Guillain-Barre Syndrome is an acute immune-mediated inflammatory disorder of the peripheral nervous system. It was first described in 1859 and 1916. Clinical features include progressive weakness starting in the legs in most cases and sometimes the arms or face. Facial weakness and respiratory impairment occur in about half of patients. Electrophysiological tests are important for diagnosis and show features like conduction block, slowed conduction velocities and prolonged latencies. Prognostic factors include age, preceding gastroenteritis, disability level at nadir, and evidence of axonal damage on electrophysiology. Most patients recover fully but some have residual deficits.
This ppt describes various movement disorders found commonly in elderly persons. It also describes hyper and hypokinetic disorder categorization with cause and pathophysiology of movement disorders.
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This ppt describes various movement disorders found commonly in elderly persons. It also describes hyper and hypokinetic disorder categorization with cause and pathophysiology of movement disorders.
Cobouw special juridisch - Beheersen van wijzigingen tijdens het bouwprocesEwout de Graaf
Artikel van Hugo-Frans Bol (directeur Driver Trett Nederland) over het omgaan met en beheersen van wijzigingen die tijdens het bouwproces kunnen ontstaan (en die vaak tot bouwgeschillen leiden).
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Pediatrics notes about "Acute flaccid paralysis". These notes were published in 2018.
You can download them from
- Telegram: https://t.me/pediatric_notes_2018
- Mediafire: http://www.mediafire.com/folder/u5u60m184t9z7/Pediatric_Notes_2018
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-All the information present from reliable sources(Text books and articles).
Done by: Abdulelah Alshammri, second year dental student.
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Bio-prospecting tools for drug discovery,
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Reverse Pharmacology.
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The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
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The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
2. • 1859, Landry published a report on 10
patients with an ascending paralysis.
• 1916, 3 French physicians (Guillain, Barré, and
Strohl) described 2 French soldiers with
-motor weakness
-areflexia
-albuminocytological dissociation
3. Clinical features
• Weakness usually starts in the legs
• In about 10 percent it begins in the arms or facial muscles
• Need for ventilatory support develops in 10 to 30 percent
• Facial weakness occurs in more than 50 percent
• Oropharyngeal weakness eventually occurs in 50 percent
• Oculomotor weakness occurs in about 15 percent
• Paresthesias in the hands and feet accompany the
weakness in more than 80 percent of patients, but sensory
abnormalities on examination are frequently mild.
• Pain, typically located in the back and extremities, can be a
presenting feature in 66 % of patients with all forms of GBS
4.
5.
6. • AIDP and the Miller Fisher -focal inflammatory
response develops against Schwann cells or
peripheral myelin.
• Infiltration of the epineural and endoneural
small vessels (mostly veins) by lymphocytes
and monocytes causes segmental myelin
degeneration throughout the nerve.
• The inflammation is more intense at the
junction of the dorsal and ventral roots.
13. Electrophysiological tests
• The most specific and sensitive tests for diagnosis of
the disease
Partial motor conduction block
Slowed nerve conduction velocities
Abnormal temporal dispersion
Prolonged distal latencies
14.
15. H-reflex
• H-reflex was the single most sensitive test for early GBS,
being absent in 97 percent tested within seven days of the
onset of neurologic symptoms.
• Monosynaptic reflex response - similar in pathway to the
tendon jerk.
• The electrical stimulus activates the Ia afferents and action
potentials travel orthodromically to the spinal cord.
• Ia afferents make excitatory monosynaptic connections to
the alpha motor neurons and a volley of action potentials is
set up in the motor nerve that runs orthodromically the
entire length of the nerve from the cell bodies to the
muscle.
16. F-response
• Recurrent firing of an anterior horn cell after it
has been invaded by an antidromic action
potential.
• To produce an F-response, an action potential
must travel twice through the proximal
segment of the motor nerve.
20. The prognosis and main prognostic indicators of Guillain-Barré
syndrome A multicentre prospective study of 297 patients(Italy)
• The chance of recovery was significantly
affected by- age
- antecedent gastroenteritis
- disability
- electrophysiology of axonopathy
- latency to nadir
- duration of active disease.
21. prognosis
• Muscle Nerve. 2006 Jun;33(6):766-70Nagasawa K, Kuwabara S,
Misawa S, Fujii K, Tanabe Y, Yuki N, Hattori T, Kohno Y.
• 31 Japanese GBS -AIDP (35%)
- AMAN (48%)
-unclassified (16%).
• By 6 months after onset, all the AIDP and 80% of the AMAN
children had regained the ability to walk.
• By 2 years, all but one of the AMAN children could walk.
• In Japanese childhood GBS, the proportion of AIDP and AMAN
appears to be similar.
• Recovery is generally favorable in both subtypes, but some of the
AMAN children experienced delayed recovery.
22. • Pediatr Neurol. 2003 Apr;28(4):295-9.(Turkey)
• Retrospective study of 23- AIDP- 44%
-AMAN- 35%
- AMSAN- 21%
• In the acute phase AMAN >AIDP (measured by GBS
scores)
• No significant difference at 6 months in GBS scores
between AIDP and axonal forms of GBS.
• After IV IG therapy, children with axonal forms recover
more slowly than those AIDP, but outcome at 12
months appears to be equally favorable in two groups.
23. McKhann GM, Griffin JW, Cornblath DR, et al
(1988)
• 245 patients
• In the multivariate analysis, four factors correlate with
poorer outcomes:
• Mean amplitude of compound muscle action potential
on stimulating distally of 20% of normal or less.
• Older age.
• Time from onset of disease of 7 days or less
• Need for ventilatory support.
• The most powerful predictor of outcome was the
abnormal mean amplitude of compound muscle action
potential on stimulating distally.
24. Rees JH, Soudain SE, Gregson NA, Hughes RA. Campylobacter jejuni
infection and Guillain-Barré syndrome. N Engl J Med 1995; 333:1374
• 96 patients with GBS and 7 patients with MFS
• Infection with C. jejuni often precedes the
Guillain-Barré syndrome and is associated
with axonal degeneration, slow recovery, and
severe residual disability.
25. Practice points
• Diagnostic criteria for the diagnosis of GBS include progressive paralysis of
more than one limb , areflexia and disease progression over less than four
weeks.
• Patients should be monitored for deteriorating bulbar function, vital
capacity, and for cardiac arrhythmia.
• A raised cerebrospinal fluid white cell count should alert the clinician to
alternative diagnoses.
• Neurophysiology is helpful to subclassify disease and predict the outcome.
• Trials of treatment show plasma exchange and IVIg to be equally effective
when given to non-ambulant patients in the first two weeks of disease.
• There is no evidence supporting the use of corticosteroids in the
treatment of GBS.
• The Miller Fisher variant of GBS is strongly associated with the presence of
anti-GQ1b antibodies, which are likely to be pathogenic.
• About 25% of patients with the commonest type of GBS in the UK–AIDP–
possess antiganglioside antibodies.
Editor's Notes
(A) Normal ulnar nerve F-wave, normal range latency (F-lat) <32 msec. (B) Abnormal ulnar nerve F-wave in Guillain-Barré syndrome: F-waves present but latency delayed at 140% upper limit of normal (courtesy of Dr David Allen, The National Hospital for Neurology and Neurosurgery, London, UK).