In the elderly osteoporotic fractures although the principles are the same but some special considerations in management of the soft tissues and the bony injuries are considered.
In the elderly osteoporotic fractures although the principles are the same but some special considerations in management of the soft tissues and the bony injuries are considered.
A fractured neck of femur (NOF) is a serious injury, especially in older people. It is likely to be life changing and for some people life threatening.
Neck of femur fractures (NOF) are common injuries sustained by older patients who are both more likely to have unsteadiness of gait and reduced bone mineral density, predisposing to fracture. Elderly osteoporotic women are at greatest risk.
The lower limb consists of various joints that provide mobility and support for activities such as walking, running, and standing.
Understanding the anatomy and function of these joints is crucial for healthcare professionals, particularly those involved in orthopedics, rehabilitation, and sports medicine.
Disorders or injuries affecting these joints can impact mobility and require specific interventions for treatment and recovery.
With the pandemic overclouding the whole world it has effected every strato of people including the Orthopaedic groups. This is to highlight the impact of COVID 19 on the orthopaedic in general.
Conservative management in 3 and 4 part proximal humerus fractureBipulBorthakur
Proximal humerus fracture is common in both young as well as elderly people with most of the elderly patients unable to undergo operative management. This study is to see the aspect of conservative management in proximal humerus fracture.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
2. Largest tubular bone in the body.
Surrounded by the largest mass of
muscle.
‘Antero-lateral’ bow – important
feature.
Isthmus – it is the region of femur
with smallest intra-medullary
diameter, it’s at the junction of
upper 1/3rd and lower 2/3rd .
3. ▪ rough crest of bone running down
middle third of posterior femur
▪ attachment site for various
muscles and fascia
▪ acts as a compressive strut to
accommodate anterior bow to
femur
4. ABDUCTORS :- They abducts hip joint and
are mainly gluteus medius and minimus.They
insert on greater trochenter , abduct proximal
femur following fracture.
ILIOPSOAS :- flex and external rotates the
proximal fragment by its attachment in lesser
trochenter.
ADDUCTOR :- Mainly Adductor longus,
Adductor magnus and Adductor brevis. Exerts
a strong axial and varus load to bone by
traction on distal part
FASCIA LATA :- acts as a tension band by
resisting the medial angulating forces of
abductor.It’s a continuation of Ilio-tibial tract
of thigh and is also known as DEEP FASCIA OF
Thigh.
5. Three compartments.
ANTERIORCOMPARTMENT - Quadriceps femoris,
iliopsoas, sartorius and pectineus. Femoral artery, vein,
nerve, lat femoral cutaneous nerve.
MEDIAL COMPARTMENT – gracilis, adductor longus,
brevis, magnus and obturator externus muscles.
Obturator artery,vein,nerve and profunda femoris
artery.
POSTERIORCOMPARTMENT –biceps femoris,
semitendinosus and semimembranosus, a portion of
the adductor magnus ( Hamstring muscles) branches
of profunda femoris artery, sciatic nerve, post femoral
cutaneous nerve.
6. Mainly from the profunda femoris,
branch of Femoral artery
One to two nutrient vessels usually
enter the bone proximally and
posteriorly along the linea aspera.
This artery then arborizes proximally
and distally to provide endosteal
circulation.
Periosteal vessels also entres along
the linea aspera.
7. Outer 1/3rd of cortex supply – periosteal vessels.
Inner 2/3rd of cortex supply – endosteal vessels.
After most of the femoral shaft fracture
- endosteal supply disrupted
- periosteal vessels proliferate to heal
- medullary vessels restored late in healing process.
8. TRAUMATIC
▪ high-energy
▪ most common in younger population
▪ often a result of high-speed motor vehicle accidents
▪ low-energy
▪ more common in elderly
▪ often a result of a fall from standing
9. Pathological fracture – elderly, inconsistent with
degree of trauma, at the weak metaphyseal-diaphyseal
junction.
10. Transverse
pure bending movement
Spiral
Rotational/twisting movement
Oblique
uneven bending movement
Segmental
More than 1 fracture line
Comminuted
Single fracture line with multiple fragments
11. Ipsilateral femoral neck fracture
▪ often basicervical, vertical, and nondisplaced
▪ missed 19-31% of time
Bilateral femur fractures
▪ significant risk of pulmonary complications
▪ increased rate of mortality as compared to unilateral fractures
Ipsilateral tibial shaft fractures
Ipsilateral acetabular fracture
12. Symptoms
▪ H/O trauma followed by inability to walk
Physical examination
Diagnostic features of fracture are
1.Bony crepitus
2.Abnormal mobility .
3. Loss of transmitted mobility
13. Type 0 • No comminution
Type I • Insignificant amount of comminution
Type II • More than 50% cortical contact
Type III • Less than 50% cortical contact
Type IV • Segmental fracture with no contact
between proximal and distal fragment
14.
15. Radiographs
AP and lateral views of femur with hip and knee
AP view of Pelvis
▪ important to rule-out coexisting femoral neck fracture
CT indications
may be considered in midshaft femur fractures to
rule-out associated femoral neck fracture
16.
17. Resuscitation of patient as per ATLS guidelines.
Airway
Breathing
Circulation
Disability
Normally 500ml -2000 ml blood loss occurs so patient
may present with shock.
Volume replenishment by IV fluids or blood
transfusion if required.
Catheterization to be done.
18. Application of below knee-skin traction with
Thomas splint should be done as early as
possible.
Stabilization should be done at the
emergency room.
19. Nonoperative
Long leg cast or hip spica cast in Paediatric age group upto 5 Years
Operative
Done after stabilization of patient usually after 5-7 days.
1. Adolescent age groups- Tension Elastic nail application,
done under IOTP without opening fracture site
2. After skeletal maturity -Antegrade intra-medullary
nail done under IOTP without opening the fracture site.