The digestive system is made up of the gastrointestinal tract and accessory organs. The gastrointestinal tract includes the mouth, esophagus, stomach, small intestine, large intestine, rectum and anus. Food is broken down mechanically and chemically as it passes through these organs. The accessory organs, including the liver, gallbladder and pancreas, produce enzymes and bile that aid in digestion. Nutrients are absorbed through the small intestine into the bloodstream and waste is eliminated as feces through the large intestine and anus.
Digestive System of the Human Body.
Detailed explaination.
According to ICSE syllabus for grade 9.
This Presentation includes: The alimentary canal, organs and their functions, secretions, processes and definitions.
Based on selina publishers- Biology Part 1 grade 9.
Digestion
Digestion may be defined as physiological process by which complex food particles are broken down into simple form which are suitable for absorption and subsequent utilization.
Digestive system
Digestive system is the system which involves organs that are responsible for the process of digestion.
Gastrointestinal Tract:
The digestive system is composed of a long muscular tube – the gastrointestinal (GI) tract, or alimentary canal – and a set of accessory organs.
Grade 7 chapter1 lesson1 - the digestive systemLermaPendon1
Lesson 2 The Digestive system
-Functions of Digestive system
-Digestion
-Types of Digestion
-Enzymes
-The role of Enzymes in Digestion
-Organs of Digestive system
-The Mouth
-the Esophagus
-Peristalsis
-The Stomach
-Chyme
-the Small Intestine
-Villi
-the Large intestine
-Bacteria and Digestion
-the Digestive system and Homeostasis
-Common Ailments and Disorders of the Digestive system
Digestive System of the Human Body.
Detailed explaination.
According to ICSE syllabus for grade 9.
This Presentation includes: The alimentary canal, organs and their functions, secretions, processes and definitions.
Based on selina publishers- Biology Part 1 grade 9.
Digestion
Digestion may be defined as physiological process by which complex food particles are broken down into simple form which are suitable for absorption and subsequent utilization.
Digestive system
Digestive system is the system which involves organs that are responsible for the process of digestion.
Gastrointestinal Tract:
The digestive system is composed of a long muscular tube – the gastrointestinal (GI) tract, or alimentary canal – and a set of accessory organs.
Grade 7 chapter1 lesson1 - the digestive systemLermaPendon1
Lesson 2 The Digestive system
-Functions of Digestive system
-Digestion
-Types of Digestion
-Enzymes
-The role of Enzymes in Digestion
-Organs of Digestive system
-The Mouth
-the Esophagus
-Peristalsis
-The Stomach
-Chyme
-the Small Intestine
-Villi
-the Large intestine
-Bacteria and Digestion
-the Digestive system and Homeostasis
-Common Ailments and Disorders of the Digestive system
Anatomy and Physiology of Digestive system.
Different Digestive process for absorption of food in GIT.
Different parts GIT Tract where food move from Mouth to the anus.
The digestive system is made up of the digestive tract and other organs that help the body break down and absorb food. It is a long, twisting tube that starts at the mouth and goes through the oesophagus, stomach, small intestine, large intestine and anus.
An overview of the GIT with detailed study of the organs, along with their anatomy and physiology. It will find u easier to go through this complex function within our body.
it shows some of the information that you are looking with. this will help to guide about this topic. This only for educational purposes especially to those teachers that are teaching in public and private schools. and, also to those students, you are free to download and use this as your visual aid.. thank you.. Miggy :)
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
2. WHAT IS DIGESTIVE SYSTEM?
• A group of organs working together to convert
food into energy
• Breakdown of food into small molecules
• Absorbs nutrients and water to feed the entire
body
3. TWO MAJOR PARTS:
1. Alimentary Canal/Gastrointestinal Tract:
Food passes through a long tube inside the body known as
the alimentary canal or the gastrointestinal tract (GI tract).
It has two openings: the mouth and the anus.
The alimentary canal is made up of the mouth, pharynx,
esophagus, stomach, small intestines, large intestines,
rectum and anus.
7. MOUTH
• Teeth mechanically break down food into
small pieces.
• Tongue mixes food with saliva (contains
amylase, which helps break down starch).
• Responsible for mastication. Mastication
is the process of chewing. Also known as
mechanical digestion.
• Bolus is the product mechanical digestion.
8. PHARYNX
• Also called the throat.
• The portion of the digestive tract that receives the food from your
mouth.
• Its muscular walls function in the process of swallowing, and it
serves as a pathway for the movement of food from the mouth to
the esophagus.
• Epiglottis is a flap-like structure at the back of the throat that
closes windpipe over the trachea preventing food from entering it.
It is located in the pharynx.
• It has 3 divisions.
9. • Nasopharynx – located
superior and posterior to the
soft palate. Contains the
pharyngeal tonsils and tubal
tonsils.
• Oropharynx – Contains
palatine and lingual tonsils.
The tonsils remove pathogens
that enter the pharynx.
• Laryngopharynx – inferior to
the epiglottis and posterior to
the larynx. This division opens
into the esophagus and larynx.
10. ESOPHAGUS
• A muscular tube connecting the pharynx to the stomach. Approximately
10 inches long.
• It moves the food from the throat to the stomach using muscle
movement called peristalsis.
• Peristalsis is a wavelike contraction from the esophagus to large
intestine.
• At the inferior end of the esophagus is muscular ring called cardiac
sphincter or cardioesophageal sphincter.
• The function of this sphincter is to close the end of the esophagus and
prevent the backflow of food from the stomach to esophagus.
11. STOMACH
• A muscular sac that is located on the left side of the abdominal
cavity, just inferior to the diaphragm.
• This major organ acts as a storage tank for food so that the body has
time to digest large meals properly.
• Mixes food with digestive juices that contain enzymes such as lipase
to break down Proteins and Lipids, the process is called chemical
digestion.
• The product of chemical digestion is called Chyme. It is a the pulpy
acidic fluid which passes from the stomach to the small intestine,
consisting of gastric juices and partly digested food.
• The pH of gastric acid is 1.5 to 3.5 in the human stomach lumen.
• The stomach also contains hydrochloric acid (HCl) that kills bacteria.
12. SMALL INTESTINE
• A long, thin tube about 1 inch in diameter and about 10 feet long.
• The entire small intestine is coiled like a hose and the inside surface is full
of many ridges and folds. These folds are used to maximize the digestion of
food and absorption of nutrients.
• By the time food leaves the small intestine, around 90% of all nutrients have
been extracted from the food that entered it.
Absorbs:
80% water
Vitamins
Minerals
Carbohydrates
Proteins
Lipids
• Nutrients from the food pass into the bloodstream through the small
13. THREE (3) PARTS OF THE SMALL
INTESTINE
1. Duodenum - the first part of the small
intestine. After foods mix with stomach
acid, they move into the duodenum,
where they mix with bile from the
gallbladder and digestive juices from the
pancreas.
2. Jejunum - the middle segment of the
small intestine. Most of the nutrients
present in food are absorbed by the
jejunum before being passed on to the
ileum for further absorption.
3. Ileum - The function of the ileum is
mainly to absorb vitamin B12 and bile
salts and whatever products of
digestion were not absorbed by the
jejunum
14.
15. LARGE INTESTINE
• A long, thick tube about 2.5 inches in diameter and about 5 feet
long. It is located just inferior to the stomach and wraps around the
superior and lateral border of the small intestine.
• The large intestine absorbs water and contains many symbiotic
bacteria that aid in the breaking down of wastes to extract some
small amounts of nutrients.
• It is where the feces are formed.
•It is also called “Colon"
16. THREE (3) PARTS OF THE LARGE
INTESTINE
1. Ascending Colon – the beginning part of
the colon which carries feces from the
cecum to the transverse colon.
2. Transverse Colon – the longest region of
the colon where much of the absorption
and feces formation takes place.
3. Descending Colon – the walls of the
descending colon absorb water as well as
remaining nutrients and vitamins from
the feces and depositing these
substances into our bloodstream before
they are eliminated from the body.
17. RECTUM
• The final straight portion of the large intestine, approximately 6
inches long.
• The rectum is a continuation of the large intestine and connects to
the anus.
• For temporary storage of feces.
• To expel solid and gaseous waste from the gastrointestinal tract.
18. ANUS
• The anus is the last part of the digestive tract. It is a 2-inch long
canal consisting of the pelvic floor muscles and the two anal
sphincters (internal and external).
• The lining of the upper anus is specialized to detect rectal contents.
It lets you know whether the contents are liquid, gas, or solid.
• The internal sphincter is always tight, except when stool enters the
rectum. It keeps us continent when we are asleep or otherwise
unaware of the presence of stool.
• When we get an urge to go to the bathroom, we rely on our external
sphincter to hold the stool until reaching a toilet, where it then
relaxes to release the contents.
19.
20. SPHINCTERS
• A ring-like muscles that contract or close a bodily opening or
passage in the alimentary canal to prevent backflow.
• 3 Sphincters in the Alimentary Canal:
1. Cardioesophageal Sphincter – prevents the backflow of food
from the stomach to espophagus.
2. Pyloric Sphincter – prevents the backflow of food from the
small intestine to stomach.
3. Anal Sphincter – prevents the release of feces/wastes.
22. LIVER
• The liver weighs about 3 pounds and is the second largest
organ in the body.
• The liver has many different functions in the body, but the
main function of the liver in digestion is the production of bile
and its secretion into the small intestine.
• Bile is a yellowish substance for fat digestion.
• Liver filters out toxins and waste including drugs and alcohol
and poisons.
23. GALL BLADDER
• A small, pear-shaped organ located just posterior to the liver.
• The gallbladder is used to store and recycle excess bile from
the small intestine so that it can be reused for the digestion of
subsequent meals.
• Stores bile from the liver, releases it into the small intestine.
• Fatty diets can cause gallstones.
24. PANCREAS
• A large gland located just inferior and posterior to the stomach. It is about 6
inches long.
• The pancreas secretes digestive enzymes into the small intestine to complete
the chemical digestion of foods, digest fats, carbohydrates and proteins.
• 2 kinds of Enzymes:
1. Amylase - a protein made by the pancreas and by glands in and around
your mouth and throat. It helps you break down carbohydrates and
starches into sugar.
2. Lipase - an enzyme that breaks down dietary fats into smaller molecules
called fatty acids and glycerol.
• Regulates blood sugar by producing hormones such as:
1. Insulin – lowers blood sugar level
2. Glucagon – increases blood sugar level
25.
26. NORMAL FLORA
• Are bacteria inside human body:
1. Colon - Escherichia Coli (E. Coli); Bacteria that causes UTI. They are
found in urine through urinalysis.
2. Stomach – Helicobacter Pylori; acidophyllic or acid-loving bacteria;
pathogenic for chronic acidity; bacteria that causes ulcer.