This document provides information on pleural effusion and thoracic empyema. It begins with objectives and introductions. It then covers anatomy and physiology of the pleura, pathogenesis and causes of pleural effusion and empyema. It discusses the classification of transudative versus exudative effusions. It also covers clinical presentation, complications, and treatment options for pleural effusion, empyema and malignant pleural effusions. Treatment methods discussed include thoracentesis, tube thoracostomy, drainage-based methods, and obliteration of the pleural space.
Empyema is a collection of pus in the cavity between the lung and the membrane that surrounds it (pleural space). Caused by an infection that spreads from the lung and leads to an accumulation of pus in the pleural space, the infected fluid can build up to a quantity of a pint or more, which puts pressure on the lungs, causing shortness of breath and pain. Risk factors include recent lung conditions like bacterial pneumonia, lung abscess, thoracic surgery, trauma or injury to the chest.
Bronchiectasis is a disease in which there is permanent enlargement of parts of the airways of the lung.[5] Symptoms typically include a chronic cough with mucus production.[3] Other symptoms include shortness of breath, coughing up blood, and chest pain.[2] Wheezing and nail clubbing may also occur.[2] Those with the disease often get frequent lung infections.[8]
Bronchiectasis may result from a number of infectious and acquired causes, including pneumonia, tuberculosis, immune system problems, as well as the genetic disorder cystic fibrosis.[11][3][12] Cystic fibrosis eventually results in severe bronchiectasis in nearly all cases.[13] The cause in 10–50% of those without cystic fibrosis is unknown.[3] The mechanism of disease is breakdown of the airways due to an excessive inflammatory response.[3] Involved airways (bronchi) become enlarged and thus less able to clear secretions.[3] These secretions increase the amount of bacteria in the lungs, resulting in airway blockage and further breakdown of the airways.[3] It is classified as an obstructive lung disease, along with chronic obstructive pulmonary disease and asthma.[14] The diagnosis is suspected based on symptoms and confirmed using computed tomography.[7] Cultures of the mucus produced may be useful to determine treatment in those who have acute worsening and at least once a year
Empyema is a collection of pus in the cavity between the lung and the membrane that surrounds it (pleural space). Caused by an infection that spreads from the lung and leads to an accumulation of pus in the pleural space, the infected fluid can build up to a quantity of a pint or more, which puts pressure on the lungs, causing shortness of breath and pain. Risk factors include recent lung conditions like bacterial pneumonia, lung abscess, thoracic surgery, trauma or injury to the chest.
Bronchiectasis is a disease in which there is permanent enlargement of parts of the airways of the lung.[5] Symptoms typically include a chronic cough with mucus production.[3] Other symptoms include shortness of breath, coughing up blood, and chest pain.[2] Wheezing and nail clubbing may also occur.[2] Those with the disease often get frequent lung infections.[8]
Bronchiectasis may result from a number of infectious and acquired causes, including pneumonia, tuberculosis, immune system problems, as well as the genetic disorder cystic fibrosis.[11][3][12] Cystic fibrosis eventually results in severe bronchiectasis in nearly all cases.[13] The cause in 10–50% of those without cystic fibrosis is unknown.[3] The mechanism of disease is breakdown of the airways due to an excessive inflammatory response.[3] Involved airways (bronchi) become enlarged and thus less able to clear secretions.[3] These secretions increase the amount of bacteria in the lungs, resulting in airway blockage and further breakdown of the airways.[3] It is classified as an obstructive lung disease, along with chronic obstructive pulmonary disease and asthma.[14] The diagnosis is suspected based on symptoms and confirmed using computed tomography.[7] Cultures of the mucus produced may be useful to determine treatment in those who have acute worsening and at least once a year
Help for medical students about topic Suppurative lung diseases - Abscess and gangrene of the lungs, Pneumothorax, Hematorax, Purulent pleurisy. And useful material as required by students. Everything is inserted as per outlines of topics.
Abnormal fluid accumulation in potential space in between parietal and visceral pleurae – there is imbalance between formation and absorption in response to injury, inflammation or both locally and systematically
Abstract Lung Abscess is a liquefactive necrosis of the lung tissue and arrangement of cavitation (in excess of 2 cm) containing necrotic debris and liquid brought about by parenchymal infection. It very well may be brought about by yearning, which may happen during changed cognizance and it for the most part causes a discharge filled depression. In addition, liquor addiction is the most widely recognized condition inclining to lung abscesses. Lung abscess is viewed as essential (60%) when it comes about because of existing lung parenchymal process and is named auxiliary when it entangles another procedure, e.g., vascular emboli or follows rupture of extrapulmonary abscess into lung. There are a few imaging strategies which can distinguish the material inside the thorax, for example, electronic tomography (CT) output of the thorax and ultrasound of the thorax. Broad Spectrum anti-biotics to cover blended vegetation is the pillar of treatment. Pneumonic physiotherapy and postural drainage are additionally significant. Surgeries are required in specific patients for pneumonic resection Keywords: Lung abscess, anti-bodies, video-assissted thoracoscopic medical procedure (VATS), thoracoscopy
Help for medical students about topic Suppurative lung diseases - Abscess and gangrene of the lungs, Pneumothorax, Hematorax, Purulent pleurisy. And useful material as required by students. Everything is inserted as per outlines of topics.
Abnormal fluid accumulation in potential space in between parietal and visceral pleurae – there is imbalance between formation and absorption in response to injury, inflammation or both locally and systematically
Abstract Lung Abscess is a liquefactive necrosis of the lung tissue and arrangement of cavitation (in excess of 2 cm) containing necrotic debris and liquid brought about by parenchymal infection. It very well may be brought about by yearning, which may happen during changed cognizance and it for the most part causes a discharge filled depression. In addition, liquor addiction is the most widely recognized condition inclining to lung abscesses. Lung abscess is viewed as essential (60%) when it comes about because of existing lung parenchymal process and is named auxiliary when it entangles another procedure, e.g., vascular emboli or follows rupture of extrapulmonary abscess into lung. There are a few imaging strategies which can distinguish the material inside the thorax, for example, electronic tomography (CT) output of the thorax and ultrasound of the thorax. Broad Spectrum anti-biotics to cover blended vegetation is the pillar of treatment. Pneumonic physiotherapy and postural drainage are additionally significant. Surgeries are required in specific patients for pneumonic resection Keywords: Lung abscess, anti-bodies, video-assissted thoracoscopic medical procedure (VATS), thoracoscopy
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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2. Objectives
By the end of this session, students should be able
to,
1) Elaborate the pathophysiology and causes of
pleural effusion and empyema thoracis
2) Identify a patient with pleural effusion/empyema
thoracis based on clinical presentation
3) Investigate a patient and come to a final
diagnosis
4) Manage a patient with pleural effusion, thoracic
empyema and their complications.
5/17/2023 MUHAS, Department of Surgery 2
3. INTRODUCTION
•Excessive accumulation of pleural fluid.
•Imbalance between production and
clearance.
•PE is not a specific disease but it is a
reflection of underlying pathology.
•Pathology can be in the lungs, pleura or
systemic.
5/17/2023 MUHAS, Department of Surgery 3
4. Pleural anatomy
•The pleura consists
of two membranes:
- Visceral pleura
- Parietal pleura
•At hilum; parietal
pleura is continuous
with the visceral
pleura
5/17/2023 MUHAS, Department of Surgery 4
5. Anatomy cont.
Normally the pleural space contains:
Clear pleural fluid ~0.3 ml/kg
Low protein content
Small number of mononuclear cells
Pleural fluid glucose equal to serum
glucose level.
5/17/2023 MUHAS, Department of Surgery 5
6. Anatomy cont.
•Pleural lining is formed by mesothelial cells.
•Below the mesothelial lining is a thin
connective tissue lining which has Blood
vessels and lymphatics which are important in
dynamics of pleural fluid formation.
•Parietal pleura has stomata allowing
passageway for liquid from pleural space to
the lymphatic system.
5/17/2023 MUHAS, Department of Surgery 6
7. Anatomy cont.
•Sensory nerve endings are there in the parietal
and diaphragmatic pleura.
•Blood vessels supplying parietal pleural
surface originate from the systemic arterial
circulation-primarily Inter Costal Arteries.
•Venous blood from the parietal pleura drains
to systemic venous system.
5/17/2023 MUHAS, Department of Surgery 7
8. Anatomy cont.
•Visceral pleura is also supplied primarily by systemic
arteries, specifically branches of bronchial arterial
circulation, but the venous drainage is in to
pulmonary venous system.
•The Lymphatic vessels that drain the pleural surfaces
transport their fluid contents to different lymph
nodes.
•Ultimately the fluid is transported to the right
lymphatic or thoracic ducts, which empty in to the
systemic venous circulation
5/17/2023 MUHAS, Department of Surgery 8
9. Physiology
•Pleural space normally contains small amount
of fluid (10 ml).
•As per recent concept, formation of fluid is
ongoing primarily from the parietal pleural
surface, and fluid is reabsorbed through the
stomata into the lymphatic channels of the
parietal pleura.
•Normally rate of formation = absorption;
about 0.02 ml/kg/hour.
5/17/2023 MUHAS, Department of Surgery 9
10. Physiology cont.
•Pleural fluid is the ultra filtrate from the
pleural capillaries.
•There are counteracting forces which are
responsible for transport of fluid; Hydrostatic
pressure - P, and Colloid oncotic pressure -
COP.
•‘P’ promotes movement of fluid out of the
capillaries and COP prohibits the movement
from the capillaries.
5/17/2023 MUHAS, Department of Surgery 10
11. Physiology cont.
Fluid movement = K[(Pc –Pis ) – σ(COPc –COPis )]
Starlings equationcan be
applied to parietal pleura:
Pc = 30 cm H2 O,
Pis (mean intrapleural pressure)=
- 5 cm H2 O,
COPc = 32 cm H2 O,
COPis = 6 cm H2 O,
=1, K=1
Fluid movement at parietal
pleura = [30-(-5)]-1(32-6)
= 9 cm H2 O
5/17/2023 MUHAS, Department of Surgery 11
12. Pathogenesis
•A change in the magnitude of any of the
factors in the Starling equation can cause
sufficient imbalance in the pleural fluid
dynamics resulting in pleural fluid
accumulation.
•Interference with resorptive process like
blockage of lymphatic drainage as occurs
when tumor cells invade the lymphatic
channels or the draining LN.
5/17/2023 MUHAS, Department of Surgery 12
17. Aetiology cont.
Causes of Exudative Effusions
•Others
•Chylothorax
•Uremia
•Sarcoidosis
•After coronary artery bypass grafting
•Radiation / Trauma
•Dressler’s syndrome
•Pulmonary embolism with infarction
•Asbestosis related
5/17/2023 MUHAS, Department of Surgery 17
18. Pleural Empyema/ Pyothorax/ Purulent
Pleuritis/ Empyema Thoracis
•Accumulation of Pus in the Pleural cavity
5/17/2023 MUHAS, Department of Surgery 18
19. Other descriptions
Weese et al. defined an empyema as pleural fluid with
• a sp. Gravity >1.018,
• a WBC count >500 cells/mm3 or
• a protein level >2.5g/dl.
Vianna defined an empyema as pleural fluid on which
• the bacterial cultures are positive or
• the WBC count is > 15,000/mm3 and
• the protein level is >3.0g/dl.
5/17/2023 MUHAS, Department of Surgery 19
20. Thoracic Empyema
•Empyema is different from an abscess because the
later is the formation and collection of pus in a
newly formed cavity within the lung parenchyma.
•Any pleural effusion associated with bacterial
pneumonia, lung abscess or bronchiectasis is a
parapneumonic effusion.
•Many complicated parapneumonic effusions are
empyemas.
5/17/2023 MUHAS, Department of Surgery 20
21. Aetiology- Thoracic empyema
NON-TRAUMATIC
• Direct extension from an
adjacent site :lung
infection
• Aspiration pneumonia
• Post-obstructive
pneumonia
• Bronchiectasis, lung
abscess
TRAUMATIC
• Instrumentation and rupture of esophagus
• Leakage of an esophageal anastomosis after
resection
• Development of a bronchopleural fistula
following pneumonectomy
• Pleural aspiration/ tube drainage
Non- surgical trauma:
• Abdominal sepsis: subphrenic abscess , liver
abscess
• Sepsis in the pharynx, thoracic spine or chest
wall may extend into the pleura via tissue
planes or mediastinum
• Gun shot wounds, blast injuries and stab
wounds.
5/17/2023 MUHAS, Department of Surgery 21
23. Aetiology - Bacteriology
•Streptococcus pneumonia: 15 – 20%
•Staphylococcus spp: 15 – 30%
•Streptococcus spp
•Gram Negatives: 20 – 50%
•Klebsiella, Enterobacter, pseudomonas,
Haemophilus, E. coli
•Anaerobes
•Fusobacterium, Bacteroides fragilis
5/17/2023 MUHAS, Department of Surgery 23
24. Pathology- Thoracic empyema
(1) Exudative STAGE (approx. 7days)
Once infected by pathogenic organisms, the
connective tissue layers within the pleural
membranes become edematous and produce an
exudation of sterile proteinaceous fluid that starts
to fill the pleural cavity.
At this stage, the pleural fluid is thin with a relatively
low white cell count and the visceral pleura and
underlying lung remain mobile.
Fluid at this stage is having a low WBC count, low
LDH level and a normal glucose level and pH.
5/17/2023 MUHAS, Department of Surgery 24
25. Pathology cont.
(2) Fibrinopurulent STAGE
•Transitional stage, from 7 to 21 days
•Newly formed layers of fibrin become laid down on the
epithelial surface within the pleural cavity, particularly
on the pleural cavity.
• The empyema fluid now becomes more thicker and
more turbid, containing, a higher white cell count.
5/17/2023 MUHAS, Department of Surgery 25
26. Pathology cont.
Fibrinopurulent STAGE…
•With the deposition of fibrin on both pleural
surfaces, lung movements in this stage may
become increasingly restricted.
•The pleural fluid ph and glucose levels becomes
progressively lower and LDH level becomes
progressively higher.
5/17/2023 MUHAS, Department of Surgery 26
27. Pathology cont.
(3) Organizational STAGE
•Thickened fibrinous layers organize as collagen and
become vascularized by an ingrowth of capillaries.
•This stage may begin within two weeks but usually
takes 4-6 weeks to develop to a point at which the
empyema cavity becomes surrounded by a cortex,
peel or rind that may be more than 2 cm thick.
5/17/2023 MUHAS, Department of Surgery 27
28. Pathology cont.
Organizational STAGE…
• This inelastic pleural peel encases the lung and renders
it virtually functionless.
• By this time the empyema contains frank pus, which
may be viscid.
• Ultimately, an inadequately treated empyema cavity
may become obliterated and its rind may calcify,
producing a so-called fibrothorax, particularly in case
of old tuberculous pleural infection.
5/17/2023 MUHAS, Department of Surgery 28
29. Pathology cont.
Organizational STAGE…
•The inner layers of the thickened empyema cortex
continue to show a considerable inflammatory cell
infiltrate and
•The fibrous outermost layers exert an increasingly
restrictive effect, both compressing the underlying
lung (the so called “trapped lung” effect) and also
tending to draw the overlying ribs together,
ultimately producing a chest deformity with a dorsal
scoliosis that is concave towards the affected side.
5/17/2023 MUHAS, Department of Surgery 29
30. Pathology cont.
Organizational STAGE…
•Dry “sicca” pleuritis stage, the inflammatory
process of the pulmonary parenchyma extends to
the visceral pleura, causing a local pleuritic
reaction.
•This leads to a pleural rub and a characteristic
pleuritic chest pain which originates from the
sensitive innervations of the adjacent parietal
pleura.
5/17/2023 MUHAS, Department of Surgery 30
31. Clinical presentation
•Depends on the nature of infecting organism.
•Competence of patients immune system.
•Ranges from complete absence of symptoms
to a severe illness with all usual manifestations
of toxicity.
5/17/2023 MUHAS, Department of Surgery 31
32. Clinical presentation cont.
•Acute empyema:
•Fever, cough with pleuritic pain
•Features of fluid in pleural space
•Decreased chest expansion
•Stony dullness with decreased VF and VR
•Absent breath sounds
•Features of the underlying condition
5/17/2023 MUHAS, Department of Surgery .
33. Clinical presentation cont.
•Sub acute and chronic empyema:
•Less severe presentation as patient often has
been on antibiotics
•Slow convalescence after a pneumonic illness
•Clinical features of fluid as above
•Features of the underlying condition; eg
bronchiectasis, lung abscess, osteomyelitis of
ribs
•Features of bronchopleural fistula or empyema
necessitans
MUHAS, Department of Surgery
5/17/2023 33
34. Causes of Chronicity
•Inadequate Tube Drainage.
•Chronic pulmonary Disease (TB or Fungal
Infection)
•Immunosuppressed patients.
•Presence of Foreign body within the pleural space.
5/17/2023 MUHAS, Department of Surgery 34
35. Complications
•Spread to the subcutaneous tissue:
•Dissection through chest wall; Empyema Necessitans
•Dissection into abdominal cavity.
•Septicaemia & septic shock.
•Pleural thickening
•Chest deformity- scoliosis
•Rupture into the lung:
Dissection into lung parenchyma
BronchoPleural fistula & pyopneumothorax
5/17/2023 MUHAS, Department of Surgery 35
36. Treatment Benign pleural
effusion
•Transudative pleural effusions are managed by
treatment of the underlying disease and usually
resolve after it has been controlled.
•Occasionally, additive intervention is required,
either because the effusion is symptomatic or
because the underlying medical problem is
refractory to maximal medical treatment
37. Treatment- malignant PE
•The optimal treatment for malignant pleural
effusion is controversial
•malignant disease of long duration can
prevent full lung expansion because of;
visceral pleural restriction
endobronchial obstruction
parenchymal fibrosis
replacement by tumor.
39. Drainage-Based Methods of Malignant
Effusion Control
• Serial thoracenteses appropriately control malignant
pleural effusions for some patients
temporarily relief, for poor prognosis pts.
• Occasionally, thoracentesis creates a hydropneumothorax
because of poor compliance or entrapment of the
ipsilateral lung.
• It can be achieved through;
1. serial percutaneous aspiration
2. Implantation of a long-term pleural catheter or
placement of a percutaneous medium durability pleural
catheter
40. THORACOCENTESIS
•Can be dose using large bore needle
•Applicable and curative in children
•May be sufficient in exudative phase
Limitation
•Thick pus
•Organized phase
•multiloculation
5/17/2023 MUHAS, Department of Surgery 40
41. Closed tube thoracostomy
•First step in adult
•Useful for fibrinopurulent and exudative stages
•Insert a thoracic catheter (relatively large 28 to
36F) tubes in 6th or 7th ICS between anterior and
posterior axillary lines and connect to UWSD
bottle
• Track above superior border of a rib to avoid damage to
neurovascular bundle
•Continuous controlled suction; reduce drainage
duration
5/17/2023 MUHAS, Department of Surgery 41
42. Closed tube thoracostomy…
•Limitation
•Tube blockage
•Multiloculation lead to inadeguate
drainage
•Presence of bronchopleural fistula
•Thick fibrous cortex limit lung expansion
5/17/2023 MUHAS, Department of Surgery 42
44. Indications for removal of tube
•Volume of the pleural drainage is less than 50ml for
24 hrs and until the draining fluid becomes clear
yellow.
•The amount of sediment (representing WBCs and
debris) in the collection system should not be more
than 5ml.
•Tube ceases to work
Because it serves no useful purpose rather it as a
conduit for pleural super-infection.
NB; daily monitoring
Drainage fluid; colour, volume, patency and gas
bubbles
5/17/2023 MUHAS, Department of Surgery 44
45. Sclerosis-Based Pleural Effusion
Management
•accelerating the process of pleurodesis
•a substance that increases the inflammatory
response and thus causes intense adhesions
within the pleural envelope
•Examples talc, Cycline Drugs and Bleomycin
46. PROGNOSIS
•Favourable in patients started on
appropriate antibiotic.
•Early chest tube drainage is beneficial.
•Decortication or open drainage has
decreased mortality and morbidity.
•Mortality 6-12%
5/17/2023 MUHAS, Department of Surgery 46
47. References
•A Manual of Clinical Surgery by S. Das. 9th Edition
•Manipal Manual of Surgery by K. Rajgopal Shenoy
4th Edition
•Schwartz’s Principles of Surgery, 11th Edition
•www.uptodate.com
5/17/2023 MUHAS, Department of Surgery 47
Editor's Notes
The parietal pleura, is separated from the visceral pleura, by a small amount of pleural fluid.
The parietal pleura covers the chest wall, mediastinum, diaphragm, and pericardium.
The visceral pleura covers the lung and separates the lobes from one another.
The pleural space is a potential space that may compress the lungs or heart with fluid, tumor, or infection.
The right and left pleural spaces are separated from one another by the mediastinum.
K=filtration coefficient (a function of the permeability of the pleural surface), P= hydrostatic press, COP= colloid oncotic press, = measure of capillary permeability to protein (called the reflection coefficient) and subscripts “c” and “is” refers to capillary and pericapillary interstitial space.
The deepest layers of the pleural membranes are relatively impervious so that infection tends to be contained within the pleural cavity itself and spread beyond it is unusual