The prevention of cruelty to animals act, 1960Ravikumar Patil
In that slides providing knowledge about the animal cruelty act, 1960 for the basic knowledge to the pharmacy students regarding subject Pharmaceutical Jurisprudence.
This presentation include the guidelines related to the pre-clinical trial on animals. animal ethics committee , act and rules , animal care requirements .
The prevention of cruelty to animals act, 1960Ravikumar Patil
In that slides providing knowledge about the animal cruelty act, 1960 for the basic knowledge to the pharmacy students regarding subject Pharmaceutical Jurisprudence.
This presentation include the guidelines related to the pre-clinical trial on animals. animal ethics committee , act and rules , animal care requirements .
pellets can be defined as multi particulate system or multiunit system
They are spherical particulates manufactured by agglomeration of the powder granules containing drug substance and excipients.
Pellets can be prepared by a special technique called Pelletization.
This technique is referred to an agglomeration process that convert fine powder or granules of bulk drug or excipient in to small , free flowing , spherical or semi spherical pellets .
Multi particular drug delivery system especially suitable for achieving controlled delay released oral formulation with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Multi particulate drug delivery system are mainly oral dosage form consisting of a multiplicity of small discrete units each exhibiting some desire characteristics.
What is pyrogens?
Sources of pyrogens and its elimination methods
Tests for pyrogens-
1. In Vitro Test / LAL Test
2. In Vivo Test / Rabbit Test.
Objective
Principle
Requirements
Procedure
Observation table
Result and interpretation
Herbal Drug Technology (B.Pharm. 6th Semester)
Definition of herbs, herbal medicine, herbal medicinal product, herbal drug preparation
Source of herbs, Selection, identification and authentication of herbal materials,
Processing of herbal raw material
LINK FOR VIDEO LECTURES
https://youtu.be/-4nzP2vOGdg
DRUG TECHNICAL ADVISORY BOARD IS IN THE PHARMACY SYLLABUS AND THE QUESTIONS ARE ASKED IN THE PHARMACY EXAMS .
SUCH AS GPAT NIPER AND SEMSESTER EXAM/
The Digital Plethysmometer is a highly useful tool to evaluate the inflammatory response experimentally induced in small rodents and to screen potential anti-inflammatory or anti-oedema properties of pharmacological substance.
Digital Plethysmometer is a micro controlled volume meter, specially designed for accurate measurement of the rat / mouse paw swelling.
The control unit can be zeroed between successive readings by pressing the reset key, so as to avoid the error arising due to adherence of water to the paw of the animal.
For screening of inflammation or oedema in mouse or rat.
Foot switch allowing rapid hands-free experiments can be used to control the end point of the measurement.
The water displacement produced by the immersion of the animal paw in the measuring tube is reflected in to the second tube, inducing the volume displacement.
This displacement value is recorded.
www.jlabexport.com/plethysmometer
The Prevention of Cruelty to Animals Act, 1960, authored by acclaimed dancer and animal lover, Rukmini Devi Arundale, is an Act of the Parliament of India enacted in 1960 to prevent the infliction of unnecessary pain or suffering on animals and to amend the laws relating to the prevention of cruelty to animals.
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
The prevention of cruelty to animals act 1960Shaik Rasheed
This presentation give the complete information regarding the The Prevention of Cruelty to Animals Act 1960 including the definitions, composition of IAEC, Breeding and stocking of animals, experiments, offences and penalties.
Regulations in India (ASU DTAB, ASU DCC), Regulation of
manufacture of ASU drugs - Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Introduction
Regulatory Requirements
Key function of regulatory agencies
Regulation in India
DRUG TECHNICAL ADVISORY BOARD
Drugs Consultative committee-DCC
Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Selection of an animal model is one of the most important steps in any of the experimental pharmacological study.
Animal model preferred for the study must be producing similar disease profile as in the human.
The term “herbal drugs” denotes plants or plant parts that have been converted into phytopharmaceuticals by means of simple processes involving harvesting, drying, and storage.
In this power points viewer will be able to know the meaning of Pharmacopoeia and its coposition. History behind the different pharmacopoeia and popular pharmacopoeia existing world wide in herbal medicines. List of different pharmacopoeias also has been included.
pellets can be defined as multi particulate system or multiunit system
They are spherical particulates manufactured by agglomeration of the powder granules containing drug substance and excipients.
Pellets can be prepared by a special technique called Pelletization.
This technique is referred to an agglomeration process that convert fine powder or granules of bulk drug or excipient in to small , free flowing , spherical or semi spherical pellets .
Multi particular drug delivery system especially suitable for achieving controlled delay released oral formulation with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Multi particulate drug delivery system are mainly oral dosage form consisting of a multiplicity of small discrete units each exhibiting some desire characteristics.
What is pyrogens?
Sources of pyrogens and its elimination methods
Tests for pyrogens-
1. In Vitro Test / LAL Test
2. In Vivo Test / Rabbit Test.
Objective
Principle
Requirements
Procedure
Observation table
Result and interpretation
Herbal Drug Technology (B.Pharm. 6th Semester)
Definition of herbs, herbal medicine, herbal medicinal product, herbal drug preparation
Source of herbs, Selection, identification and authentication of herbal materials,
Processing of herbal raw material
LINK FOR VIDEO LECTURES
https://youtu.be/-4nzP2vOGdg
DRUG TECHNICAL ADVISORY BOARD IS IN THE PHARMACY SYLLABUS AND THE QUESTIONS ARE ASKED IN THE PHARMACY EXAMS .
SUCH AS GPAT NIPER AND SEMSESTER EXAM/
The Digital Plethysmometer is a highly useful tool to evaluate the inflammatory response experimentally induced in small rodents and to screen potential anti-inflammatory or anti-oedema properties of pharmacological substance.
Digital Plethysmometer is a micro controlled volume meter, specially designed for accurate measurement of the rat / mouse paw swelling.
The control unit can be zeroed between successive readings by pressing the reset key, so as to avoid the error arising due to adherence of water to the paw of the animal.
For screening of inflammation or oedema in mouse or rat.
Foot switch allowing rapid hands-free experiments can be used to control the end point of the measurement.
The water displacement produced by the immersion of the animal paw in the measuring tube is reflected in to the second tube, inducing the volume displacement.
This displacement value is recorded.
www.jlabexport.com/plethysmometer
The Prevention of Cruelty to Animals Act, 1960, authored by acclaimed dancer and animal lover, Rukmini Devi Arundale, is an Act of the Parliament of India enacted in 1960 to prevent the infliction of unnecessary pain or suffering on animals and to amend the laws relating to the prevention of cruelty to animals.
A comprehensive interpretation of pellets based on their definitions, advantages, disadvantages, mechanism of pellet formation and growth, pelletization techniques, formulation requirements, and the equipment system for manufacture of pellets.
The prevention of cruelty to animals act 1960Shaik Rasheed
This presentation give the complete information regarding the The Prevention of Cruelty to Animals Act 1960 including the definitions, composition of IAEC, Breeding and stocking of animals, experiments, offences and penalties.
Regulations in India (ASU DTAB, ASU DCC), Regulation of
manufacture of ASU drugs - Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Introduction
Regulatory Requirements
Key function of regulatory agencies
Regulation in India
DRUG TECHNICAL ADVISORY BOARD
Drugs Consultative committee-DCC
Schedule Z of Drugs & Cosmetics Act for ASU drugs.
Selection of an animal model is one of the most important steps in any of the experimental pharmacological study.
Animal model preferred for the study must be producing similar disease profile as in the human.
The term “herbal drugs” denotes plants or plant parts that have been converted into phytopharmaceuticals by means of simple processes involving harvesting, drying, and storage.
In this power points viewer will be able to know the meaning of Pharmacopoeia and its coposition. History behind the different pharmacopoeia and popular pharmacopoeia existing world wide in herbal medicines. List of different pharmacopoeias also has been included.
Pharmaceutical Jurisprudence. Based on the PCI Syllabus. Ethics to be considered for handling the animals in experiments. Reference from Pharmaceutical Jurisprudence by B. M. Mithal.
Animal Testing: Rationale for conducting studies, CPCSEA Guidelines
The use of animals in research is currently an essential component of the drug discovery process.
Animals help us advance our scientific understanding, serve as models to study disease, help us develop and test potential new medicines and therapies.
Animal testing has benefited researchers in understanding how to treat and prevent various conditions such as high blood pressure, diabetes, tuberculosis, polio, muscular dystrophy, and Parkinson's disease.
Education:
Undergraduate teaching to demonstrate effects of various drugs although this has been phased out in most institutes.
Postgraduate teaching to demonstrate the effects of various drugs, to determine the nature of an unknown drug for bioassay, screening methods and to learn skills e.g. administering drugs.
Research:
A larger number and a greater variety of animals are used in pure research than in applied research. This usually involves studies on embryogenesis, developmental biology, behaviour and breeding in Fruit flies, nematodes, mice and rats.
INTRODUCTION
The motto of Prevention of Cruelty to Animals (PCA) Act 1960 as amended in 1982 is to prevent infliction of unnecessary pain or suffering on animals.
The Central Government has constituted a Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), which is duty bound to take all such measures as may be necessary to ensure that animals are not subjected to unnecessary pain or suffering before, during or after the performance of experiments on them.
The goal of these guidelines is to promote the human care of animal used in biomedical and behavioural research and testing.
To avoid/minimize pain and suffering inflicted on experimental animals
Inspection of animal house facilities
It provides guidelines for -
Proper care, housing, breeding, maintenance, handling and use of experimental animals.
Source of experimental animals
Acceptable experimental procedures for anaesthesia and euthanasia.
Registration of establishments conducting animal experimentation or breeding of animals for this purpose.
Selection and assignment of nominees for the Institutional Animal Ethics Committees (IAEC) of the registered establishments.
Approval of Animal House Facilities on the basis of reports of inspections conducted by CPCSEA.
Permission for conducting experiments involving use of animals.
Recommendation for import of animals for use in experiments.
Action against establishments in case of established violation of any legal norm/stipulation.
Conduct of Training Programmes for the Nominees of CPCSEA.
Conduct/Support of Conference/Workshop on Animal Ethics.
To assure quality maintenance and safety of animals used in laboratory studies while conducting biomedical and behavioural research and testing of products.
Quarantine
2. Personal hygiene
3. Environment
4. Physical facility
5. Animal husbandry
6. Animal disposal
7. Documentation
Question Bank Extracted from Previous Year University Question Papers for M.PHARMACY DEGREE
SEMESTER-I PHARMACEUTICS - DRUG DELIVERY SYSTEMS [MPH PAPER II (102T)]
QUESTION BANK FOR UNIT - 1, 2 & 4
Dr. A. SUMATHI - Transdermal Delivery of VaccinesSumathi Arumugam
M.Pharm - Drug Delivery System Syllabus includes Vaccine Delivery System. Transdermal Delivery of Vaccines is a part of vaccine delivery which describes the various barriers & approaches for delivery of vaccines via skin.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
1. CPCSEA GUIDELINES
BALAN NANDU 1
CPCSEA GUIDELINES
Committee for the Purpose of Control and Supervision of Experiments on Animals
1. Statutory body formed by the Act of the Indian Parliament under the Prevention of
Cruelty to Animals Act, 1960
2. Formed in 1964
3. Revived in 1998, under the committed chairpersonship of Meneka Gandhi
4. Headquarters at Chennai
5. Includes various guidelines and sub committees
6. CPCSEA – National level expert committee to scrutinize and approve the research
projects conducted using animals
7. Introduced a national “Good Laboratory Practice” document
8. Introduced the credo of 3R principles
2004 – CPCSEA officially accepts the concept of the 4th R “investigators have a
moral responsibility to take care of laboratory animals after use”
9. This committee is composed of
Members of the scientific community
Regulatory authorities
Animal activists
The committee has 10 experts and 3 official members
10. Ministry of Environment and Forests (Animal welfare) – CPCSEA
IAEC – Institutional animals ethical committee
IBSC/IBC - Institutional biosafety ethical committee
11. CPCSEA and IAEC
Role of CPCSEA is to monitor animal experiments through ethics committees
set up in institutions (IAEC)
CPCSEA Nominee – important link between CPCSEA and IAEC
IAEC scrutinize all project proposals for experimentation on animals
For small animals- give the final approval
For large animals- make its recommendation to SCLA (Sub-Committee
on Large Animals)
12. IAEC composition
A Biological Scientist
Two Scientists from different bio disciplines
A Veterinarian involved in care of Animals
Scientist In-Charge of Animal House Facility
The Chairman (preferably Head of the Institution / Department) and Member
Secretary need to be nominated from the above five members
Other members: Main Nominee, Link Nominee, Scientist from outside and
Socially Aware Nominee nominated by CPCSEA
The validity of IAEC is for 3 years
13. CPCSEA Goals
To promote the humane care of animals used in research
To provide specifications that will enhance animals well being and quality of
research
Objectives – Effective functioning of Institutional animal ethical committee
2. CPCSEA GUIDELINES
BALAN NANDU 2
14. Main Activities
Registration of establishments
i. for experiments on animals
ii. for Breeding of animals
Approval of Animal House Facilities
Permission of Committee for Conducting Experiments
15. CPCSEA guidelines – Veterinary care
Provided by a veterinarian
Daily observation of animals adopted
16. CPCSEA guidelines – Quarantine, Stabilization and Separation
Quarantine period for small lab animals – one week to one month
Quarantine period for large lab animals – up to 6 weeks
Physiologic, psychological, and nutritional stabilization required
Physical separation of animals by species to prevent anxiety and behavioral
changes
17. Animal procurement and transportation
Procurement of animals done from established commercial animal vendors
During transport, stress avoided by
Use of transport containers (cages or crates) of appropriate size
Permissible number of animals accommodated in each container
18. Experimental area
Experiments should be carried out in a separate area away from the place
where they are housed
Separate functional areas for
Surgical support
Treatment of animals
Post operative and intensive care
19. Physical facilities
Building materials – Durable, moisture- proof, fire resistant and pest resistant
Corridor(s) – Wide enough to facilitate the movement of personnel and
equipment
Animal room doors should fit properly; It should not be rust
Exterior windows – Windows are not recommended
Floors – Smooth, moisture proof, non-absorbent, skid proof floors
Drains – Proper drainage; Floors should be sloped
Storage areas – Designed for feed, bedding, cages, and materials not in use
20. Environment
Temperature Humidity control between 18-29o
C range of 30-70%
Ventilation designed with 12-15 air cycles per hour
Power and lighting System should be safe
Fluorescent lights are efficient
Emergency backup needed
Noise control – noise free environment
Concrete walls are more effective
3. CPCSEA GUIDELINES
BALAN NANDU 3
21. Animal husbandry – CAGING OR HOUSING SYSTEM
The housing system should provide
Adequate space,
Freedom of movement
Normal postural adjustments
Comfortable environment
Easy access to food and water
Adequate ventilation
22. Food and water
Food should be palatable, non-contaminated, and nutritionally adequate
Should have continuous access to fresh, potable uncontaminated drinking
water
Feed should contain essential bits, minerals, carbohydrates
Feed should not contain moisture, crude fibre, crude protein and crude fat,
insecticides, hormones, antibiotics, fumigants or potential toxicants, heavy
metals
23. Bedding
Should be absorbent
Should be free from toxic chemicals
Should be removed and replaced periodically with fresh materials
Ideal to change the bedding twice a week
24. Sanitation and cleanliness
Animal rooms, corridors, storage spaces, and other areas should be cleaned
with appropriate detergents and disinfectants
Wastes should be removed regularly and frequently (waste disposal –
incineration)
Cages should be sanitized before animals are placed in them
25. Proper maintenance of records
Should maintain the SOP’s (Standard Operating Procedure)
Proper selection of animal facility staff required
Anaesthesia should be complete and without any pain
Euthanasia – can be done when animal required to be sacrificed or termination
of an experiment or otherwise for ethical reasons