This document summarizes diseases of the esophagus, stomach, and duodenum. It describes the structure and functions of the esophagus, including that it connects the throat to the stomach and contains two sphincters. Diseases that can affect the esophagus include inflammation, cancer, Barrett's esophagus, and gastroesophageal reflux disease (GERD). The document also briefly outlines common diseases of the stomach and duodenum, such as ulcers and gastritis.