Extrapyramidal Symptoms
Dr. Aziz Mohammad
FCPS (Psychiatry)
Asstt; Professor of Psychiatry
KMC/KTH
Learning Objectives
 Know About:
 the Pyramidal and Extrapyramidal Systems of Brain
 Anatomy of the Basal Ganglia
 A case scenario of Extrapyramidal Side Effect of an
apparently safe medication.
 Different Extrapyramidal Symptoms and their
Treatments.
Credit: Extrapyramidal and Pyramidal Tracts - Descending Tracts of the Spinal Cord | (Includes
Lesions)
Uploaded to YouTube by: Rhesus Medicine, Feb 1, 2021
Basal Ganglia Anatomy
ANATOMY
 Caudate nucleus
 Putamen
 Globus pallidus
 Substantia nigra
 Subthalamic nucleus
 Thalamus
Basal Ganglia
The “basal ganglia” refers to a group of
subcortical nuclei responsible primarily for
motor control, as well as other roles such as
 Motor learning,
 Executive functions
 Behaviors, and
 Emotions
Disruption of the basal ganglia network forms the
basis for several psychiatric and movement
disorders.
Case Scenario
 A 16 years old boy is brought by his worried
parents at mid night to the casualty department
with twisting of his neck to one side for the past
30 minutes. His father reports intake of some
syrup for nausea & vomiting advised by a
general practitioner in the morning.
 What is this condition called and which
medication is responsible for it?
 How will you treat this case?
Dopaminergic Pathways
By User:Slashme; Patrick J. Lynch; User:Fvasconcellos - self-made; re-use File:Brain bulbar region.svg,
CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=44402772
Dopaminergic Pathways
Acute Dystonia
Causes of Acute Dystonia
Treatment of Acute Dystonia
 Inj: Procyclidine 10 mg IM stat
Treatment of Acute Dystonia
 Inj: Benztropine mg IM stat
Parkinsonism
Switch to Atypical Antipsychotics
Treatment of Parkinsonism
 Tab: Procyclidine 5mg
Neuroleptic Malignant Syndrome
Medications associated with
NMS
Complications of NMS
Management of NMS
Tardive Dyskinesia (TD)
Tardive Dyskinesia (Cont..)
The End

Extrapyramidal symptoms

Editor's Notes

  • #8 The “basal ganglia” refers to a group of subcortical nuclei within the brain responsible primarily for motor control, as well as other roles such as motor learning, executive functions, emotional behaviours, and play an important role in reward and reinforcement, addictive behaviours and habit formation.
  • #9 Motor Control is defined as the process of initiating, directing, and grading purposeful voluntary movement. Executive functions are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals. Behaviour is the way in which one acts or conducts oneself, especially towards others. Emotions: a conscious mental reaction (such as anger or fear) subjectively experienced as strong feeling usually directed toward a specific object and typically accompanied by physiological and behavioral changes in the body
  • #17 Schizophrenia Parkinson's disease, attention deficit hyperactivity disorder (ADHD), substance abuse disorder (addiction), and restless legs syndrome (RLS) can be attributed to dysfunction in specific dopaminergic pathways.