This document provides an overview of epidemiology. It defines epidemiology as the study of disease distribution and determinants in populations. It discusses the history of epidemiology, including John Snow's work identifying contaminated water as the cause of a cholera outbreak. The document also covers epidemiological concepts like the epidemiologic triad of agent, host, and environment; the chain of infection; and the tasks of an epidemiologist like surveillance, investigation, and research.
As per John M. Last (1988) Epidemiology is the study of the distribution and determinants of health related states or events in specified populations, and the application of this study to the control of health problems.
Development over the centuries of Human Civilization concepts of disease causation remained transforming and still not reached the perfection.
Pre-modern era theories of Disease causation: Religions often attributed disease outbreaks or other misfortunes to divine retribution - punishment for mankind's sins.
and imbalance among four vital "humors“ within us. Hippocrates; Yellow Bile, Black Bile, Phlegm and Blood
Miasma Theory: 500 BC Miasmas are poisonous emanations from putrefying carcasses, vegetables, molds and also the invisible particles. This theory led to explanation of several outbreaks of cholera, plague and malaria (Mal-aria= bad air).
Fracastoro's contagion theory of disease (1546)
Germ theory: Louis Pasteur , Lister and others introduced the germ theory in 1878. In 1890 Robert Koch proposed specific criteria that should be met before concluding that a disease was caused by a particular bacterium. Only single germ is responsible for causation of a specific disease.
Webs of Causation: Epidemiological concept
Introduction to Epidemiology
At the end of this session the participants will be able to:
Discuss the historical evolution of epidemiology
Explain the usage of epidemiology
List the core epidemiological functions
Explain types of epidemiological studies
Health is a multifactorial
The factors which determine the health of an individual are many, some are inside the body ( genetic/ intrinsic) and some are outside the body ( environmental factors)
The interaction of these factors may either promote or deteriorate the health.
The important determinants of health are,
CM 1.3 Agent Host and environmemtal factors ,epidemiological triad ,multi fac...Anjali Singh
This lecture is for the First Year Students -Agent Host and environmental factors(CM3.1) -Causation of disease has given various concepts- ranging from older theories to modern theories
Older theories started from 10,000 years ago back till the early 19th century which was based on supernatural theory, bad air, living things generation form non-living things
These theories were followed by the germ theory of disease given in 1960 by Louis Pasteur when he demonstrated the presence of bacteria in the air and disapproved of the spontaneous generation of disease
1873 advanced germ theory was established
1877 Robert Koch showed that anthrax is caused by bacteria
After that gonococcus, typhoid cholera, TB, and diphtheria bacterium were discovered and finally, medicine shed the dogma of magic and superstition and wore the robe of scientific knowledge
Observingthedistributionofdiseaseorhealth related events in human population.
• Identify the characteristics with which the disease is associated.
• Basically 3 questions are asked who, when and where.
• Who means the person affected, where means the place and when is the time distribution.
“The study of the distribution and determinants of health-related states or events in specified population and the application of the study to control of health problems.”
As per John M. Last (1988) Epidemiology is the study of the distribution and determinants of health related states or events in specified populations, and the application of this study to the control of health problems.
Development over the centuries of Human Civilization concepts of disease causation remained transforming and still not reached the perfection.
Pre-modern era theories of Disease causation: Religions often attributed disease outbreaks or other misfortunes to divine retribution - punishment for mankind's sins.
and imbalance among four vital "humors“ within us. Hippocrates; Yellow Bile, Black Bile, Phlegm and Blood
Miasma Theory: 500 BC Miasmas are poisonous emanations from putrefying carcasses, vegetables, molds and also the invisible particles. This theory led to explanation of several outbreaks of cholera, plague and malaria (Mal-aria= bad air).
Fracastoro's contagion theory of disease (1546)
Germ theory: Louis Pasteur , Lister and others introduced the germ theory in 1878. In 1890 Robert Koch proposed specific criteria that should be met before concluding that a disease was caused by a particular bacterium. Only single germ is responsible for causation of a specific disease.
Webs of Causation: Epidemiological concept
Introduction to Epidemiology
At the end of this session the participants will be able to:
Discuss the historical evolution of epidemiology
Explain the usage of epidemiology
List the core epidemiological functions
Explain types of epidemiological studies
Health is a multifactorial
The factors which determine the health of an individual are many, some are inside the body ( genetic/ intrinsic) and some are outside the body ( environmental factors)
The interaction of these factors may either promote or deteriorate the health.
The important determinants of health are,
CM 1.3 Agent Host and environmemtal factors ,epidemiological triad ,multi fac...Anjali Singh
This lecture is for the First Year Students -Agent Host and environmental factors(CM3.1) -Causation of disease has given various concepts- ranging from older theories to modern theories
Older theories started from 10,000 years ago back till the early 19th century which was based on supernatural theory, bad air, living things generation form non-living things
These theories were followed by the germ theory of disease given in 1960 by Louis Pasteur when he demonstrated the presence of bacteria in the air and disapproved of the spontaneous generation of disease
1873 advanced germ theory was established
1877 Robert Koch showed that anthrax is caused by bacteria
After that gonococcus, typhoid cholera, TB, and diphtheria bacterium were discovered and finally, medicine shed the dogma of magic and superstition and wore the robe of scientific knowledge
Observingthedistributionofdiseaseorhealth related events in human population.
• Identify the characteristics with which the disease is associated.
• Basically 3 questions are asked who, when and where.
• Who means the person affected, where means the place and when is the time distribution.
“The study of the distribution and determinants of health-related states or events in specified population and the application of the study to control of health problems.”
CHAPTER 1 ITRODUCTION TO EPIDEMIOLOGICAL METHODS.pptxjohnsniky
Technique:
The needle is held with the needle holder and it should enter the tissues at right angles and be no less than 2-3mm from the incision.
The needle is then carried through the tissue where it follows the needle’s curvature.
Sutures of any type that are placed in the interdental papilae should enter and exit the tissue at a point located below the imaginary line that forms the base of the triangle of the interdental papilla.
Epidemiology is: a) a quantitative basic science based on a working knowledge of statistics, probability, and sound research methods; b) a causal reasoning method based on the development and testing of morbidity and mortality hypotheses; and c) a tool for promoting and protecting public health action based on science, causal reasoning, and practical common sense.
Epidemiology is the study of the distribution of health related events. It is concerned with epidemic of communicable disease, non communicable infectious disease, chronic disease,maternal-child health, occupational health, environment health etc.
Introduction to Epidemiology
History of Epidemiology.
Definition of Epidemiology and its components.
Epidemiological Basic concepts.
Aims of Epidemiology.
Ten Uses of Epidemiology.
Scope or The Areas of Application .
Types of Epidemiological Studies.
Structure and function of of Pulp-Dentin complexPournami Dathan
The dentin and pulp are considered a complex by its similar embryology and function. It is in our practice to distinguish both by its unique functions it serves in our tooth.
Oral Candidiasis also referred to as oral thrush is commonly encountered in a daily life of a dentist. An overview on this topic for undergraduate students.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. CONTENTS
INTRODUCTION
HISTORY
AIMS OF EPIDEMIOLOGY
EPIDEMIOLOGIC TRIAD
CHAIN OF INFECTION
TASKS OF AN EPIDEMIOLOGIST
CONCLUSION
3. INTRODUCTION
• Epidemiology is the
cornerstone of public
health, and shapes policy
decisions and evidence –
based practice by
identifying risk factors
for disease and targets
for preventive health
care.
4. DEFINITIONS
• Epidemiology is the branch of medical science
which deals with the treatment of epidemics.
(Thomas Parkin,1873)
• The study of the distribution and determinants
of disease frequency in man. (MacMahon,1960)
5. THE MOST WIDELY ACCEPTED THEORY
• Epidemiology is the study of the distribution and
determinants of health-related states or events, in
specified populations and the application of this
study to the control of diseases and other health
problems.
• (John.M.Last ,1998)
6. ETYMOLOGY
• The word ‘Epidemiology’ is based on the Greek
words :
• Epi = upon, or befall;
• Demos = people
• Logos = study, knowledge
7.
8. HISTORY TIMELINE
CIRCA 400 B.C.
first person known to
have examined the
relationships
between the
occurrence of
disease and
environmental
influences.
Snow conducted
studies of cholera
outbreaks both to
discover the cause of
disease and to
prevent its
recurrence.
Epidemiologists
focused their
methods on acute
infectious and non-
infectious diseases.
There has been an
explosion in the
development of
research methods
and the theoretical
underpinnings of
epidemiology.
1854 1930 - 1940 WORLD WAR
10. 1854
• John Snow, famous for his investigations into the
causes of the 19th century cholera epidemics.
• He is known as the ‘Father of Modern
Epidemiology’.
• Snow conducted studies of cholera outbreaks
both to discover the cause of disease and to
prevent its recurrence.
• This has been perceived as a major event in the
history of public health and regarded as the
founding event of the science of epidemiology
having shaped public health policies around the
world.
11. AIMS OF EPIDEMIOLOGY
• According to the International Epidemiological Association (IEA),
Epidemiology has three main aims :
• To describe and analyse disease occurrences and the distribution in
human populations. (Descriptive Epidemiology)
• To identify the etiologic factors in the pathogenesis of disease.
(Analytical Epidemiology)
• To provide the data essential in planning, implementation and
evaluation of services for the prevention, control and treatment of
disease and setting up priorities among those services.
(Experimental Epidemiology)
13. DEFINITION
• The triad consists of external agent, a susceptible host,
and an environment that brings the host and agent
together.
• In this model, disease results from the interaction
between the agent and the susceptible host in an
environment that supports transmission of the agent
from a source to that host.
14. AGENT
• The first link in the chain of disease transmission is
a disease agent.
• The disease may have a single agent, but more
factors are responsible for disease transmission.
16. OTHER AGENTS:
• Mechanical Agents
• Nutritional Agents
• Social Agents
• Hormonal and Chromosomal
factors
17. HOST
• It refers to the human who is susceptible to the disease.
• A variety of factors intrinsic to the host, sometimes called
risk factors can influence an individual’s exposure,
susceptibility or response to a causative agent.
• Susceptibility and response to an agent are influenced by
factors such as age, gender, hereditary, nutrition,
occupation, custom habits, immunity, marital status,
socio-economic status and life-style factors.
18. ENVIRONMENT
• It refers to extrinsic factors that affect the agent and the
opportunity for exposure.
• Environmental factors such as geology, and climate,
biologic factors such as insects that transmit the agent,
and socio-economic factors such as crowding, sanitation,
and the availability of health services.
20. CHAIN OF INFECTION
• The traditional epidemiologic triad model holds that infectious
diseases results from the interaction of agent, host and environment.
• Transmission occurs when the agent leaves its reservoir or host
through a portal of exit, is conveyed by some mode of transmission
and enters through an appropriate portal of entry to infect a
susceptible host. This sequence is sometimes called the chain of
infection.
21.
22. PORTAL OF EXIT : The path by which an
pathogen leaves the host.
MODE OF TRANSMISSION : An infectious agent
may be transmitted from its natural reservoir to a
susceptible host in different ways.
PORTAL OF ENTRY : The portal of entry refers to
the manner in which a pathogen enters a
susceptible host.
SUSCEPTIBLE HOST : It depends on the genetic,
constitutional factors, specific immunity, and non-specific
factors that affect an individual’s ability to resist infection or
to limit the pathogenicity.
RESERVOIR : The habitat in which the agent
normally lives, grows and multiplies.
23. DISEASE PREVENTION
AND CONTROL
• Knowledge of the portals of exit and entry and
modes of transmission provides a basis for
determining appropriate control measures.
• Early diagnosis
• Epidemiological Investigation
• Isolation
• Treatment
• Quarantine
24. TASKS OF AN EPIDEMIOLOGIST
• Surveillance
• Investigation
• Analysis and Interpretation
• Communication
• Evaluation
• Research
• Management
25. CONCLUSION
• As the basic science of public health, epidemiology includes the study of
frequency, patterns, and causes of health-related states or events in populations,
and the application of that study to address public health issues.
• Epidemiologists use a systematic approach to assess the What, Who, Where,
When, and Why/How of these health states or events.
• Core epidemiologic tasks of a public health epidemiologist include public health
surveillance, field investigation, research, evaluation, and policy development. In
carrying out these tasks, the epidemiologist is almost always part of the team
dedicated to protecting and promoting the public's health.
26. REFERENCES
• SOBEN PETER - ESSENTIALS OF PUBLIC HEALTH DENTISTRY
(5th Edition)
• https://en.wikipedia.org/wiki/Epidemiology
• http://www.who.int/topics/epidemiology/en/