1. The document discusses the anatomy and biomechanics of the foot, including the arches and their supporting structures.
2. It then focuses on flat foot, its types and causes, as well as posterior tibial tendon dysfunction which is a common cause of acquired flat foot in adults.
3. Treatment options for flat foot include conservative measures as well as various surgical procedures depending on the severity and underlying cause, such as arthrodesis and tendon transfers.
Patella dislocation is a common problem in the young. Recurrence of dislocation can be significant problem causing pain and discomfort. The assessment and guidelines towards non-surgical and surgical treatment options are discussed here.
Patella dislocation is a common problem in the young. Recurrence of dislocation can be significant problem causing pain and discomfort. The assessment and guidelines towards non-surgical and surgical treatment options are discussed here.
Posterolateral corner injuries of knee joint Samir Dwidmuthe
Missed posterolateral corner injuries of knee joint is a common cause for failure of ACL and PCL reconstruction only next to malpositioned tunnels.
Isolated PLC injuries are uncommon, making up <2% of all acute knee ligamentous injuries. Covey JBJS 2001
Incidence of PLC injuries associated with concomitant ACL and PCL disruptions are much more common (43% to 80%). Ranawat JAAOS 2008
A recent (MRI) analysis of surgical tibialplateau fractures demonstrated an incidence of PLC injuries in 68% of cases. Gardner JOT 2005
Take home message
PLC injuries to be ruled out in every case of ACL& PCL rupture.
Neurovascular integrity to be checked in every case.
Grade I & II can be managed conservatively.
Grade III Acute- Repair.
Grade III Chronic- Anatomic PLC recon.
Beware of varus knee alignment.
Posterolateral corner injuries of knee joint Samir Dwidmuthe
Missed posterolateral corner injuries of knee joint is a common cause for failure of ACL and PCL reconstruction only next to malpositioned tunnels.
Isolated PLC injuries are uncommon, making up <2% of all acute knee ligamentous injuries. Covey JBJS 2001
Incidence of PLC injuries associated with concomitant ACL and PCL disruptions are much more common (43% to 80%). Ranawat JAAOS 2008
A recent (MRI) analysis of surgical tibialplateau fractures demonstrated an incidence of PLC injuries in 68% of cases. Gardner JOT 2005
Take home message
PLC injuries to be ruled out in every case of ACL& PCL rupture.
Neurovascular integrity to be checked in every case.
Grade I & II can be managed conservatively.
Grade III Acute- Repair.
Grade III Chronic- Anatomic PLC recon.
Beware of varus knee alignment.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
1. FLAT FOOT- POSTERIOR
TIBIALIS TENDON
DYSFUNCTION- ACCESSORY
NAVICULARIS
RIZQI D ROSANDI
FK UNIVERSITAS BRAWIJAYA
APRIL 2020
Pengampu : dr. Ananto Satyo Pradana,
Sp. OT
3. • The foot is able to sustain large weight-bearing
stresses while accommodating to a variety of
surfaces and activities.
• The foot must be stable to provide an adequate
base of support and function as a rigid lever for
pushing-off when walking, running, or jumping.
• The foot must also be mobile to adapt to uneven
terrain, absorb shock as the foot hits the ground,
4.
5.
6. ARCHES OF THE FOOT
The arches of the foot, formed by the tarsal
and metatarsal bones, strengthened by
ligaments and tendons, allow the foot to
support the weight of the body in the erect
posture with the least weight.
7. USE OF THE ARCHED FOOT
Supports body weight in upright posture
Acts as a lever to propel the body forwards in walking,
running and jumping
Acts as a shock absorber
Concavity of the arches protects the soft tissues of the sole
against pressure
8. Medial longitudinal arch
• Higher than lateral
• Composed of – Calcaneous
- Talus
- Navicular
- 3 cuneiform
- 3 metatarsals
• Talar head is key stone of this arch
9. • Tibialis anterior attached to – 1st metatarsal,medial cuneiform –
strength for this arch.
• Peroneus longus tendon – pass laterally to this arch providing
support
10. Lateral longitudinal Arch
• Flatter than medial
longitudinal arch.
• Rests on the ground during
standing.
• It is made up of – calcaneous,
cuboid, 2 lateral metatarsals.
11. Transverse arch
• Runs from side to side
• It is formed by – cuboid,
cuneiforms, bases of
metatarsals
• Medial and lateral parts
of longitudinal arch act as
pillars
• Tendons of fibularis
longus and tibialis
posterior
13. Integrity of bony arches
• Maintained by passive factors and dynamic
supports
14. Passive factors• Shape of the united bones (bony
congruency)
• Four successive layers of fibrous
tissue – bowstring the longitudinal
arch
– Plantar aponeurosis
– Long plantar ligament
– Plantar calcaneocuboid (short
plantar) ligament
– Plantar calcaneonavicular
(spring) ligament
15. Dynamic supports
• Active bracing action of intrinsic muscles of foot
• Active and tonic contraction of muscles with long
tendons extending in to foot
– Flexor hallusis and digitorum longus – longitudinal arch
– Fibularis longus and tibialis posterior – transverse arch
• Plantar ligaments and plantar aponeurosis bear
greatest stress and important in maintaining arches
16. MECHANISM OF ARCH SUPPORT
SHAPE OF BONES
• Bones are wedge-shaped with the thin edge lying inferiorly
• This applies particularly to the bone occupying the center of
the arch“keystone”
24. Definition
• Absence of normal medial longitudinal arch
• Instep of the foot collapses and comes in
contact with the ground.
• In some individuals, this arch never develops
25. • Flat feet are a common condition.
• In infants and toddlers, the longitudinal arch is not developed
and flat feet are normal.
• The arch develops in childhood
• By adulthood (12-13yrs), most people have developed
normal arches
28. Types
• Flexible –on weight bearing it disappears and
on non weight bearing it reappears
• Rigid – acceptable medial longitudinal arch
does not seen even on non weight bearing
• Flexible, painless is most common
disappears Appears
29. Etiology
Flexible
Developmental – the most common
Hypermobile (ligamentous hyperlaxity; Ehlers-Donlos, Marfans)
Neurogenic (rare and usually cause the reverse-Pes Cavus)
Rigid
Congenital (Tarsal coalition,Vertical talus)
Aquired (inflammatory)
30. SYMPTOMS
• Deformity
• Foot pain ,ankle pain, leg pain
• Heel tilts away from the midline of the body more than
usual
• Abnormal shoe wear
31.
32. FLAT FEET CAN produce
• Tendonitis. posterior tibial tendon and it can either fail,
rupture, stretch or just hurt. This condition is called
POSTERIOR TIBIAL DYSFUNCTION (PTD OR TPD) .
• Arthritis.
• Plantar fasciitis
• Bunions & Hammertoes
• Corns and callosities
33. Radiography
• Asymptomatic flatfoot radiological evaluation unnecessary
• First Anteroposterior and lateral views of the foot should
be taken to evaluate severity of deformity
• Antero-posterior ankle to rule out valgus at the distal end of
tibia
• Special view - 45 degree eversion oblique for accessory
navicular bone
34. Radiography
• AP standing view is to asses heel valgus
, talocalcaneal (Kite’s) angle more than
35 degree is associated with incresed
heel valgus
• CT scan accurately defines anatomy
of subtalar joint , allows surgical
planning if it is involved.
35. Meary’s Angle
• Most common angle to indicate
flat foot
• Intersects at apex of the
deformity
• Meary’s angle - between long
axis of talus and long axis of
first metatarsal on a standing
lateral X ray
36. Normal Meary's angle:long axis
of the talus should bisect the
navicular and first metatarsal
0 degrees – normal
0 – 15 degrees – mild
15 – 40 degrees – moderate
> 40 degrees – severe
The long axis of the talus is angled plantarward in relation to
the first metatarsal, consistent with pes planus
38. Pedobarography
A record of pressure can be obtained
by making the patient to stand and
walk on a force plate.
Mainly used to compare pre & post
operative function
39. Treatment
0-3 years old:
No treatment unless very
strong family hx of
persistent flatfeet
Orthotic shoes with thomas
heels , medial heel wedges
and navicular pads
Convince the parents.
40. 3-9 years
• Conservative management
• No surgery
• Custom orthosis inserted
with leather ,cork, propylene
41. Exercise
Toe-walking and multiple toe-ups
If tendo-achilles is contracted, stretching it actively and passively is an
important form of management
Grasping marbles with toes Heel to toe walking
Playing in sand
Ballet dancing
Walking on a supination board
42.
43. 10-14 yrs
• No symptom- No treatment
• Symptomatic – conservative management
initially
• Surgical
44. Surgical treatment
Indications
1. Pain
2. Failure to respond to orthotic control
3. Ulceration or callus under the head of the plantiflexed
talus
4. Excessive shoe wear
45. Surgical treatment
• The surgeon , patient, and parents must be willing to
exchange loss of eversion and inversion of the foot
for relief of pain and disability .
46. Surgical treatment
• Arthrodesis for relieving painful flat foot have been
most successful when the subtalar joint is involved .
• Although midtarsal arthtrodesis without inclusion of
the subtalar joint has gained popularity
48. Durham Plasty for Pes Planus
A, Incision.
B, Elevation of posterior tibial
tendon.
C, Elevation of osteo-periosteal
flap from proximal to distal.
D, Arthrodesis of navicular–first
cuneiform joint.
E, Extent of arthrodesis resection
through midfoot.
F, Internal fixation of navicular–
first cuneiform joint.
49. •
pull the posterior tibial tendon taut
into its prepared bed on the plantar
surface of the waist of the
navicular, and tie the suture
dorsally
50. • Lengthening of lateral
column of the foot by
inserting a tibial bone graft
and calcaneocuboidal
fusion
Calcaneal osteotomy (Dilwyn- Evana, Mosca)
51. • Symptomatic patients with excessive heel valgus , a calcaneal osteotomy
is intended to displace the posterior part of the calcaneum medially , to
restore normal weight bearing alignment
Posterior calcaneal displacement osteotomy (koutsgiannis)
53. AGE
• Usually done after the age of 12
• Triple arthrodesis tend to have a high (50%) failure rate in
children under 10 years of age;
• contra-indicated in young children (less than 10-12 yrs)
because the procedure limits foot growth
58. Pathoanatomy
Foot deformity
pes planus
hindfoot valgus
forefoot varus
forefoot abduction
Early Disease Late Disease
• Early tenosynovitis PPTD
• leads to loss of medial longitudinal
arch dynamic stabilization
• PTTD attritional failure of static
hindfoot stabilizers & collapse of the
medial longitudinal arch
• Fixed degenerative joint changes occur
at late stages
61. Clinical Presentation
Symptoms
Physical Exam
• Medial ankle/ foot pain &
weakness
• Progressive loss of arch
• Lateral ankle pain
Inspection & Palpation:
• Pes planus
• Hindfoot valgus deformity
• Forefoot abduction
• Tenderness in tip of medial
Range of Motion:
• Single-limb heel rise
• PTT power
• Deformity – flexible or fixed
62. Imaging
Radiographs :
Ankle AP/ Lateral
Ankle Mortise
MRI :
Tendon degeneration and arthritic changes in the talonavicular, subtalar,
and tibiotalar joints
Ultrasound:
• increasing role in the evaluation of pathology within the PTT
71. Clinical presentation
• Often incidental, many patients are asymptomatic
• Pain
• Prominence of medial aspect of foot
• On attempted inversion of the foot against resistance
, Tibialis posterior tendon is inserted into the bump
and this maneuver produces pain
72. Radiography
• Special view - 45 degree eversion oblique for
accessory navicular bone
• Antero-Posterior view and Lateral weight bearing
views of the foot should be taken to evaluate other
deformities
73.
74. Radiological types
• TypeI– Small ossicle in the substance of Tibialis
Posterior tendon (os tibiale externum or naviculam
secondorium )
• Type II –Triangular frangment larger than type I connected
to navicular bone by a cartilaginous synchondrosis
• Type III – Cornuate navicular resulting from fusion of the
accessory navicular with main body of navicular
77. Kidners procedure• Excision of accessory
navicular bone and rerouting
of tibialis Posterior tendon
into a more plantar position
(navicular)
• Parents should be informed
before surgery that pain
may not be alleviated
completely