This document provides information about emulsions, including:
1. Emulsions are biphasic liquid preparations containing two immiscible liquids, one dispersed as globules in the other with an emulsifying agent. There are two types: oil-in-water and water-in-oil.
2. Various tests can identify the emulsion type, like the dilution test. Stability is important and factors like creaming, sedimentation, cracking can cause instability.
3. The stability of emulsions depends on factors like chemical decomposition, physical changes, microbial growth, and phase inversion. Proper formulation and storage conditions can help minimize instability.
Fats and oils are composed of molecules known as triglycerides, which are esters composed of three fatty acid units linked to glycerol. An increase in the percentage of shorter-chain fatty acids and/or unsaturated fatty acids lowers the melting point of a fat or oil.
Fats and oils are composed of molecules known as triglycerides, which are esters composed of three fatty acid units linked to glycerol. An increase in the percentage of shorter-chain fatty acids and/or unsaturated fatty acids lowers the melting point of a fat or oil.
Rheology is the science that study flow of fluids. Viscosity is the main parameter of flow. Newtonian & non newtonian are the two types of flow behavior according to newtons law of flow. non-newtonian flow can be plastic, pseudoplastic, dilatant, thixotropic, antithixotropic or rheopexy. viscosity can be determined by using various viscometers such as capillary viscometer, cup & bob viscometer, cone & plate viscometer, falling sphere viscometer, brookfield viscometer, etc. factors affeting viscosity are intrinsic, extrinsic or temperature dependence.
This presentation consists of the info about the pharmaceutical emulsions , definition, types,preparations,methods,formulation,emulsifying agents ....
this presentation is very useful for the b.pharm students for a brief idea ...
Rheology is the science that study flow of fluids. Viscosity is the main parameter of flow. Newtonian & non newtonian are the two types of flow behavior according to newtons law of flow. non-newtonian flow can be plastic, pseudoplastic, dilatant, thixotropic, antithixotropic or rheopexy. viscosity can be determined by using various viscometers such as capillary viscometer, cup & bob viscometer, cone & plate viscometer, falling sphere viscometer, brookfield viscometer, etc. factors affeting viscosity are intrinsic, extrinsic or temperature dependence.
This presentation consists of the info about the pharmaceutical emulsions , definition, types,preparations,methods,formulation,emulsifying agents ....
this presentation is very useful for the b.pharm students for a brief idea ...
aqueous one known as a direct emulsion. Stabilization of O/W emulsion is often performed with hydrophilic-hydrophobic particles. The hydrophilic end of the emulsifier molecule has an affinity for water, and the hydrophobic end is drawn to the fat/oil. Vigorously mixing the emulsifier with the water and oil creates a stable emulsion. For example, milk is oil in the water type of emulsion. In this mixture, fat globules are dispersed in the water.
Emulsion water in oil (W/O) is composed of an aqueous phase dispersed in the oil phase. A water-in-oil emulsion is much fattier than a direct emulsion. Margarine is a water-in-oil emulsion.
Other emulsions, such as oil in water in oil, or water in oil in water, exist as well. Blood is also an emulsion consisting of negatively charged colloidal particles, which are albuminoid substances.
Go to:
Issues of Concern
Emulsions are a sub-class of colloids, which are two-phase systems of matter.
Although the terms colloid and emulsion are sometimes used indistinctly, emulsion applies only when both dispersed, and continuous phases are liquids. A colloid is a mixture of a compound that is in a solid, liquid, or gas state and a liquid. The critical difference between a colloid and an emulsion is that colloid can form when any state of matter (solid, gas, or liquid) combine with a liquid. In contrast, the emulsion has two liquid components that are initially immiscible with each other.
Emulsions, as liquids, do not demonstrate a static internal structure. Emulsions are thermodynamically unstable as both the dispersed and continuous phases can revert as separate phases, oil, and water, by fusion or the coalescing of droplets. Industries use emulsifying agents, eg, surfactants, to maintain a static structure.[1]
Usually, the phase in which the surfactant exhibits the greatest solubility is the continuous phase. Thus, hydrophilic surfactants foster O/W emulsions, whereas lipophilic surfactants promote W/O emulsions.
Go to:
Clinical Significance
Emulsions are frequently used in pharmaceuticals, personal hygiene products, and cosmetics. These are usually oil and water emulsions, albeit dispersed. These emulsions are called creams, ointments, balms, pastes, films, or liquids, depending on their oil-to-water ratios, the addition of other additives, and their intended administration route. Emulsions allow the encapsulation of an active ingredient in the dispersed phase to protect it from degradation and preserve its activity in a sustained manner. They are used to make medications more palatable, to improve their effectiveness via dosage control of active ingredients, and to provide better aesthetics for topical drugs such as ointments.
Intravenous and parenteral emulsions may be used for nutritive therapy applications when a patient is unable to consume food or receive nutrition. Fat emulsions serve as dietary complements for patients who cannot get the required fat solely from their diet. The compound may be given as
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
How to Split Bills in the Odoo 17 POS ModuleCeline George
Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
The Art Pastor's Guide to Sabbath | Steve ThomasonSteve Thomason
What is the purpose of the Sabbath Law in the Torah. It is interesting to compare how the context of the law shifts from Exodus to Deuteronomy. Who gets to rest, and why?
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Home assignment II on Spectroscopy 2024 Answers.pdf
EMULSIONS PPT.pptx
1. MS. RAMANDEEP KAUR
M.PHARM (PHARMACEUTICS)
ASSISTANT PROFESSOR
PHARMACY ACADEMY
IFTM UNIVERSITY, MORADABAD
2. EMULSIONS
Emulsion is a biphasic liquid preparation containing two immiscible liquids one of which is
dispersed as minute globules into the other with the help of an emulsifying agent.
The liquid that is broken up into globules is called dispersed phase & the liquid in which the
globules are dispersed in known as continuous phase.
TYPES OF EMULSION
They are two types
• Oil in water:
In O/w type, oil is dispersed phase & water is continuous phase. In oil in water type,
oil is surrounded by water. So the un-pleasant taste & odour of the oil is masked. Therefore
o/w type of emulsion is preferable for internal use.
• Water in oil:
In w/o type water is the dispersed phase & oil is in the continuous phase. In w/o type,
water is surrounded by oil. So application on the skin may be easier. Therefore w/o type of
emulsion preferable for external use.
3. o/w type w/o type
1.Dilution test:
If water is added to o/w type the preparation
remains homogeneous. But if oilis added, oil
separates out as layer.
2.Dye test:
Mix scarlet red an oil soluble dye with o/w type.
Take one drop is placed on the glass slide &
focused under microscope. If dispersed phase
appears in colour, it is saidto be o/w type.
3.Electrical conductivity test:
O/w type conducts electricity. A pair of electrodes
is connected to a low voltage lamp. The electrodes
are dipped in o/w typeof emulsion & current is
passed. The bulb glows.
4. fluorescence test:
Water does not produce fluorescence inuv light
under microscope. A drop of emulsion is examined
in uv light under microscope. The spotty
fluorescence is produced providing that oil in
dispersed
Phase.
1.If water is added to w/o type the preparation
remains homogeneous. But if water is added,
the water separates out aslayer.
2.Mix scarlet red with w/o type of emulsion. Take
one drops with w/o is placedon a glass slide &
focused under the microscope. If the dispersed
phase appears colourless. It is said to be w/o
type.
3.W/o type does not conduct electricity. Apair of
electrodes is connected to a low voltage lamp.
The electrodes dipped in w/o type emulsion &
current is passed. The bulb does not glow.
4. Many oils produce florescence whenexpose to
uv light .A drop of Emulsion is examined in
uvlight. The entire field is produced.
Florescence proving that oil in continues
phase.
Different tests for the identification of emulsion type.
4. Examples for natural emulsion:
Milk is an example for o/w emulsion. Butter is an example for w/o emulsion.
EMULSIFYING AGENTS/ SURFACTANTS
Surfactants are materials get adsorbed at the interface between the two phases. The surface adsorption
lowers or decreases the tension between the two phases. It causes the inter mix of the phases with each other.
Hence to reduce surface tension surfactants are used.
They are classified as follows:
•Natural Emulgents from vegetable sources: These are anionic in nature & produce o/w type emulsions.
They act as primary emulgents & stabilizers. Ex: acacia, tragacanth, agar, pectin
•Natural emulsifying agents from animal sources:
•Gelatin: It occurs in two forms Pharmagol A- used in acidic PH Pharmagol B-used in alkaline PH
•Egg Yolk
•Wool Fat
•Semi synthetic polysaccharides: These produce o/w type of emulsion
Ex: Methyl cellulose, sodium CMC
•Synthetic Emulgents:
•Anionic: Its anionic part is responsible for emulsifying activity.
Ex: - Soaps & sodium lauryl sulphate
•Cationic: Its cationic part is responsible for emulsification. Ex: - Cetrimide, Benzalkonium chloride.
They produce o/w type emulsion.
•Non-Ionic: They do not ionize in aqueous solution. These are stable at wide range of pH & are not affected
by addition of acids & electrolytes.
•In-organic Emulgents: Ex: - Milk of magnesia, magnesium oxide, magnesium aluminium silicate &
bentonite.
•Alcohols: Ex: - Cetyl alcohol, stearyl alcohol, glycerol mono- stearate. Carbo waxes.
5. METHODS OF PREPARATION OF EMULSIONS
I. Small scale method:
In small scale method, stable emulsions are prepared by 3 methods. They are
•Dry gum method: It involve the following steps
a) The mortar & pestle should be absolutely dry.
b) Measure the required quantity of oil in a clean measuring cylinder & transfer it into a dry
motor.
c) Add the calculated amount of gum acacia to the mortar.
d) The gum (1 part) is triturated with oil (4parts) in a dry motor thoroughly to form a uniform
mixture.
e) Add required quantity of water (2parts) and triturate till clicking sound is produced & the
product becomes white. This indicates the formation of emulsion, called primary emulsion.
f) If any solid ingredients are present in the formation. They should be dissolved in small
portion of water.
g) If any other soluble ingredients are to be added it must be incorporated after making
primary emulsion.
h) Then more water is added to produce the required value.
6. Type of oil Primary emulsion formula
Oil Water Gum
1. fixed oils ex: -
Arachis oil castoroil
4 2 1
2. Mineral oilEx: -
Liquid Paraffin
3 2 1
3. Volatile oil Ex: -
Turpentine
oil cinnamon oil
2 2 1
4. Oleo – resinEx: -
male fern
extract, balsam of
tolu, balsam ofPeru
1 2 1
7. •Wet gum method: -
The proportion of oil, gum, water is same as dry gum method for primary emulsion. The
method of preparation of primary emulsion is similar to dry gum method but it a slower
technical. But it gives better result than dry gum method. It is as follows.
a) Calculated quantity of gum acacia is triturated with required quantity of water form
mucilage.
b) To this, add oil in small portions with rapid triturating until the product becomes white
& clicking sound is produced. i.e. the formation of primary emulsion.
c) If any solid ingredients are present in the formation. They should be dissolved small
portion of water.
d) If any should ingredients is to be added it must be incorporated after make primary
emulsion.
e) The more water is added to produce the required volume.
8. •Bottle method:
1.In this method, oil is taken in a large bottle and then powdered dry gum is
added.
2.The bottle is shaken vigorously until the oil and gum are mixed thoroughly.
3.Then the calculated amount of water is added all at once and the bottle is shaken
vigorously until primary emulsion is formed.
4.If any solid ingredients are present in the formulation, they should be dissolved
in small portion of water.
5.This solution and other liquids are added to the primary emulsion and shaken
thoroughly. Then more water is added to produce the required volume.
II) Large scale method:
In large scale method, stable emulsions are prepared by using homogenizer
& colloidal mill.
9. STABILITY OF EMULSIONS
Stability: A formulated emulsion should retain its original characters like size of the emulsion
and their uniform distribution throughout the continuous phase
The following are some of the symptoms of instability of emulsions:
•Creaming:
Creaming is defined as the upward movement of the dispersed phase towards the surface and
forms a thick layer at the surface of the emulsion.
Reason for creaming:
1.The size of globules.
2.The viscosity of continuous phase.
3.The difference between the densities of the dispersed phase and continuous phase.
4.The temperature.
To prevent creaming:
•By reducing size of globules
•By increasing the viscosity if continuous phase
10. •By reducing the difference between the densities of the dispersed phase and continuous phase.
•By storing the emulsion in a cool place.
•Sedimentation:
Definition: It is defined as the downward movement of the dispersed phase towards the bottom
& forms a separate layer over the sediment particles.
Reasons for sedimentation:
1.The size of the globules
2.The difference between the densities of the dispersed phase & continuous phase.
Prevention: Sedimentation can be reduced by the following ways.
•By reducing the size of the globules.
•By reducing the difference between the densities of dispersed phase & continuous phase.
•Cracking:
Cracking can be defined as the separation of the dispersed phase and continuous phase as two
separate layers. They cannot be re-dispersed on shaking.
Cracking may be caused by physical or chemical or microbial effects. They change the nature of
the emulsifying agent & reduce the emulsifying property.
11. FACTORS AFFECTING THE CRACKING OF EMULSIONS
1. Chemical factors:
Decomposition or precipitation of emulsifying agents.
•Acids: Acids decompose alkali soaps & the emulsion separate into two phases
•Electrolytes: Electrolytes like sodium chloride precipitate the sodium soap & the emulsion
separates into two phases.
•Alcohols: Alcohol precipitates the gum & the protein emulsifying agent. The emulsion is
separated into two phases.
2. Physical factors:
•Addition of opposite type of emulsifying agent emulsifying agent: By adding of o/w type of
emulsifying agent to a w/o type of emulsion, the emulsion separates into two phases. Ex:
Agitation of soft to a calcium soap emulsion.
•Addition of common solvent: Addition of solvent in which both dispersed phase & the
continuous phase are soluble. The emulsion from the phase system & destroy the emulsion. Ex:
Addition of alcohol to turpentine oil, for soft soap emulsion.
•Addition of excess dispersed phase: If the dispersed phase is incorporated to the emulsion the
dispersed globules coagulate & the emulsion separates into two phases.
Ex: Addition of turpentine oil to the turpentine oil soft soap emulsion.
12. 4. Phase inversion:
Change of phase that is o/w type of emulsion changes into w/o type of emulsion and vice versa is
known as phase inversion.
Reason for phase inversion:
1.By the addition of electrolyte.
2.By changing the phase volume ratio
3.By temperature changes.
To minimize phase inversion:
•By using the proper emulsifying agent in sufficient concentration.
•By keeping the concentration of dispersed phase between 30 to 60 percent.
•By storing the emulsion in a cool place.
•By increasing the temperature: If increase in temperature the viscosity of the emulsion
will be decreased & causes creaming. The creaming is more liable to crack the emulsion.
3. Microbial factor:
If the emulsion is not used immediately & does not contain preservative. There may be
growth of mould & bacteria in the emulsion. It destroys the emulsifying agent. It causes
separation of emulsion into two phases.