Connective tissue

1. DEVELOPMENT OF CONNECTIVE TISSUE
Mesenchyme Loose Connective Tissue
Mesenchymal
Cells
Fibroblasts
Fibers

2. Cell Lineage from Mesenchymal Cells

3. TYPES OF CONNECTIVE TISSUE
Loose Connective
Tissue
Dense Irregular
Connective Tissue
Dense Regular
Connective Tissue
(e.i. mesentery, omentum) (e.i. dermis of skin) (e.i. tendons, ligaments,
cornea)

4. DENSE IRREGULAR CONNECTIVE TISSUE
(DERMIS OF SKIN)

5. DENSE REGULAR CONNECTIVE TISSUE
Tendon (longitudinal Section) Tendon (tranverse Section)

6. ELASTIC CONNECTIVE TISSUE IN BLOOD VESSEL WALL
Internal
elastic
lamina

7. CONNECTIVE TISSUE FIBERS
Collagenous Fibers
(bundles)
Reticular Fibers
(networks)
Elastic Fibers
(anastomosing bundles)

8. RETICULAR CONNECTIVE TISSUE
reticular fibers
(argyrophilic)

9. COLLAGEN
FIBER
BUNDLE
Fiber
Fibril
Microfibril
Periodic Bands
Tropocollagen
alpha 1 peptide
alpha 2 peptide
TEM of Collagen Fibers SEM of Collagen Fibers

10. SCANNING EM OF COLLAGEN FIBER BUNDLES

11. procollagen
tropocollagen
ground
substance
(mucopolysaccharide)
RER
TEM of Fibroblast and Collagen Bundles
Collagen Types
I - skin, bone, tendon cornea (most common type)
II- cartilage, embryonic cornea
III- reticular fibers, loose c.t., blood vessel walls, dermis
IV- basal lamina of epithelium
(no fibers, mat of randomly-oriented molecules)
FIBROBLAST
collagen fiber
bundles

12. TEM OF FIBROBLAST WITH COLLAGEN BUNDLES

13. FIXED CONNECTIVE TISSUE CELL TYPES
Fibroblast
(fiber producing cell)
Fibrocyte
(mesenchymal- pluropotent)
Adipocytes
(fat storage)
Fixed Macrophage
(histiocyte)

14. Adipocytes
fibroblast
Macrophage (light micrograph)
TEM of Macrophage
Fixed Connective Tissue Cells

15. MONONUCLEAR PHAGOCYTIC SYSTEM
Mononuclear
wandering
cell
coalescence
Giant Cell
Macrophages Osteoclasts Kupffer Cells
Microglial
Cells
Sinusoidal
Endothelia
lymph nodes
bone marrow
connective tissue
lung
serous cavities
spleen
bone
resorption
liver
sinusoids
central
nervous
system
liver
spleen
marrow
Monocyte
(reticuloendothelial system)
( all characterized by phagocytic activity)

16. LYMPHOCYTES AND PLASMA CELLS
(Agents of the immune response)
differentiation stimulated by
immune activation
Lymphocytes Plasma Cells
(produce
immunoglobulins
-antibodies)

17. EOSINOPHILES MAST CELLS
actively phagocytic
destroy immune complexes
(antigen-antibody)
Secretion Products:
1. Slow-reaction substance of anaphalaxis
2. Heparin- anticoagulant
3. Histamine- stimulates inflammation
4. Serotonin- vasoconstrictor
5. Eosinophil Chemotactic Factor

18. Connective Tissue Cells
Macrophage
Plasma Cell
Lymphocyte

19. TRANSMISSION EM OF AN EOSINOPHILE

20. TRANSMISSION EM OF A MAST CELL