Major depressive disorder is a mood disorder characterized by persistent low moods and loss of interest in activities. Common symptoms include feelings of sadness, changes in appetite and sleep, low energy, and difficulty concentrating. Depression is caused by a combination of biological, genetic, and environmental factors. Treatments include antidepressant medication and psychotherapy. The document then provides a fictionalized account of a teenager's experience with depression including losing friends, headaches, quitting activities, thoughts of suicide, and treatment with therapy and medication.