2. Sodium Valproate is a Broad spectrum
antiepileptic Drug affective to all types of
seizures.
Also called as antiseizure Drug
Its also used as a Mood Stebilizer
Trade Names :
Encorate Choron
Vaiparin
Epilex
Epival
INTRODUCTION
5. ACTION
Broad Spectrum Antiepileptic
Acts by multiple mechanisms :
Blockade of use dependent Na+ channel
Inhibition of Ca++
Enhanced Release of inhibitory transmitter GABA
Blockade of NMDA glutamate receptor
6.
7. PHARMACOKINETICS
•Oral absorption is good it is 90% bonds to
plasma proteins
•Completely metabolized in liver by oxydation
•Excreated in urine
•The steady half life of valproate is about 8-17
hours but anticonvulsant effects are long
lasting
12. Anorexia
Aabdominal cramps with diarrhoea
Hepatic failure,Hepatitis,Jaundice
Hematolgical
Prolonged bleeding time
leukopenia
thrombocytopenia
13. bone marrow depression
anemia
Other-Skin rashes
Hair loss
Overdose
Deep coma
Pulmonary edema
Death
Rare
Irreversible hepatic necrosis(below 2 year childrans)
Neural Tube Defect /Spina Bifida (Pregnancy)
14. NURSES RESPONSIBALITY
Nursing Diagnosis:
Risk for injury related to drug side effects
Noncompliance related to medical regimen knowledge
deficit
Knowledge deficit related to drug therapy
Ineffective therapeutic regimen management
Situational low self esteem related to social role change
Risk for injury related to recurrent seizure by drug
withdrawal
15. Assessment :
Detailed History Collection about Liver problem
&Kidney Disorders
Periodical checking Liver Function Test ,BUN,
Creatinine, potassium & Serum ,CBC tests
Monitoring Vitals Mainly BP, Therapeutic
effectiveness is indicated by Decreased BP
16. Implication:
Do not mix Valproate Syrup with any carbonate Drink
Never Concurrent administer clorazipam & Valproate
Should not chew tablets
Monitor for any adverse reactions
17. oWomen who become pregnant should immediately
inform their physicians (prevention of neural tube defects)
oWeight gain is a common side effect especially in long
term treatment & can be treated by limited calorie intake.
oClear explanation about Side Effects
oEducation related to Medication
Time
Missed Dose
Discontinuation
oOver Dose Management
oMedical alert bracelet
oFollow up
PATIENT TEACHING