African trypanosomiasis resistance in cattle by a transgenic approachILRI
We propose a new strategy for creating resistance in cattle to African trypanosomiasis, a major disease that affects agricultural production in broad regions of Africa. The long-term aim is to generate genetically modified cattle, which carry a gene that imparts resistance to African trypanosomes. The gene, APOL1, encodes the key trypanolytic component of Baboon’s protective Trypanosome Lytic Factor (TLF) against both cattle and human-infective trypanosomes. TLFs are only found in humans, gorillas, sooty mangabys, mandrills and baboons and govern resistance to different African trypanosome species.
African trypanosomiasis resistance in cattle by a transgenic approachILRI
We propose a new strategy for creating resistance in cattle to African trypanosomiasis, a major disease that affects agricultural production in broad regions of Africa. The long-term aim is to generate genetically modified cattle, which carry a gene that imparts resistance to African trypanosomes. The gene, APOL1, encodes the key trypanolytic component of Baboon’s protective Trypanosome Lytic Factor (TLF) against both cattle and human-infective trypanosomes. TLFs are only found in humans, gorillas, sooty mangabys, mandrills and baboons and govern resistance to different African trypanosome species.
Importance of livestock and the technological and policy challenges facing th...ILRI
Presented by Michael Blϋmmel, Phil Toye, Okeyo Mwai, Ian Wright, Tom Randolph and Steve Staal at the Global feed and food congress, Sun City, South Africa, 10-12 April 2013
Measuring and mitigating the risk of mycotoxins in maize and dairy products for poor consumers in Kenya, Johanna Lindahl (ILRI) and Alexia Pretari (IFPRI)
Overview of Community Based Breeding Program and implementation procedureILRI
Presented by Tesfaye Getachew, ICARDA, at the SmaRT Ethiopia workshop and field day on Small Ruminant Community Based Breeding Program (CBBP), Hosaena, Ethiopia, 27–28 March 2018
Value chain actors’ practices associated with the spread of African swine fev...ILRI
Paper presented by Michel Dione, Emily Ouma, Felix Opio, Peter Lule, Brian Kawuma and Danilo Pezo (ILRI) at the Joint International Conference of the Association of Institutions for Tropical Veterinary Medicine and the Society of Tropical Veterinary Medicine, Berlin, 4–8 September 2016
Participatory evaluation of cattle fattening innovations of smallholder farm...ILRI
Poster prepared by Azage Tegegne, Yoseph Mekashaand Tesfaye Dubale for the Tropentag 2016 Conference on Solidarity in a Competing World—Fair Use of Resources, Vienna, Austria, 19–21 September 2016
Presented by Karen Marshall at the Piggery Production Value Chain Stakeholder Workshop for Designing a Pig Breeders’ Registration Scheme, Entebbe, Uganda, 10 May 2018
Increasing productivity of chickens through the African Chicken Genetic Gains...ILRI
Presented by Jasmine E. Bruno at the Workshop on Technologies, Platforms and Partnerships in Support of the African Agricultural Science Agenda, Abidjan, Cote d’Ivoire, 4-5 April 2017
Increasing productivity of chickens through the African Chicken Genetic Gains...ckmtraining
Presented by Jasmine E. Bruno at the Technologies, Platforms and Partnerships in Support of the African Agricultural Science Agenda, Abidjan, Cote d’Ivoire, 5th April 2017
The productivity of developing country livestock production systems lags well behind that of the developed world. Addressing this issue is one important route to poverty alleviation, improved food security and environmental sustainability (because, generally, the lower the productivity of livestock systems the higher the environmental impact per unit of product). Low productivity can be attributed to a number of inter-related factors including (depending on the system) high disease burdens and weak animal health-care systems, poor quality and insufficient animal feed, use of breed-types that are not optimal, and other social and economic constraints.
This poster shows how the rapidly developing field of genomics can contribute to improved productivity in developing country livestock production systems.
Importance of livestock and the technological and policy challenges facing th...ILRI
Presented by Michael Blϋmmel, Phil Toye, Okeyo Mwai, Ian Wright, Tom Randolph and Steve Staal at the Global feed and food congress, Sun City, South Africa, 10-12 April 2013
Measuring and mitigating the risk of mycotoxins in maize and dairy products for poor consumers in Kenya, Johanna Lindahl (ILRI) and Alexia Pretari (IFPRI)
Overview of Community Based Breeding Program and implementation procedureILRI
Presented by Tesfaye Getachew, ICARDA, at the SmaRT Ethiopia workshop and field day on Small Ruminant Community Based Breeding Program (CBBP), Hosaena, Ethiopia, 27–28 March 2018
Value chain actors’ practices associated with the spread of African swine fev...ILRI
Paper presented by Michel Dione, Emily Ouma, Felix Opio, Peter Lule, Brian Kawuma and Danilo Pezo (ILRI) at the Joint International Conference of the Association of Institutions for Tropical Veterinary Medicine and the Society of Tropical Veterinary Medicine, Berlin, 4–8 September 2016
Participatory evaluation of cattle fattening innovations of smallholder farm...ILRI
Poster prepared by Azage Tegegne, Yoseph Mekashaand Tesfaye Dubale for the Tropentag 2016 Conference on Solidarity in a Competing World—Fair Use of Resources, Vienna, Austria, 19–21 September 2016
Presented by Karen Marshall at the Piggery Production Value Chain Stakeholder Workshop for Designing a Pig Breeders’ Registration Scheme, Entebbe, Uganda, 10 May 2018
Increasing productivity of chickens through the African Chicken Genetic Gains...ILRI
Presented by Jasmine E. Bruno at the Workshop on Technologies, Platforms and Partnerships in Support of the African Agricultural Science Agenda, Abidjan, Cote d’Ivoire, 4-5 April 2017
Increasing productivity of chickens through the African Chicken Genetic Gains...ckmtraining
Presented by Jasmine E. Bruno at the Technologies, Platforms and Partnerships in Support of the African Agricultural Science Agenda, Abidjan, Cote d’Ivoire, 5th April 2017
The productivity of developing country livestock production systems lags well behind that of the developed world. Addressing this issue is one important route to poverty alleviation, improved food security and environmental sustainability (because, generally, the lower the productivity of livestock systems the higher the environmental impact per unit of product). Low productivity can be attributed to a number of inter-related factors including (depending on the system) high disease burdens and weak animal health-care systems, poor quality and insufficient animal feed, use of breed-types that are not optimal, and other social and economic constraints.
This poster shows how the rapidly developing field of genomics can contribute to improved productivity in developing country livestock production systems.
Planting the orchard – an ILRI livestock vaccine initiative (ILVAC)ILRI
The goal of ILRI’s Vaccine Biosciences group is to build a hub of research excellence dedicated to developing vaccine-based solutions to reduce disease burdens that limit livestock productivity in smallholder and pastoral farming systems.
The known and the unknowns: A multipathogen survey to identify diseases in c...ILRI
Livestock farmers in Africa are facing important challenges on animal health. Diseases of cattle are reported by farmers as an important factor limiting productivity and income generation. Limited capacity and infrastructure of government services for disease identification and control. Lack of systematic disease surveillance – Ad hoc surveys give biased picture on priority diseases.
Competitive smallholder livestock in Botswana: Results of a livestock value c...ILRI
The smallholder livestock sector in Botswana faces a challenge in exploiting the growing national and regional demand for meat, as well as preferential access to the EU market. The incentives for value addition in pursuit of these markets appear to be limited. There is also limited evidence of innovation in the value chain, particularly for small stock. This poster gives details from a study that explores the existing value chains in which livestock products are produced and traded.
Infectious bursal disease in Ethiopian village chickensILRI
Poster prepared by J. Bettridge, S. Lynch, C. Brena, K. Melese, T. Dessie, Z. Gutu, T. Taye, O. Hanotte, P. Kaiser, P. Wigley and R. Christley for Annual Meeting of the Society of Veterinary Epidemiology and Preventive Medicine, Madrid, Spain, 20-22 March 2013.
Factors affecting profit efficiency among smallholder beef producers in BotswanaILRI
Botswana’s livestock sector provides about two thirds of national agricultural value added and beef production is a vital part of the rural economy as a source of income and employment. However, throughout the beef value chain, high costs of Sanitary and Phyto-sanitary (SPS) compliance are apparent, and on the demand side, reductions in EU beef support prices have adversely affected competitiveness and the country is unable to utilise fully its preferential access to EU import markets. This poster presents information on a study to measure competitiveness in Botswana's beef value chain and identify the factors affecting it, so as to advocate change in Botswana’s smallholder livestock systems.
Improved farm productivity through crop–livestock interventions in the Democr...ILRI
Poster prepared by Michael Handlos (ILRI) and Flemming Nielsen (IITA) for the Joint International Conference of the Association of Institutions for Tropical Veterinary Medicine and the Society of Tropical Veterinary Medicine, Berlin, 4–8 September 2016
Digestibility and metabolizable energy of selected tropical feedstuffs estima...ILRI
Poster prepared by Alice A. Onyango, Uta Dickhoefer, Klaus Butterbach-Bahl and John P. Goopy for the Tropentag 2016 Conference on Solidarity in a Competing World—Fair Use of Resources, Vienna, Austria, 19–21 September 2016
A snapshot of some communication and knowledge management approaches used by...ILRI
Presented by Peter Ballantyne at the EC SHARE–FAO Coordination and Experience Sharing Forum on Food Security–Resilience Building, Addis Ababa, 7-8 December
Innovative use of conventional and new technologies to unravel breed options ...ILRI
Presented by J.M.K. Ojango, R. Mrode and A.M. Okeyo at the 1st World Congress on Innovations for Livestock Development: Fostering Innovations for the Livestock Industry, Nakuru, Kenya, 26–30 June 2016
Beef Cattle Production and Wealth Creation: Evidence from Improved Boran Catt...Premier Publishers
The study was conducted to assess Improved Boran production and their crosses under ranching conditions. Growth performance, reproductive performance, carcass traits and their profitability were analyzed using primary data from Beef Research Institute, Lanet Centre and secondary data from desktop study. Cash flow analysis was used to compute the profitability of Improved Borans under free range production system as well as a hypothetical case of intensive system. The Boran breeding bulls, steers, were identified as the major receipts. The Centre reported the average birth, weaning, and yearling steer weights of Improved Boran at 26.8kg, 149kg (7 months) and 202 kg respectively. Yearling steer weights for Boran crossed with Sahiwal weighed 207kg. Calve survival rate was 94.20% and 95.2% for Improved Boran and Boran crossed with Sahiwal respectively. A gross profit at 99.8% and 98.6% of total unit operating cost for Improved Boran and Boran crosses enterprises respectively was reported under free range system. A hypothetical case of 100 Improved Boran steers under feedlotting for three months reported gross profit at 65.6% of total unit operating cost. However, the unit cost of production in free range system was lower than intensive and the entrepreneur should seize the opportunity of economics of scale.
Animal genetic resources for improved productivity under harsh environmental ...SIANI
Indigenous livestock breeds are well adapted to tropical and harsh environments, but usually rather unproductive. Therefore, crossbreeding with exotic breeds has been practiced, and often found to be successful in the first generation, but with disastrous results later on. Therefore, there is a great need for developing breeding strategies for specific populations of indigenous livestock, both in order to conserve genes necessary for survival under harsh environments, and for genetic improvement of productivity. The objective of this project is to explore the opportunities for genetic improvement of primarily two livestock populations considered of specific importance for food security in Eastern Africa, due to their resilience as regards adverse climatic stress or ability to withstand specific disease challenges in the tropics. In the first case, focus will be on the Red Maasai sheep and its crosses in Kenya and Tanzania. This breed has shown a high degree of resistance to gastrointestinal parasites and ability to withstand drought. However, there is no breeding strategy in place and this project will adopt a value chain approach with the farmers and retailers to establish appropriate breeding objectives and selection practices. We will furthermore study production systems, animal usage, survival, production, et cetera, using various interview methods and also further develop an already created production recording system. In the second study we have focused on comparing four Ethiopian cattle breeds with respect to trypanotolerance and productivity and found that one breed, the Sheko, is clearly superior. We will carry out a workshop with researchers, extension officers and farmers on how to amplify the genes for trypanotolerance into the cattle populations kept in tsetse infested areas.
Senegal dairy genetics: Comparing traditional and new breeds of dairy animals ILRI
Poster prepared by Karen Marshall, Stanly Tebug, Jarmo Juga, Miika Tapio and Ayao Missohou for the Workshop on Food and Nutrition Security in Africa, Helsinki, Finland, 16 June 2014
Improving the utilization of sweetpotato and other roots and tuber crop resid...ILRI
Presented by Danilo Pezo, Peter Lule, and Gerald Kyalo at the Workshop on Improving the Utilisation of Sweet Potato and other Roots and Tuber Crop Residues for Pig Feeds in Uganda, Kampala, Uganda, 11 February 2015.
Agriculture is the main stay of the Uganda’s economy employing 65.6 per cent (UBOS 2009) of the labour force and contributing 21 percent to the Gross Domestic Product (GDP).
Agricultural production in Uganda is dominated by smallholder farmers engaged in crop farming, livestock keeping, forestry, horticulture and fishing.
Livestock production - the livestock sector in Uganda contributes about 17% of the national Agriculture Gross Domestic Product in the form of milk and meat.
Cattle population at 11.4 million with ~ 10.6% improved cattle.
Bovine mastitis has a negative impact through economic losses in the dairy sector across the globe. A cross sectional study was carried out from September 2015 to July 2016 to determine the prevalence of bovine mastitis, associated risk factors and isolation of major causative bacteria in lactating dairy cows in selected districts of central highland of Ethiopia. A total of 304 lactating cows selected randomly from five districts were screened by California Mastitis Test (CMT) for subclinical mastitis. Based on CMT result and clinical examination, over all prevalence of mastitis at cow level was 70.62% (214/304).
Two hundred fourteen milk samples collected from CMT positive cows were cultured for isolation of major causative bacteria. From 214 milk samples,187 were culture positive and the most prevalent isolates were Staphylococcus aureus 42.25% (79/187) followed by Streptococcus agalactiae 14.43%
(27/187). Other bacterial isolates were included Coagulase Negative Staphylococcus species 12.83% (24/187), Streptococcus dysgalactiae 5.88% (11/187), Escherichia coli 13.38% (25/187) and Entrococcus feacalis 11.23% (21/187) were also isolated. Moreover, age, parity number, visible teat abnormalities,husbandry practice, barn fl oor status and milking hygiene were considered as risk factors for the occurrence of bovine mastitis and they were found significantly associated with the occurrence of mastitis (p < 0.05). The findings of this study warrants the need for strategic approach including dairy extension that focus on enhancing dairy farmers’ awareness and practice of hygienic milking, regular screening for subclinical mastitis, dry cow therapy and culling of chronically infected cows.
Improving small ruminant productivity and livelihood through feed and health ...africa-rising
Poster prepared by Sadat Salifu, Augustine Ayantunde, Addah Weseh, Franklin Avornyo and Solomon Konlan for the Africa RISING Science for Impact Workshop, Dar es Salaam, 17-19 January 2017
Animal genetic resources for improved productivity under harsh environmenta...ILRI
Presented by Jan Philipsson, Emelie Zonabend, Erling Strandberg, James Audho, Julie Ojango and Okeyo Mwai at the Swedish University of Agricultural Sciences (SLU) Global Workshop, Uganda, December 2012
Uganda, December 2012
Similar to Improved dairy cattle for enhanced livelihoods and food and nutritional security in Senegal (20)
Small ruminant keepers’ knowledge, attitudes and practices towards peste des ...ILRI
Presentation by Guy Ilboudo, Abel Sènabgè Biguezoton, Cheick Abou Kounta Sidibé, Modou Moustapha Lo, Zoë Campbell and Michel Dione at the 6th Peste des Petits Ruminants Global Research and Expertise Networks (PPR-GREN) annual meeting, Bengaluru, India, 28–30 November 2023.
Small ruminant keepers’ knowledge, attitudes and practices towards peste des ...ILRI
Poster by Guy Ilboudo, Abel Sènabgè Biguezoton, Cheick Abou Kounta Sidibé, Modou Moustapha Lo, Zoë Campbell and Michel Dione presented at the 6th Peste des Petits Ruminants Global Research and Expertise Networks (PPR-GREN) annual meeting, Bengaluru, India, 29 November 2023.
A training, certification and marketing scheme for informal dairy vendors in ...ILRI
Presentation by Silvia Alonso, Jef L. Leroy, Emmanuel Muunda, Moira Donahue Angel, Emily Kilonzi, Giordano Palloni, Gideon Kiarie, Paula Dominguez-Salas and Delia Grace at the Micronutrient Forum 6th Global Conference, The Hague, Netherlands, 16 October 2023.
Milk safety and child nutrition impacts of the MoreMilk training, certificati...ILRI
Poster by Silvia Alonso, Emmanuel Muunda, Moira Donahue Angel, Emily Kilonzi, Giordano Palloni, Gideon Kiarie, Paula Dominguez-Salas, Delia Grace and Jef L. Leroy presented at the Micronutrient Forum 6th Global Conference, The Hague, Netherlands, 16 October 2023.
Food safety research in low- and middle-income countriesILRI
Presentation by Hung Nguyen-Viet at the first technical meeting to launch the Food Safety Working Group under the One Health Partnership framework, Hanoi, Vietnam, 28 September 2023
Presentation by Hung Nguyen-Viet at the first technical meeting to launch the Food Safety Working Group under the One Health Partnership framework, Hanoi, Vietnam, 28 September 2023
Reservoirs of pathogenic Leptospira species in UgandaILRI
Presentation by Lordrick Alinaitwe, Martin Wainaina, Salome Dürr, Clovice Kankya, Velma Kivali, James Bugeza, Martin Richter, Kristina Roesel, Annie Cook and Anne Mayer-Scholl at the University of Bern Graduate School for Cellular and Biomedical Sciences Symposium, Bern, Switzerland, 29 June 2023.
Assessing meat microbiological safety and associated handling practices in bu...ILRI
Presentation by Patricia Koech, Winnie Ogutu, Linnet Ochieng, Delia Grace, George Gitao, Lily Bebora, Max Korir, Florence Mutua and Arshnee Moodley at the 8th All Africa Conference on Animal Agriculture, Gaborone, Botswana, 26–29 September 2023.
Ecological factors associated with abundance and distribution of mosquito vec...ILRI
Poster by Max Korir, Joel Lutomiah and Bernard Bett presented the 8th All Africa Conference on Animal Agriculture, Gaborone, Botswana, 26–29 September 2023.
Practices and drivers of antibiotic use in Kenyan smallholder dairy farmsILRI
Poster by Lydiah Kisoo, Dishon M. Muloi, Walter Oguta, Daisy Ronoh, Lynn Kirwa, James Akoko, Eric Fèvre, Arshnee Moodley and Lillian Wambua presented at Tropentag 2023, Berlin, Germany, 20–22 September 2023.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Improved dairy cattle for enhanced livelihoods and food and nutritional security in Senegal
1. #
Key results
Cattle keeping, including for dairy, is an important
livelihood activity of the rural poor in Senegal.
There are large (up to eight-fold) differences in profit to
dairy cattle keeping households, depending on which
breed or crossbreed of cattle is kept, and the livestock
management practices utilized (Figure 1).
The highest household profit was obtained by keeping
crosses of traditional Indigenous Zebu with newly
introduced Bos Taurus, under good management
conditions. This increase in profit was largely driven by
higher milk-offtake.
Improved dairy cattle for enhanced
livelihoods and food and nutritional
security in Senegal
Karen Marshall1, Stanly Tebug1, Jarmo Juga2, Miika Tapio3, Ayao Missohou4
1The International Livestock Research Institute, 2Helsinki Univeristy, 3Natural Resources Institute Finland,
4Inter-State School of Veterinary Science and Medicine, The University of Dakar
End-users and impact
Improved livelihoods of the rural poor in Senegal, through the
adoption of more profitable dairy cattle breed-types.
Enhanced policy on dairy cattle genetic resource use,
including in relation to their public artificial insemination
program for dairy cattle implemented by the Senegalese
government.
Enhanced food and nutritional security to poor consumers in
Senegal, through the increased availability and
accessibility of milk and other dairy productis, should the
uptake of new dairy breed-types catalyse further
transformation of the dairy cattle value-chain.
Figure 1. Household profit associated with the keeping of
different breeds of cattle under different management levels#.
#For a simulated herd size of eight adult cows and a non-transhumant herd, and taking
into account all costs and benefits associated with the household dairy enterprise.
Significance of the research results
This is the first study comparing household profit of keeping
different breeds and crossbreeds of dairy cattle in West
Africa of which we are aware. It provides a significant
evidence base for livestock keepers, other value chain
actors, and policymakers to make better and more
informed decisions on dairy cattle genetic resource use.
0
100,000
200,000
300,000
400,000
500,000
Indigenous
Zebu
Indigenous
Zebu
Indigenous
Zebu by
Guzerat
Indigenous
Zebu by
Guzerat
Indigenous
Zebu by Bos
Taurus
Indigenous
Zebu by Bos
Taurus
High Bos
Taurus
Poorer
management
Better
management
Poorer
management
Better
management
Poorer
management
Better
management
Better
management
Profit(CFApercowperannum)
Breed / crossbreed and level of animal management
Requirements for dairy cattle keepers to engage in, and
optimally benefit from, this technology are:
the availability and accessibility of crossbred semen,
via the public and/ or private sectors;
access to credit to support initial investment;
capacity building on management of the crossbred
dairy cattle; and
strengthened access to inputs—particularly feed—and
markets.
As dairy cattle keeping households become more
commercially orientated (sell more milk), the control of
income from the sale of milk starts to shift from women
to men. Thus, as household dairy enterprises
commercialise, gender transformative approaches may
be required for eqitable benefit to all household
members.
This poster is licensed for use under the Creative Commons Attribution 4.0 International Licence. March 2016