Extinction refers to the dimming of light when viewed through a mineral under cross-polarized light in a petrographic microscope. There are four main types of extinction: parallel extinction occurs when the mineral's long axis or cleavage plane is parallel to the vibration direction of light; inclined extinction occurs when these are not parallel in monoclinic and triclinic minerals; symmetrical extinction occurs when the vibration direction bisects two cleavage planes; and some minerals lack distinct cleavage planes and therefore have no measurable extinction angle. The extinction angle is the amount of rotation required for a mineral to become extinct and is a diagnostic characteristic.
Historical geology Is the branch which deals with the history of the rocks of the earth’s crust with special emphasis on their approximate time of formation and the climate changes they have undergone since their formation.
ELEMENTS OF CORRELATION, STRUCTURAL FEATURES, METHOD OF STRATIGRAPHIC CORRELATION ,
Three principle kinds of correlations
Hi I'm Misson Choudhury , A Post Graduate student, Graduated from Utkal university and Now pursuing my m.sc in applied geology at Bangalore university, Bangalore, i love geological mapping,drawing,hill climbing and tracking..
The current ppt discusses the different types of lineations formed due to deformation.
Lineations are genetically related to the foliation planes on which they occur, particularly where both are shaped by mineral orientations. Therefore, the planar and linear fabrics are both together aspects of the same three-dimensional geometry, which is related to the shape of the finite strain ellipsoid or,
more important still, to the history of incremental strains.
Historical geology Is the branch which deals with the history of the rocks of the earth’s crust with special emphasis on their approximate time of formation and the climate changes they have undergone since their formation.
ELEMENTS OF CORRELATION, STRUCTURAL FEATURES, METHOD OF STRATIGRAPHIC CORRELATION ,
Three principle kinds of correlations
Hi I'm Misson Choudhury , A Post Graduate student, Graduated from Utkal university and Now pursuing my m.sc in applied geology at Bangalore university, Bangalore, i love geological mapping,drawing,hill climbing and tracking..
The current ppt discusses the different types of lineations formed due to deformation.
Lineations are genetically related to the foliation planes on which they occur, particularly where both are shaped by mineral orientations. Therefore, the planar and linear fabrics are both together aspects of the same three-dimensional geometry, which is related to the shape of the finite strain ellipsoid or,
more important still, to the history of incremental strains.
POLARIZATION - BIREFRINGENCE AND HUYGEN'S THEORY OF DOUBLE REFRACTION Anuroop Ashok
SIMPLE AND ACCESSIBLE SLIDES ON POLARIZATION. IT INCLUDES SLIDES ON DOUBLE REFRACTION , CALCITE CRYSTALS, HUYGEN'S THEORY , NEGATIVE AND POSITIVE CRYSTALS,...
This presentation covers topics related to polarization of light, methods of producing polarised light, optical activity, birefringence etc.
This would help for quick revision of the topics.
An Introduction to Crystallography, Elements of crystals crystal systems: Cubic (Isometric) System,Tetragonal System, Orthorhombic System, Hexagonal System; Trigonal System, Monoclinic System, Triclinic System
1_ Introduction to Optical Mineralogy, Light & Theories-converted.pdfAdnanKhan153072
introduction to optical minerology and description about optical properties of mineral and importance and uses of optical minerology and how to identify a mineral through its optical properties.
WHAT IS AN EARTHQUAKE?
Where Do Earthquakes Happen?
Why Do Earthquakes Happen?
How Are Earthquakes Studied?
How To Locate The Earthquake's Epicenter?
SCALES FOR EARTHQUAKE MEASUREMENT
What Are Earthquake Hazards?
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. INTRODUCTION : EXTINCTION
• When cross polarized light dims as viewed through a thin section of
a mineral with a petrographic microscope, that phenomena is
called “extinction.”
• Isotropic minerals and substances (like glass) are completely extinct under
cross polars.
• Anisotropic minerals specifically will show one extinction for each 90 degrees
of stage rotation.
3. EXTINCTION ANGLE
• The angle between the length or a prominent cleavage in a mineral and a vibration
direction is a diagnostic property called the extinction angle. Or the angle through
which a crystal is revolved from a definite line (such as that of the
crystallographic axis) to the plane of maximum extinction.
• To determine the extinction angle Rotate the stage of the microscope until the length or
cleavage of the mineral is aligned with the north-south cross hair.
• The extinction angle is the measure between the cleavage direction or habit of
a mineral and the extinction.
4. TYPES OF EXTINCTION
Four major types of extinction are:
1. Parallel Extinction
2. Inclined Extinction
3. Symmetrical Extinction
4. No Extinction Angle
5.
6. 1. PARALLEL EXTINCTION
• Extinction is said to be parallel if the long direction of the crystal or a prominent
cleavage plane is oriented N-S or E-W when the mineral goes extinct.
• 90 degrees would be considered zero degrees, and is known as parallel extinction.
• Only occurs in minerals where the crystallographic axes are at 90 degrees to one
another (Hexagonal, Tetragonal, and Orthorhombic).
• Either the slow ray or fast ray vibration direction is parallel to the trace of cleavage or
length of the mineral.
7. 2. INCLINED EXTINCTION
• It occurs when the elongate direction of the mineral or the direction of
cleavage is NOT E-W or N-S when the mineral goes extinct.
• This type of extinction occurs in minerals where all of the crystallographic
axes are not perpendicular (Monoclinic and Triclinic).
• The extinction angle will be greater than 0°. Neither vibration direction is
aligned parallel to the trace of the cleavage of the length of the mineral.
8. 3. SYMMETRICAL EXTINCTION
• The phenomenon which occurs when the vibration direction of the
light bisects the angles between two sets of cleavages (as seen in
basal sections of pyroxenes and amphiboles).
• Symmetrical extinction may be observed in minerals that display either two
cleavages or two distinct crystal faces.
9. 4. NO EXTINCTION ANGLE
• Many minerals lack distinct cleavages or do not display an elongation or crystal
faces. Although they go extinct once every 90° of stage rotation, there is no
cleavage, elongation or crystal face from which to measure an extinction angle. In
these situations we say that the mineral has no extinction angle.