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Developmental toxicology 18 nov-11-1

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Iyad Abou Rabii
Iyad Abou Rabii

The document discusses developmental toxicology and how drugs and toxins can affect fetal development. It explains how substances cross the placenta and impact the fetus. Certain drugs are particularly dangerous at specific stages of pregnancy like organ formation or growth. Narcotics, some medications, alcohol, tobacco, and chemical toxins all pose risks like low birth weight, birth defects, and developmental delays if the mother is exposed during pregnancy. More research is needed to fully understand how different exposures may differentially impact the fetus and child's health.

Health & Medicine
1 of 38
Developmental Toxicology Iyad ABOU RABII BDS, OMS, MD, PhD
Why studying Developmental Toxicology and Pharmacology? ,[object Object],[object Object],[object Object],[object Object]
How Drugs Cross the Placenta ,[object Object],[object Object]
How Drugs Cross the Placenta Only a thin membrane (placental membrane) separates the mother's blood in the intervillous space from the fetus's blood in the villi. Drugs in the mother's blood can cross this membrane into blood vessels in the villi and pass through the umbilical cord to the fetus.
Pharmacokinetics and metabolism of the drug or chemical ,[object Object]
Pharmacokinetics and metabolism of the drug or chemical ,[object Object]
Pharmacokinetics and metabolism of the drug or chemical ,[object Object]
Pharmacokinetics and metabolism of the drug or chemical ,[object Object]
Pharmacokinetics and metabolism of the drug or chemical ,[object Object]
Which Toxics are Dangerous? ,[object Object],[object Object],[object Object],[object Object]
Drugs and the Stages of Pregnancy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drugs and the Stages of Pregnancy ,[object Object],[object Object],[object Object]
Drugs and the Stages of Pregnancy ,[object Object],[object Object]
Drugs and the Stages of Pregnancy ,[object Object],[object Object],[object Object],[object Object]
Drugs and the Stages of Pregnancy ,[object Object],[object Object]
Drugs and Toxics affecting Development : Narcotics
Drugs affecting Development : Narcotics ,[object Object],[object Object]
Drugs affecting Development : Narcotics ,[object Object],intracranial hemorrhage
Drugs affecting Development : Medications ,[object Object]
Drugs affecting Development : Medications ,[object Object],defects of the face
Drugs affecting Development : Medications ,[object Object],[object Object],[object Object],[object Object],Cleft palate
Drugs affecting Development : Medications ,[object Object],[object Object],[object Object]
Drugs affecting Development : Medications ,[object Object]
Drugs affecting Development : Medications ,[object Object],[object Object],[object Object]
Drugs affecting Development : Medications ,[object Object],[object Object]
Drugs affecting Development : Medications ,[object Object],[object Object],[object Object]
Tetracycline
Drugs affecting Development : Medications ,[object Object],defects of the lungs
Drugs affecting Development : Medications ,[object Object],[object Object],nderdevelopment of the lower jaw
Toxics affecting Development : Alcohol ,[object Object],[object Object],[object Object]
Toxics affecting Development: Alcohol ,[object Object],[object Object]
Toxics affecting Development : Tobacco ,[object Object],[object Object]
Chemical Toxics affecting Development ,[object Object],[object Object],[object Object],[object Object],[object Object],abnormal skull calcification
Chemical Toxics affecting Development ,[object Object],[object Object],Facial dysmorphology
Chemical Toxics affecting Development ,[object Object],cerebellum hypoplasia microcephaly
Conclusion ,[object Object],[object Object]
Conclusion ,[object Object]
Keep in mind ,[object Object],[object Object]

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Developmental toxicology 18 nov-11-1

  • 1. Developmental Toxicology Iyad ABOU RABII BDS, OMS, MD, PhD
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  • 4. How Drugs Cross the Placenta Only a thin membrane (placental membrane) separates the mother's blood in the intervillous space from the fetus's blood in the villi. Drugs in the mother's blood can cross this membrane into blood vessels in the villi and pass through the umbilical cord to the fetus.
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  • 16. Drugs and Toxics affecting Development : Narcotics
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Editor's Notes

  1. A miscarriage is the spontaneous loss of a fetus before the 20th week of pregnancy. (Pregnancy losses after the 20th week are called preterm deliveries.)