This document provides information about drug nanocrystals including their definition, properties, preparation methods, applications, and case studies. It defines drug nanocrystals as pure solid drug particles with a mean diameter below 1000 nm. The main preparation methods described are media milling, high-pressure homogenization, and precipitation. Applications discussed include oral, ophthalmic, parenteral, and respiratory drug delivery due to properties like increased dissolution velocity and saturation solubility from smaller particle size. Two case studies on valasartan and simvastatin nanocrystals are also summarized.
Introduction
Structure
Niosomes Vs. Liposome
Advantages & Disadvantages
Properties of Niosomes
Method of Manufacturing
Evaluation of Niosomes
Applications
Marketed products
Introduction
Structure
Niosomes Vs. Liposome
Advantages & Disadvantages
Properties of Niosomes
Method of Manufacturing
Evaluation of Niosomes
Applications
Marketed products
Introduction
Need of Nanosuspension
Advantages of Nanosuspension
Disadvantages of Nanosuspension
Method Of Preparation
Formulation Considerations
Characterization of Nanosuspension
Current Marketed Formulations
Pharmaceutical Applications
Nanoparticles consists of organic and inorganic materials. Nanocrystals are aggregates of atoms that combine into a “cluster” and are pure drug crystals with sizes in the nanometer range stabilized or surrounded by a thin coating of surfactant. Todays nanocrystal formulation preparation method characterised as “bottom up” “top down” and “bottom up” spray drying methods. The majority of nanocrystal medicinal products are presently approved for oral ingestion and treatment of disorders other than cancer. Smurti Magar | Prof. Santosh Waghmare | Dr. Hemant Kamble "Nanocrystals-As Drug Delivery System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-3 , April 2022, URL: https://www.ijtsrd.com/papers/ijtsrd49563.pdf Paper URL: https://www.ijtsrd.com/humanities-and-the-arts/other/49563/nanocrystalsas-drug-delivery-system/smurti-magar
A Nanosuspension is a submicron colloidal dispersion of drug particles. A pharmaceutical nanosuspension is defined as very finely colloid, Biphasic, dispersed, solid drug particles in an aqeous vehicle , size below 1µm ,without any matrix material, stabilized by surfactants and polymers , prepared by suitable methods for Drug Delivery applications, through various routes of administration like oral ,topical ,parenteral ,ocular and pulmanary routes.
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
Introduction
Need of Nanosuspension
Advantages of Nanosuspension
Disadvantages of Nanosuspension
Method Of Preparation
Formulation Considerations
Characterization of Nanosuspension
Current Marketed Formulations
Pharmaceutical Applications
Nanoparticles consists of organic and inorganic materials. Nanocrystals are aggregates of atoms that combine into a “cluster” and are pure drug crystals with sizes in the nanometer range stabilized or surrounded by a thin coating of surfactant. Todays nanocrystal formulation preparation method characterised as “bottom up” “top down” and “bottom up” spray drying methods. The majority of nanocrystal medicinal products are presently approved for oral ingestion and treatment of disorders other than cancer. Smurti Magar | Prof. Santosh Waghmare | Dr. Hemant Kamble "Nanocrystals-As Drug Delivery System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-3 , April 2022, URL: https://www.ijtsrd.com/papers/ijtsrd49563.pdf Paper URL: https://www.ijtsrd.com/humanities-and-the-arts/other/49563/nanocrystalsas-drug-delivery-system/smurti-magar
A Nanosuspension is a submicron colloidal dispersion of drug particles. A pharmaceutical nanosuspension is defined as very finely colloid, Biphasic, dispersed, solid drug particles in an aqeous vehicle , size below 1µm ,without any matrix material, stabilized by surfactants and polymers , prepared by suitable methods for Drug Delivery applications, through various routes of administration like oral ,topical ,parenteral ,ocular and pulmanary routes.
Colloidal particles ranging in size between 10 & 1000 nm are known as nanoparticles.
SLNs are new generation of submicron sized lipid emulsion where the liquid lipid(oil) has been substituted by a solid lipid.
Example: Capture - Dior
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Ten Important Life Lessons on Nano Medicine Research Paper Taught Usscience journals
Journal of Nano medicine & Nanotechnology is a scholarly open access journal that covers a wide range of themes in this field, including molecular nanotechnology, nano sensors, nano particles, nano drugs, Nano materials, nano biotechnology, nano bio pharmaceutics, nano electronics, and nano robotics. This peer reviewed journal strictly adhered to the standard review process to enhance the quality of the publication.
Preparation and characterization of nimesulide loaded cellulose acetate hydro...Jing Zang
The aim of this study is to prepare nimesulide loaded cellulose acetate hydrogen phthalate nanoparticles by salting out technique. In this study Cellulose acetate Hydrogen phthalate was taken as polymer. Nimesulide was selected as a model drug. This technique is suitable for drugs and polymers that are soluble in polar solvents such as acetone or ethanol. The effect of drug concentration and polymer concentration on nanoparticle size, shape, uniform size distribution and stability was studied. Nanoparticles were evaluated for particle size, zetapotential and particle size distribution. Size of the particle was measured by SEM.(Scanning electron microscope).Surface charge and stability of the resultant nanoparticles was determined by Zetasizer. Particle size distribution was determined by Photon Correlation Spectroscopy (PCS) with a Malvern Zetasizer Nano-ZS. The cellulose acetate hydrogen phthalate concentration and nimesulide concentration was varied from 5mg/ml to 10 mg/ml. The effect of drug and polymer concentrations on nanoparticle size, shape, particle size distribution was studied. Increased drug concentration has no impact on the particle size. The size of the particle was found to be decreased with increased polymer concentration. Increased polymer concentration has resulted in uniform particle size distribution. Higher the polymer concentrations and lower the drug concentrations resulted in uniform particle size distribution.
nanoparticle is part of novel drug delivery system. in this presentation we will study about the concept of nanoparticle, classification of nanoparticle, method of preparation, advantages & disadvantages with marketed formulation.
Surface-Functionalized Nanoparticles for Controlled Drug Delivery: The effectiveness of the surface-functionalized nanoparticles, which consist of copolymers with functional molecules
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
Acetabularia Information For Class 9 .docxvaibhavrinwa19
Acetabularia acetabulum is a single-celled green alga that in its vegetative state is morphologically differentiated into a basal rhizoid and an axially elongated stalk, which bears whorls of branching hairs. The single diploid nucleus resides in the rhizoid.
2. FLOW OF PRESENTATION.
• INTRODUCTION.
• NEED OF IT.
• PROPERTIES.
• METHODS OF PREPARATION
• APPLICATIONS.
3. Difference between Nano
crystals and drug Nano crystals.
Nano crystals are the substances in which the
drug is combined with the polymer like PVP.
Whereas drug Nano crystals includes only the
drug which is in the Nano crystals form.
4. INTRODUCTION.
➢ What is DRUG NANOCRYSTALS?
Drug Nano crystals are pure solid drug particles with a mean
diameter below 1000 nm.
The term drug Nano crystals implies a crystalline state of the
discrete particles, but depending on the production method they
can also be partially or completely amorphous.
Drug Nano crystals have to be distinguished from polymeric
nanoparticles, which consist of a polymeric matrix and an
incorporated drug.
These do not consist of any matrix material.
Drug Nano crystals are formed by decreasing the particle size ,
causing an increase in solubility of the drug.
Thus this technology is explored to increase the bioavailability of
sparingly water soluble drugs.
5. NEED OF DRUG NANOCRYSTALS
At present , about 40% of the drugs in the developing stage are
poorly water soluble and these also shows problems in the
formulation of dosage form.
70% of the potential drug candidates are discarded due to low
bioavailability.
For class II drugs like itraconazole and carbamazepine which are very
poorly soluble in aqueous and organic phase , the problem is much
more complex.
Various approaches are made to resolve the problems of solubility
and bioavailability of drugs by following methods: Micronization , co
- solvency , salt formation , micro emulsions , etc.
6. Many of these techniques are not universally applicable to all drugs
nor they are applicable to drugs which are not soluble in both
aqueous and organic media.
A different but simple approach is needed to tackle the formulation
problem to improve their efficacy and to optimize the therapy with
respect to pharmacokinetics.
7. METHODS OF PREPARATIONS
Media Milling method
High-pressure homogenization
Precipitation are the main methods employed for the
production of drug Nano crystals.
8. BOTTOM – UP TECHNIQUES
PRECIPITATION TECHNIQUE:
A poor water-soluble drug is dissolved in an
organic medium, which is water miscible.
Pouring of this solution into a non solvent, such as
water, will cause a precipitation of finely
dispersed drug Nano crystals.
9. Lyophilization is recommended to preserve
the particle size .
The increased viscosity of the aqueous phase
can reduce particle growing. But this
technology has not been applied to a product
to date.
A problem associated with this technology is
that the formed nanoparticles need to be
stabilized to avoid growth in micrometer
crystals.
10. TOP – DOWN TECHNIQUES
1. Pearl/ball milling method:
Marketed preparations includes Megace ES, Rapamune , Tricor.
2. High pressure homogenisation technique:
11. TOP – DOWN TECHNIQUE
PEARL / MILLING TECHNIQUE:
Small milling pearls or large milling balls are used as
milling media.
With a reduction in the size of grinding media in a media
mill, the number of contact points is increased
exponentially resulting in improved grinding and
dispersing action (i.e., leading to smaller particles).
12. The pearls or balls consist of ceramics (cerium- or
yttrium-stabilized zirconium dioxide), stainless
steel, glass, or highly cross-linked polystyrene resin-
coated beads.
PROBLEM ASSOCIATED:
With the pearl milling technology is the erosion
from the milling material during the milling process.
18. 1.Increase of dissolution velocity by
surface area enlargement
Noyes Whitey equation, where dX/dt =dissolution rate, Xd =amount
dissolved, A=particle surface area, D=diffusion coefficient, V=volume of
fluid available for dissolution, Cs=saturation solubility, h=effective
boundary layer thickness.
↓size ↑surface area
By Noyes
Whitney
Equation
So, micronization is
done to ↑
bioavailability
→dissolution of rate
limiting
Moving to
nanonization→
↑ surface area &
dissolution
velocity
19. 2. Increase in saturation solubility
Is a constant depends on
COMPOUND<DISSOLUTIO
N MEDIUM
& TEMPERATURE
Drug Nanocrystal
has ↑ saturation
solubility
This ↑ with ↓
particle size.
23. OPHTHALMIC DRUG DELIVERY
Ex: Budesonide, Dexamethasone, Hydrocortisone,
Prednisolone And Fluorometholone.
Causes
Improved
bioavailability
Long lasting drug
action.
SIGNIFICANCE
Absence of
irritancy due to
smaller size &
aqueous medium
Muco
adhesiveness
causing ↑
bioavailability.
24. PARENTERALS
Particles >5µm is not used
Smallest size of blood capillary is 5µm→capillary blockade &
embolism
Also, Administration into body cavities is also of great interest,
as it ↑ tolerability
To achieve a local treatment or to have a depot with slow release
(e.g. into the blood).
26. Case study 1
EVALUATION OF NANOCRYSTALS OF VALSARTAN
(antihypertensive) FOR SOLUBILITY ENHANCEMENT.
1. PREPARATION OF VALSARTAN NANOCRYSTALS
Valsartan nanocrystals were prepared by antisolvent precipitation
technique, introduction of the drug solution to the antisolvent (water).
It is beneficial if it solubilize the drug in large amount and possesses a
fast diffusion rate to the antisolvent water; while the stabilizer need to
have good affinity for drug crystals and possess a fast diffusion rate
and effective adsorption onto the drug crystals surface in the water-
solvent mixture.
In this work, among the water-miscible solvent candidates ethanol
and acetone, acetone was selected due to its highest capacity to
solubilize valsartan (>100 mg/ml).
27. •Nine batches of valsartan nanocrystals were prepared containing
drug (valsartan):polymer (PVP K30) in the ratio of 1:1, 1:5, 1:9 under
1000 rpm, 900 rpm and 800 rpm respectively.
EVALUATION OF VALSARTAN NANOCRYSTALS
In- vitro dissolution of pure Valsartan and Valsartan Nanocrystals
28. The dissolution studies for pure valsartan and optimized
formulation of Valsartan Nanocrystals (V2) were carried out in
0.1N HCl using USP Type II apparatus at 50 rpm and
37˚C.Valsartan nanocrystals released 86.32 % of drug in
solution after 40 min where pure drug released 48.44
29. DISCUSSION:
It was observed that dissolution rate of
the drug is more in Valsartan nanocrystals
than pure drug.
It can be concluded that dissolution rate
has been enhanced with nanocrystals .
30. Case study 2
Preparation And Characterization Of Simvastatin Nanosuspension By
Homogenization Method.
Preparing Nanosuspension:
Simvastatin nanosuspension is prepared by high pressure
homogenization method. Simvastatin powder (1% w/v) was dispersed
in aqueous surfactant solution using magnetic stirrer. After drug
dispersion first size reduction step is carried out using ultra turax T25
basic homogenizer at 9500 rpm for 10 min. Then obtained mixture is
homogenized using micron lab 40 homogenizer (APV systems,
Germany). The homogenization steps includes first two steps with
100 bar pressure and next two cycles with 500 bar pressure as
initial step. Finally the suspension is homogenized for 15 cycles with
31. In-Vitro Drug Release Studies:
The in-vitro release of simvastatin and the nanosuspension was carried
out in USP dissolution test apparatus using paddle method at a rotation
speed of 50 RPM. The dissolution profile of was carried out in freshly
prepared acidic buffer (pH-1.2) and also in phosphate buffer (pH 7.0)
containing 0.5% sodium lauryl sulphate. 10 mg of pure drug and
nanosuspension equivalent to 10 mg of plain simvastatin was taken and
placed in dissolution medium. The volume and temperature of
dissolution medium were 900 ml and 37.0 ± 0.2°c, respectively. 5ml of
samples were withdrawn at fixed time interval and were filtered. An
equal volume of freshly prepared dissolution medium was replaced to
maintain the sink condition. The filtered samples were analysed at 238
nm using Shimadzu UV Visible spectrophotometer.
34. RESULTS & DISCUSSIONS.
The particle size distribution studies showed that all the formulation
particle size was in the range of 240-244 nm and where as
unprocessed drug shows 31.49 μm sizes. All the formulations having
a particle size in the nanometer range and showing ideal surface
morphology.
In-vitro drug release data shows the increased dissolution rate of
formulations compared to unprocessed drug.
Also, the FN3 showed comparatively an increased solubility and
permeability as compared to other formulations and unprocessed
drug.
35. REFERENCES
Advanced Drug Delivery Reviews 63 (2011) 456–469
International Journal Of Pharmtech Research , July- sept 2009, Vol.1, No.3, Pg
682-694
Sarnes A, Liu P, Puranen J, Rönkkö S, Laaksonen T, Kalesnykas G, Oksala O, Ilkka J,
Laru J, Järvinen K, Hirvonen J, Peltonen L. Brinzolamide Nano Crystal Formulations
For Ophthalmic Delivery: Reduction Of Elevated Intraocular Pressure In Vivo.
Submitted Manuscript, 2013.
World Journal Of Pharmacy And Pharmaceutical Sciences , Volume 3, Issue 3,
1414-1427, Research Article, ISSN 2278 – 4357
International Journal Of Pharmtech Research, CODEN (USA): IJPRIF ISSN : 0974-
4304 Vol.5, No.1, Pg 193-197, Jan-mar 2013.