Pediatrics notes about "Pediatric Drowning". These notes were published in 2018.
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Drowning occurs when a person experiences respiratory impairment from submersion or immersion in liquid. There are several types of drowning including wet, dry, secondary, and immersion syndrome. The pathophysiology involves hypoxemia, hypothermia, and fluid and electrolyte disturbances depending on if the drowning occurred in freshwater versus saltwater. Management at the scene focuses on airway, breathing, circulation and rapid removal from the water. Prognosis depends on the extent of cerebral hypoxia and injury, time to resuscitation, and need for continued resuscitation efforts.
Here are the steps to calculate fluid and electrolyte deficits and replacement for this infant:
1. Percent dehydration = (Pre-illness weight - Current weight) / Pre-illness weight x 100 = (7kg - 6.3kg) / 7kg x 100 = 10%
2. Fluid deficit = Percent dehydration x Pre-illness weight = 10% x 7kg = 0.7L
3. Na+ deficit = Fluid deficit x Proportion from ECF x Na+ concentration in ECF
= 0.7L x 0.6 x 145 mEq/L = 72.6 mEq
4. K+ deficit = Fluid deficit x Pro
An 8 year old female presented with signs of septic shock including a heart rate of 180, respiratory rate of 35, and hypotension. Initial assessments found a temperature of 39.9°F, respiratory rate of 32 breaths/min, blood pressure of 70/50 mmHg, and oxygen saturation of 90% on room air. The patient appeared tired and had delayed capillary refill of 4 seconds.
Paediatric septic shock remains a significant cause of morbidity and mortality worldwide. Early goal directed therapy is crucial and aims to achieve specific clinical targets within 6 hours such as a central venous pressure of 8-12 mmHg, mean arterial pressure over 65 mmHg, urine output over 0.5 ml/kg/
This document discusses chronic kidney disease (CKD) in pediatrics. It defines CKD as kidney damage lasting at least 3 months as determined by structural abnormalities and/or a glomerular filtration rate below 60 mL/min/1.73m2. The stages of CKD are described based on GFR. Common causes in children include congenital abnormalities and glomerulonephritis. The pathogenesis involves hyperfiltration injury and other factors like proteinuria that accelerate kidney damage. Management aims to address complications through careful monitoring, nutrition, treatment of mineral bone disorders, and controlling blood pressure and electrolyte abnormalities.
This document provides an overview of diarrhea in children, including definitions, epidemiology, etiology, pathophysiology, clinical manifestations, complications, evaluation, and management. Some key points include:
- Diarrhea is defined as >3 loose stools per day or watery stool of any frequency. It is a leading cause of death in children under 5 years old.
- Common causes are viral (e.g. rotavirus), bacterial (e.g. E.coli), and parasitic (e.g. Giardia).
- Complications include dehydration, malnutrition, and electrolyte imbalances.
- Management involves oral rehydration, continued feeding, and treating the underlying cause
Leukemias are the most common cancers in children, with acute lymphoblastic leukemia (ALL) accounting for 73% of cases and acute myeloid leukemia (AML) accounting for 18% of cases. ALL peaks between ages 2-5 years and accounts for 25-30% of all childhood cancers. Treatment involves induction, consolidation/intensification, and continuation phases using chemotherapy protocols over 2-3 years. Supportive care and risk stratification are important for managing treatment and prognosis.
This document discusses the approach to hypoglycemia in childhood. It begins by defining hypoglycemia and describing the importance of glucose for brain development. It then discusses the pathophysiology of hypoglycemia, focusing on how the body maintains blood glucose levels through glycogenolysis, gluconeogenesis, and lipolysis. The clinical features of hypoglycemia are presented, distinguishing between sympathetic overactivity and neuroglycopenic symptoms. Common etiologies like hyperinsulinism, metabolic disorders, and systemic illnesses are outlined. The document concludes with recommendations for investigating hypoglycemia, managing acute episodes, and treating underlying causes to prevent long-term neurological consequences.
This document discusses the evaluation and differential diagnosis of short stature in children. It defines short stature as a height more than 2 standard deviations below the mean for age and sex. The evaluation involves taking a history, performing a physical exam, assessing growth parameters, growth velocity, midparental height, bone age, and indications for further investigations. Common causes discussed are familial short stature, constitutional short stature, and pathological short stature. Treatment options mentioned include growth hormone, oxandrolone, IGF-1, and aromatase inhibitors.
Drowning occurs when a person experiences respiratory impairment from submersion or immersion in liquid. There are several types of drowning including wet, dry, secondary, and immersion syndrome. The pathophysiology involves hypoxemia, hypothermia, and fluid and electrolyte disturbances depending on if the drowning occurred in freshwater versus saltwater. Management at the scene focuses on airway, breathing, circulation and rapid removal from the water. Prognosis depends on the extent of cerebral hypoxia and injury, time to resuscitation, and need for continued resuscitation efforts.
Here are the steps to calculate fluid and electrolyte deficits and replacement for this infant:
1. Percent dehydration = (Pre-illness weight - Current weight) / Pre-illness weight x 100 = (7kg - 6.3kg) / 7kg x 100 = 10%
2. Fluid deficit = Percent dehydration x Pre-illness weight = 10% x 7kg = 0.7L
3. Na+ deficit = Fluid deficit x Proportion from ECF x Na+ concentration in ECF
= 0.7L x 0.6 x 145 mEq/L = 72.6 mEq
4. K+ deficit = Fluid deficit x Pro
An 8 year old female presented with signs of septic shock including a heart rate of 180, respiratory rate of 35, and hypotension. Initial assessments found a temperature of 39.9°F, respiratory rate of 32 breaths/min, blood pressure of 70/50 mmHg, and oxygen saturation of 90% on room air. The patient appeared tired and had delayed capillary refill of 4 seconds.
Paediatric septic shock remains a significant cause of morbidity and mortality worldwide. Early goal directed therapy is crucial and aims to achieve specific clinical targets within 6 hours such as a central venous pressure of 8-12 mmHg, mean arterial pressure over 65 mmHg, urine output over 0.5 ml/kg/
This document discusses chronic kidney disease (CKD) in pediatrics. It defines CKD as kidney damage lasting at least 3 months as determined by structural abnormalities and/or a glomerular filtration rate below 60 mL/min/1.73m2. The stages of CKD are described based on GFR. Common causes in children include congenital abnormalities and glomerulonephritis. The pathogenesis involves hyperfiltration injury and other factors like proteinuria that accelerate kidney damage. Management aims to address complications through careful monitoring, nutrition, treatment of mineral bone disorders, and controlling blood pressure and electrolyte abnormalities.
This document provides an overview of diarrhea in children, including definitions, epidemiology, etiology, pathophysiology, clinical manifestations, complications, evaluation, and management. Some key points include:
- Diarrhea is defined as >3 loose stools per day or watery stool of any frequency. It is a leading cause of death in children under 5 years old.
- Common causes are viral (e.g. rotavirus), bacterial (e.g. E.coli), and parasitic (e.g. Giardia).
- Complications include dehydration, malnutrition, and electrolyte imbalances.
- Management involves oral rehydration, continued feeding, and treating the underlying cause
Leukemias are the most common cancers in children, with acute lymphoblastic leukemia (ALL) accounting for 73% of cases and acute myeloid leukemia (AML) accounting for 18% of cases. ALL peaks between ages 2-5 years and accounts for 25-30% of all childhood cancers. Treatment involves induction, consolidation/intensification, and continuation phases using chemotherapy protocols over 2-3 years. Supportive care and risk stratification are important for managing treatment and prognosis.
This document discusses the approach to hypoglycemia in childhood. It begins by defining hypoglycemia and describing the importance of glucose for brain development. It then discusses the pathophysiology of hypoglycemia, focusing on how the body maintains blood glucose levels through glycogenolysis, gluconeogenesis, and lipolysis. The clinical features of hypoglycemia are presented, distinguishing between sympathetic overactivity and neuroglycopenic symptoms. Common etiologies like hyperinsulinism, metabolic disorders, and systemic illnesses are outlined. The document concludes with recommendations for investigating hypoglycemia, managing acute episodes, and treating underlying causes to prevent long-term neurological consequences.
This document discusses the evaluation and differential diagnosis of short stature in children. It defines short stature as a height more than 2 standard deviations below the mean for age and sex. The evaluation involves taking a history, performing a physical exam, assessing growth parameters, growth velocity, midparental height, bone age, and indications for further investigations. Common causes discussed are familial short stature, constitutional short stature, and pathological short stature. Treatment options mentioned include growth hormone, oxandrolone, IGF-1, and aromatase inhibitors.
Neonatal polycythemia is defined as a venous hematocrit greater than 65%. It can be normovolemic, hypervolemic, or hypovolemic. Common causes include placental transfusion, maternal conditions like diabetes, and intrauterine hypoxia. Symptoms include poor feeding, lethargy, and cardiac or neurological issues. Screening is recommended for small or large infants and those with risk factors. Management may involve partial exchange transfusion to lower the hematocrit if symptoms are present or it is over 70% without symptoms. Studies found partial exchange transfusion effectively reduces hematocrit but did not find clinical benefits in asymptomatic infants.
This document provides guidance on diagnosing and treating diarrhoea in infants and young children. It defines diarrhoea and outlines signs of dehydration. Dehydration is classified as none, some or severe based on symptoms like restlessness, sunken eyes and skin pinch test. Treatment plans involving oral rehydration solution and continued feeding are provided according to dehydration level. Persistent and bloody diarrhoea require additional treatment and follow up. The guidelines aim to safely treat diarrhoea at home or refer urgently when needed.
Congenital syphilis occurs when the syphilis spirochete infects a fetus in utero. Without treatment, approximately 25% of infants with congenital syphilis will die either during pregnancy or shortly after birth. Manifestations of congenital syphilis are divided into infantile forms that occur in the first two years of life, and tardive forms that occur later. Common infantile symptoms include nasal discharge, rashes, liver and bone abnormalities. Late or tardive syphilis develops in nearly half of untreated infants and can cause facial deformities, bone abnormalities, and damage to internal organs like the liver.
The document discusses drowning, including epidemiology, pathophysiology, treatment, and prevention. It notes that drowning is the second leading cause of accidental death for children under 15 and describes the populations most at risk, such as toddlers near bodies of water, adolescents engaging in risky behavior, and elders. The pathophysiology of drowning involves central nervous system and pulmonary injury. Treatment involves rapid rescue, CPR, oxygen, warming, and monitoring for complications like pneumonia or ARDS. Prevention strategies target education and reducing access to water, with an emphasis on constant supervision of children.
Nephrotic syndrome is a manifestation of glomerular disease characterized by nephrotic range proteinuria, hypoalbuminemia, edema, and hyperlipidemia. It is most common in children ages 1.5-6 years and affects boys more than girls. Causes include genetic, secondary, and idiopathic factors. Treatment involves managing edema, infections, and proteinuria with corticosteroids, diuretics, and immunosuppressants. Prognosis is generally good for steroid-responsive nephrotic syndrome but poorer for steroid-resistant cases. Complications can include infections, thrombotic events, and renal failure.
An 11-year-old girl presented with 3 days of fever and left ankle pain. Initial examination and x-rays were normal. She returned with worsening symptoms and was found to have a hot, swollen ankle. MRI revealed subperiosteal abscess and osteomyelitis of the distal tibia. Blood and joint fluid cultures grew Staphylococcus aureus. Osteomyelitis is most commonly caused by S. aureus spreading hematogenously to the metaphysis of long bones in children. Presentation varies by age but may include pain, fever, and reduced mobility. Diagnosis relies on clinical suspicion as initial tests and x-rays may be normal. Advanced imaging and culture of infected sites are important
This presentation was done by Dr. Julius P. Kessy,MD. An intern Doctor at Dodoma Regional Referral Hospital (DRRH) during pediatrics unit clinical meeting and supervised by Dr. Christina K. Galabawa,MD,Mmed2, Pediatrics and Child Health, University of Dodoma (UDOM) in November, 2017.
Nutritional refeeding syndrome kwashiorkar and marasmus indore pedicon 2014Rajesh Kulkarni
This document provides information on the management of severe acute malnutrition (SAM) in children, including refeeding syndrome. It describes a case of an 18-month-old boy admitted with SAM who deteriorated on the third day of treatment. It then discusses refeeding syndrome, its pathophysiology, clinical manifestations, and electrolyte deficiencies. Guidelines are provided for monitoring patients and correcting electrolyte abnormalities during nutritional rehabilitation. The document outlines protocols for the stabilization and rehabilitation phases of SAM treatment, including feeding amounts and micronutrient supplementation.
This document provides an overview of neonatal jaundice, including its epidemiology, pathophysiology, etiology, clinical presentation, management, and complications. Key points include:
- Neonatal jaundice is common, occurring in 50-80% of newborns, and is usually harmless. It is caused by elevated bilirubin levels in the blood.
- Jaundice can be physiological or pathological. The causes and management differ depending on whether the elevated bilirubin is conjugated or unconjugated.
- Evaluation involves clinical exam, bilirubin levels, and other tests to determine the underlying cause. Management includes phototherapy, exchange transfusion, or pharmacotherapy depending on
This document discusses approaches to diagnosing and treating hypertension in children. It defines hypertension and outlines stages of severity. In infants and young children, hypertension is usually secondary to an underlying condition, while adolescents can develop primary or essential hypertension. Evaluation involves measuring blood pressure properly, considering causes of secondary hypertension, assessing for target organ damage like left ventricular hypertrophy, and determining if hypertension is primary or secondary. Treatment involves lifestyle changes, weight management if overweight, and potentially medications to lower blood pressure below guidelines.
Failure to thrive is defined as sustained weight loss or failure to gain weight resulting in a child's weight falling below normal growth curves. It can be caused by inadequate nutrition intake, increased calorie needs, or issues with absorption. Evaluation involves assessing growth charts, nutrition intake, physical exam for signs of organic disease, and laboratory tests if indicated. Management goals are nutritional rehabilitation, treating any underlying medical causes, and addressing psychosocial factors. The prognosis depends on the etiology, with psychosocial causes having risks of developmental delays and organic causes having variable outcomes based on the specific condition.
This document provides an overview of acute kidney injury (AKI) in neonates. It discusses the definition, incidence, pathophysiology, risk factors, clinical features, management and outcomes of AKI. The presentation covers neonatal renal physiology, the classification of AKI, common causes of pre-renal, intrinsic renal and post-renal AKI. It also describes the challenges in diagnosing AKI in neonates and the approach to evaluating a neonate with suspected AKI, including relevant laboratory and imaging tests.
The document provides an overview of diarrhea including definitions, causes, clinical features, diagnosis, evaluation of dehydration, treatment including oral rehydration solutions, and prevention. It discusses approaches to acute, prolonged, persistent, and chronic diarrhea. Evaluation involves assessing dehydration, laboratory tests, and considering various infectious, inflammatory, and structural etiologies.
A preterm newborn developed respiratory distress soon after birth, with signs including grunting and cyanosis. Evaluation found respiratory distress syndrome (RDS). The baby was treated with nasal CPAP, surfactant, and mechanical ventilation. RDS is caused by surfactant deficiency in premature infants, resulting in alveolar collapse and impaired gas exchange. Management includes respiratory support, surfactant replacement therapy, and care to prevent complications.
Precocious puberty is defined as the onset of secondary sexual characteristics before age 8 in girls and 9 in boys. It can be classified as central (gonadotropin-dependent) or peripheral (gonadotropin-independent) puberty. Central puberty is treated with GnRH agonists to slow progression, while peripheral causes like tumors require treatment of the underlying condition. Evaluation involves assessing pubertal development, growth, bone age, and hormone levels to distinguish central from peripheral puberty and identify any lesions.
This document discusses the diagnosis and management of pediatric hypoglycemia. It defines hypoglycemia as blood glucose levels less than 40-45 mg/dl accompanied by symptoms. It outlines the causes, symptoms, definitions, and treatment approaches for both transient neonatal hypoglycemia and persistent neonatal hypoglycemia. It also discusses childhood hypoglycemia, including common etiologies like hormone deficiencies, insulin excess, and metabolic diseases. The document provides guidance on diagnosing and managing acute hypoglycemic episodes in infants and children.
This document provides an overview on approaching and managing a child with jaundice. It begins by defining jaundice as a visible manifestation of increased bilirubin levels. It then discusses the burden of jaundice in newborns, describing how most will experience some jaundice in the first week due to immature bilirubin metabolism. The document outlines how to classify jaundice as physiological or pathological based on clinical signs and bilirubin levels. For pathological jaundice, the main treatment approaches of phototherapy and exchange transfusion are described. The document provides guidance on evaluating the potential causes of jaundice and managing cases based on whether the hyperbilirubinemia is conjugated or
This document discusses various endocrine disorders that can cause short stature in children, including hypothyroidism, Cushing's syndrome, and delayed puberty. It provides details on symptoms, causes, diagnostic tests, and treatment options for each condition. The document also covers other endocrine-related topics such as acromegaly, diabetes insipidus, juvenile diabetes, goiter, hypo- and hyperparathyroidism. Management involves addressing the underlying endocrine abnormality through medications, hormone replacement, and surgery when necessary.
A 7-month old girl presented with recurrent episodes of cyanosis in her extremities lasting 2-3 hours, occurring 2-3 times per day. On examination, she was afebrile with normal vital signs and clear lungs. Diagnostic tests including bloodwork and imaging were performed. Further questioning and laboratory testing revealed the diagnosis.
Cyanosis refers to a bluish discoloration of the skin from poorly oxygenated blood. It can be central or peripheral in origin. Causes include abnormal hemoglobins, anemia, congenital heart defects involving decreased pulmonary blood flow, and pulmonary diseases. Cyanotic spells are acute hypoxic attacks seen in conditions like tetralogy of Fallot and present with increased
1. Drowning is defined as respiratory impairment from submersion in a liquid medium and is a major cause of accidental death, especially in children ages 1-14.
2. Management of drowning victims involves resuscitation, treatment of hypoxic-ischemic encephalopathy, and prevention of complications.
3. Prevention strategies focus on supervision during water activities, swimming lessons, CPR training, and safety measures around pools.
Neonatal polycythemia is defined as a venous hematocrit greater than 65%. It can be normovolemic, hypervolemic, or hypovolemic. Common causes include placental transfusion, maternal conditions like diabetes, and intrauterine hypoxia. Symptoms include poor feeding, lethargy, and cardiac or neurological issues. Screening is recommended for small or large infants and those with risk factors. Management may involve partial exchange transfusion to lower the hematocrit if symptoms are present or it is over 70% without symptoms. Studies found partial exchange transfusion effectively reduces hematocrit but did not find clinical benefits in asymptomatic infants.
This document provides guidance on diagnosing and treating diarrhoea in infants and young children. It defines diarrhoea and outlines signs of dehydration. Dehydration is classified as none, some or severe based on symptoms like restlessness, sunken eyes and skin pinch test. Treatment plans involving oral rehydration solution and continued feeding are provided according to dehydration level. Persistent and bloody diarrhoea require additional treatment and follow up. The guidelines aim to safely treat diarrhoea at home or refer urgently when needed.
Congenital syphilis occurs when the syphilis spirochete infects a fetus in utero. Without treatment, approximately 25% of infants with congenital syphilis will die either during pregnancy or shortly after birth. Manifestations of congenital syphilis are divided into infantile forms that occur in the first two years of life, and tardive forms that occur later. Common infantile symptoms include nasal discharge, rashes, liver and bone abnormalities. Late or tardive syphilis develops in nearly half of untreated infants and can cause facial deformities, bone abnormalities, and damage to internal organs like the liver.
The document discusses drowning, including epidemiology, pathophysiology, treatment, and prevention. It notes that drowning is the second leading cause of accidental death for children under 15 and describes the populations most at risk, such as toddlers near bodies of water, adolescents engaging in risky behavior, and elders. The pathophysiology of drowning involves central nervous system and pulmonary injury. Treatment involves rapid rescue, CPR, oxygen, warming, and monitoring for complications like pneumonia or ARDS. Prevention strategies target education and reducing access to water, with an emphasis on constant supervision of children.
Nephrotic syndrome is a manifestation of glomerular disease characterized by nephrotic range proteinuria, hypoalbuminemia, edema, and hyperlipidemia. It is most common in children ages 1.5-6 years and affects boys more than girls. Causes include genetic, secondary, and idiopathic factors. Treatment involves managing edema, infections, and proteinuria with corticosteroids, diuretics, and immunosuppressants. Prognosis is generally good for steroid-responsive nephrotic syndrome but poorer for steroid-resistant cases. Complications can include infections, thrombotic events, and renal failure.
An 11-year-old girl presented with 3 days of fever and left ankle pain. Initial examination and x-rays were normal. She returned with worsening symptoms and was found to have a hot, swollen ankle. MRI revealed subperiosteal abscess and osteomyelitis of the distal tibia. Blood and joint fluid cultures grew Staphylococcus aureus. Osteomyelitis is most commonly caused by S. aureus spreading hematogenously to the metaphysis of long bones in children. Presentation varies by age but may include pain, fever, and reduced mobility. Diagnosis relies on clinical suspicion as initial tests and x-rays may be normal. Advanced imaging and culture of infected sites are important
This presentation was done by Dr. Julius P. Kessy,MD. An intern Doctor at Dodoma Regional Referral Hospital (DRRH) during pediatrics unit clinical meeting and supervised by Dr. Christina K. Galabawa,MD,Mmed2, Pediatrics and Child Health, University of Dodoma (UDOM) in November, 2017.
Nutritional refeeding syndrome kwashiorkar and marasmus indore pedicon 2014Rajesh Kulkarni
This document provides information on the management of severe acute malnutrition (SAM) in children, including refeeding syndrome. It describes a case of an 18-month-old boy admitted with SAM who deteriorated on the third day of treatment. It then discusses refeeding syndrome, its pathophysiology, clinical manifestations, and electrolyte deficiencies. Guidelines are provided for monitoring patients and correcting electrolyte abnormalities during nutritional rehabilitation. The document outlines protocols for the stabilization and rehabilitation phases of SAM treatment, including feeding amounts and micronutrient supplementation.
This document provides an overview of neonatal jaundice, including its epidemiology, pathophysiology, etiology, clinical presentation, management, and complications. Key points include:
- Neonatal jaundice is common, occurring in 50-80% of newborns, and is usually harmless. It is caused by elevated bilirubin levels in the blood.
- Jaundice can be physiological or pathological. The causes and management differ depending on whether the elevated bilirubin is conjugated or unconjugated.
- Evaluation involves clinical exam, bilirubin levels, and other tests to determine the underlying cause. Management includes phototherapy, exchange transfusion, or pharmacotherapy depending on
This document discusses approaches to diagnosing and treating hypertension in children. It defines hypertension and outlines stages of severity. In infants and young children, hypertension is usually secondary to an underlying condition, while adolescents can develop primary or essential hypertension. Evaluation involves measuring blood pressure properly, considering causes of secondary hypertension, assessing for target organ damage like left ventricular hypertrophy, and determining if hypertension is primary or secondary. Treatment involves lifestyle changes, weight management if overweight, and potentially medications to lower blood pressure below guidelines.
Failure to thrive is defined as sustained weight loss or failure to gain weight resulting in a child's weight falling below normal growth curves. It can be caused by inadequate nutrition intake, increased calorie needs, or issues with absorption. Evaluation involves assessing growth charts, nutrition intake, physical exam for signs of organic disease, and laboratory tests if indicated. Management goals are nutritional rehabilitation, treating any underlying medical causes, and addressing psychosocial factors. The prognosis depends on the etiology, with psychosocial causes having risks of developmental delays and organic causes having variable outcomes based on the specific condition.
This document provides an overview of acute kidney injury (AKI) in neonates. It discusses the definition, incidence, pathophysiology, risk factors, clinical features, management and outcomes of AKI. The presentation covers neonatal renal physiology, the classification of AKI, common causes of pre-renal, intrinsic renal and post-renal AKI. It also describes the challenges in diagnosing AKI in neonates and the approach to evaluating a neonate with suspected AKI, including relevant laboratory and imaging tests.
The document provides an overview of diarrhea including definitions, causes, clinical features, diagnosis, evaluation of dehydration, treatment including oral rehydration solutions, and prevention. It discusses approaches to acute, prolonged, persistent, and chronic diarrhea. Evaluation involves assessing dehydration, laboratory tests, and considering various infectious, inflammatory, and structural etiologies.
A preterm newborn developed respiratory distress soon after birth, with signs including grunting and cyanosis. Evaluation found respiratory distress syndrome (RDS). The baby was treated with nasal CPAP, surfactant, and mechanical ventilation. RDS is caused by surfactant deficiency in premature infants, resulting in alveolar collapse and impaired gas exchange. Management includes respiratory support, surfactant replacement therapy, and care to prevent complications.
Precocious puberty is defined as the onset of secondary sexual characteristics before age 8 in girls and 9 in boys. It can be classified as central (gonadotropin-dependent) or peripheral (gonadotropin-independent) puberty. Central puberty is treated with GnRH agonists to slow progression, while peripheral causes like tumors require treatment of the underlying condition. Evaluation involves assessing pubertal development, growth, bone age, and hormone levels to distinguish central from peripheral puberty and identify any lesions.
This document discusses the diagnosis and management of pediatric hypoglycemia. It defines hypoglycemia as blood glucose levels less than 40-45 mg/dl accompanied by symptoms. It outlines the causes, symptoms, definitions, and treatment approaches for both transient neonatal hypoglycemia and persistent neonatal hypoglycemia. It also discusses childhood hypoglycemia, including common etiologies like hormone deficiencies, insulin excess, and metabolic diseases. The document provides guidance on diagnosing and managing acute hypoglycemic episodes in infants and children.
This document provides an overview on approaching and managing a child with jaundice. It begins by defining jaundice as a visible manifestation of increased bilirubin levels. It then discusses the burden of jaundice in newborns, describing how most will experience some jaundice in the first week due to immature bilirubin metabolism. The document outlines how to classify jaundice as physiological or pathological based on clinical signs and bilirubin levels. For pathological jaundice, the main treatment approaches of phototherapy and exchange transfusion are described. The document provides guidance on evaluating the potential causes of jaundice and managing cases based on whether the hyperbilirubinemia is conjugated or
This document discusses various endocrine disorders that can cause short stature in children, including hypothyroidism, Cushing's syndrome, and delayed puberty. It provides details on symptoms, causes, diagnostic tests, and treatment options for each condition. The document also covers other endocrine-related topics such as acromegaly, diabetes insipidus, juvenile diabetes, goiter, hypo- and hyperparathyroidism. Management involves addressing the underlying endocrine abnormality through medications, hormone replacement, and surgery when necessary.
A 7-month old girl presented with recurrent episodes of cyanosis in her extremities lasting 2-3 hours, occurring 2-3 times per day. On examination, she was afebrile with normal vital signs and clear lungs. Diagnostic tests including bloodwork and imaging were performed. Further questioning and laboratory testing revealed the diagnosis.
Cyanosis refers to a bluish discoloration of the skin from poorly oxygenated blood. It can be central or peripheral in origin. Causes include abnormal hemoglobins, anemia, congenital heart defects involving decreased pulmonary blood flow, and pulmonary diseases. Cyanotic spells are acute hypoxic attacks seen in conditions like tetralogy of Fallot and present with increased
1. Drowning is defined as respiratory impairment from submersion in a liquid medium and is a major cause of accidental death, especially in children ages 1-14.
2. Management of drowning victims involves resuscitation, treatment of hypoxic-ischemic encephalopathy, and prevention of complications.
3. Prevention strategies focus on supervision during water activities, swimming lessons, CPR training, and safety measures around pools.
Drowning can cause hypoxic brain injury, pulmonary edema, hypothermia, and multi-organ dysfunction. Prognosis is poor if the victim was submerged for over 10 minutes, CPR lasted over 25 minutes, or their initial pH or core temperature was severely low. Prevention through supervision, CPR training, and lifejacket use is crucial to reducing drowning deaths and disabilities.
This document provides guidelines for monitoring patients with septic shock and surviving sepsis. It defines key terms like sepsis, severe sepsis, septic shock, and refractory septic shock. It discusses the pathophysiology of sepsis and how it leads to organ dysfunction. It also outlines the Surviving Sepsis Bundle care guidelines for initial resuscitation and infection management, including measuring lactate levels, administering antibiotics and fluids, and achieving hemodynamic and tissue perfusion targets within 3-6 hours. The guidelines recommend protocolized, quantitative resuscitation for sepsis-induced hypoperfusion.
Multisystem inflammatory syndrome with covid 19 in pediatricsMounika Bhallam
Multisystem Inflammatory Syndrome with COVID-19 in pediatrics:- this topic will make u to get knowledge in MISC condition in children and management of covid child with MISC along with Nursing care
Submersion injuries can cause drowning, near-drowning, or secondary drowning. Drowning is a leading cause of accidental death, especially in children under 5. Near-drowning can cause hypoxic injury, fluid overload, pulmonary injury, and hypothermia. Treatment involves airway management, oxygenation, ventilation, warming, and monitoring for secondary complications. Prognosis depends on factors like submersion time, response to resuscitation, and neurological status. Prevention focuses on education, supervision, and safety measures.
This document discusses pediatric drowning. It begins with terminology used in drowning and then covers epidemiology, noting it is a leading cause of death worldwide in boys aged 5-14 and the second leading cause of death in US children aged 1-4. Mechanisms, injuries, and presentations are described for different age groups. Pathophysiology explores effects of drowning on the lungs, brain, and autonomic function. Pre-hospital care emphasizes removing the child from water and starting CPR. The trauma evaluation and treatments in the emergency department are outlined. Prevention strategies target fencing pools for toddlers and supervision for children, while advising life jackets and avoiding alcohol for adolescents.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
The document provides information on submersion injury or near-drowning, including definitions, epidemiology, pathophysiology, clinical manifestations, investigations, treatment procedures, prognosis, prevention measures, and a painting illustrating how quietly drowning victims are often discovered. It notes that drowning is a leading cause of injury death among children globally and in the Philippines specifically. The pathophysiology involves hypoxia from fluid aspiration into the lungs from submersion. Treatment involves aggressive warming, ventilation, and monitoring for complications like respiratory failure or multiple organ dysfunction. Prognosis depends on factors like response to resuscitation and neurological status upon arrival to emergency care.
Let us lear about managing near drowning or submersion injury in children with PGY3 student , Dr Mohd Zahran Mohamed Zaki.
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Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues. Globally, sepsis kills about 8 million people annually. Early recognition and treatment are key to improving outcomes. The first hours after diagnosis are especially critical, as mortality increases by about 8% every hour that antibiotics are delayed. Prompt administration of broad-spectrum antibiotics and fluid resuscitation can significantly reduce mortality from sepsis.
This document provides an overview of shock in children, including:
1. Definitions of shock and the pathophysiology involving reduced tissue perfusion and oxygen delivery.
2. The epidemiology and classifications of different shock types, including hypovolemic, distributive, cardiogenic, and obstructive shock.
3. Details on the causes, signs, symptoms, and stages of specific shock types like septic, hemorrhagic, and cardiogenic shock.
4. The goals of evaluating and managing shock in children, including rapid assessment of appearance, breathing, circulation, history, and physical exam findings.
Drowning is a leading cause of accidental death in children worldwide. It occurs most commonly in males ages 1-5 years due to inadequate supervision near bodies of water. Drowning causes hypoxemia which quickly leads to respiratory and cardiac arrest. Survivors can have long-term pulmonary, neurological, cardiovascular and other injuries. Prompt rescue and resuscitation efforts on scene improve outcomes. In the hospital, management focuses on rewarming, correcting hypothermia, hypoxemia and other physiological derangements to prevent secondary neurological injury.
This document discusses Neonatal Cold Injury Syndrome (NCIS), also known as sclerema neonatorum. It describes the etiology as being mainly due to cold stress in newborns. The main clinical features are low body temperature and scleredema, which is hardening of the skin and subcutaneous tissues. In severe cases, NCIS can lead to multiple organ dysfunction. The document outlines risk factors, pathophysiology, clinical presentation, diagnosis, differential diagnosis, and treatment approaches such as rewarming and supportive care.
Environmental Emergencies Board Review 2013 Tim O'KelleyTroy Pennington
This document discusses various environmental emergencies including submersion, hypothermia, hyperthermia, frostbite, and thermal burns. It provides details on the pathophysiology, risk factors, signs and symptoms, diagnosis, and management of each condition. For submersion it notes that drowning is caused by asphyxiation from liquid inhalation and discusses epidemiology, pathophysiology involving wet or dry drowning, risk factors, and management including rescue breathing and airway support. For hypothermia and hyperthermia it outlines mechanisms of heat conservation and loss, degrees of each condition based on temperature, etiologies, associated signs and symptoms, potential complications, diagnostic tests, and rewarming
1) Environmental emergencies can involve submersion, hypothermia, or hyperthermia. Submersion can cause drowning or near-drowning through asphyxiation or laryngospasm.
2) Hypothermia occurs when the body loses heat faster than it can produce it, leading to a core body temperature below 95°F. It has mild, moderate, and severe stages associated with different symptoms. Rewarming methods range from passive to active external to active internal depending on severity.
3) Hyperthermia is elevated body temperature due to failed thermoregulation, usually from environmental factors like heat or humidity that prevent cooling. It progresses from heat cramps to
Neonatal Cold Injury Syndrome (NCIS), also known as sclerema neonatorum, is caused by cold stress in newborns. Key factors contributing to NCIS include immature temperature regulation, large surface area relative to body size, and limited brown fat metabolism in newborns. Symptoms include low body temperature, hardening of the skin (scleredema), and in severe cases, multiple organ dysfunction. Treatment focuses on restoring normal body temperature and correcting any organ dysfunction through rewarming, fluid/nutrition support, and treating complications.
Environmental Medicine drowning and electrical injuries.pptxOpeyemi Muyiwa
This document provides an overview of environmental medicine as it relates to drowning and electrical injuries. It defines drowning and discusses epidemiology, risk factors, pathophysiology, symptoms, diagnosis, treatment and prevention of drowning. Globally, drowning causes 380,000 deaths per year. Risk factors include lack of supervision for children and alcohol use for adults. Pathophysiology involves laryngeal spasm and hypoxia/asphyxiation. Treatment focuses on rescue breathing, warming, and monitoring for complications. Prevention strategies target child supervision and barriers around pools. The document also covers definitions, pathophysiology involving current strength and duration, symptoms, diagnosis, and treatment of electrical injuries as well as prevention through insulation and circuit breakers
This document defines and describes near drowning, its causes, signs and symptoms, pathophysiology, diagnostic workup, and management. Near drowning occurs when a person suffers respiratory impairment from submersion in liquid. Common causes are accidents near water and inability to swim. Signs include cold skin, coughing, and shortness of breath. Pathophysiology involves involuntary inhalation of water leading to hypoxia, tissue damage, and cardiac issues. Diagnostic workup includes blood gases, imaging, and monitoring for arrhythmias and hypothermia. Management focuses on airway support, oxygen, treating hypothermia and hypoxia, and monitoring for pulmonary edema.
This document summarizes current concepts regarding drowning. It defines drowning as a process causing respiratory impairment from liquid submersion or immersion. Risk factors include male sex, young age, alcohol use, low income, lack of supervision, and aquatic exposure. Pathophysiology involves pulmonary injury from liquid inhalation and central nervous injury from hypoxia. Treatment involves pre-hospital CPR, maintaining airway and oxygenation in the emergency department, and monitoring for complications like sepsis or renal failure in the ICU. Prevention strategies are also discussed.
Similar to Pediatric Drowning; Pediatrics 2018 (20)
Basics of MRI interpretation; December 2022.pptxKareem Alnakeeb
This document provides an overview of MRI basics including:
1) How MRI scanners work by using magnetic fields and radio waves to produce images mapping proton distribution and energy.
2) The differences between T1- and T2-weighted images and how they highlight different tissues.
3) How specialized sequences like STIR, FLAIR, and DWI provide additional clinical information.
4) The use of contrast agents and their role in identifying abnormal tissues.
5) The importance of a systematic approach to MRI interpretation and relating findings to clinical information.
6) Key safety considerations for MRI scanning.
The rule of 4 of the brainstem:
A simplified method for understanding brainstem anatomy and brainstem vascular syndromes
https://onlinelibrary.wiley.com/doi/10.1111/j.1445-5994.2004.00732.x
How to Read a Research Article? By Dr. Nizar Saleh Abdelfattah, 2017Kareem Alnakeeb
This presentation is created by Dr. Nizar Saleh Abdelfattah in 2017. He used it in his episodes of "Research Fundamentals For Dummies" on YouTube.
https://www.youtube.com/playlist?list=PLuDFktFSWZ_XVufo7h9bDIerKoo7s3ouA
* The original presentation on Mediafire:
http://www.mediafire.com/file/mu5dml695g5r8qf/How-to-Research-by-Nizar-Abdelfattah.pptx/file
Some notes in Cardiothoracic surgery. These notes were published in 2019.
You can download the file from:
- Mediafire: http://www.mediafire.com/file/zrxenwq4tjdnhsj/file
Refractive procedures; Ophthalmology - April 2017Kareem Alnakeeb
This document summarizes various refractive procedures for correcting vision problems. It discusses procedures for myopia, hyperopia, astigmatism, and presbyopia, including surface ablation, LASIK, phakic implants, clear lens extraction, and conductive keratoplasty. For presbyopia, multifocal lenses, monovision, and intracorneal inlays are addressed. The document was prepared by Kareem Fisal Alnakeeb for the Ophthalmology Department at Mansoura University in Egypt.
Management of twin pregnancy with single fetal demise; Obstetrics - October 2019Kareem Alnakeeb
This document summarizes the current management of single fetal demise (sIUFD) in twin pregnancies. It discusses that sIUFD occurs in 3.7-6.8% of twin pregnancies and increases risks for the surviving twin. The management approach depends on chorionicity, gestational age, and whether the demise occurred in the first, second, or third trimester. For monochorionic twins after the first trimester, the surviving twin has increased risks of death, neurological issues, and preterm birth due to shared blood flow between twins. Conservative monitoring is recommended when possible to allow further fetal development, though delivery may be considered if the in utero environment is deemed hostile.
Addisonian crisis; pharmacology - 25 March 2016Kareem Alnakeeb
An Addisonian crisis is a medical emergency caused by severe adrenal insufficiency and insufficient levels of the hormone cortisol. It can occur in patients with undiagnosed or untreated Addison's disease when they are under stress. Signs and symptoms include confusion, vomiting, diarrhea, fever, and electrolyte imbalances that can cause hypoglycemia, hyponatremia, and hyperkalemia. Treatment involves aggressive fluid resuscitation, glucose supplementation, electrolyte correction, glucocorticoid replacement, and treating any underlying infections. Prevention relies on patient education, carrying medical identification, and maintaining treatment during stressful periods. With prompt treatment, prognosis is good, but lack of treatment can lead to shock,
Referred pain, also known as reflective pain, is pain perceived in a location other than where the painful stimulus originates. There are several proposed mechanisms to explain referred pain, with the convergence-projection theory being the most widely accepted. This theory suggests that afferent nerve fibers from different structures converge on the same spinal cord neurons, resulting in pain being perceived elsewhere. Other mechanisms like central sensitization may also play a role in referred pain. Certain organs have characteristic referred pain patterns, such as cardiac pain often radiating to the left arm, helping clinicians diagnose conditions.
This document discusses the structure and development of ovarian follicles. It begins by describing the basic components of follicles: the oocyte, granulosa cells, and theca layers. It then explains the development of follicles from primordial to Graafian stage, including the roles of FSH and LH. Finally, it discusses ovulation and the formation and function of the corpus luteum, as well as clinical significance regarding cysts and ultrasound imaging of follicles.
The document summarizes the structure and development of ovarian follicles. It describes the four stages of follicular development: primordial, primary, secondary (antral), and tertiary (Graafian). Key points include that ovarian follicles contain a single oocyte and support cells, develop in response to FSH and LH, and either ovulate during each menstrual cycle or become atretic. The dominant follicle develops into a corpus luteum which secretes progesterone to support early pregnancy.
Metabolic basis of Atherosclerosis; Biochemistry - February 2015Kareem Alnakeeb
This document defines atherosclerosis and its causes and risk factors. It discusses how atherosclerosis is initiated by inflammation in artery walls in response to LDL particles. As LDL particles accumulate in arteries, they can become oxidized, attracting macrophages. If macrophages cannot process the oxidized LDL, foam cells form, which can rupture and further narrow arteries. Risk factors include older age, male sex, diabetes, high LDL and low HDL cholesterol levels, smoking, and genetic factors. Diagnosis involves medical tests, and treatment includes medications, surgery, lifestyle changes, and managing underlying conditions like high blood pressure and cholesterol.
Anatomy of the cerebrum; Anatomy - January 2015Kareem Alnakeeb
The document provides detailed information about the structure and functions of the cerebrum. It describes the lobes, sulci, gyri, poles and borders of each cerebral hemisphere. It then outlines the primary motor, sensory and association cortices and their functions. Specifically, it discusses the primary motor cortex, premotor cortex, supplementary motor cortex, frontal eye field, Broca's area, primary somatosensory cortex, primary auditory cortex, primary visual cortex, Wernicke's area and their roles in movement, speech, senses and language.
This document provides information on lung cancer, including non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). It discusses risk factors like smoking, symptoms, diagnosis, staging, pathology, and treatment approaches. The main types of lung cancer - NSCLC subtypes like adenocarcinoma and squamous cell carcinoma, as well as SCLC - are described in terms of characteristics, histology, and prognosis. Diagnostic tests include imaging, biopsy procedures, and staging evaluations. Treatment depends on cancer type and extent of disease, and may involve surgery, radiation, chemotherapy, or a combination.
Summary notes of Anesthesia. These notes were published in 2020.
You can download them from:
-Mediafire: http://www.mediafire.com/file/wkey81yff7kv3j1/Anesthesia_Q%2526A_2020.pdf/file
Pediatrics notes about "Wheezy chest". These notes were published in 2018.
You can download them also from
- Telegram: https://t.me/pediatric_notes_2018
- Mediafire: http://www.mediafire.com/folder/u5u60m184t9z7/Pediatric_Notes_2018
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
Visit Us: https://drdeepikashomeopathy.com/service/irregular-periods-treatment/
STUDIES IN SUPPORT OF SPECIAL POPULATIONS: GERIATRICS E7shruti jagirdar
Unit 4: MRA 103T Regulatory affairs
This guideline is directed principally toward new Molecular Entities that are
likely to have significant use in the elderly, either because the disease intended
to be treated is characteristically a disease of aging ( e.g., Alzheimer's disease) or
because the population to be treated is known to include substantial numbers of
geriatric patients (e.g., hypertension).
Congestive Heart failure is caused by low cardiac output and high sympathetic discharge. Diuretics reduce preload, ACE inhibitors lower afterload, beta blockers reduce sympathetic activity, and digitalis has inotropic effects. Newer medications target vasodilation and myosin activation to improve heart efficiency while lowering energy requirements. Combination therapy, following an assessment of cardiac function and volume status, is the most effective strategy to heart failure care.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Nano-gold for Cancer Therapy chemistry investigatory projectSIVAVINAYAKPK
chemistry investigatory project
The development of nanogold-based cancer therapy could revolutionize oncology by providing a more targeted, less invasive treatment option. This project contributes to the growing body of research aimed at harnessing nanotechnology for medical applications, paving the way for future clinical trials and potential commercial applications.
Cancer remains one of the leading causes of death worldwide, prompting the need for innovative treatment methods. Nanotechnology offers promising new approaches, including the use of gold nanoparticles (nanogold) for targeted cancer therapy. Nanogold particles possess unique physical and chemical properties that make them suitable for drug delivery, imaging, and photothermal therapy.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
After getting it read you will definitely understand the topic.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Dr. Tan's Balance Method.pdf (From Academy of Oriental Medicine at Austin)GeorgeKieling1
Home
Organization
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
Tele Optometry (kunj'sppt) / Basics of tele optometry.
Pediatric Drowning; Pediatrics 2018
1. Pediatric Drowning
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Emergency 2018
Kareem Alnakeeb
Pediatric Drowning
- Drowning is the process of experiencing respiratory impairment from submersion/
immersion in liquid ( WHO 2005 )
• Drowning vs near-drowning
• Near-fatal drowning
• Secondary drowning
• Wet drowning
• Dry drowning
“ World report on child injury prevention “
Q1 : What is the most common injury Presenting to the ER?
A: Falls
Q2 : What is the most common fatal Preventable Childhood Injury?
A : Road Traffic Accidents Then Drowning
Scope of the report :
- Children under 18 years old
Leading causes of unintentional injuries :
1. Road traffic injuries
2. Drowning
3. Burns
4. Falls
5. Poisoning
Injuries represent a large proportion of child
deaths, in particular for older children
• With ↑ in age , children have
- Communicable diseases
- ↑ Non-communicable diseases
- ↑ Injuries
Abandoned terminology:
Definition:
Epidemiology:
2. Pediatric Drowning
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Kareem Alnakeeb
Child injuries are strongly related to social determinants;
- Low Income Countries → higher rate of unintentional injuries
- High Income Countries → lower rate of unintentional injuries
Child injury prevention is cost effective;
Financial savings from selected injury prevention interventions
Expenditure of US$ 1 each on Savings (US$)
Smoke alarms 65
Child restraints 29
Bicycle helmets 29
Prevention counseling by pediatricians 10
Poison control services 7
Road safety improvements 3
Facts:
- 480 children die from drowning every day
- For every 1 death, 4 others hospitalized & 14 seen in the ER
- Each year 2-3 million children come close to drowning.
- Most common in children under 5 years
- Socioeconomic status
o Low Income Countries : open waters
o High Income Countries : swimming pools
The type of water:
- Freshwater:
• Natural bodies of water : ( Rivers - Lakes – Ponds )
• Domestic sites : ( Pools - Spas - Bathtubs – Toilets )
- Saltwater
Temperature:
- Warm-water drowning: temperatures ≥ 20°C
- Cold-water drowning: temperatures < 20°C
( energy expenditure with demands → tissue injury )
Outcome:
- Fatal drowning: any death related to drowning
- Non-fatal drowning: those not ending in mortality.
Classification:
3. Pediatric Drowning
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Kareem Alnakeeb
- Males more than females beyond infancy
- Young age and adolescents
- Epilepsy
- Cardiac arrhythmias especially with Long QT syndrome (LQTS)
- Hypoglycemia prior to swimming
- Drug abuse, alcohol
Asphyxia is the most important pathophysiology.
- Aspiration → Coughing and laryngospasm → Hypoxia, hypercarbia, and acidosis.
- With further hypoxia → laryngospasm abates → More aspiration → Cerebral hypoxemia →
Loss of consciousness and apnea.
I. Pulmonary pathology Hypoxia
a. Intrapulmonary shunting due to
- Bronchospasm
- Aspirated fluid in the alveolar space
- Atelectasis
- Surfactant washout
- Surfactant inactivation
- Surfactant decreased production due to alveolar damage.
b. Raised pulmonary vascular resistance
c. Pulmonary edema
d. Chemical pneumonitis
e. Acute Lung Injury (ALI)
f. ARDS
Risk Factors:
Pathophysiology:
No clinically significant differences in pulmonary injury between freshwater and saltwater
4. Pediatric Drowning
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Kareem Alnakeeb
II. Cardiovascular pathology
- Decreased myocardial contractility
- Increased peripheral VR: initially high BP
- Low COP
- Congestion of central veins
- Reduced ADH
- Diuresis
- Hypotension
- Hypovolemia ; Capillary leak
- Tachycardia, bradycardia, pulseless electrical activity, and finally asystole ;
Hypoxia, acidosis, and/or hypothermia
- Ventricular fibrillation is not as common ; Hypothermia → NO DC shock
III. Brain Injury
- Energy failure “Mismatch () demand & supply i.e. H2o & O2 “
- Lipid peroxidation
- Production of free radicals
- Inflammatory responses
- Release of excitotoxic neurotransmitters.
- Disruption of neuronal and glial functions.
- Neuronal losses
IV. Other systems
a. Metabolic acidosis
b. Renal insufficiency
Anoxia
Shock
Myoglobinuria, or hemoglobinuria.
c. SIRS, sepsis
d. DIC
e. Infection e.g. Acanthamoeba causes Meningitis ( ttt: Metronidazole )
5. Pediatric Drowning
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Kareem Alnakeeb
( Lay person rescue - Pre-Hospital by EMS - ER Management - PICU Management )
I. Pre-Hospital
a) Mouth to mouth breathing ; ( For oxygenation & lung inflation )
- Immediate
- Better performed while still in water
- Not waiting for by attempting to drain water from the lungs
- May be all that is needed if there is some spontaneous circulation
b) Chest compressions;
- Once on solid ground, should be initiated if signs of life are absent.
c) Cervical spine immobilization;
- should be performed in cases with a history of diving.
II. ER Management ( For oxygenation )
A and B
If No intubation If Intubation
• Spontaneously breathing
• Maintaining SaO2 > 90% on Fio2 < 50%
• CPAP
• Non-invasive bi-level ventilation
• Secure airway, prevents aspiration
• Rapid sequence induction (RSI);
Sellick maneuver : firm pressure over the Cricoid to
collapse the esophagus & prevent gastric aspiration
• NG tube
• High PEEP “Positive end-expiratory pressure “
C
- Aggressive fluid therapy → NS 20 ml/kg boluses
- Dobutamine is preferred → Inotrope + Vasodilator
- Maintain normal BP
Management :
6. Pediatric Drowning
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Kareem Alnakeeb
Warming
Passive external rewarming
- Remove wet clothing
- Insulate with warm blankets/forced air warming blankets
Active external rewarming
- Hot packs and heat lamps to trunk of body only
- Heated air blower
Active internal rewarming (if core temperature ≤ 30°C)
- Warmed intravenous fluids (40°C-44°C)
- Warmed humidified oxygen (42°C-46°C)
- Peritoneal lavage (potassium chloride free fluid)
- Bladder wash with warm fluids
Hypothermia
- If child remains unconscious, Keep moderate hypothermia (temp. 320C- 340C)
for 12-72 hours by Cool blanket / cool cap to brain demand
ER Investigations – monitoring
- Pulse oximetry
- NG tube
- ABG only if there is severe hypoxemia
- Check blood sugar
- Check electrolytes
- No need for CXR
- CT only if suspecting traumatic brain injury
7. Pediatric Drowning
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Kareem Alnakeeb
III. PICU
Neuro-intensive Care (Brain Resuscitation)
- Aggressive management of seizures .. Continuous EEG monitoring
- Aggressive management of fever
- Moderate hypothermia (temp. 320
C- 340
C )
- Moderate fluid restriction
- Controlled hyperventilation
- Barbiturate coma ±
- Corticosteroids ±
- Continuous muscular paralysis ±
- Mannitol ±
ALI - ARDS
- Lung protective ventilation
• PIP < 25 torr
• Vte 6-8 mL/kg
• FiO2 <0.60
• High PEEP
- Caveats
• High PEEP may increase ICP.
• High PEEP may reduce venous return
• Permissive hypercapnia is UNSUITABLE
- Continue MV for at least 24 hours
• Avoid re-emerging pulmonary oedema (secondary drowning)
• Adequate chance for pneumocyte regeneration
- Reduce FiO2 to < 50% as soon as possible
• Avoid Oxygen toxicity
- Exogenous surfactant (case reports only)
- Prone positioning due to VQ mismatch (cycles of supination & pronation)
- Nitric oxide (NO)
- ECMO “ Extracorporeal membrane oxygenation “
- No need for prophylactic antibiotics
- Treatment of pneumonia (>24 hours)
8. Pediatric Drowning
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Kareem Alnakeeb
Continued CVS support
- Rarely needed
- Aim at normal BP and organ perfusion
Metabolism
- Tight glycemic control
- Monitoring of electrolytes
- Fluid shifts
• Fresh water: hyponatremia and hypotonic hemolysis
• Sea water: hypernatremia, hyperchloremia and volume contraction
• These shifts are RARELY of clinical significance
Poor prognostic signs ;
- Unwitnessed event
- Prolonged time to resuscitation
- The need for CPR at the scene
- The need for continued CPR in the ED,
- Prolonged coma
Outcome :