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P R E S E N T E D B Y : D R . M A H E S H Y A D A V ( P . G . )
R E F E R E N E C E ( N E L S O N 2 1 T H S O U T H I N D I A A S I A E D I T I O N
A N D I N D E R B I R S I N G H T E X T B O O K O F E M B R Y O L O G Y )
DEVELOPMENT OF HEART
AND FETAL CIRCULATION
 INTRODUCTION
 CHANGES IN SINU-ATRIAL ORIFICE
 FORMATION OF ATRIA
 FORMATION OF INTER ATRIAL SEPTUM
 DEVELOPMENT OF RIGHT ATRIUM AND LEFT ATRIUM
 DEVELOPMET OF VENTRICLES
 DEVELOPMENT OF INTER VENTRICULAR SEPTUM
 FETAL CIRCULATION
 CHANGES AFTER BIRTH IN CIRCULATION
INTRODUCTION
 It is splanchnopleuric mesodermal in origin , from the cardiogenic
area(19days) .
 First seen in the from of two Endothelial heart tubes – Right and left .
 These endothelial tubes fuse together to form a single tube which shows
series of dilation
1. Bulbus cordis
2. Ventricle
3. Atrium
4. Sinus venosus
FORMATION OF A.V. CUSHION
FORMATION OF INTER ATRIAL SEPTUM
DEVELOPMENT OF RIGHT ATRIUM
DEVELOPMENT OF LEFT ATRIUM
1. Left half of the primitive atrial chamber .
2. Left half of the atrio- ventricular canal .
3. Absorbed proximal parts of the pulmonary veins .
DEVELOPMENT OF VENTRICLES
CONGENITAL ANAMOLY OF THE HEART
1. ACYANOTIC CONEGENITAL HEART DISEASE(LEFT TO
RIGHT SHUNT
o PATENT DUCTUS ARTERIOSUS
o ATRIAL SEPTAL DEFECT
o VENTRICULAR SEPTAL DEFECT
o COARTICATION OF AORTA
2. CYANOTIC CONGENITAL HEART DISEASE
o TETRALOGY OF FALLOT
o TRANSPOSITION OF GREAT ARTERIES
o TRUNCUS ARTERIOSUS
o TRICUSPID ATRESIA
FETAL CIRCULATION
 DEFINITION: The fetal circulation is the circulatory system of a
human fetus, often encompassing the entire fetoplacental circulation
which includes the umbilical cord and the blood vessels within
the placenta that carry fetal blood.
PATHWAY
Placenta
Umbilical Vein
Umbilical Arteries
Liver
Ductus Venosus
Inferior
Venacava
Right Atrium
Foramen Ovale
Right Lung
Arch of Aoarta
Ductus Arteriosus
Left Atrium
Left Ventricle
Right Ventricle
Portal Vein
Umbilical Cord
2umbilical arteries:
return non-oxygenated blood, fecal waste,
CO2 to placenta
1umbilical vein:
brings oxygenated blood and nutrients to the fetus
PATHWAY
Oxygenated blood from the placenta
through umbilical vein
fetus
liver
Receives deoxygenated blood from the portal vein
through ductus venosus
Inferior vena cava
Right atrium of heart
through foramen ovale
Left atrium of the heart
Left ventricle of the heart
During ventricular systole
Left ventricular blood Right ventricular blood
pumped with < o2 content
Ascending aorta and distributed is discharged
by their branches to the heart, Pulmonary arteries
head,neck,brain,arms. Ductus
arteriosus
Descending aorta
Hypogastric arteries
Umbilical arteries
Placenta
During fetal life
350ml per kg per min
Cardiac Output
Following birth
500ml per min
Heart Rate 120-140per min
At birth
 Clamping the cord shuts down low-pressure system
 Increased atmospheric pressure(increased systemic vascular
resistance) causes lungs to inflate with oxygen
 Lungs now become a low-pressure system
CHANGES IN THE FETAL CIRCULATION AFTER BIRTH
Shunt Functional closure Anatomical
closure
Remnant
Ductus
arteriosus
10 – 96 hrs after birth 2 – 3 wks after
birth
Ligamentum
arteriosum
Formamen
ovale
Within several mins
after birth
One year after
birth
Fossa ovalis
Ductus
venosus
Within several mins
after birth
3 – 7 days after
birth
Ligamentum
venosum
 THANK U

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Development of Heart and Fetal circulation

  • 1. P R E S E N T E D B Y : D R . M A H E S H Y A D A V ( P . G . ) R E F E R E N E C E ( N E L S O N 2 1 T H S O U T H I N D I A A S I A E D I T I O N A N D I N D E R B I R S I N G H T E X T B O O K O F E M B R Y O L O G Y ) DEVELOPMENT OF HEART AND FETAL CIRCULATION
  • 2.  INTRODUCTION  CHANGES IN SINU-ATRIAL ORIFICE  FORMATION OF ATRIA  FORMATION OF INTER ATRIAL SEPTUM  DEVELOPMENT OF RIGHT ATRIUM AND LEFT ATRIUM  DEVELOPMET OF VENTRICLES  DEVELOPMENT OF INTER VENTRICULAR SEPTUM  FETAL CIRCULATION  CHANGES AFTER BIRTH IN CIRCULATION
  • 3. INTRODUCTION  It is splanchnopleuric mesodermal in origin , from the cardiogenic area(19days) .  First seen in the from of two Endothelial heart tubes – Right and left .  These endothelial tubes fuse together to form a single tube which shows series of dilation 1. Bulbus cordis 2. Ventricle 3. Atrium 4. Sinus venosus
  • 4.
  • 5.
  • 6.
  • 8. FORMATION OF INTER ATRIAL SEPTUM
  • 9.
  • 11. DEVELOPMENT OF LEFT ATRIUM 1. Left half of the primitive atrial chamber . 2. Left half of the atrio- ventricular canal . 3. Absorbed proximal parts of the pulmonary veins .
  • 12.
  • 14.
  • 15. CONGENITAL ANAMOLY OF THE HEART 1. ACYANOTIC CONEGENITAL HEART DISEASE(LEFT TO RIGHT SHUNT o PATENT DUCTUS ARTERIOSUS o ATRIAL SEPTAL DEFECT o VENTRICULAR SEPTAL DEFECT o COARTICATION OF AORTA
  • 16. 2. CYANOTIC CONGENITAL HEART DISEASE o TETRALOGY OF FALLOT o TRANSPOSITION OF GREAT ARTERIES o TRUNCUS ARTERIOSUS o TRICUSPID ATRESIA
  • 17. FETAL CIRCULATION  DEFINITION: The fetal circulation is the circulatory system of a human fetus, often encompassing the entire fetoplacental circulation which includes the umbilical cord and the blood vessels within the placenta that carry fetal blood.
  • 18. PATHWAY Placenta Umbilical Vein Umbilical Arteries Liver Ductus Venosus Inferior Venacava Right Atrium Foramen Ovale Right Lung Arch of Aoarta Ductus Arteriosus Left Atrium Left Ventricle Right Ventricle Portal Vein
  • 19. Umbilical Cord 2umbilical arteries: return non-oxygenated blood, fecal waste, CO2 to placenta 1umbilical vein: brings oxygenated blood and nutrients to the fetus
  • 20. PATHWAY Oxygenated blood from the placenta through umbilical vein fetus liver Receives deoxygenated blood from the portal vein through ductus venosus Inferior vena cava Right atrium of heart through foramen ovale Left atrium of the heart Left ventricle of the heart
  • 21. During ventricular systole Left ventricular blood Right ventricular blood pumped with < o2 content Ascending aorta and distributed is discharged by their branches to the heart, Pulmonary arteries head,neck,brain,arms. Ductus arteriosus Descending aorta Hypogastric arteries Umbilical arteries Placenta
  • 22. During fetal life 350ml per kg per min Cardiac Output Following birth 500ml per min Heart Rate 120-140per min
  • 23. At birth  Clamping the cord shuts down low-pressure system  Increased atmospheric pressure(increased systemic vascular resistance) causes lungs to inflate with oxygen  Lungs now become a low-pressure system
  • 24. CHANGES IN THE FETAL CIRCULATION AFTER BIRTH Shunt Functional closure Anatomical closure Remnant Ductus arteriosus 10 – 96 hrs after birth 2 – 3 wks after birth Ligamentum arteriosum Formamen ovale Within several mins after birth One year after birth Fossa ovalis Ductus venosus Within several mins after birth 3 – 7 days after birth Ligamentum venosum