This document provides information about several mood disorders: major depressive disorder, persistent depressive disorder, bipolar disorder types I and II, disruptive mood dysregulation disorder, premenstrual dysphoric disorder, and cyclothymic disorder. For each disorder, the document outlines key criteria for diagnosis, prevalence statistics, potential causes, and common treatment options involving medication and therapy.
This slide contains information regarding mood disorder and depression. This can be helpful for proficiency level and bachelor level nursing students. Your feedback is highly appreciated.
Quick review of the essential points— DSM5 diagnosis criteria, assessments, treatments—of Alcohol Use disorder to better prepare for the National Clinical Mental Health Counseling Exam. This can be used like flashcards or as a presentation.
Depressive Disorders: An Overview of Full Spectrum. Dr. Ashok Kumar Batham.DrAshok Batham
Medical specialists outside the area of psychiatry and those who practice family medicine generally get fragmented information about mental depression. Therefore, an endeavour has been made to provide a complete overview of various depressive disorders, such as, Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD) or Dysthymia, Disruptive Mood Dysregulation Disorder (DMDD), Premenstrual Dysphoric Disorder (PMDD), Substance/Medication Induced Depressive Disorder, Depressive Disorder Due to Another Medical Condition, and other depressive disorders. DSM-5 diagnostic criteria of each of these disorders are given along with vignettes of diagnosis and treatment of the same are presented. Hopefully, this slide share will help non-psychiatrists to understand the complete spectrum of depressive disorders.
This slide contains information regarding mood disorder and depression. This can be helpful for proficiency level and bachelor level nursing students. Your feedback is highly appreciated.
Quick review of the essential points— DSM5 diagnosis criteria, assessments, treatments—of Alcohol Use disorder to better prepare for the National Clinical Mental Health Counseling Exam. This can be used like flashcards or as a presentation.
Depressive Disorders: An Overview of Full Spectrum. Dr. Ashok Kumar Batham.DrAshok Batham
Medical specialists outside the area of psychiatry and those who practice family medicine generally get fragmented information about mental depression. Therefore, an endeavour has been made to provide a complete overview of various depressive disorders, such as, Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD) or Dysthymia, Disruptive Mood Dysregulation Disorder (DMDD), Premenstrual Dysphoric Disorder (PMDD), Substance/Medication Induced Depressive Disorder, Depressive Disorder Due to Another Medical Condition, and other depressive disorders. DSM-5 diagnostic criteria of each of these disorders are given along with vignettes of diagnosis and treatment of the same are presented. Hopefully, this slide share will help non-psychiatrists to understand the complete spectrum of depressive disorders.
Suffering from Major Depressive DisorderRachelVira
This a project for a high school AP Psychology course. This is a fictionalized account of having a psychological ailment. For questions about this blog project or its content please email the teacher, Laura Astorian: laura.astorian@cobbk12.org
Quick review of the essential points— DSM5 diagnosis criteria, assessments, treatments—of these disorders to better prepare for the National Clinical Mental Health Counseling Exam. This was informed by several exam prep programs, and can be used like flashcards or as a presentation.
Case study CC26-year-old white female. Individual is AO x3.MaximaSheffield592
Case study
CC
26-year-old white female. Individual is A/O x3. Individual reports she was placed on medication during recent inpatient admission to psychiatric facility. Individual reports “it works a little too well. It makes me sleepy.” She reports originally going to the psychiatric facility because she could not sleep. Individual reports being diagnosed with Bipolar disorder. She reports losing 14 pounds within one week. Individual reports taking Gabapentin 600 mg in the morning, 600 mg at noon, and 1200 mg at night, and Abilify 5 mg at night. Individual complains of sleeping too much at night. Individual rates life 8/10 with 10 being total happiness. She denies S/I, H/I. individual reports that she has highs and lows. She reports she tried Lithium during inpatient admission “I had a really bad reaction. I had diarrhea.” DX; Bipolar I disorder (mixed); Mild depression. Plan; Gabapentin 600 mg tablet, 1.5 tablet nightly, Gabapentin 600 mg one tablet twice daily, Aripiprazole 5 mg one tablet nightly.
Mental function
PHQ-9 total core: 4, GAD-7 total score: 6
Vitals
Ht: 5’11”
Wt: 169 lbs
BMI: 23.57
Pain: 0/10
HPI
“Everything hit me like a freight train in January. I could not sleep.” Individual denies childhood trauma.
PMHx
Bipolar disorder
Hallucinations, delusions – Reports hallucinations and delusions when medications were adjusted.
Hyperlipidemia
PSHx
Comments: teeth pulled; cyst cut in back
FHx
Comments: Mother (living) Father (living), skin cancer (mets to brain)
Soc Hx
Alcohol: do not drink
Drug Abuse: No illicit drugs
Tobacco: Never smoker
Ob Preg Hx
Age of menses: 12
Allergies
No known medication allergies
ROS
Psychiatric: (+) change in mood, (-) depression, (-) sadness interfering with function, (+) anxiety, (+) nervousness, (-) sleep disturbance, (-) suicidal/homicidal ideations, (-) hopelessness, (+) worthlessness, (-) delusions, (-) hallucinations
Bipolar and Related Disorders
Bipolar and related disorders are separated from the depressive disorders in DSM-5 and placed between the chapters on schizophrenia spectrum and other psychotic disorders and depressive disorders in recognition of their place as a bridge between the two diagnostic classes in terms of symptomatology, family history, and genetics. The diagnoses included in this chapter are bipolar I disorder, bipolar II disorder, cyclothymic disorder, substance/medication-induced bipolar and related disorder, bipolar and related disorder due to another medical condition, other specified bipolar and related disorder, and unspecified bipolar and related disorder.
The bipolar I disorder criteria represent the modern understanding of the classic manic-depressive disorder or affective psychosis described in the nineteenth century, differing from that classic description only to the extent that neither psychosis nor the lifetime experience of a major depressive episode is a requirement. However, the vast majority of individuals whose symptoms meet the criteria for a ful ...
Presentation on Mood Disorders: Major Depressive Disorder, Bipolar I Disorder, etc.
Presentation for doctoral program class at Saybrook University, San Francisco. Fall 2009
This PPT discusses the Mood Disorders. The Major Depressive Disorder as well as Bipolar Disorder with it's types. It throws light on the treatment of the disorders as well. The medical conditions associated with these disorders are also discussed. Hope these slides will help you.
Cyclothymia and Substance/Medication-Induced Bipolar and Related DisorderNancy Dela Cruz
This presentation was used as a requirement for a course. This is about the type 3 of Bipolar Disorder which is Cyclothymia and the Substance/Medication-Induced Bipolar and Related Disorder. All information are from the DSM V.
Fear The emotional response to real or perceived imminent
threat
Anxiety A feeling of apprehension or fear. The source of this is not always known or recognized
Phobias
Fear about a specific object or situation that is out of proportion
Agoraphobia Condition in which the patient fears places from
which escape might be dificult
Diagnostic Criteria:
exposure to actual or threatened death, serious, or sexual violence in one( or more) of the following ways:
1) Directly experiencing the traumatic events.
2) Witnessing in person
3) Learning that the traumatic event occur to close family member or friend.
4) Experiencing repeated or extreme exposure to aversive details of the traumatic events.
A D D I C T I O N : A chronic, neurobiologic disease characterized by impaired control over drug use, compulsive use,
continued use despite harm, and cravings.
D E P E N D E N C E : A psychological craving for, habituation to, abuse of, or physiologic reliance on a chemical
substance .
T O L E R A N C E : A need for a markedly increased amounts of substance to achieve intoxication or desired effect. W I T H D R A W : Substance specific syndrome that occur after stopping or reducing the amount of substance over a
prolonged period of time
Jim Ellermeyer and the students do some role playing. Does this sound familiar? We look at how do we deal with our internal thoughts and day to day using DEER MAN skills.
Homework: Go to a good friend or partner. Ask what attracts them to you. Write those down to become your mantra every morning to get some positivity in your life!
Want an audio version? Subscribe to our Podcast on iTunes, Spreaker, or iHeartRadio!
Follow the Educational Grand Rounds Playlist on Youtube!
Follow us on Twitter, Facebook, or Google+ to get updated with the link when do occasional talks LIVE via Google Hangout OnAir!
The following is for educational purposes only. It is not intended as a substitute for medical or psychological advice, diagnosis, or treatment. The content should not be used for self-diagnosis, or treatment of any health-related condition. As always, seek the advice of your health care provider with any questions regarding a medical or mental health condition. Opinions expressed are the personal opinions and do not represent S’eclairer Behavioral Therapy.
Find out more at www.seclairer.com
Jim Ellermeyer and the students discuss how music and spirituality are connected as they are joined by Ruthann Valentine, and treated to a musical treat from James Buckley.
Want an audio version? Subscribe to our Podcast on iTunes, Spreaker, or iHeartRadio!
Follow the Educational Grand Rounds Playlist on Youtube!
Follow us on Twitter, Facebook, or Google+ to get updated with the link when do occasional talks LIVE via Google Hangout OnAir!
The following is for educational purposes only. It is not intended as a substitute for medical or psychological advice, diagnosis, or treatment. The content should not be used for self-diagnosis, or treatment of any health-related condition. As always, seek the advice of your health care provider with any questions regarding a medical or mental health condition. Opinions expressed are the personal opinions and do not represent S’eclairer Behavioral Therapy.
"Sleep Disorders: Sleeping Soundly for Restless Souls" Dr Azmat Qayyam S'eclairer
Find out more at www.seclairer.com
From Lifestyle Medicine Conference 2015. Watch all of the videos from this conference at: https://www.youtube.com/playlist?list=PLF24m4x5knUGADtwpzNPSfUz4QOf4J0Kr
From Lifestyle Medicine Conference 2015, May 2, 2015 in Blairesville, PA
Educational Grand Rounds: Reshaping the MindS'eclairer
This week, James Ellermeyer and the students talk about the neuroscience of learning new behaviors or rewriting your brain’s owner’s manual, including discussion about Neuroplasticity, the buddha mind, and more!
Find out more at www.seclairer.com
Want an audio version? Subscribe to our Podcast on iTunes, Spreaker, or iHeartRadio!
Follow the Educational Grand Rounds Playlist on Youtube!
Want to join us for the live discussion? Check out our Social Media in the noon hour every Monday as we sit down on Google Hangout OnAir! Follow us on Twitter, Facebook, or Google+ to get updated with the link when we start!
The following is for educational purposes only. It is not intended as a substitute for medical or psychological advice, diagnosis, or treatment. The content should not be used for self-diagnosis, or treatment of any health-related condition. As always, seek the advice of your health care provider with any questions regarding a medical or mental health condition. Opinions expressed are the personal opinions and do not represent S’eclairer Behavioral Therapy.
James Ellermeyer leads a discussion about our use of TIME. How do we interpret time? How do we perceive it? Why does it move so fast? Why do we need to take a moment away from running from the clock?
Want an audio version? Subscribe to our Podcast on iTunes, Spreaker, or iHeartRadio!
Follow the Educational Grand Rounds Playlist on Youtube!
Want to join us for the live discussion? Check out our Social Media in the noon hour every Monday as we sit down on Google Hangout OnAir! Follow us on Twitter, Facebook, or Google+ to get updated with the link when we start!
The following is for educational purposes only. It is not intended as a substitute for medical or psychological advice, diagnosis, or treatment. The content should not be used for self-diagnosis, or treatment of any health-related condition. As always, seek the advice of your health care provider with any questions regarding a medical or mental health condition. Opinions expressed are the personal opinions and do not represent S’eclairer Behavioral Therapy.
Jame Ellermeyer and the students discuss the science behind Mindfulness and Meditation as they perform a mindfulness exercise writing left handed, the results and why.
Want an audio version? Subscribe to our Podcast on iTunes, Spreaker, or iHeartRadio!
Follow the Educational Grand Rounds Playlist on Youtube!
Want to join us for the live discussion? Check out our Social Media in the noon hour every Monday as we sit down on Google Hangout OnAir! Follow us on Twitter, Facebook, or Google+ to get updated with the link when we start!
Educational Grand Rounds: Diabetes and Lifestyle ModificationS'eclairer
Dr. Zahida Chaudhary presents a slide deck on Diabetes along with James Ellermeyer as they discuss what our society is doing to contribute to the problem and what we can do to change it in our own lives on a case by case basis.
The Intersection of Science & Spirituality Lewis Mehl-Madrona, MD S'eclairer
Lewis Mehl-Madrona, MD, Ph.D.
Dr. Mehl-Madrona graduated from Stanford University
School of Medicine and trained in family medicine,
psychiatry, and clinical psychology. He has been on
the faculties of several medical schools, most recently as
associate professor of family medicine at the University of
Saskatchewan College of Medicine. He is working with
aboriginal communities to develop uniquely aboriginal
styles of healing and health care for use in those communities. He is
also currently working with Am’rita, Inc., to develop a program for
people with schizophrenia that involves healing through community.
The author of Coyote Medicine, Coyote Healing, and Coyote Wisdom,
a trilogy of books on what Native culture has to offer the modern
world, he is of Cherokee and Lakota heritage.
The Pursuit of Medicinal Plants, Sacred Seeds, and Modern Natural Medicines ...S'eclairer
Daniel T. Wagner, R.Ph., MBA, Pharm.D.
Dr. Dan Wagner, founder of NutriFarmacy in Wildwood, PA, a
Pharmacist who has traveled extensively to research plant medicines
in the rainforests of Belize, Costa Rica, Ecuador, Cuba and Western
Africa, and has incorporated his knowledge and experience into his
natural pharmacy practice.
Sleep Apnea: Do you Sleep Poorly and Experience Daytime Tiredness? Azmat Q...S'eclairer
Azmat Qayyum, MD
Assistant Professor, University of Pittsburgh, McKeesport Hospital;
Board Certified in Pulmonary Critical Care and Sleep Medicine;
Director Centerpointe Sleep Lab; Monroeville, PA
Understanding the Fundamentals of Brain Health and Chronic Diseases Safdar...S'eclairer
Safdar I. Chaudhary, MD
Medical Director S’eclairer; Clinical Assistant Professor, Chatham
University; Board Certified in Adult Psychiatry by American Board of
Psychiatry and Neurology
Dr. Zahida Chaudhary and James Ellermeyer talk about toxins in our environment, including what they do to our body. They also take a look specifically at DDT and the process of it getting into the public long before we could determine it’s negative effects.
Want an audio version? Subscribe to our Podcast on iTunes!
Follow the Educational Grand Rounds Playlist on Youtube!
Want to join us for the live discussion? Check out our Social Media in the noon hour every Monday as we sit down on Google Hangout OnAir! Follow us on Twitter, Facebook, or Google+ to get updated with the link when we start!
Restore Your Failing Vision Now with Dr. Dennis J. CourtneyS'eclairer
Dr. Courtney started his career as a high school teacher and his passion for learning motivated him to earn a medical degree in anesthesiology. After studying at West Penn Hospital, he founded his own practice and began incorporating alternative and complementary medicine in 1994, finding many of his patients with serious health problems were not interested in traditional medical approaches. Dr. Courtney and his patients eagerly pursue alternatives to traditional procedures not usually seen in orthodox western medicine. He is actively involved in physician organizations that promote integrated medicine such as the Executive Boards of both ACAM (American College for the Advancement of Medicine) and ICIM (The International College of Integrated Medicine). He is a respected authority on natural and integrative disciplines and is mentor to physicians and patients alike.
Working closely with Dr Edward Kondrot for over 10 years, Dr Courtney has founded the Pittsburgh Eye Protocol, an affiliate of the Healing Eye and Wellness Center located in Dade City Florida. Dr Kondrot is the world's leading homeopathic ophthalmologist, and is renowned for his 3-day Healing the Eye Treatment, which will be the topic of discussion for this Psychiatric Grand Rounds.
Dr. Courtney produces the radio show "AM-Impact On Your Health" 3 days a week on an all health talk radio station KHB 620. It is also available LIVE on the Internet Mon, Wed and Fri at 8:00am Eastern, on Dr. Courtney's YouTube Channel, where archives of over 10 years of past shows are available
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Feeling Moody? Is it just a bad mood or is it a disorder?
1. www.seclairer.com S’Eclairer 724-468-3999
Feeling Moody?
Is it just a bad mood or is it a disorder?
Mood Disorders
Major Depressive disorder
Persistent Depressive Mood
Disorder (Dysthymia)
Bipolar Disorder (I & II)
Disruptive Mood Dysregulation
Disorder
Cyclothymic Disorder
Major Depressive
Disorder
Prevalence: 7%; 18-29 years old; Female>Male
DDx: Manic episodes with irritable mood or mixed episodes, mood disorder
due to another medical condition, substance/medication-induced depressive
or bipolar disorder, ADHD, adjustment disorder with depressed mood,
sadness
Criteria:
Must have 5+ of the following symptoms during a 2W period:
At least 1 of the symptoms must be – 1) depressed mood or 2) loss of interest
or pleasure
A. Depressed mood most of the day, as indicated by either subjective
report or observation made by others
B. Markedly diminished interest or pleasure in activities
C. Significant weight loss when not dieting, weight gain, or decrease or
increase in appetite
D. Insomnia or hypersomnia
E. Psychomotor agitation or retardation
F. Fatigue or loss of energy
G. Feelings of worthlessness or excessive or inappropriate guilt
H. Diminished ability to think or concentrate, or indecisiveness
I. Recurrent thoughts of death (not just fear of dying), recurrent
suicidal ideation without a specific plan, or a suicide attempt or a
specific plan for committing suicide
Cause: Decreased serotonin, decreased dopamine, genetics
Treatment: Anti-depressant medications (SSRI, SNRI, NDRI, TCA,
MAOI) and therapy
Premenstrual Dysphoric Disorder
2. 2
2
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724-468-3999
Disruptive Mood Dysregulation Disorder
Prevalence: Male>Female, 2-5%
DDx: Bipolar disorder, oppositional defiant disorder, ADHA, MDD, anxiety disorders, Autism spectrum
disorder, intermittent explosive disorder
Criteria:
A. Severe recurrent temper outbursts (verbal or behavioral) that are out of proportion to the situation
B. Temper outbursts are inconsistent with developmental level
C. Occur 3 or more times a week
D. Mood between outbursts is irritable or angry most of the day almost everyday
E. Criteria 1-4 have persisted for 12 months or more and have not been absent for more than three
consecutive months
F. Outbursts are present in two or more settings
G. Diagnosis should not be made before age 6 or after 18
H. Onset of symptoms is usually before age 10
I. There has never been a distinct period lasting more than 1 day during which the full symptom
criteria except duration for a manic or hypomanic episode have been met
J. The behaviors do not occur exclusively during an episode of major depressive disorder
K. The symptoms are not attributable to the physiological effects of a substance or to another medical
or neurological condition
Persistent Depressive Mood
Disorder (Dysthymia)
Prevalence: 0.5-1.5%
DDx: Major depressive disorder, psychotic disorders,
depressive or bipolar and related disorder d/t another
medical condition, substance/medication-induced
depressive or bipolar disorder, personality disorders
Criteria:
A. Depressed mood for at least 2 yrs
B. The presence of 2+ or more of the following
symptoms:
1. Poor appetite or overeating
2. Insomnia or sleeping too much
3. Low energy or fatigue
4. Low self-esteem
5. Poor concentration or difficulty making
decisions
6. Feelings of hopelessness
Treatment: Anti-depressant medications (SSRI, SNRI,
NDRI, TCA, MAOI) and therapy
3. 3
3
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724-468-3999
Premenstrual Dysphoric
Disorder (PMDD)
Prevalence: 3-8% of women in the US
Causes: theories of imbalance between estrogen and
progesterone, serotonin imbalance during a normal cycle
DDx: anemia, anxiety disorder, bipolar disorder,
depression, dysthymic disorder, hyperprolactinemia,
hyperthyroidism, panic disorder, personality disorder,
somatoform disorders
Criteria:
A. At least 5 symptoms must be present in the final week before onset of
menses, start to improve within a few days after onset, and minimal or absent
in the week post menses
B. One or more of the following
1. Marked affective lability
2. Irritability, anger, or increased interpersonal conflicts
3. Depressed mood, feelings of hopelessness, or self-deprecating thoughts
4. Anxiety tension and or feeling on edge
C. One or more to reach five symptoms combined with criterion 2
1. Decreased interest in activity
2. Subjective difficulty concentration
3. Lethargy or lack of energy
4. Change in appetite (overeating or food cravings)
5. Hypersomnia or insomnia
6. Feeling overwhelmed or out of control
7. Physical symptoms like breast tenderness, joint pain, bloating, or weight gain
D. Symptoms interfere with daily life
E. Symptoms are not exacerbations of another disorder
F. Criterion 1 should be confirmed after 2 symptomatic cycles
G. Not attributed to substance use/ abuse or medical condition
Treatment: Cognitive behavioral therapy, buspirone
4. 4
4
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341 Story Rd Export, PA
724-468-3999
Bipolar Disorder (I & II)
Manic Episode:
A. A period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently
increased goal-directed activity or energy, lasting at least 1 week.
B. During the period of mood disturbance and increased energy or activity, 3+ of the following symptoms (4, if the
mood is only irritable) are present:
1. Inflated self-esteem or grandiosity.
2. Decreased need for sleep.
3. More talkative than usual or pressure to keep talking.
4. Flight of ideas or subjective experience that thoughts are racing.
5. Distractibility (attention easily drawn to unimportant or irrelevant external stimuli)
6. Increase in goal-directed activity (socially, at work or school, or sexually) or psychomotor agitation (i.e.,
purposeless non-goal-directed activity).
7. Excessive involvement in activities that have a high potential for painful consequences (e.g., engaging in
unrestrained buying sprees, sexual indiscretions, or foolish business investments).
C. The mood disturbance is sufficiently severe to cause impairment in social or occupational functioning or to
necessitate hospitalization to prevent harm to self or others, or there are psychotic features.
D. The episode is not attributable to the effects of a substance or to another medical condition.
Hypomanic Episode:
A. Same as A of Manic Episode
B. Same as B of Manic Episode
C. The episode is associated with an unequivocal change in functioning that is uncharacteristic of the individual when
not symptomatic.
D. The disturbance in mood and the change in functioning are observable by others.
E. The episode is not severe enough to cause marked impairment in social or occupational functioning or to necessitate
hospitalization. If there are psychotic features, the episode is, by definition, manic.
F. The episode is not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication, other
treatment).
Depressive Episode:
A. 5+ of the following symptoms have been present during the same 2-week period and represent a change from
previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
1. Depressed mood
2. Markedly diminished interest or pleasure in activities
3. Significant weight loss when not dieting or weight gain, decrease or increase in appetite
4. Insomnia or hypersomnia
5. Psychomotor agitation or retardation.
6. Fatigue or loss of energy
7. Feelings of worthlessness or excessive or inappropriate guilt
8. Diminished ability to think or concentrate, or indecisiveness.
9. Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a
suicide attempt or a specific plan for committing suicide.
B. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of
functioning.
C. The episode is not attributable to the physiological effects of a substance or another medical condition.
5. 5
5
www.seclairer.com S’Eclairer
341 Story Rd Export, PA
724-468-3999
Bipolar I
Prevalence: 0.6%, slightly more common in males
DDx: Major depessive disorder, other bipolar
disorders
Cause: Unknown, genetic component
Criteria:
A. Criteria have been met for at least one manic
episode
B. The occurrence of the manic and major
depressive episodes is not better explained by
another psychiatric disorder.
Bipolar II
Prevalence: 0.3-0.8%
DDx: Major depessive disorder, other bipolar
disorders, personality disorders, panic or other
anxiety disorder, cyclothymic disorder, substance-use
disorder, ADD/ADHD.
Cause: Unknown, genetic component
Criteria:
A. Criteria have been met for at least one
hypomanic episode & at least one major
depressive episode
B. There has never been a manic episode.
C. The occurrence of the hypomanic episode
and major depressive episode is not better
explained by another psychiatric disorder
D. The symptoms cause clinically significant
distress or impairment in social,
occupational, or other important areas of
functioning.
Treatment of Bipolar I & II:
• Mood stabilizer (Lithium)
• Anticonvulsant (valproic acid, depakote)
• Antipsychotics (Abilify, seroquel, zyprexa,
resperidol, etc…)
• Antidepressant (SSRI, SNRI,
Benzodiazepine)
Cyclothymic Disorder
Prevalence: 0.4-1%
DDx: seizures, substance-use, medication, other
mood disorders, personality disorders
Criteria:
A. Numerous periods of hypomanic as well
as depressive symptoms for at least 2Y (at
least 1Y for children and adolescent)
B. Individual has not been symptom free for
more than 2 months in these 2 Y.
C. Criteria for hypomanic, major depressive
or manic has never been met.
D. Symptoms cause clinically significant
distress or impairment in social,
occupational, or other important areas of
functioning.
E. Symptoms are not better explained by
other mental disorder such as
schizoaffective disorder, schizophrenia,
schizophreniform, delusional disorder and
other psychotic disorders.
F. Symptoms are not attributable to the
physiological effects of a substance-use or
another medical conditions (e.g.,
hyperthyroidism)
Treatment: Anti-psychotic drugs such as lithium,
carbamazepine, and valproic acid, psychotherapy.
Bipolar I & II