Vancomycin is a glycopeptide antibiotic used to treat infections caused by Gram-positive bacteria including infections of the intestines that cause colitis. It is available as capsules, oral powder, and injectable forms in various strengths from 125mg to 10g. Vancomycin works by inhibiting cell wall synthesis in bacteria. It has various uses to treat infections and is mostly excreted unchanged in urine. Common side effects include nausea, diarrhea, and red man syndrome. Dosage depends on the infection being treated and is adjusted in renal impairment.
Pharmacological Classification, Mechanism of Action, Clinical Uses, Administration Routes, Dosing for Adults and Pediatrics, Pharmacokinetics, Dose Adjustments, Patient Counseling, Adverse Effects, Drug Interactions, Contraindications, Personal Experience with Ondansetron, Future Clinical Uses of Ondansetron
The fixed dose combination of trimethoprim and sulfamethoxazole is called cotrimoxazole.
Adverse Drug Reaction, Spectrum, Resistance and Use of Cotrimoxazole.
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body.
is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox)), herpes zoster
In this presentation, mainly I concentrated on Metronidazole, which is an anti-biotic; and talking about it's pharmacokinetics, drug indication, contraindication, adverse drug reactions and taking the drug during pregnancy and lactation, finally I hope you enjoy it as much as I DID, SALAAM.
The current slide include the pharmacology og cephalosporins.
Contents
Introduction to Cephalosporins
Classification of Cephalosporins
Cefazolin
Cephalexin
Cefuroxime
Cefuroxime axetil
Cefotaxime
Cefixime
Cefpodoxime proxetil
Cefepime
Adverse effects of Cephalosporins
Uses of Cephalosporins
Pharmacological Classification, Mechanism of Action, Clinical Uses, Administration Routes, Dosing for Adults and Pediatrics, Pharmacokinetics, Dose Adjustments, Patient Counseling, Adverse Effects, Drug Interactions, Contraindications, Personal Experience with Ondansetron, Future Clinical Uses of Ondansetron
The fixed dose combination of trimethoprim and sulfamethoxazole is called cotrimoxazole.
Adverse Drug Reaction, Spectrum, Resistance and Use of Cotrimoxazole.
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body.
is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox)), herpes zoster
In this presentation, mainly I concentrated on Metronidazole, which is an anti-biotic; and talking about it's pharmacokinetics, drug indication, contraindication, adverse drug reactions and taking the drug during pregnancy and lactation, finally I hope you enjoy it as much as I DID, SALAAM.
The current slide include the pharmacology og cephalosporins.
Contents
Introduction to Cephalosporins
Classification of Cephalosporins
Cefazolin
Cephalexin
Cefuroxime
Cefuroxime axetil
Cefotaxime
Cefixime
Cefpodoxime proxetil
Cefepime
Adverse effects of Cephalosporins
Uses of Cephalosporins
ROLE OF PHARMACIST IN PREVENTION & MANAGEMENT OF DRUG INTERACTIONSKomal Haleem
This presentation describes the steps to be performed by a pharmacist to play a major role in prevention and management of drug interactions and includes a case study.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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2. •Vancomycin is a glycopeptide antibiotic used
in the prophylaxis and treatment of infections
caused by Gram-positive bacteria.
•Vancomycin is used to treat infections of the
intestines that cause colitis (inflammation of
the large intestine).
DESCRIPTION
4. PREPARATIONS
125 mg
250mg
500 mg
750mg
1g
5g
10g
- Capsules, oral
- Injection, lyophilized powder for solution:
- Injection, frozen, premixed solution:
500 mg per 100 mL
750 mg per 150 mL
1 g per 200 mL
5. INDICATIONS AND USAGE
ORAL
• Treatment of Clostridium difficile –associated diarrhea
• Treatment of staphylococcal enterocolitis.
PARENTERAL
• Treatment of serious or severe infections caused by
susceptible strains of methicillin-resistant
(beta-lactam–resistant) staphylococci
• Treatment of staphylococcal, streptococcal, enterococcal,
or diphtheroid endocarditis.
13. IV: about 75% is excreted in the urine by
glomerular filtration (in the first 24 hrs).
Mean half-life is 4 to 6 hrs.
Oral: feces
14. SPECIAL POPULATIONS
RENAL FUNCTION IMPAIREMENT:
Slows excretion of vancomycin
In anephric patients: half-life is 7.5 days.
Dosage adjustment is required.
ELDERLY:
Total systemic and renal Cl may be reduced.
Dosage adjustment is required.
16. Endocarditis (staphylococcal, streptococcal,
enterococcal, diphtheroid), staphylococcal
infections
IV 500 mg every 6 h or
1 g every 12 h at a rate
no faster than 10
mg/min or over at least
60 min, whichever is
longer.
IV 10 mg/kg per
dose given every 6
h over at least 60
min.
IV initial dose of 15
mg/kg, followed by 10
mg/kg every 12 h in the
first week of life and
every 8 h thereafter up
to 1 month of age.
17. C. difficile –associated diarrhea
PO 125 mg 4 times daily for
10 days.
PO 40 mg/kg/day in 3 or 4
divided doses for 7 to 10
days; max dosage is 2 g/day.
18. Staphylococcal enterocolitis
PO 500 mg to 2 g in 3 or 4
divided doses for 7 to 10
days.
PO 40 mg/kg/day in 3 or 4
divided doses for 7 to 10
days
21. GI
Nausea; abdominal pain; diarrhea, vomiting; flatulence;
antibiotic-associated colitis.
Genitourinary
UTI; nephrotoxicity including increased blood creatinine,
renal failure, and renal impairment
Local
Injection-site inflammation.
Respiratory
Dyspnea, wheezing.
Red man syndrome
Flushing of the face, neck, upper chest,
and extremities
Hypokalemia
Pyrexia
22. PRECAUTIONS
Pregnancy
Category C (injection); Category B (oral).
Lactation
Excreted in breast milk.
Renal Function
Dosage adjustments required; use with caution.
Children
Confirming serum levels is recommended.
Elderly
Adjust dosage schedules.
Administration
Give by secure IV route. May minimize thrombophlebitis by
giving slowly as dilute infusion.
25. DRUG INTERACTIONS
ANESTHETICS
• increased risk of hypersensitivity &
infusion-related reactions
INDOMETHACIN • increases vancomycin toxicity in neonates.
METHOTREXATE
• increases methotrexate toxicity
NON DEPOLARIZING
MUSCLE RELAXANTS
• neuromuscular blockade may be enhanced
AMINOGLYCOSIDES,
AMPHOTERICIN B,
BACITRACIN, CISPLATIN,
POLYMIXIN B
• increases risk of nephrotoxicity and/or
neurotoxicity.
26. Storage & Stability
Parenteral
Store vials at 68° to 77°F.
After reconstitution,
vials may be stored in a
refrigerator for 14 days.
Oral
Store at 59° to 86°F.
27. PATIENT COUNSELING
Explain that IV medication is given at regular intervals
to maintain blood levels.
Tell patients to report hearing loss, ringing in ears, or
vertigo to their health care provider.
Identify symptoms of potential
adverse reactions.
Tell patients to maintain adequate
fluid intake.
Tell patients not to stop taking
vancomycin, even if they start to
feel better.
29. Prednisone is a corticosteroid. It prevents the release
of substances in the body that cause inflammation.
Prednisone also suppresses the immune system.
Prednisone is used as an anti-inflammatory or an
immunosuppressant medication
DESCRIPTION
33. PHARMACOLOGY
Intermediate-acting glucocorticoid
that depresses formation, release, and
activity of endogenous mediators of
inflammation, including
prostaglandins, kinins, histamine,
liposomal enzymes, and complement
system.
Also modifies body's immune
response.
35. Absorption
Rapid, almost complete.
Distribution
Crosses placenta.
Metabolism
Mainly hepatic, also renal and in the tissue. Prednisone
is inactive and rapidly metabolized to active
prednisolone.
Elimination
Renal. Plasma t ½ is 3.4 to 3.8 h.
Peak
1 to 2 h.
Duration
1.25 to 1.5 days.
37. Adults
PO 5 to 60 mg/day.
COPD Adults
PO 30 to 60 mg/day for 1 to 2 wk, then taper.
Duchenne Muscular Dystrophy Adults
PO 0.75 to 1.5 mg/kg/day.
Graves Ophthalmopathy Adults
PO 60 mg/day; taper to 20 mg/day.
40. Estrogens, ketoconazole,
oral contraceptives
Decreased Cl of prednisone.
Nondepolarizing muscle relaxants
May potentiate, counteract, or have no effect on
neuromuscular blocking action.
Salicylates
Reduced serum levels and efficacy of salicylates.
Somatrem
Inhibition of growth-promoting effects of somatrem.
Theophylline
Alterations in pharmacologic activity of either agent.
43. Genitourinary
Increased or decreased motility and number of
spermatozoa.
Hematologic
Leukocytosis.
Metabolic
Sodium and fluid retention; hypokalemia; hypokalemic
alkalosis; metabolic alkalosis; hypocalcemia.
GI
Pancreatitis; abdominal distention; ulcerative
esophagitis; nausea; vomiting; increased appetite and
weight gain; peptic ulcer with perforation and
hemorrhage; small and large bowel perforation.
45. Adrenal suppression
Cardiovascular effects
Hepatitis
Immunosuppression
Infections
Ocular effects
Use systemic drug cautiously in ocular herpes simplex
because of possible corneal perforation.
Ophthalmic use
Peptic ulcer
Stress
Withdrawal
Abrupt discontinuation may result in adrenal insufficiency.
46. OVERDOSAGE
Cushingoid changes, Moonfaced, central obesity
hirsutism, acne, ecchymoses, hypertension,
osteoporosis, myopathy
sexual dysfunction
diabetes mellitus, hyperlipidemia
peptic ulcer, GI bleeding
increased susceptibility to infection
electrolyte and fluid imbalance
psychosis
48. DESCRIPTION
Salbutamol tablets belong to a group of medicines called
selective beta-2-adrenergic agonists, which can be used to
relax the muscles of the airways.
Salbutamol is available for administration by the following
routes:Inhalation, tablet, elixir, intravenous injection,
subcutaneous injection,intramuscular injection
49. INDICATIONS
Salbutamol is a beta-adrenergic stimulant which has a highly
selective action on beta2-receptors in bronchial smooth muscle
and in therapeutic dosage, little or no action on cardiac beta1-
receptors.
Salbutamol has an advantage in asthma treatment by
minimising side effects associated β1 receptor stimulation
50. •Asthma, to relieve the narrowing of the airways
•Chronic bronchitis
•Emphysema
•Prevention of premature labour.
USAGE
53. METABOLISM
Salbutamol absorbed in the gastrointestinal tract
has a substantial first pass metabolism and is
metabolized into Phenolic Sulfate.
Inhaled Salbutamol acts directly on smooth
muscle of the upper airways bypassing
metabolism in the liver.
55. DOSAGE AND ADMINISTRATION
Ventolin S.R. Tablets must be swallowed whole with a glass of
water and not chewed or crushed.
Adults:
Usual dose is 4mg three or four times a day. Your doctor may
increase this gradually up to a maximum of 8mg three or four
times a day. Some patients may be treated successfully with
2mg three or four times a day.
56. Children 2-6 years:
1-2mg three or four times a day.
Children 6-12 years:
2mg three or four times a day.
Children over 12 years:
2-4mg three or four times a day.
Children under 2 years:
Not recommended.
Premature labour:
The maintenance dose is 4mg three or four times a day.
DOSAGE AND ADMINISTRATION
57. CONTRA-INDICATIONS
Ventolin oral preparations are contra-indicated in patients with
a history of hypersensitivity to any of their components.
Intravenous salbutamol and occasionally salbutamol tablets are
used in the management of premature labour uncomplicated by
conditions such as placenta praevia, antepartum heamorrhage
or toxaemia of pregnancy.
Salbutamol presentation should not be used for threatened
abortion.
58. WARNINGS
Increase use of short-acting inhaled beta2-agonists to control
symptoms indicates deterioration of asthma control.
Sudden and progressive deterioration in asthma control is
potentially life-threatening and consideration should be given
to starting or increasing corticosteroid therapy.
If dose fails to give usual relief, medical advice should be
sought.
59. PRECAUTIONS
Salbutamol and non-selective beta-blocking drugs, such as
propranolol, should not usually be prescribed together.
Salbutamol should be administrated cautiously to the patients
suffering from thyrotoxicosis.
Particular caution is advised in acute severe asthma, as this
effect may be potentiated by concomitant treatment with
xanthine derivatives, steroids, diuretics and by hypoxia.
60. Administration of drugs during pregnancy should
only be considered if the expected benefit to the
mother is greater than any possible risk to the fetus.
PREGNANCY
61. Salbutamol is probably secreted in breast milk, its
use in nursing mothers is not recommended unless
the expected benefits outweigh any potential risk. It
is not known whether salbutamol in breast milk has
a harmful effect on the neonate.
LACTATION
62. SIDE EFFECTS
Ventolin oral preparations may cause a fine tremor of
skeletal muscle in some patients.
Occasionally headaches.
Feeling of tension in some patients.
Hypersensitivity reactions including angioedema,
urticaria, bronchospasm, hypotension and collapse have
been reported very rarely.
63. An allergic reaction (hypersensitivity): swelling of the face, lips,
throat or tongue, pale or red irregular raised patches with severe
itching (hives), difficulty breathing, low blood pressure, collapse.
Increased lactic acid in the body: rapid breathing, being sick,
stomach pain.
Low blood potassium: muscle twitching or weakness, an irregular
heart beat.
SIDE EFFECTS
64. Salbutamol is not contra-indicated in patients
under treatment with monoamine oxidase
inhibitors ( MAOIs).
DRUG INTERACTIONS
nostrils). The rest of the respiratory tract, open wounds, intravenous catheters, and theurinary tract are also potential sites for infection (MRSA)
Vancomycin is added to the bacterial environment while it is trying to synthesize new cell wall. Here, the cell wall strands have been synthesized, but not yet cross-linked.
Vancomycin recognizes and binds to the two D-ala residues on the end of the peptide chains. However, in resistant bacteria, the last D-ala residue has been replaced by a D-lactate, so vancomycin cannot bind.
In resistant bacteria, cross-links are successfully formed. However, in the non-resistant bacteria, the vancomycin bound to the peptide chains prevents them from interacting properly with the cell wall cross-linking enzyme.
In the resistant bacteria, stable cross links are formed. In the sensitive bacteria, cross-links cannot be formed and the cell wall falls apar
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