp is less the heat is lost from
the body.
• Lost through
Conduction (by surface)
Radiation(by means of transfer heat by infrared
electromagnetic radiation)
Convection ( conducted to the surrounding air)
Evaporation (evaporate through skin lung).
Panting ( rapid shallow breathing with dribbling of saliva)
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15. Regulation of body temp
• Body temp is regulated by hypothalamus which
has 2 centers
Heat loss center
Situated in preoptic nucleus of anterior hypothalamus .
neurons are heat sensitive nerve cells called thermoreceptors.
It stimulate cutaneous vasodilatation and sweating . Removal
or lesion of this nucleus increase the body temp.
Heat gain center;
Otherwise called as heat production center. Situated in
posterior hypothalamic nucleus. If it stimulated cause shivering.
Removal or lesion lead fall in body temp
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16. Mechanism of temperature regulation:
• When body temp ↑
• blood temp also↑,
• Blood stimulates thermoreceptor
• Now it brings the temp to normal by two
mechanisms.
Promotion of heat loss
i. Increasing the secretion of sweat
ii. Inhibiting the sympathetic center in posterior
hypothalamus. ( this cause cutaneous vasodilation, so
blood flow through skin causing excess sweating)
Prevention of heat production
By shivering and chemical reactionMurugavel.R.MSc Nursing, Associate
professor.
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17. Mechanism of temperature regulation:
• When body temp ↑
• 2 mechanism activated to bring back to normal
temp
i. prevention of heat loss.
ii. Promotion of heat production.
• Prevention of heat loss;
When body temp decreases , the preoptic
thermoreceptors are not inhibited. This causes
cutaneous vasoconstriction.
The blood flow ↓, so heat loss is prevented.
Murugavel.R.MSc Nursing, Associate
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18. Mechanism of temperature regulation:
ii. Promotion of heat production:
Shivering .
The primary motor center for shivering is situated in
posterior hypo thalamus near the wall of the III ventricle.
When body temp is low, it is activated by heat gain center
& shivering occurs.
Increased metabolic reaction.
Sympathetic center is stimulated by heat gain center
This stimulates adrenaline & noradreline, these hormones
accelerating cellular metabolism activities & produce heat.
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19. Mechanism of temperature regulation:
• Hypothalamus secretes thyrotrophic releasing
hormone, it cause release of thyroid
stimulating hormone from pituitary gland, it in
turn increases release of thyroxine from
thyroid, that also increases metabolic
activities in the body & increase heat
production.
Murugavel.R.MSc Nursing, Associate
professor.
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20. Mechanism of temperature regulation:
Hypothalamus secretes thyrotrophic
releasing hormone
it release thyroid stimulating hormone
from pituitary gland
it increases release of thyroxine from
thyroid
increases metabolic activities in the
body
increase heat production.
Murugavel.R.MSc Nursing, Associate
professor.
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