The document discusses imaging of congenital heart diseases, describing the main types of defects such as atrial septal defects (ASD), ventricular septal defects (VSD), and patent ductus arteriosus (PDA). It provides details on the anatomy, classifications, imaging findings, and clinical presentations of each type of defect. Examples of echocardiograms and chest x-rays are shown to illustrate the imaging appearance of various congenital heart abnormalities.
This presentation is almost a complete Pictoral view of Radiograph chest.
This presentation will help radiologist in daily reporting.
This presentation will help physicians, surgeons, anesthetist and almost all medical professionals in diagnosing commonly presenting cardiac diseases.
This will also help all in preparaing TOACS examination.
This presentation is almost a complete Pictoral view of Radiograph chest.
This presentation will help radiologist in daily reporting.
This presentation will help physicians, surgeons, anesthetist and almost all medical professionals in diagnosing commonly presenting cardiac diseases.
This will also help all in preparaing TOACS examination.
This is a chapter from Grainger and Allison. I have Coolected all images from chapter 19 with caption in this presentation.
In my opinion it will be very benificial to have this in your android. ,
This presentation is a complete atlas of normal anatomy particularly vasculature of heart on MDCT Angio.
It helps guide radiologist and Cardiologist in understanding normal heart on 3-D imaging. After Studying this it will be very easy to pick abnormal. Dr. Muhammad Bin Zulfiqar
This is a chapter from Grainger and Allison. I have Coolected all images from chapter 19 with caption in this presentation.
In my opinion it will be very benificial to have this in your android. ,
This presentation is a complete atlas of normal anatomy particularly vasculature of heart on MDCT Angio.
It helps guide radiologist and Cardiologist in understanding normal heart on 3-D imaging. After Studying this it will be very easy to pick abnormal. Dr. Muhammad Bin Zulfiqar
A detailed discussion on embryogenesis of heart and ennumeration of all congenital diseases and description of cyanotic congenital heart disease , each disease in detail.
Generally occurs secondary to pulmonary atresia with intact IVS .
Pathophysiology- it develops because of a reduction in the blood flow secondary to inflow impedence from tricuspid atresia or outflow impedence from pulmonary arterial atresia .
Typical findings- a small , hypertrophic RV and a small or absent pulmonary artery
The lecture is for medical student. It is from Dr RUSINGIZA Emmanuel, MD, senior lecture at UR( UNIVERSITY OF RWANDA) .
It will help to understand heart diseases in newborn, infants and children.
Fetal Vascular Rings: Beyond The Anomalies of The Aortic Archpateldrona
Different anomalies related to the inappropriate development of the ductus arteriosus or the aortic arch have been described, in some cases accompanied with chromosomal or morphological anomalies, and also being able to form a vascular ring that can compromise the postnatal life
Fetal Vascular Rings: Beyond The Anomalies of The Aortic Archnavasreni
Different anomalies related to the inappropriate development of the ductus arteriosus or the aortic arch have been described, in some cases accompanied with chromosomal or morphological anomalies, and also being able to form a vascular ring that can compromise the postnatal life.
Fetal Vascular Rings: Beyond The Anomalies of The Aortic ArchSarkarRenon
Different anomalies related to the inappropriate development of the ductus arteriosus or the aortic arch have been described, in some cases accompanied with chromosomal or morphological anomalies, and also being able to form a vascular ring that can compromise the postnatal life.
Fetal Vascular Rings: Beyond The Anomalies of The Aortic ArchAnonIshanvi
Different anomalies related to the inappropriate development of the ductus arteriosus or the aortic arch have been described, in some cases accompanied with chromosomal or morphological anomalies, and also being able to form a vascular ring that can compromise the postnatal life.
Fetal Vascular Rings: Beyond The Anomalies of The Aortic Archgeorgemarini
Different anomalies related to the inappropriate development of the ductus arteriosus or the aortic arch have been described, in some cases accompanied with chromosomal or morphological anomalies, and also being able to form a vascular ring that can compromise the postnatal life
Fetal Vascular Rings: Beyond The Anomalies of The Aortic Archkomalicarol
Different anomalies related to the inappropriate development of the ductus arteriosus or the
aortic arch have been described, in some cases accompanied with chromosomal or morphological anomalies, and also being able to form a vascular ring that can compromise the postnatal life. For this reason, a complete fetal anatomy examination and cardiovascular study is
needed to discard possible other malformations or ultrasound markers for fetal syndromes. A
detailed prenatal diagnosis of the type of ductal arch anomaly and possible vascular ring can
give us a postnatal prognosis and help pediatricians with the management of symptomatic
neonates
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Introduction
• The heart is the first organ to form and become functional ,
emphasizing the importance of transport of material to and from
the developing infant. It originates about day 18 or 19 from the
mesoderm and begins beating and pumping blood about day 21 or
22. It forms from the cardiogenic region near the head and is visible
as a prominent heart bulge on the surface of the embryo. Originally,
it consists of a pair of strands called cardiogenic cords that quickly
form a hollow lumen and are referred to as endocardial tubes.
3. • These then fuse into a single heart tube and differentiate into five
parts, the truncus arteriosus, bulbus cordis, primitive
ventricle, primitive atrium, and sinus venosus, starting about
day 22. The primitive heart begins to form an S shape within the
pericardium between days 23 and 28. The internal septa begin to
form about day 28, separating the heart into the atria and
ventricles, although the foramen ovale persists until shortly after
birth. Between weeks five and eight, the atrioventricular valves
form. The semilunar valves form between weeks five and nine.
4. CONGENITAL HEART DISEASE
• Definition:
• Congenital heart diseases are structural or functional circulation
system anomalies which provide clinical symptoms at birth or
in other life periods.
5. MAIN CATEGORIES OF CONGENIAL HEART
DISEASES
1.Diseases with left-to-right shunt.
2.Diseases with prevailing right-to-left shunt.
3. Valves stenosis and valves or ventricules hypoplasia.
4.Anomalies of great vessels.
5. Position anomalies.
6. Other congenital syndromes.
6. Another division:
Cyanotic HD with decreased pulmonary flow
• Tetralogy of Fallot (ToF), pulmonary atresia with/without ventricular septum
defect (PA + VSD), tricuspid atresia (TA), Ebstein anomaly.
with increased pulmonary flow
• Transposition of great arteries (TGA), common ventricle (CV), anomalous
pulmonary venous connection (PAPVC, TAPVC) .
with pulmonary stasis
• TAPVC with pulmonary veins stenosis, cor triatriatum, mitral stenosis
7. • Another division:
Non cyanotic HD with pulmonary vein stasis
Critical aortic coarctation, mitral stenosis, pulmonary veins’ stenosis, hypoplasia
of the left heart syndrome (HLHS)
with increased pulmonary flow
Ventricle septum defect (VSD), patent ductus arteriosus (PDA), atrial septum
defect (ASD), atrio-ventricular septum defect („common canal” – AVSD), truncus
arteriosus comunis (TAC), aorto-pulmonary window (A-P W)
8. • Another division:
Non cyanotic HD with normal pulmonary flow
Aortic stenosis (AS), coarctation of aorta (CoA), pulmonary stenosis (PS),
vascular ring, corrected TGA
10. About 80% of all congenital heart diseases are following eight:
ASD, VSD, PDA, AS, PS, CoA, ToF, TGA,
11. Protocols of the examination in CT and MR:
- general anesthesia in children
- very good venous access (central)
- maximum short time
- maximum temporal and spatial resolution
- optimalization of the parameters
12. MR TECHNIQUES
For morphological information
- „Black blood” spin-echo (SE)
- „White blood” fast gradient echo, steady-state free precession (SSFP)
- Contrast enhansed angiography MR
13. For functional information
-Cine imaging fast gradient echo
-Velocity-encoded cine (VEC) MRI
ECG gated (non-gated SSFP in children), slice thickness 5 mm (3 mm), gap
between slices 1 mm, respiratory compensation, gadolinium-enhanced for
3D
14. INDICATIONS FOR MR IN CHD
1.Complex CHD
2. Different anomalies of aorta
3. Post-operative patient
The first choice in older children and adults
15. PROTOCOL FOR CT
- flow?
• from 0.5 ml/sec (newborn)
- delay?
• test bolus!
- ml of non-ionic contrast?
• up to 3 ml/kg b.w. in newborn
• up to 2 ml/kg b.w. the rest
16. Test-bolus to determine correct timing of contrast enhancement (left)
and region of interest placement in the ascending aorta (right).
24. 1- ASD
ASDs are seen in 1 per 1,500 live births and account for
30–40 % of all adult congenital heart disease
There are five types of ASD according to their
location within the septum:
1-Secundum ASD. 60-90% of all ASDs. usually an
isolated abnormality.
2-Primum ASD. 5-20% ...
3-Sinus venosus. 5% ...
4-Coronary sinus type ASD ("unroofed coronary
sinus") <1%
5-common atrium, combination of two or more defects.
25. ASD associated with;
Down syndrome –ASD primum
Holt Oram syndrome ASD secondum
Lautembacher syndrome –ASD+ Mitral stenosis
ASD is more common in females, small defect usually
asymptomatic presented in 4th and 5th decades.
26. Chest x -ray findings
• Cardiomegaly RT.side.
• Normal left heart
• RA enlargement.
• RV enlargement.
• Full pulmonary conus.
• Increased pulmonary vascular
marking, Plethoric lung fields
28. Panels (a) and (b) Large secondum ASD (black arrowheads) associated with right atrial (panels a and b)
and right ventricular enlargement (panel a), indicating volume overload. Note a good tissue rim, exceeding
3 mm in all directions (black arrows) in both panels.
Marilyn J. Siegel2, Tomasz Miszalski-Jamka3, 4 and Robert Pelberg1
ASD
SECONDUM
30. Primum atrial septal defect (ASD). An axial CT shows
the ASD (black arrowhead) located between the level of
the fossa ovalis and atrioventricular valves. This defect
occurs in the lower part of the atrial septum close to the
ventricular inlet valves.
ASD PRIMUM
Marilyn J. Siegel2, Tomasz Miszalski-Jamka3, 4 and Robert Pelberg1
31. Maximum intensity projections of the sinus venosus atrial septal defect .
Here panels (a), (b), and (c) are axial views each showing 1 of the 3
anomalous pulmonary veins (black arrows, white arrows) entering the
superior vena cava (asterisk). Panel (c) illustrates the SVC straddling both
atria (black arrowhead). The persistent left-sided SVC is again noted by
the black asterisk. White asterisk superior vena cava.
Sinus Venosus ASD
Always with PAPVC
Marilyn J. Siegel2, Tomasz Miszalski-Jamka3, 4 and Robert Pelberg1
32. A- Axial steady-state free precession (SSFP) image of 43-year-old woman shows sinus venosus defect (straight arrow)
between superior vena cava (SVC) and left atrium (LA). Note also anomalous right upper lobe pulmonary vein (curved
arrow) opening into SVC.
B-Short-axis SSFP image of 54-year-old woman shows inferior sinus venosus defect (straight arrow) between inferior vena
cava (IVC) and left atrium (LA), with jet (curved arrow) extending from LA to IVC.
A
B
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
33. UNROOFED ASD
Represents an unroofed coronary sinus atrial septal defect in a 33 year old patient with repair in childhood who now presents
with right sided heart failure and evidence of an intracardiac shunt. Panel (a) demonstrates a persistent left sided superior vena
cava entering the coronary sinus. A calcified septal closure patch which does not cover the entire defect is also demonstrted
(arrow). Panel (b) demonstrates an intra-atrial communication via the unroofed coronary sinus.
Marilyn J. Siegel2, Tomasz Miszalski-Jamka3, 4 and Robert Pelberg1
34. Axial and sagittal SSFP images show complete unroofing of coronary
sinus (arrow) and direct communication between it and left atrium
(LA). Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
35. COMMON ATRIUM
Common atrium (confluence of two or more
types of ASD defects) is characterized by
complete absence of atrial septum and occurs in
association with other complex defects,
frequently heterotaxy syndrome. It is very rarely
seen in the adult population .
Marilyn J. Siegel2, Tomasz Miszalski-Jamka3, 4 and Robert Pelberg1
36. PATENT FORAMEN OVALE
Patent foramen ovale (PFO) is the most common form of interatrial
communication. It is caused by a failure of fusion of the flap valve of
the fossa ovalis. The prevalence of PFO declines progressively with
age (34 % up to age 30 years, 25 % for age 30–80 years, and 20 %
older than 80 years).
Two types of PFO exist. The first is the incompetent valve type and
results in right-to-left shunting only when right atrial pressure exceeds
that of the left atrium such as during a Valsalva maneuver.
The second type is called the stretched type and is due to high left
atrial pressure (such as seen in left heart failure) which stretches the
fossa ovalis flap valve to the point of incompetence, resulting in a left-
to-right shunt. While a single defect is most common in PFO, multiple
fenestrations may also be seen.
Marilyn J. Siegel2, Tomasz Miszalski-Jamka3, 4 and Robert Pelberg1
37. A- Four-chamber steady-state free precession (SSFP) image of 61-year-old woman shows patent foramen ovale
(arrow) in midportion of interatrial septum.
B- SSFP image of 37-year-old woman shows small patent foramen ovale (straight arrow) with shunting of blood
(curved arrow) from left atrium (LA) to right atrium (RA).
A B
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
38. ATRIAL SEPTALANEURYSM
Atrial septal aneurysm (ASA) is associated with a PFO in
30 % of the cases . ASA is defined as an abnormal bulging
of the interatrial septum with an excursion of at least 10
mm and a base span of at least 15 mm.
This is thought to be due to redundancy of the valve of the
fossa ovalis and/or excessive mobility of the atrial septum
with ballooning into the right or left atrial chamber. ASA
may be associated with mitral valve prolapse and atrial
arrhythmias.
Marilyn J. Siegel2, Tomasz Miszalski-Jamka3, 4 and Robert Pelberg1
39. Four-chamber steady-state free
precession (SSFP) image of 42-
year-old woman shows normal
appearance of atrial septal occluder
device (arrow). No residual shunt is
seen.
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
40. 2-VSD
•VSD is the overall second most common congenital cardiac
disease (20%) and is often associated with other congenital
cardiac anomalies, such as tetralogy of Fallot, transposition of
the great arteries, atrioventricular canal, and a single ventricle.
VSD may also be acquired after acute myocardial infarction,
chest trauma, cardiac interventions, or endocarditis.
41. VSDsmay be classified into four main categories according to their location and
the appearance of the margins of defects.
Type I defects are also known as outlet defects. 5% of all VSDs and are located in the
outlet portions of the left and right ventricles. The superior edge of the VSD is the
joined annulus of the aortic and pulmonary valves. Because the aortic and pulmonary
valves are in fibrous continuity, this type of defect may also be referred to as a supra-
cristal, sub-pulmonary, infundibular, or conoseptal defect.
Type II defects are also called infra- cristal, subaortic, perimembranous, or
paramembranous defects. These defects are the most common type of VSD,
constituting 75% of all cases. They occur around the membranous septum and are
associated with a muscular defect. The defect is just inferior to the aortic valve, and
the annulus of the tricuspid valve contributes to the rim of the defect.
42. • Type III defects, also called atrioventricular (AV) canal, AV septal, or
inlet septal defects, are located in the posterior region of the septum
beneath the septal leaflet of the tricuspid valve. These defects account
for 10% of all VSD types.
• Type IV is muscular defect account for 10% of all VSDs . They may
be single, but are commonly multiple. the multiple defects occur in the
apical trabecular septum.
43. Hemodynamics:
LVRVPALALV
Enlarged RV, LV, LA and PA
In case of Eisenmenger syndrome
there is right ventricular to left
ventricular flow.
Clinical:
Smallasymptomatic
Largecongestive heart faliure by 2-3 months
VSD
44. Chest X ray finding;
Small VSD, normal chest Xray.
Larger VSDs may show cardiomegaly
(particularly left atrial enlargement
although the right and left ventricle can
also be enlarged). A large VSD may also
show features of pulmonary arterial
hypertension, pulmonary edema, pleural
effusion and increased pulmonary
vascular markings
VSD
45. Chest examination in a 26-year-old man with a muscular VSD. A, Posteroanterior examination shows dilation of the main
pulmonary artery (MP) and hilar right (1 arrow) and left (2 arrow) pulmonary arteries. The upper (3 arrow) and lower (4
arrow) lobe pulmonary arteries are sharp and dilated as well, indicating shunt vascularity. Narrowing of the superior
mediastinum (5 arrow) and displacement of the heart toward the left indicate right heart volume loading. B, Lateral
examination shows filling of the retrosternal space, indicating right heart and main pulmonary artery enlargement. The left
bronchus (1 arrow) is displaced, and the inferior retrocardiac space is filled, indicating left atrial and ventricular
enlargement.
46. 6-year-old boy with a membranous VSD. A, Posteroanterior examination showing typical signs
of shunt vascularity and cardiac enlargement. Right heart enlargement is indicated by the
leftward displacement of the heart from the midline. B, Lateral examination shows filling of the
retrosternal clear space (indicating right heart and pulmonary artery enlargement), and filling of
the superior and inferior retrocardiac space, indicating left atrial and left ventricular
enlargement.
49. TTE in subcostal four-chamber view shows a membranous VSD (arrow)
50.
51. Small defect Expectant (closes spontaneously)
Large defect Septal occluding device
A- FETAL SUBAORTIC VSD WITH OVER-RIDING -- B --MUSCULAR VSD
A B
52. Patent ductus arteriosus or arteriosum (PDA) is a
persistent patency of the ductus arteriosus, a normal
connection of the fetal circulation between the aorta and the
pulmonary arterial system that develops from the 6th aortic
arch.
Epidemiology
PDAs occur in ~1 in 2000 full-term neonates with a F:M of
2:1
3-PDA
53. Normally closes functionally at 48 hrs &
anatomically at 4 wks
Hemodynamics:
AortaPALALV
LA, LV, Aorta & PA are enlarged
Associations:
Pulmonary atresia, COA
Highest incidence in premature infants with RDS
Clinical:
F > M
Small asymptomatic; Large CHF by 2-3
months
Treatment:Indomethacin, Catheter closure or
55. Patent ductus arteriosus. Volume render CT and Sagittal steady-state free
precession image of 32-year-old man shows patent ductus arteriosus
(straight arrow) connecting aortic isthmus with main pulmonary artery
(PA), with high-velocity jet (curved arrow) present throughout cardiac
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
56. PDA with jet flow from aorta to PA
Sagittal coronal
59. 4-Aorto-pulmonary window
• An aortopulmonary window defect is an abnormal
communication between the ascending aorta and main
pulmonary artery. The presence of both aortic and pulmonic
valves and of an intact ventricular septum distinguishes it
from truncus arteriosus.
• The pulmonary artery and left heart chambers are typically
enlarged. Other associated anomalies include VSD, aortic
coarctation, and patent ductus arteriosus. Aortopulmonary
window defect requires surgical repair during infancy.
60. aortopulmonary window
defect. Axial SSFP image of
27-year-old woman shows
communication (arrow)
between aorta (AO) and main
pulmonary artery (PA)
consistent with
aortopulmonary window
defect.
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
61. Aortopulmonary shunts.A Line
diagram illustrates various
surgically created
aortopulmonary shunts.
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
62. Coronal MR angiography image of 21-
year-old man after surgical repair of
tetralogy of Fallot shows absence of right
subclavian artery (arrowheads), which
was taken down for Blalock-Taussig
shunt. Note normal left subclavian artery
(arrow).
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
64. In an atrioventricular defect (i.e., an endocardial cushion defect),
defects of the atrial ostium primum and ventricular inlet septum are
associated with a common atrioventricular valve and abnormal
arrangement of the valve leaflets. The various types of atrioventricular
defects include a complete type (ostium primum ASD, inlet VSD, and
cleft mitral and tricuspid valves); a partial type (ostium primum ASD,
no interventricular shunt, normal atrioventricular valves); and a
common atrium . Direct shunting from the left ventricle into the right
atrium may develop. In the most severe form, all four chambers
communicate causing left-to-right and right-to-left shunting
Gerbode defect
65. Gerbode defect
A Gerbode defect usually congenital and could be acquired, the acquired defects
are seen below the level of insertion of the tricuspid valve in the interventricular
septum and are caused by surgery, infective endocarditis, or myocardial
infarction .
66. • Hemodynamics:
A-V septal defect
RA, RV, LA, LV & PA are enlarged, Not Aorta
• Radiographic features:
CXR: cardiomegaly, enlarged PA
Angiography: goose-neck deformity of LVOT on RAO view
• Associations:
Down $ (40%)
• Clinical:
congestive heart faliure by 2-3 months
• Treatment:
Surgical closure before 2 years
68. AVSD. Axial SSFP image of 2-year-
old girl shows atrioventricular septal
defect with ostium primum atrial
septal defect (arrowhead) and inlet
ventricular septal defect (arrow).
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
69. Gooseneck deformity
• The gooseneck-shaped deformity in endocardial cushion defect is
caused by a deficiency of both the conus and sinus portions of the
Interventricular septum, with narrowing of the left ventricular outflow
tract. The concavity of the interventricular septum below the mitral
valve, along with the elongation and narrowing of the left ventricular
outflow tract, produces a characteristic shape that has been compared
to a sitting goose with an elongated neck on the anteroposterior
projection in left ventricular angiography.
71. 6-Anomalous pulmonary venous return
• In total anomalous pulmonary venous return (TAPVR) all of
the pulmonary veins drain into the right atrium or a systemic
venous channel at supracardiac, cardiac, or infra-
diaphragmatic levels. Connections may rarely exist at more
than one level. The supracardiac type most commonly
involves a vertical vein that connects to the brachiocephalic
vein. In the cardiac type, the anomalous vein drains directly
into the right atrium or coronary sinus. The infra-
diaphragmatic type typically drains into the portal vein.
Venous obstruction may be present.
72. • In PAPVR, one to three pulmonary veins drain into the
systemic venous circulation, either directly into the right
atrium or into systemic veins, resulting in a partial left-to-
right shunt. PAPVR is usually an incidental finding occurring
in 0.7% of the population .
• It most commonly affects the left upper lobe (47%), draining
into the left brachiocephalic vein , followed by the right upper
lobe (38%), right lower lobe (13%), and left lower lobe (2%)
.
73. • PAPVR is bilateral in 4% of patients. A sinus venosus ASD
occurs in 42% of people with PAPVR of the right upper lobe .
MRI can easily identify and quantify a sinus venosus ASD
and associated anomalous pulmonary veins that are otherwise
occult on echocardiography. Transverse plane acquisitions
and 3D MRA or 3D whole-heart SSFP sequences can depict
these lesions. Flow into the right atrium can be confirmed and
quantified with velocity-encoded phase-contrast MRI .
74. • Scimitar syndrome (i.e., hypo genetic lung or venolobar
syndrome) is characterized by anomalous drainage of part of
or of the entire right lung into the IVC, coronary sinus, right
atrium, azygos vein, portal vein, or hepatic vein in addition to
hypoplasia of the right lung and right pulmonary artery. The
anomalous pulmonary vein curves medially toward the
diaphragm and the IVC, giving the characteristic appearance
of a scimitar .
76. • Hemodynamics:
- Some (not all) pulmonary veins drain into RA
or systemic veins
- RA, RV & PA are enlarged
• Types:
Supracardiac (SVC, Azygous vein) resemble
Cardiac (RA, coronary sinus) ASD
Infracardiac (IVC, portal vein) Scimitar $
• Associations:
ASD (sinus venosus defect)
Hypogenetic lung $ -- Scimitar $
77. Three-dimensional volume-rendered
image of 28-year-old woman shows
anomalous drainage of right superior
pulmonary vein (straight arrow) into
superior vena cava (curved arrow). RA =
right atrium.
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
78. Axial steady-state free precession
image of 43-year-old woman shows
vertical vein (straight arrow) that
drains left upper lobe into left
brachiocephalic vein (curved
arrow).
Prabhakar Rajiah1 and Jeffrey P. Kanne2October 2011, Volume 197, Number 4
79. • Curved vessel at the right cardiophrenic angel. (curved tubular
structure running parallel to the right heart).
• Hypogenic right lung.
• Increased pulmonary vascularity.
• Radiologically similar to ASD.
SCIMITAR SYNDROME
84. • Types:
Vavular (dome-shaped, dysplastic Noonan $)
Peripheral (main PA, bifurcation, multiple peripheral)
• Hemodynamics:
Obstruction of RV outflow
RV is enlarged (hypertrophy)
Post-stenotic dilatation of Main & left PA in Valvular type
• Radiographic features:
Dilated main &/or left PA, may show mural calcifications
RV hypertrophy
PULMONARY STENOSIS
92. COA
Coarctation of the aorta accounts for 5%–10%
of congenital cardiac lesions and is usually sporadic.
However, it occurs with increased frequency
among patients with Turner syndrome,
20%–36% of whom are affected. Clinical manifestations vary from
congestive heart failure in infancy to hypertension with differential
pressures between the upper and lower extremities in adulthood.
93. COA
Two classic radiologic signs associated with aortic coarctation are
the figure-of-three sign and the reverse figure-of-three sign. The
aortic segment affected by coarctation has a shape that resembles
the number 3 on frontal chest radiographs. The reverse figure-of-
three sign, a mirror image of the number 3, is observed on the left
anterior oblique view during barium esophagography. This sign is
seen in 50%–66% of adults with aortic coarctation
94. Types:
Infantile type (diffuse, pre-ductal)
Adult type (localized, post or peri-ductal)
Hemodynamics:
Pre-ductal: R-L shunt via PDA or VSD
Post-ductal: L-R shunt via PDA
Collaterals to descending aorta via IMA, periscapular through intercostals
Associations:
Coarctation $: COA, PDA, VSD
Turner $, Marfan $
Bicuspid aortic valve
Circle of Willis Aneurysm
Clinical:
BP difference between arms and legs
Diffuse type: congestive heart faliure in noenates
Treatment:
Resection & anastomosis, patch angioplasty, balloon angioplasty
COARCTATION OF AORTA
105. I AA
According to the Celoria-Patton classification of IAA ;
type A is defined as interruption distal to the left subclavian artery (42%
of cases);
type B, the interruption is between the left common carotid artery and
subclavian artery (53%).
type C, the interrupted segment is between the innominate artery and
left common carotid artery (4%).
106. • Occluded Aortic segment
• Mostly at the arch
• Associated with VSD, PDA, DORV
• Radiographic features:
• No aortic knob, large PA
• Neonatal pulmonary edema
Interrupted Aortic Arch
108. Just a kink figure 3
No mediastinal widening
No rib notching
No functional stenosis
High riding aortic arch
No collateral
50-80% bicuspid aortic valve
Buckle in descending aorta
Pseudo coarctation of aorta