Europe has diverse geography due to its location between Asia and Africa. It contains many peninsulas and mountain ranges that divide the continent. The Alps and Pyrenees form natural borders, while rivers like the Danube flow through multiple countries. Europe's climate varies significantly from polar in the north to Mediterranean in the south. Overall, Europe's unique geography and location have shaped its development over the past 200 million years.
Welcome to the land of colorful customes- the Deccan Plateau of India; this presentation serves to give you a kaleidoscopic pleasure trove for the discerning visitors.
Europe introduction, Europe general geography,.... Europe main Rivers....Western uplands, Eastern Uplands.. main geographic divisions of Europe... Natural vegetation and Animal life of europe
Welcome to the land of colorful customes- the Deccan Plateau of India; this presentation serves to give you a kaleidoscopic pleasure trove for the discerning visitors.
Europe introduction, Europe general geography,.... Europe main Rivers....Western uplands, Eastern Uplands.. main geographic divisions of Europe... Natural vegetation and Animal life of europe
South America is a continent of Extremes from the largest forest to the driest place on Earth:
It is home to the World’s largest river, the Amazon River.
It is Home to the World’s driest place, The Atacama Desert.
It is home to the largest Oxygen producer, The Amazon Rainforest.
Vampire Bats dwell in the rainforest and can spread the rabies virus.
Brazil is the largest country in South America, covering approx. 47.3% of the continent's land area and encompassing around half of the continent's population.
South America is a continent of Extremes from the largest forest to the driest place on Earth:
It is home to the World’s largest river, the Amazon River.
It is Home to the World’s driest place, The Atacama Desert.
It is home to the largest Oxygen producer, The Amazon Rainforest.
Vampire Bats dwell in the rainforest and can spread the rabies virus.
Brazil is the largest country in South America, covering approx. 47.3% of the continent's land area and encompassing around half of the continent's population.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. • Approximately 200 million years ago, there was only
one continent, Pangea.
• It was in the Southern Hemisphere.
• It eventually separated into the continents we know
today .
3. List of continents by population
The following table summarizes area and
population of each continent by decreasing area.
AREA AND POPULATION OF THE CONTINENTS
CONTINENT AREA (KM2) POPULATION
Asia 43,820,000
4,164,252,000
Africa 30,370,000 1,022,234,000
America 42,330,000 934,611,000
Antarctica 13,720,000 4,490
Europe 10,180,000 738,199,000
Australia 9,008,500 29,127,000
4. Europe
• Europe is the second smallest of the continents.
• It has the third highest population.
• It has a population of more than 730 million
which represents about 11 per cent of the world
population.
• Nowadays, there are approximately 50
countries.
8. Landforms of Europe
• Europe has unique geography and weather
patterns so the landscape, waterways and
climate vary greatly.
• Europe is called a “peninsula of peninsulas”.
as it is a large peninsula of Asia.
• The landforms also include islands, plains
and mountain ranges.
9. There are six major peninsulas in Europe:
• Northern peninsulas: Jutland peninsula
and Scandinavian peninsula.
• Southern peninsulas: Italian peninsula,
Iberian peninsula , Balkan peninsula
and Crimean peninsula.
10.
11.
12. Which countries are covered by the
different peninsulas?
SCANDINAVIAN
PENINSULA
Norway and Sweden.
JUTLAND
PENINSULA
Denmark and the northern portion of Germany.
ITALIAN
PENINSULA
Italy, San Marino and the Vatican City.
IBERIAN
PENINSULA
Spain, Portugal, and Andorra.
BALKAN
PENINSULA
Albania, Bosnia and Herzegovina, Bulgaria
Croatia, Greece, Macedonia, Montenegro
Romania, Serbia, Kosovo, Italy*, Slovenia, Turkey
CRIMEAN
PENINSULA
Nowadays the sovereignty over the peninsula
is currently disputed between Ukraine and
the Russian Federation.
14. • North and east of the continent: plains and
large areas of lowlands.
• South: we find here many different
mountains.
• The most important mountain chains are:
The Scandinavian Mountains, Ural
Mountains, Pennines, Alpes, Carpathian
Mountains, Transylvanian Alps ,Massif
Central,Pyrenees, Apennines, Dinaric Alps,
Balkan Mountains, Caucasus Mountains and
The Meseta Plateau.
15. The Alps
• The Alps are the highest and most extensive mountain
range system in Europe, stretching approximately 1,200
kilometres across eight countries:
• Austria, France, Germany, Italy,
Liechtenstein, Monaco, Slovenia, and Switzerland.
• Cuts Italy off from the rest of Europe.
Mont Blanc is the highest peak.
16. Pyrenees
• It forms a natural border between France
and Spain and separates the Iberian
Peninsula from the rest of continental
Europe. It extends for about 500 km.
• Aneto is the highest peak.
17. The Apennine Mountains
They are a mountain range consisting of
parallel smaller chains extending 1,200 km.
They divide the Italian peninsula between
east and west.
Corno Grande is the highest point.
18. The Balkan Mountains
• These mountains stretch from the east
of Serbia to the Black Sea at the east
of Bulgaria.
• They extend for about 530 km .
• The highest peak is Botev.
19. The Caucasus Mountains
• They are a mountain system in Eurasia between
the Black Sea and the Caspian Sea
• They form a natural barrier between Europe and
Asia to the south.
• They contain Europe's highest mountain, Mount
Elbrus, 5,642 metres.
20. Ural Mountains ( or the Urals)
• The mountain range forms part of the
conventional boundary between the continents
of Europe and Asia.
• They extend about 2,500 km and cover Russia
and Kazakhstan.
• Mount Narodnaya is the highest point.
22. • There are many rivers in Europe and their
characteristics vary according to the ocean
or sea they flow into.
• Rivers that flow into the Artic Ocean are
long with regular course and in winter they
are frozen.
• Rivers that flow into the Atlantic Ocean
are short with high volume of water.( The
Seine and theThames).
23. • Rivers that flow into the Mediterranean
Sea: They are short with irregular water
flow.( Po and Rhone).
• Rivers that flow into the Caspian Sea and
Black Sea : They are long and regular
(Volga and Danube).
• There are many medium size lakes in
Central Europe, for example the Lake
Constance and Lake Geneva.
24. IMPORTANT RIVERS
• The Danube: It is located in Central and Eastern
Europe. It is Europe's second-longest river. It
is 2,850 km in length, and it flows through 10
countries:
Germany, Austria,Slovakia,Hungary,Croatia,
Serbia, Romania,Bulgaria, Moldova, Ukraine.
• The Rhine : It is the second-longest river in Central
and Western Europe.
• It flows through 6 countries: Switzerland,
Liechtenstein, Austria, Germany, France,
Netherlands.
25. • The Seine: It has 776-kilometres long river
and an important commercial waterway
within the Paris Basin in the north of
France.
• The Elbe : Rising in the Czech Republic, it
flows north through Germany, ending in
the North Sea.
• The Volga: It is he longest river in Europe
in terms of length, discharge, and
watershed. It flows through central Russia.
It's 3,692 km long.
26. • The Thames: This river flows through
southern England. It is the second longest
river in England and the second longest in
UK.
• It’s 346 km long.
27.
28. CLIMATE IN EUROPE
• Europe has many different climates depending on the country
location within de continent.
Polar climate: Coldest climate on Earth.Very low temperatures (-50
in winter). Flora: very restricted but we find Tundra.
Alpine climate: ( covers the high mountains regions) Cool
temperatures in summer and very cold in winter. Heavy rain and
snow. Flora: coniferous and pine trees.
Continental climate: (covers the Eastern Europe)
Hot summers and cold winters. Low rainfall and occasional storms in
summer. Flora: Steppes and taiga.
Mediterranean climate: (covers Southern Europe and the area along
the Mediterranean Sea). High temperatures in summer and cool in
winter. Low precipitation but higher in autumn. Flora: evergreen
trees.
Oceanic climate: Central and Western Europe). Mild temperatures in
summers with high precipitation all year. Flora: broadleaf forests.