This document discusses the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), which is a statutory body formed under the Prevention of Cruelty to Animals Act in India. It oversees animal experimentation through Institutional Animal Ethics Committees (IAEC). The CPCSEA introduces guidelines for animal housing, care, experimental facilities, and promotes the 3R principles of replacement, reduction and refinement of animal use in research. It is composed of scientists, regulators and animal activists who monitor compliance through IAECs at the institutional level.
toxicology study according to OECD guidelines, organisation for economic co-orporation and developement, jasdeep singh , maharaja ranjit singh punjab technical university bathinda
toxicology study according to OECD guidelines, organisation for economic co-orporation and developement, jasdeep singh , maharaja ranjit singh punjab technical university bathinda
This presentation is about the basic responsibilities and functions of CDSCO explaining the regulatory body's constitution, comprising of functions of state licensing authority and port offices covering the guidelines for new drug approval process, clinical trails and medical devices. this presentation also give a basic note on SUGAM
Introduction to pre clinical screening of drugsKanthlal SK
Various Techniques and Methods for screening of new chemical entities in preclinical aspects (both invitro & invivo) for effective and safe clinical usage.
The NDA application is the vehicle through which drug sponsors, such as biotech and pharmaceutical companies, formally propose that the FDA approve a new pharmaceutical for sale and marketing
Common laboratory animals, Classification of Experimental Animals, Handling and application of different species and strains of animals,Different strains of laboratory animals, application and common diseases.
Requirements And Guidelines For Permission To Import / or Manufacture of New Drugs For Sale or To Undertake Clinical Trials
Schedule Y was introduced under the Drugs and Cosmetics Act 1940, to
introduce requirements for countries to get permission for:
Importing
Manufacturing new drugs
Conducting Clinical Trials.
Application for permission
Clinical Trial
Studies in specific population
Post marketing surveillance
Special studies: BA/BE studies
This presentation will help understanding the vast process of rat and mice handling and oral routes of drug administration through acute class method (OECD: 423).
This presentation is about the basic responsibilities and functions of CDSCO explaining the regulatory body's constitution, comprising of functions of state licensing authority and port offices covering the guidelines for new drug approval process, clinical trails and medical devices. this presentation also give a basic note on SUGAM
Introduction to pre clinical screening of drugsKanthlal SK
Various Techniques and Methods for screening of new chemical entities in preclinical aspects (both invitro & invivo) for effective and safe clinical usage.
The NDA application is the vehicle through which drug sponsors, such as biotech and pharmaceutical companies, formally propose that the FDA approve a new pharmaceutical for sale and marketing
Common laboratory animals, Classification of Experimental Animals, Handling and application of different species and strains of animals,Different strains of laboratory animals, application and common diseases.
Requirements And Guidelines For Permission To Import / or Manufacture of New Drugs For Sale or To Undertake Clinical Trials
Schedule Y was introduced under the Drugs and Cosmetics Act 1940, to
introduce requirements for countries to get permission for:
Importing
Manufacturing new drugs
Conducting Clinical Trials.
Application for permission
Clinical Trial
Studies in specific population
Post marketing surveillance
Special studies: BA/BE studies
This presentation will help understanding the vast process of rat and mice handling and oral routes of drug administration through acute class method (OECD: 423).
This presentation include the guidelines related to the pre-clinical trial on animals. animal ethics committee , act and rules , animal care requirements .
Research Methodology (M. Pharm, IIIrd Sem.)_UNIT_IV_CPCSEA Guidelines for Lab...Prachi Pandey
CPCSEA guidelines for laboratory animal facility: Goals, veterinary care, quarantine,
surveillance, diagnosis, treatment and control of disease, personal
hygiene, location of animal facilities to laboratories, anesthesia, euthanasia, physical facilities, environment, animal husbandry, record keeping, SOPs, personnel and
training, transport of lab animals.
Research Methodology (M. Pharm, IIIrd Sem.)_UNIT_IV_CPCSEA Guidelines for Lab...RAHUL PAL
CPCSEA guidelines for laboratory animal facility: Goals, veterinary care, quarantine,
surveillance, diagnosis, treatment and control of disease, personal
hygiene, location of animal facilities to laboratories, anesthesia, euthanasia, physical facilities, environment, animal husbandry, record keeping, SOPs, personnel and
training, transport of lab animals.
Pharmaceutical Jurisprudence. Based on the PCI Syllabus. Ethics to be considered for handling the animals in experiments. Reference from Pharmaceutical Jurisprudence by B. M. Mithal.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. CPCSEA
Committee for the Purpose of Control and Supervision
of Experiments on Animals (CPCSEA)
Statutory body formed by the Act of the Indian
Parliament under the Prevention of Cruelty to Animals
Act, 1960
Formed in 1964
Revived in 1998, under the committed chairpersonship
of Meneka Gandhi
Head quarters at Chennai
Includes various guidelines and sub committees
3. CPCSEA
National level expert committee to scrutinize and approve
the research projects conducted using animals.
Introduced a national “Good Laboratory Practice”
document
Introduced the credo of 3R principles
2004 – CPCSEA officially accepts the concept of the 4th R
“investigators have a moral responsibility to take care of
laboratory animals after use”
4. CPCSEA
This committee is composed of
Members of the scientific community
Regulatory authorities
Animal activists.
The committee has 10 experts and 3 official members
6. CPCSEA and IAEC
Role of CPCSEA is to monitor animal experiments
through ethics committees set up in institutions(IAEC)
CPCSEA Nominee –important link between CPCSEA
and IAEC
IAEC scrutinize all project proposals for
experimentation on animals.
For small animals- give the final approval
For large animals- make its recommendation to SCLA
(Sub-Committee on Large Animals)
7. IAEC composition
--A Biological Scientist.
--Two Scientists from different bio disciplines.
--A Veterinarian involved in care of Animals.
--Scientist In-Charge of Animal House Facility.
The Chairman (preferably Head of the Institution /
Department) and Member Secretary need to be
nominated from the above five members.
Other members : Main Nominee, Link Nominee,
Scientist from outside and Socially Aware Nominee
nominated by CPCSEA.
The validity of IAEC is for 3 years.
8. CPCSEA
Goals:
To promote the humane care of animals used in
research.
To provide specifications that will enhance animals well
being and quality of research.
Objective:
Effective functioning of Institutional animal ethical
committee
9. Main Activities
Registration of establishments
for experiments on animals
for Breeding of animals
Approval of Animal House Facilities
Permission of Committee for Conducting Experiments
10. CPCSEA guidelines
Veterinary care:
Provided by a veterinarian
Daily observation of animals adopted
Quarantine, Stabilization and Separation:
Quarantine period for small lab animals : one wk to one mth-
large lab animals : up to 6 weeks
Physiologic, psychological and nutritional stabilization required
Physical separation of animals by species to prevent anxiety and
behavioral changes
11. Animal procurement and tranportation
Procurement of animals done from established
commercial animal vendors.
During transport, stress avoided by:
Use of transport containers (cages or crates) of
appropriate size
Permissible number of animals accommodated in each
container
12. Experimental area:
Experiments should be carried out in a separate area
away from the place where they are housed.
Separate functional areas for
surgical support
treatment of animals
post operative and intensive care
13. Physical facilities
Building materials Durable, moisture- proof, fire resistant
and pest resistant
Corridor(s) Wide enough to facilitate the
movement of personnel and equipment
Animal room doors Should fit properly , should not be rust
Exterior windows Windows are not recommended
Floors Smooth, moisture proof , nonabsorbent,
skid proof floors
Drains Proper drainage,
Floors should be sloped
Storage areas Designed for feed, bedding, cages and
materials not in use.
14. Environment
Temperature
Humidity control
between 18-29o
C
range of 30-70%
Ventilation designed with 12-15 air cycles per
hour.
Power and lighting System should be safe
Fluorescent lights are efficient
Emergency backup needed
Noise control noise free environment
Concrete walls are more effective
15. Animal husbandry
CAGING OR HOUSING SYSTEM
The housing system should provide
Adequate space,freedom of movement,normal postural
adjustments
Comfortable environment
Easy access to food and water
Adequate ventilation
16. Food and water
Food should be palatable, non-contaminated, and
nutritionally adequate
Should have continuous access to fresh, potable
uncontaminated drinking water
Feed should contain Feed should not contain
moisture
crude fibre, crude
protein and crude fat
essential bits, minerals,
carbohydrates
insecticides, hormones,
antibiotics, fumigants or
potential toxicants.
heavy metals
17. Bedding
Should be absorbent, free from toxic
chemicals
Should be removed and replaced periodically with fresh
materials
Ideal to change the bedding twice a week
18. Sanitation and cleanliness
Animal rooms, corridors, storage spaces, and other
areas should be cleaned with appropriate detergents and
disinfectants
Wastes should be removed regularly and frequently
(waste disposal – incineration)
Cages should be sanitized before animals are placed in
them
19. Proper maintence of records must
Should maintain the SOP’s
Proper selection of animal facility staff required
Anaesthesia should be complete and without any pain
Euthanasia :done when animal required to be sacrificed
or termination of an experiment or otherwise for ethical
reasons
recombinant DNA, infectious agents, and other potentially hazardous biologics carries inherent safety risks. Working at an appropriate biosafety containment level and with the appropriate safety precautions is essential for mitigating those risks.