This document discusses faciobrachial dystonic seizures (FBDS) as a prodrome of limbic encephalitis associated with antibodies against voltage-gated potassium channels. FBDS are brief, stereotyped seizures involving facial grimacing and arm posturing. They often precede cognitive impairment in limbic encephalitis. While EEG has a low yield, clinical identification of FBDS provides an opportunity for early immunotherapy to prevent sequelae. FBDS and associated limbic encephalitis are responsive to treatments like immunotherapy and steroids.
Metabolic encephalopathy diagnosis and managementRobert Robinson
Overview of the diagnosis and management of metabolic encephalopathy for third year medical students in the Personalized Education Program portion of the third year curriculum at SIU Medicine
For intraoperative monitoring, it is most
important to know how the various nuclei of the
ascending auditory pathways are connected and
how these nuclei together with the fiber tracts
that connect them produce electrical activity
when the ear is stimulated with transient sounds.
Please find the power point on Benign Paroxysmal Positional Vertigo (BPPV). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Metabolic encephalopathy diagnosis and managementRobert Robinson
Overview of the diagnosis and management of metabolic encephalopathy for third year medical students in the Personalized Education Program portion of the third year curriculum at SIU Medicine
For intraoperative monitoring, it is most
important to know how the various nuclei of the
ascending auditory pathways are connected and
how these nuclei together with the fiber tracts
that connect them produce electrical activity
when the ear is stimulated with transient sounds.
Please find the power point on Benign Paroxysmal Positional Vertigo (BPPV). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Vestibular function tests are essential tests in otorhinolaryngology examination, especially examination of ear.
This presentation explains about all the important vestibular function tests.
Generic Mestinon for Treatment of Myasthenia Gravis, Paralytic Ileus & Posto...The Swiss Pharmacy
Generic Mestinon (Distinon Tablets) is used to treat muscle weakness in people with myasthenia gravis, and to combat the effects of curariform drug toxicity. It is also used to treat
paralytic ileus, postoperative urinary retention and orthostatic hypotension.
This presentation looks at some of the common conditions that can present with hemiplegia. Stroke is the commonest, however, there are several other causes that need to be considered in a patient presenting with hemiplegia.
Vestibular function tests are essential tests in otorhinolaryngology examination, especially examination of ear.
This presentation explains about all the important vestibular function tests.
Generic Mestinon for Treatment of Myasthenia Gravis, Paralytic Ileus & Posto...The Swiss Pharmacy
Generic Mestinon (Distinon Tablets) is used to treat muscle weakness in people with myasthenia gravis, and to combat the effects of curariform drug toxicity. It is also used to treat
paralytic ileus, postoperative urinary retention and orthostatic hypotension.
This presentation looks at some of the common conditions that can present with hemiplegia. Stroke is the commonest, however, there are several other causes that need to be considered in a patient presenting with hemiplegia.
Dr. john millichap kcnq2 Cure summit professional track learn more at kcnq2cu...scottyandjim
Dr. John Millichap speaking at 2014 Denver KCNQ2 Cure summit professionals track at Children's Hospital of Colorado. More information at www.kcnq2cure.org
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
3. • 63 years old police officer presented with a history of four weeks of
brief episodes, each lasting for less than 10 seconds of jerking
movements of right hemi face and right arm occasionally precipitated
by startle.
• 48 years old lady right side facial twitching with associated short term
memory problems, low mood and vagueness of speech. The fingers of
the right hand is going in to spasms so that it mimic closed beak of a
bird. The frequency of these attacks were 7-8 per day. Rising
epigastric sensation followed by head go blank.
4. Faciobrachial dystonic seizures (FBDS)
• Adults ( Mean – 58 / youngest seen 28 years)
• Frequent (6 – 360/day)
• Brief (seconds)
• Dystonic (Ipsilateral face grimacing and arm posturing)
• Stereotyped
• Precede the cognitive impairment
5. Other features
• Alteration of awareness
• Vocalization
• Falls due to leg involvement
• Electric like epigastric sensation
• Piloerection and pupillary changes
• Stimulus sensitivity
6.
7.
8. • FBDS as a prodrome of Limbic encephalitis (LE) associated with
antibodies (Abs) to the voltage-gated potassium channels (VGKCs)
• VGKC complex antibodies such as
- leucine-rich glioma inactivated-1 (Lgi1)3,4
- contactin-associated protein 2 (Caspr2),3
9.
10. FBDS features in the study group
• N = 29 – 26 developed LE
- 3 no LE
• Median age – 64 (36 – 83)
• M:F – 19:10
• Seizure frequency – 50 (6- 360) per day
• Seizure triggers – Auditory – 8
- Emotion – 6
11. FBDS as a Clinically Identifiable Prodrome
to Limbic Encephalitis
• Twenty of the other 26 (77%) patients with LE developed FBDS before
the onset of amnesia and confusion, with a median lag of 36 days
• Three patients (10%) never experienced LE.
• There were no clinically identifiable triggers for the apparent switch
from a period of FBDS alone to the development of (often dense)
amnesia
• The majority of patients had FBDS that increased in frequency until
they reached a maximum at around the time of onset of LE
12. • The LE was similar to that described previously, with
amnesia (100%)
confusion (88%)
hallucinations (35%)
sleep disturbances (31%), including REM behavior disorder, hypersomnolence, and insomnia
• During the period of LE 70% patients also developed other nondystonic seizure types, including
- generalized tonic-clonic seizures
- typical complex partial medial temporal lobe seizures
- simple partial seizures with piloerection
13. Investigations During FBDS with out cognitive impairment
• MRI – normal 9/9 (100%)
• Serum sodium – normal 13/13 (100%)
• Positive VGKC ab for LGi1 (3/4)
• EEG demonstrated ictal epileptiform abnormalities in 24%
- temporal
- frontal
- fronto-temporal
14.
15. Investigations during and after LE
• VGKC-complex Abs
- Lgi1antibody positive – 88%
- (12% also had Caspr2 antibodies)
- No VGKC-complex–specific target determined – 12%
• Serum sodium <135mmol - 88%
16. EEG during LE
• Interictal EEG abnormalities (65%) included
- diffuse mild slowing
- bilateral frontotemporal slowing
- temporal sharp waves
• No EEG abnormalities in 35% of patients
17. Imaging
• Normal brain MRI - (46%)
• Bilateral and unilateral medial temporal lobe high T2 signal changes
(50%) and caudate/putamen (4%)
• PET showed altered glucose metabolism in the temporal region and
basal ganglia
• SPECT showed hypometabolic and hyperperfusion in the temporal
lobe
18. Typical medial temporal lobe high signal
from magnetic resonance imaging (MRI) is
shown during periods of amnesia
19. PET and SPECT images in 7 patients showed
basal ganglia and temporal lobe
abnormalities, which included
(E) temporal lobe PET bilateral
hypermetabolism
(F) right hypometabolism
(G) SPECT left hypoperfusion
Three examples of metabolic changes within
the basal ganglia are shown in H and I
(bilateral hypermetabolism) and J (left
hypermetabolism)
20. Response to Treatments
• AED effect on FBDS frequency was generally poor, and only 14%
showed a good (20–50%) or excellent (>50%) reduction in FBDS
frequency within 1 month of treatment
• FBDS response to immunotherapy was excellent
- Iv Ig
- PE
- Steroids (IV/oral)
- Rituximab
21.
22. • There was an excellent correlation between seizure reduction and fall
in VGKC-complex Abs
• Relapses are not common in VGKC-complex Ab-associated LE.
However, 15% of these patients relapsed after weaning prednisolone
from 50 to 60mg down to 30mg over 3 months or after IvIg only.
• The FBDS were highly responsive to reinstitution of prednisolone
23. Follow up
• No patient has developed a tumor after a median follow-up of 2.75
years (range, 0.5–8 years)
24.
25.
26. • JAMA Neurol. 2014 Jan;71(1):79-82. doi:
10.1001/jamaneurol.2013.5179.
• Limbic encephalitis associated with anti-voltage-gated potassium
channel complex antibodies mimicking Creutzfeldt-Jakob disease.
• 58-year-old man who had a rapid onset of progressive confusion,
twitching of the face and hand, and abnormal basal ganglia detected
by magnetic resonance imaging. His conditions were initially
diagnosed as Creutzfeldt-Jakob disease (CJD). Faciobrachial dystonic
seizures, possibly pathognomonic for the VGKCC syndrome, had been
misdiagnosed as myoclonus. Treatment led to a complete resolution
of his symptoms.
27. • Arch Neurol. 2008 Oct; 65(10): 1341–1346.
• Voltage-Gated Potassium Channel Autoimmunity Mimicking
Creutzfeldt-Jakob Disease
• Clinical, radiologic, electrophysiologic, and laboratory findings in VGKC
autoantibody–associated encephalopathy may be confused with
those of CJD. Serologic evaluation for markers of neurologic
autoimmunity, including VGKC autoantibodies, may be warranted in
suspected CJD cases.
28. Summary
• FBDS as a prodrome of Limbic encephalitis (LE) associated with
antibodies (Abs) to the voltage-gated potassium channels (VGKCs)
• Clinical identification is very important as the yield of intraictal EEG is
only 24%
• Gives a therapeutic window for immunotherapy which will prevent
sequelae (cognitive impairment and cerebral atrophy)
• Well-established immunotherapy-responsive condition
• Usually without an associated tumor