This document discusses proposed criteria for patient selection for transcatheter mitral valve repair using the MitraClip device. It outlines anatomical and clinical considerations for both degenerative and functional mitral regurgitation. Experience from high-volume centers indicates MitraClip can be effective for selected patients at high risk for surgery, though longer-term data is still needed, especially for functional MR. A multidisciplinary team approach is important to thoroughly evaluate each patient's suitability and discuss risks versus benefits of MitraClip versus surgery.

1. Proposed criteria for patient selection for transcatheter mitral valve repair . Francesco Maisano MD, FESC (Milan, IT) San Raffaele Hospital Cardio-thoracic and Vascular Department

2. Disclosure Statement of Financial Interest Within the past 12 months, I or my spouse/partner have had a financial Interest /arrangement or affiliation with the organization(s) listed below Affiliation/Financial Relationship Company Grant/ Research Support: Consulting Fees/Honoraria: Abbott, Edwards, Nycomed, Medtronic, St Jude, ValtechCardio Major Stock Shareholder/Equity Interest: Royalty Income: Edwards Ownership/Founder: 4Tech Salary: Intellectual Property Rights: ValtechCardio, 4Tech Other Financial Benefit:

9. Degenerative MR

10. Degenerative MR Multiple lesions

11. Functional MR

12. Anatomic Measurements P=0.05 P=0.1 San Raffaele Preliminary data

14. Tenting area and QRS duration p=0.002 P=0.01 San Raffaele Preliminary data

15. Jet extension (%) Jet extension/IC diameter p=0.01

16. Jet extension