This document discusses a case of a 45-year-old female bank officer presenting with weakness and clumsiness in her right hand over the past 3-4 weeks. On examination, she showed wasting of the thenar muscle and weakness of thumb and finger movements. Nerve conduction studies showed reduced motor responses in the median and ulnar nerves without slowing. Electromyography revealed generalized reduction of motor units. The patient was diagnosed with amyotrophic lateral sclerosis based on meeting diagnostic criteria. The document then provides background information on ALS and discusses differential diagnoses considered for the patient's symptoms.