Drug delivery system based on gold nanostars
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This document summarizes a student's design of a photodelivery drug system using gold nanostars covered with polyacrylic acid modified with β-cyclodextrin. The system aims to have nanoparticles with strong near-infrared absorption and high light-to-heat conversion. β-cyclodextrin would store the drug (e.g. doxorubicin), and the coating would provide stability. The student's experiments show the system has over 90% drug loading capacity and can release 6% of the drug under near-infrared light irradiation.
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ChinaNANO2007
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Drug delivery system based on gold nanostars
- 1. Design of a photodelivery system based on gold nanostars, covered with poliacrylic acid modified with β – cyclodextrin. AUTHOR: CARLOS MARANGE TUTOR: PhD. ROBERTO CAO MILÁN FACULTY OF CHEMISTRY| UNIVERSITY OF HAVANA
- 2. Aspects to consider in the development of a drug delivery system based on nanoparticles 1- Nanoparticles with strong absorption in the near infrared region with high efficiency in the conversion of light into heat. 2- Substance capable of storing the drug of interest. 3- Stability in physiological environment.
- 3. Gold nanoparticles properties Biocompatibility High chemical stability Surface plasmon resonance can be tuned to the near infrarred
- 5. Surface plasmon resonance Scattering of light Heating
- 6. UV spectrum characteristic of a nanostars Branches Core
- 7. Absorption zones in human tissue 650 1100
- 9. + -------- Doxorubicin Cyclodextrin Carolin Thiele, D.A., Gregor Jung, Gerhard Wenz, Inclusion of chemotherapeutic agents in substituted beta-cyclodextrin derivatives. J Incl Phenom Macrocycl Chem, 2011. 69: p. 303–307.
- 10. Interactions by hydrogen bonds and electrostatically, carboxyl groups can be activated to covalently conjugate proteins succinylated cyclodextrin polymer aminated cyclodextrin polymer
- 12. Results obtained Charging capacity of 36% Photorelease capacity of 6%
- 13. Redesigning the drug delivery system
- 15. Schematic representation of the proposed system Au
- 16. Doxorubicin β - Cyclodextrin Polyacrylic acid Gold Nanostar
- 18. Gold nanostars synthesis [Reaction schema]
- 19. Synthesis of polyacrylic acid modified with β - Cyclodextrin [Reaction schema]
- 20. Results
- 21. TEM
- 22. Stability in physiological environment ~ 900 nm Abs Wavelength (nm)
- 23. Determining the charge capacity of the system Calibration curve for doxorubicin Adsorption isotherm 90% by weight
- 24. 90 % > 36 % Payload capacity
- 25. Higher payload report of doxorubicin found (2010) Around 60 % Jian You, G.Z., and Chun Li, Exceptionally High Payload of Doxorubicin in Hollow Gold Nanospheres for Near-Infrared Light- Triggered Drug Release. ACSNANO, 2010. 4(2): p. 1033–1041.
- 26. Photorelease study Laser’s characteristics Power: 500 mW/cm Wavelength: 800 nm Diameter: 6 mm 2
- 27. Conclusions - The system reported has a high charge capacity compared to others in the literature. - It is possible to release the drug under irradiation with near infrared light even with a laser of low power.