The document discusses chickenpox (varicella), a highly infectious disease caused by the varicella zoster virus. It is usually characterized by a vesicular skin rash that becomes itchy and forms scabs. Chickenpox spreads easily through the air via coughing/sneezing or direct contact with fluid from blisters. Symptoms include a rash that starts on the face/scalp and spreads to the torso and extremities. A vaccine was developed in 1974 and is part of routine childhood immunization schedules in some countries.
A disease is a condition that impairs the proper function of the body or of one of its parts. Every living thing, both plants and animals, can succumb to disease. Hundreds of different diseases exist.
Each has its own particular set of symptoms and signs, clues that enable a physician to diagnose the problem.
Every disease has a cause, although the accuses of some remain to be discovered. Every disease also displays a cycle of onset, or beginning, course, or time span of affection, and end, when it disappears or it partially disables or kills its victim.
A disease is a condition that impairs the proper function of the body or of one of its parts. Every living thing, both plants and animals, can succumb to disease. Hundreds of different diseases exist.
Each has its own particular set of symptoms and signs, clues that enable a physician to diagnose the problem.
Every disease has a cause, although the accuses of some remain to be discovered. Every disease also displays a cycle of onset, or beginning, course, or time span of affection, and end, when it disappears or it partially disables or kills its victim.
Powerpoint Presentation of Why Do We Fall Ill? is a presentation about health, diseases, types of diseases, and list of 5 main diseases.
Hope you LOVE it!!!!!!!!!!!!
Chapter - 13, Why do we fall ill, Science, Class 9Shivam Parmar
I have expertise in making educational and other PPTs. Email me for more PPTs at a very reasonable price that perfectly fits in your budget.
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Chapter - 13, Why do we fall ill, Science, Class 9
HEALTH
FACTORS THAT DETERMINE BETTER HEALTH
WHAT DO YOU MEAN BY A DISEASE?
DISEASE - FREE DIFFERENT FROM BEING HEALTHY?
HOW CAN WE STAY DISEASE FREE?
HOW CAN WE IDENTIFY A DISEASE?
ACUTE DISEASES AND CHRONIC DISEASES
FACTORS CAUSES DISEASES?
CAUSES OF DISEASE
INFECTIOUS AND NON-INFECTIOUS CAUSES OF DISEASE
INFECTIOUS AGENTS
SEVERAL TYPES OF DISEASES
INFLAMMATION
PRINCIPLES OF TREATMENT
ANTIBIOTICS AREN’T EFFECTIVE AGAINST VIRUSES?
PRINCIPLES OF PREVENTION
WHAT IS THE IMMUNE SYSTEM?
Every topic of this chapter is well written concisely and visuals will help you in understanding and imagining the practicality of all the topics.
By Shivam Parmar (Entrepreneur)
Powerpoint Presentation of Why Do We Fall Ill? is a presentation about health, diseases, types of diseases, and list of 5 main diseases.
Hope you LOVE it!!!!!!!!!!!!
Chapter - 13, Why do we fall ill, Science, Class 9Shivam Parmar
I have expertise in making educational and other PPTs. Email me for more PPTs at a very reasonable price that perfectly fits in your budget.
Email: parmarshivam105@gmail.com
Chapter - 13, Why do we fall ill, Science, Class 9
HEALTH
FACTORS THAT DETERMINE BETTER HEALTH
WHAT DO YOU MEAN BY A DISEASE?
DISEASE - FREE DIFFERENT FROM BEING HEALTHY?
HOW CAN WE STAY DISEASE FREE?
HOW CAN WE IDENTIFY A DISEASE?
ACUTE DISEASES AND CHRONIC DISEASES
FACTORS CAUSES DISEASES?
CAUSES OF DISEASE
INFECTIOUS AND NON-INFECTIOUS CAUSES OF DISEASE
INFECTIOUS AGENTS
SEVERAL TYPES OF DISEASES
INFLAMMATION
PRINCIPLES OF TREATMENT
ANTIBIOTICS AREN’T EFFECTIVE AGAINST VIRUSES?
PRINCIPLES OF PREVENTION
WHAT IS THE IMMUNE SYSTEM?
Every topic of this chapter is well written concisely and visuals will help you in understanding and imagining the practicality of all the topics.
By Shivam Parmar (Entrepreneur)
Whooping cough is a highly contagious disease caused by pertussis bacteria and may lead to death, particularly in infants less than 12 months of age. Whooping cough is preventable but Although it can be prevented by routine vaccination, it still affects many people, it can have serious complications including death. Management is only supportive. The majority need to be vaccinated to help protect those too young to be vaccinated.
Chickenpox -symptoms |tests |management ( medical information ) martinshaji
Chickenpox is a highly contagious viral infection that causes an acute fever and blistered rash, mainly in children.
The name may be derived from the French term for chick pea, chiche pois. Another theory is that the word 'chicken' was derived from a slang term for 'child'. Chickenpox is also known as varicella.
please comment
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communicable diseases by radhika kulvi msc nursingRadhika kulvi
A communicable disease is one that is spread from one person to another through a variety of ways that include: contact with blood and bodily fluids; breathing in an airborne virus; or by being bitten by an insect.
Reporting of cases of communicable disease is important in the planning and evaluation of disease prevention and control programs, in the assurance of appropriate medical therapy, and in the detection of common-source outbreaks. California law mandates healthcare providers and laboratories to report over 80 diseases or conditions to their local health department. Some examples of the reportable communicable diseases include Hepatitis A, B & C, influenza, measles, and salmonella and other food borne illnesses.
How do these communicable diseases spread?
How these diseases spread depends on the specific disease or infectious agent. Some ways in which communicable diseases spread are by:
Physical contact with an infected person, such as through touch (staphylococcus), sexual intercourse (gonorrhea, HIV), fecal/oral transmission (hepatitis A), or droplets (influenza, TB)
Contact with a contaminated surface or object (Norwalk virus), food (salmonella, E. coli), blood (HIV, hepatitis B), or water (cholera);
Bites from insects or animals capable of transmitting the disease (mosquito: malaria and yellow fever; flea: plague); and
Travel through the air, such as tuberculosis or measles.
In humans the respiratory tract is
the part of the anatomy that has to
do with the process of respiration.
The respiratory tract is divided into
3 segments:
Upper respiratory tract: nose and nasal passages, paranasal sinuses, and throat or pharynx
Respiratory airways: voice box or larynx, trachea, bronchi, and bronchioles
Lungs: respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli
Why You Should Get Your Baby Immunized Now.docxJanicaRoiceCua
Do you know how many germs lurk in your home? In other words, how many dirty little creatures there are that are looking to make your life miserable? The answer? A lot!
Epidemiology Prevention and control of chickenpoxspmdoc
Chickenpox, also known as varicella, is a highly contagious viral infection. It causes an itchy rash and flu-like symptoms. The virus can be spread through the air or by touching the rash. Vaccination and good hygiene practices are key to preventing its spread.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. Some Of The Sub - Headings Of The PPT Presentation : Type Of Disease :
___ Acute
___ Chronic…
OR
___Infectious
___Non-Infectious…
Causes Of Diseases.
Means Of Spread.
Symptoms.
Preventions and Controls.
Some Diagrams…
3. Chickenpox (or chicken pox) is a
highly Infectious disease caused by
primary infection with varicella zoster
virus (VZV).It usually starts with
vesicular skin rash mainly on the body and head
rather than at the periphery and becomes itchy,
raw pockmarks, which mostly heal without
scarring. On examination, the observer typically
finds skin lesions at various stages of healing and
also ulcers in the oral cavity and tonsil areas.
4. The Chicken Pox can spread easily. You can get it from an
infected person who sneezes, coughs, or shares food or drinks. You
can also get it if you touch the fluid from a chickenpox blister.
A person who has chickenpox can spread the virus even before he
or she has any symptoms. Chickenpox is most easily spread from 2
to 3 days before the rash appears until all the blisters have crusted
over.
You are at risk for chickenpox if you have never had the illness
and have not had the chickenpox vaccine. If someone you live
with gets chickenpox, your risk is even higher because of the close
contact.
5. The early (prodromal) symptoms in adolescents and adults are
nausea, loss of appetite, aching muscles, and headache. This is
followed by the characteristic rash and/or oral sores, malaise, and a
low-grade fever that signal the presence of the disease. Oral
manifestations of the disease (enanthem) not uncommonly may
precede the external rash (exanthem). The rash begins as small red
dots on the face, scalp, torso and upper arms and legs; progressing
over 10–12 hours to small bumps, blisters and pustules; followed
by umbilication and the formation of scabs. Commonly, visible evidence
of the disease develops in the oral cavity & tonsil areas in the form of
small ulcers which can be painful or itchy or both; this exanthema
(internal rash) can precede the exanthema (external rash) by 1 to 3
days or can be concurrent. These symptoms of chickenpox appear 10 to
21 days after exposure to a contagious person. Adults may have a more
widespread rash and longer fever, and they are more likely to
experience complications, such as varicella pneumonia.
7. A varicella vaccine was first developed by Michiaki Takahashi in 1974
derived from the Oka strain. It has been available in the US since 1995 to
inoculate against the disease. Some countries require the varicella
vaccination or an exemption before entering elementary school. Protection
from one dose is not lifelong and a second dose is necessary five years
after the initial immunization, which is currently part of the routine
immunization schedule in the US.The chickenpox vaccine is not part of the
routine childhood vaccination schedule in the UK. In the UK, the vaccine
is currently only offered to people who are particularly vulnerable to
chickenpox. A vaccinated person is likely to have a milder case of
chickenpox if infected.
9. Asthma is a common Chronic inflammatory disease of
the Airways characterized by variable and recurring symptoms,
reversible Airflow Obstruction and Bronchospasm. People who
suffer from this chronic condition (long-lasting or recurrent) are
said to be asthmatic.
The inside walls of an asthmatic's airways are swollen or
inflamed. This swelling or inflammation makes the airways
extremely sensitive to irritations and increases your susceptibility to
an allergic reaction.
10. There are four types of causes of
this dis-ease, they are : Environmental
Genetic
Hygienic hypothesis
Exacerbation.
11. Environmental :-
Many environmental factors have been associated with asthma's
development and exacerbation including allergens, air pollution, and
other environmental chemicals. Smoking during pregnancy and after
delivery is associated with a greater risk of asthma-like symptoms.
Low air quality from factors such as traffic pollution or high ozone levels,
has been associated with both asthma development and increased
asthma severity. Exposure to indoor volatile organic compounds may be a
trigger for asthma; formaldehyde exposure, for example, has a positive
association. Also, phthalates in PVC are associated with asthma in
children and adults.
Asthma is associated with exposure to indoor allergens. Common indoor
allergens include: dust mites, cockroaches, animal dander, and mold.
Efforts to decrease dust mites have been found to be ineffective. Certain
viral respiratory infections, such as respiratory syncytial
virus and rhinovirus, may increase the risk of developing asthma when
acquired as young children. Certain other infections, however, may
decrease the risk.
12. The hygiene hypothesis attempts to explain the increased rates of asthma
worldwide as a direct and unintended result of reduced exposure, during
childhood, to non-pathogenic bacteria and viruses. It has been proposed
that the reduced exposure to bacteria and viruses is due, in part, to
increased cleanliness and decreased family size in modern societies.
Exposure to bacterial endotoxin in early childhood may prevent the
development of asthma, but exposure at an older age may provoke
bronchoconstriction. Evidence supporting the hygiene hypothesis includes
lower rates of asthma on farms and in households with pets.
Use of antibiotics in early life has been linked to the development of
asthma. Also, delivery via caesarean section is associated with an
increased risk (estimated at 20–80%) of asthma—this increased risk is
attributed to the lack of healthy bacterial colonization that the newborn
would have acquired from passage through the birth canal. There is a link
between asthma and the degree of affluence.
13. GSTM1 IL10 CTLA-4 SPINK5 LTC4S IL4R
ADAM33
genes
genetic association
CD14
specific single nucleotide polymorphism
endotoxin
14. Exacerbation
Some individuals will have stable asthma for weeks or months
and then suddenly develop an episode of acute asthma. Different
individuals react differently to various factors. Most individuals
can develop severe exacerbation from a number of triggering
agents.
Home factors that can lead to exacerbation of asthma
include dust, animal dander (especially cat and dog
hair), cockroach allergens and mold. Perfumes are a common
cause of acute attacks in women and children. Both viral and
bacterial infections of the upper respiratory tract can worsen the
disease. Psychological stress may worsen symptoms—it is
thought that stress alters the immune system and thus increases
the airway inflammatory response to allergens and irritants.
15.
16. The evidence for the effectiveness of measures to prevent the development of
asthma is weak. Some show promise including: limiting smoke exposure both in
utero and after delivery, breastfeeding, and increased exposure to daycare or large
families but none are well supported enough to be recommended for this
indication. Early pet exposure may be useful. Results from exposure to pets at
other times are inconclusive and it is only recommended that pets be removed from
the home if a person has allergic symptoms to said pet. Dietary restrictions during
pregnancy or when breast feeding have not been found to be effective and thus are
not recommended. Reducing or eliminating compounds known to sensitive people
from the work place may be effective. It is not clear if annual influenza
vaccinations effects the risk of exacerbations. Immunization; however, is
recommended by the World Health Organization {WHO}.