1) Analgesics are important therapeutic agents in dentistry for treating pain. Common analgesics include acetaminophen, NSAIDs like ibuprofen, and opioids like codeine.
2) Combining analgesics that work through different mechanisms can provide better pain relief than single agents alone. Acetaminophen is often combined with opioids. NSAIDs allow for lower opioid doses to reduce side effects.
3) The combination of acetaminophen with codeine, hydrocodone, or tramadol provides effective relief of mild to moderate dental pain with fewer side effects than opioids alone. Ibuprofen combined with codeine or oxycodone also enhances analgesia.
This easy and fresh lecture explain to undergraduate and newly-graduated dentists an important topic in dentistry, pain-relievers. Analgesics are used very often in dentistry and a clinical guide seems necessary.
Classification of Impaction and Methods & Techniques of Third molar/Manidibular impaction removal,Flap designs of impaction removal techniques and more
This easy and fresh lecture explain to undergraduate and newly-graduated dentists an important topic in dentistry, pain-relievers. Analgesics are used very often in dentistry and a clinical guide seems necessary.
Classification of Impaction and Methods & Techniques of Third molar/Manidibular impaction removal,Flap designs of impaction removal techniques and more
Antibiotics used in dentistry
Terminologies
History
Classification of antibiotics
Principles of antibiotics use
Commonly used antibiotics
Drug interaction
Drug combination
Antibiotic resistance
Summary
Local anesthesia has been defined as loss of sensation in a circumscribed area of the body caused by depression of excitation in nerve endings or inhibition of the conduction process in peripheral nerves.
Antibiotics used in dentistry
Terminologies
History
Classification of antibiotics
Principles of antibiotics use
Commonly used antibiotics
Drug interaction
Drug combination
Antibiotic resistance
Summary
Local anesthesia has been defined as loss of sensation in a circumscribed area of the body caused by depression of excitation in nerve endings or inhibition of the conduction process in peripheral nerves.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Analgesics in maxillofacial surgery by Dr. Amit Suryawanshi .Oral & Maxillo...All Good Things
Description:
Hi. This is Dr. Amit T. Suryawanshi. Oral & Maxillofacial surgeon from Pune, India. I am here on slideshare.com to share some of my own presentations presented at various levels in the field of OMFS. Hope this would somehow be helpful to you making your presentations. All the best & your replies are welcomed!
Analgesics general dentistry /certified fixed orthodontic courses by Indian d...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
State of the art comprehensive training-Faculty of world wide repute &Very affordable.
a detailed description of pain and therpaeutic options available and clinical assessment of pain, approach to the patient with pain, assessment of intensity of pain, nsaids and opioids, tca. WHO pain ladder, chronic opioid therapy
Aggressive preemtive multimodal including epidural or nerve block not only produce optimal analgesia but also may prevent the occurrence of chronic pain after surgical
Paracetamol as a single analgesic is only for mild and moderate pain.
However it can be combined with many analgesics to provide strong effect.
So, it can be the basic regiment for Multimodal Analgesia.
Brief Synopsis of Analgesics used in Dentistry for Pain Control & Management with Dosage Information & Severity Encountered during Drug Metabolism & Administration.
Pharmacology of Chronic Pain Treatment Addiction and Risks Michael Changaris
Currently, we are in the middle of an epidemic. More people die from addiction to pain medications then die from car accidents.
This lecture explores the biopsychosocial model of chronic pain. It includes pharmacotherapy, psychotherapeutic and other treatment modalities.
Embark on a journey to better understand and conquer pain with our comprehensive Pain Management presentation. Pain is a universal human experience, and this expertly crafted PowerPoint (PPT) offers a multifaceted exploration of pain, its causes, assessment, and various strategies for effective pain management.
Our presentation begins by introducing the complexity of pain, encompassing its various types, from acute and chronic to neuropathic and nociceptive. It delves into the physiological, psychological, and social dimensions of pain, providing a holistic perspective on this intricate phenomenon.
Learn about the underlying mechanisms of pain, including nociception, pain pathways, and the role of neurotransmitters. With this foundational knowledge, you'll be better equipped to understand how pain can manifest in different medical conditions and situations.
The assessment and diagnosis of pain are crucial components of effective pain management. Our PPT guides you through a comprehensive overview of pain assessment tools, emphasizing the importance of a patient-centered approach. Explore the significance of pain scales, questionnaires, and patient self-reporting to accurately evaluate pain intensity and quality.
One of the key strengths of our Pain Management presentation is its focus on diverse strategies for pain relief. You'll discover an array of treatment options, from pharmacological interventions and non-pharmacological approaches to alternative therapies and interventional procedures. This wealth of information is invaluable for healthcare professionals and individuals seeking pain relief.
Furthermore, the presentation includes insights into the management of specific pain conditions, such as chronic pain, cancer pain, and postoperative pain. These sections offer evidence-based guidance on tailoring treatments to individual needs and circumstances.
Pain doesn't only affect the body—it also has profound psychological and emotional implications. Our PPT explores the psychosocial aspects of pain, including the biopsychosocial model, pain-related anxiety and depression, and the importance of psychological support in pain management.
As you delve into the Pain Management presentation, you'll encounter real-life case studies, practical tips, and the latest advancements in pain management, ensuring you stay current with evolving practices in the field.
For both healthcare professionals and patients, this presentation serves as an indispensable resource. It empowers individuals to take control of their pain management journey and equips healthcare providers with the knowledge and tools necessary to deliver the best possible care.
With our visually engaging and informative PPT, you'll acquire a profound understanding of pain and the means to manage it effectively. Begin your journey towards pain relief and improved quality of life with our Pain Management presentation today.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. misconceptions about the pain
1. The Dentist is the best judge of pain.
2. A person with pain will always have
obvious signs such as moaning, abnormal
vital signs, or not eating.
3. Pain is a normal part of aging.
4. Addiction is common when opioid
medications are prescribed.
3. misconceptions about the pain
5. Morphine and other strong pain
relievers should be reserved for the late
stages of dying.
6. Morphine and other opioids can easily
cause lethal respiratory depression.
7. Pain medication should be given only
after the resident develops pain.
8. Anxiety always makes pain worse.
4. Ceiling effect
• The term ceiling effect has two distinct meanings,
referring to the level at which an independent
variable no longer has an effect on a dependent
variable,
• In case of Analgesics, a ceiling effect in treatment, is
pain relief by some kinds of Analgesics drugs,
which have no further effect on pain above a
particular dosage level
6. Acetaminophen
Opoid non-opoid?
– Nonopioid analgesic generally used for
mild to moderate pain.
Dose
– Adults: 0.5–1 g every 4–6 hours.
– 6–12 years, 250–500 mg every 4–6 hours.
– 1–5 years, 120–250 mg every 4–6 hours.
7. Acetaminophen
Indication
– Acetaminophen appears to be a
good analgesic for mild pain, but its
relatively short-acting
analgesia limits its usefulness as a
monotherapy for the treatment
of moderate to severe postoperative
pain
9. NSAIDs
• Examples
– COX1 and COX-2 :
Ibuprofen, ketorolac,
flurbiprofen, ketoprofen, diclofenac,
aspirin and
– COX-2 :
celecoxib ,rofecoxib, and Nimesulide
10. Nimesulide
Indication
– Acute pain
Dose
– 100 mg Twice a day
Contraindication
– Renal failure, papillary and tubular
necrosis.
– Asthma,
– Liver failure
11. Opioids
• Opioids act on the central nervous
system
• Side effects
– nausea, constipation, dizziness,
sedation and respiratory depression
12. Opioids
• Although opioids as a class are
effective analgesics, some
commonly used formulations show
poor analgesic efficacy for dental
pain, and similar results can be
achieved with other drugs with
less severe side effects
13. Other Opioids
• Codeine alone has not been found as
effective as other common analgesics
for relief of post extraction pain.
• Oxycodone, hydrocodone and
propoxyphene are about as effective as
codeine, and dihydrocodeine,
14. Tramadol
• Tramadol is a synthetic, centrally
acting analgesic indicated for moderate
to moderately severe pain.
• Dose
50 -100 mg then 50 -100 mg every 4-6 h
(400 mg/day maximum)
15. Tramadol
• The serious side effects typically
associated with opioids—such as
dependence,sedation, respiratory
depressionand constipation—occur less
frequently with it.
• The side effects commonly seen with
tramadol include
nausea, dizziness, drowsiness and
19. Why Combination
• The goal of combining analgesics with different
mechanisms of action is to use lower doses of the
component drugs.
• Increasing range of action by combining a fast-
onset, short-acting analgesic (such as
acetaminophen) for milder pain with a slower-
onset, longer-duration analgesic (such as codeine
or tramadol)
• Targeting different pain pathways simultaneously
20. Acetaminophen
combinations
• Acetaminophen is an effective
analgesic for mild pain, but to manage
more severe pain it typically is
combined with codeine or one of its
derivatives.
21. Acetaminophen
combinations
• Analgesic advantages for oral surgery
are optimal with acetaminophen 1,000
mg combined with codeine 60 mgor a
codeine derivative such as oxycodone
10 mg with acetaminophen 1,000.
22. Acetaminophen
combinations
• a higher dose of hydrocodone, such as
7.5 mg, combined with acetaminophen
500 mg had slightly more analgesic
efficacy than did codeine 30 mg plus
acetaminophen 300 mg
• Both treatments resulted in analgesia
that began 30 minutes after
administration of the drug and
continued for five hours
23. Acetaminophen
combinations
• tramadol 150 mg alone has been shown
to have better efficacy overall than the
combination of propoxyphene 65 mg
and acetaminophen 650 mg
• the combination of tramadol 75 mg
with acetaminophen 650 mgprovided
more effective, rapid and long-acting
pain relief than did tramadol or
acetaminophen alone
24. NSAID combinations
• Similar to acetaminophen, NSAIDs
have a ceiling effect and
therefore should be combined with
other analgesics for total pain
relief after major surgery.
• NSAIDs also allow for a
significant dose reduction of opioids
and hence can be useful in
minimizing opioid side effects
25. NSAID combinations
• The combination of ibuprofen 400 mg
and codeine 60 mg is superior to
ibuprofen 400 mg alone
• Ibuprofen 400 mg and oxycodone 10
mg provided a faster onset of relief
from dental pain than did ibuprofen 400
mg alone
26. NSAID combinations
• The combination of ibuprofen 400 mg
with hydrocodone 15 mg was superior
to the combination of acetaminophen
600 mg with codeine 60 mg in
providing analgesia after third-molar
extraction
• Tramadol plus ibuprofen increased the
efficacy of pain relief in patients with
various types of dental pain
27.
28. Reference
• Bjorkman R, Hallman KM, Hedner J, Hedner T, Henning M. Acetaminophen
blocks spinal hyperalgesia induced by NMDA and
• Moore PA, Crout RJ, Jackson DL, Schneider LG, Graves RW, Bakos L.
Tramadol hydrochloride: analgesic efficacy compared with codeine, aspirin with
codeine, and placebo after dental extraction. J Clin Pharmacol 1998;38:554–60.[
• Merskey H, Bogduk N. Classification of chronic pain: Descriptions of chronic
pain syndromes and definitions of pain terms. 2nd ed. Seattle: IASP Press; 1994.
• Niv D, Devor M. Transition from acute to chronic pain. In: Aronoff GM, ed.
Evaluation and treatment of chronic pain. 3rd ed. Baltimore: Williams & Wilkins;
1998:27–45.
• Urquhart E. Analgesic agents and strategies in the dental pain model. J Dent
1994;22:336–41.
• Woolf CJ. Recent advances in the pathophysiology of acute pain. Br J Anaesth
1989;63(2):139–46.
• Dworkin RH. Which individuals with acute pain are most likely to develop a
chronic pain syndrome? Pain Forum 1997;6:127–36.
.
29. • Mok MS, Lee CC, Perng JS. Analgesic effect of tramadol and diclofenac in
combined use (abstract). Clin Pharmacol Ther 1996;59:132.
• Broome IJ, Robb HM, Raj N, Girgis Y, Wardall GJ. The use of tramadol following
day: case oral surgery. Anaesthesia 1999;54:289–92
• Sunshine A. New clinical experience with tramadol. Drugs 1994;47(supplement
1):8–18.
• Szmyd L, Shannon IL, Mohnac AM. Control of postoperative sequelae in impacted
third molar surgery. J Oral Ther Pharmacol 1965;1:491–6
• Medve R, Wang J, Karim R. Tramadol and acetaminophen tablets for dental pain.
Anesth Prog 2001;48(3):79–81
• Cooper SA, Beaver WT. A model to evaluate mild analgesics in oral surgery
outpatients. Clin Pharmacol Ther 1976;20:241–50.
• Gardner GC, Simkin PA. Adverse effects of NSAIDs. Pharm Ther 2000;16:750–5.
• Singh G, Ramey DR. NSAID-induced gastrointestinal complications: the ARAMIS
perspective—1997. J Rheumatol 1998;51(supplement):8–16