2. Cefixime
Binds to one of the penicillin binding
proteins (PBPs) which inhibits the final
transpeptidation step of the peptidoglycan
synthesis in the bacterial cell wall
Inhibiting biosynthesis and arresting cell
wall assembly
Bacterial cell death
Mechanism of action of Cefixime
3. Benefits of Cefixime
Broad spectrum
Active against Gram Negative Enterobacteriaceae
Anti-pseudomonal
Resistant to beta-lactamase
4. Safe & Suitable for use in children
Safe for use in children of age 6 months and above.
Moreover, in its long history of clinical use in the world, no
significant side effects have been observed in children to
elderly with cefixime.
5. Convenient dosage schedule
Patients Dosage
Children 8 mg/kg/day in two divided doses or
once daily
Children with typhoid fever 20 mg/kg/day in two divided doses
