1) The heart develops from angioblastic tissue in the splanchnopleuric mesoderm and initially forms as a linear heart tube. 2) The heart tube loops to the right, forming the basic chambers - the truncus arteriosus, bulbous cordis, ventricle, atrium and sinus venosus. 3) Septa then develop to divide the chambers - the atrial septum forms from the septum primum, while the interventricular septum grows up from the floor of the heart tube.

1. DEVELOPMENT OF CVS

2. Heart develops from ANGIOBLASTIC tissue from
SPLANCHNO PLEURIC MESODERM
K/a
CARDIOGENIC AREA.
Heart lies ventral to FOREGUT and dorsal to Pericardial
Cavity.

3. Cardiogenic Area and the Pericardial Cavity are in front of the
Buccopharyngeal Membrane.
C. 21 days.
D. 22 days.

4. The developing Endocardial Heart Tube and its investing layer
bulge into the Pericardial Cavity.

5. FUSION OF HEART TUBES

6. Two heart tubes fuses from
Cranially – Caudal
Series of dilatation is seen:
Truncus Arteriosus
Bulbous Cordis
Ventricle
Atrium
Sinus Venosus
Atrium and Ventricle
connected by
Atrio -Ventricular Canal.

10. Series of dilatation is seen after Fusion of Heart Tubes.

11. Formation of the
Cardiac loop
in Pericardial
Cavity.
The primitive
ventricle is
moving ventrally
to right
while the atrial
region is moving
dorsally to left.

12. Heart 28 days.
The bulbus cordis is
divided into the truncus
arteriosus,
conus cordis, and
trabeculated part of the
right ventricle.
Broken line,
pericardium.

13. Fusion near sinus
venosus is partial so
Right and Left Horns
are formed.
1 Vitelline Vein from
Yolk sac, 1 Umbilical
vein from placenta , 1
from common cardinal
vein from body wall
joins SINUS VENOSUS.

14. Right Horn of SINUS VENOSUS absorbed in COMMON ATRIAL
CHAMBER and form Right Atrium.
So Right Cardinal vein= Terminal part of SUPERIOR VENACAVA
Right Vitelline Vein= Terminal part of IVC
LEFT HORN of sinus venosus form part of CORONARY SINUS.
All open in the Right Atrium

16. Development of the
Sinus Venosus at 24
days (A) and 35 days
(B).
Broken line, the
entrance of the Sinus
Venosus into the
Atrial Cavity.

17. SEPTUM PRIMUM: Septum arises from roof of atrial chamber
towards Atrio- Ventricluar Canal.
The lower edge of Septum primum seperated to form FORAMEN
PRIMUM.
Atrio Ventricular growth occurs and fuses with SEPTUM
PRIMUM.
Before this closure, of Foramen Primum, the upper part of
septum primum breaks and form FORAMEN SECUNDUM.
At this stage the left atrium receives blood form right atrium.

19. A. 5 weeks. B. Fetal stage.

20. SEPTUM SECUNDUM arises from roof of atrial chamber
between septum spurium and septum primum.
Grows and overlaps Foramen Secundum. Right and left atrium
communicates thro’ FORAMEN OVALE.
Lower ends of septum secundum/ Crista Dividens is thick and
firm.
While the edge of septum primum which formed the lower
boundary of foramen secundum is thin and mobile as a flap.

22. After birth left atrium begins to receive blood from lungs and pressure
within this chamber increases than right. This causes the closure of
Foramen Ovale.

23. After the formation of Inter atrial Septum, Sinus Venosus is
absorbed into Right Atrium.
Sinu- Atrial Orifice:
Margin of this orifice is bounded by distinct lips= Right and left
Venosus Valves. The upper end of two valves fuses to form Septum
Spurium.
The left valve and septum spurium fuses with Interatrial septum.
The right venous valve stretched out, and form 2 muscular bands=
Superior and Inferior Limbic Bands.

24. A. 5 weeks. B. Fetal stage.

26. These 3 Parts form:
Crista Terminalis
The valve of Inferior
venacava
Valve of coronary sinus

27. Formation of Inter-Ventricular Septum
Conus merges within the
cavity of Primitive
Ventricle & bulbo-
ventricular sulcus
disappears.
The bulbo-Ventricular
Cavity contains:
Lower Dilated Part- formed
by Primitive Ventricle
Upper Conical Part- formed
by Conus

28. Parts of A-V Chamber

29. The Cavity is divided as such that:
Each half communicates with corresponding Atrium
Right Ventricle opens onto Pulmonary Trunk and left
Ventricle opens onto Aorta.

30. A septum- Interventricular septum
grows upward form the floor of
bulbo-ventricular cavity
Divides the lower dilated part into
right and left half.
It partially fuses with the Atrio-
Ventricular Cushions/ Septum
Intermedium.

31. Right and left bulbar ridges
arise in the wall of the
conical upper part of the
Bulbo-Ventricular Cavity.
This is continuous with the right
and left endocardial cushions
that separate the Aortic and
Pulmonary openings.
This ridges together form Bulbar
Septum.
Bulbar Septum grow towards
Inter-Ventricular Septum but
leave a gap b/w them.

32. • This gap is filled by the
proliferation of AV
Cushions.
• The membranous part
of Inter Ventricular
Septum divided into:
Anterior part
Posterior part
Anterior part is derived
from proliferation of
Endocardial Cushions.

33. The membranous part of Inter Ventricular

34. Anterior Part: Seperates
Ventricles
Posterior Part: Seperates
left ventricle from right
Atrium
Inter atrial and
interventricular septa
don’t meet the AV
Cushions in same line.

35. Spiral Septum appears with
in the Truncus arteriosus and
divides into Ascending Aorta
and Pulmonary Trunk.
Right and left Truncus
swelling/ Cushions appears
and fusion occurs in such
that Pulmonary trunk lies
ventral to Aorta.
Pulmonary and Aortic Valves
are formed by the
Endocardal Cushions in
Truncus Arteriosus and
Conus.

36. Right and left Truncus
swelling/ Cushions appears
and fusion occurs in such
that Pulmonary trunk lies
ventral to Aorta.
Pulmonary and Aortic
Valves are formed by
the Endocardal
Cushions in Truncus
Arteriosus and Conus.

38. Formation of Pulmonary Veins
While Septum Primum
forming, a single Pulmonary
Vein opens into left half of
ATRIUM.
Divides into right and left
half again bifurcates to
drain corresponding lung
bud.
Soon they are absorbed into
the Atrium two from each
side open into ATRIUM.

39. Atrial septa at
various stages
C. 33 days
D. 33 days
E. 37 days
F. Newborn.
G. New born

40. Developmental Anamolies in Heart:

42. Main
intraembryonic
and
extraembryonic
arteries (red) and
veins (blue) in a 4-
mm embryo (end
of the fourth
week).
Only the vessels
on the left side of
the embryo are
shown