the presentation gives a detail information about the seronegative spondyloarthropathy. this ppt also provide recent evidences to frame the rehab protocol.
The Role Of Transition Metals & Reactive Oxygen Species (ROS) In Alzheimer's ...Pırıl Erel
This powerpoint discusses the role of transition metals and amyloid plaque formation in Alzheimer’s disease (AD) and how metal ion chelators may be employed as therapeutic agents for AD. It describes the disorder, how it progresses and what happens to the brain tissue.
Furthermore, within the presentation I describe a drug which chelates metals including a description about the chemical formulation of these drugs and how the drug can be preventative of AD.
the presentation gives a detail information about the seronegative spondyloarthropathy. this ppt also provide recent evidences to frame the rehab protocol.
The Role Of Transition Metals & Reactive Oxygen Species (ROS) In Alzheimer's ...Pırıl Erel
This powerpoint discusses the role of transition metals and amyloid plaque formation in Alzheimer’s disease (AD) and how metal ion chelators may be employed as therapeutic agents for AD. It describes the disorder, how it progresses and what happens to the brain tissue.
Furthermore, within the presentation I describe a drug which chelates metals including a description about the chemical formulation of these drugs and how the drug can be preventative of AD.
Metal Ion Neurotoxicity-role of pro-inflammatory mediatorspriyamalik43
a good pharmaceutical target for neurodegenerative disease treatment. It has been demonstrated that the neurological system is impacted by aluminium, arsenic, cadmium, lead, manganese, mercury, nitric oxide, cobalt, copper, calcium, lithium, iron, nickel, bismuth, selenium, and zinc. The degree of the immune response in the brain required to successfully manage infections without leading to neuropathology is still unknown—heavy-metal-produced neurotoxic activity, indicating the important participation of mitochondrial dysfunction triggered cell death.As a result, performs a key anti-inflammatory role by reducing microglial activation and supporting a well-regulated immune response, which is lacking during the pathophysiology of Neurotoxicity.
Neuroradiology in multiple sclerosis
MRI in diagnosis of MS
MRI in D.D. of MS
MRI in monitoring disease progression and response to DMT
New imaging techniques
Brain MRI biomarkers for improved follow up of people with Multiple Sclerosis...Wim Van Hecke
MRI is increasingly used for the diagnosis and follow-up of people with Multiple Sclerosis (MS). However, there is a need for objective MRI biomarkers that can be used in clinical practice. This is now possible. By sending MRI data to a icometrix, reliable and objective reports of brain atrophy and lesion load can be obtained.
Neurological SystemThe nervous system is a collection of nerves .docxmayank272369
Neurological System
The nervous system is a collection of nerves and specialized cells forming a spectacular network of connections which transmit signals between different parts of the body. It controls the activities of all body organs and tissues. Structurally, it is organized into two parts: the central nervous system, comprising the brain and spinal cord, and the peripheral nervous system, which connects the central nervous system to other parts of the body.
The aging process is associated with many biological, physiological, environmental, psychological, behavioral, and physical processes. These changes often result in several complex health conditions dubbed geriatric syndromes. Most cells have a short life span and are easily regenerated and replaced by new cells in the human body. On the other hand, nerve cells are generated in vivo, have a longer life span, and are usually not replaced when they die or are destroyed.
Several changes occur in the central nervous system. Firstly, nerve cells and supporting neuroglia are gradually lost with age. On the other hand, the remaining cells function less efficiently, and there is an increased concentration of harmful materials such as free radicals and iron in the remaining brain tissue (Knight & Nigam, 2017). Secondly, there is a decrease in brain mass leading to decreased function of affected areas such as the cerebral cortex, hippocampus, and motor cortex, manifesting as impairments in higher functions, memory loss, and gait. Thirdly, the ventricles increase in size and due to the loss of cells lining the ventricles. Fourthly, there is a decrease in cerebral blood flow and diminished integrity of the blood-brain barrier over time. There is also a decline in the production of neurotransmitters. Lastly, age-related changes to the vertebrae and intervertebral discs may increase pressure on the spinal cord and its branching nerve roots. This can slow down nerve impulses' conduction along motor neurons, contributing to reduced muscular strength (Manini et al., 2013).
There is a slowed nerve conduction in the peripheral nervous system attributed to decreased axonal length, loss of mitochondria, and degeneration of peripheral neurons' myelin sheath. This may result in decreased sensation, slower reflexes, and clumsiness. On top of that, damaged neurons are not repaired efficiently in older adults, and some are not repaired at all.
The decrease in brain function with aging may impair mental function seen in neurodegenerative conditions such as delirium and dementia. Delirium is defined as an acute confusional state characterized by an acute decline in attention-focus, perception, cognition, and consciousness. In contrast, dementia is an acquired global impairment of intellect, memory, and personality but without impaired consciousness.
The two conditions are similar in that they exhibit similarities in their presentation: impaired memory and judgment, confusion, disorientation, and varia.
A brief description of different methods (in use or proposed) of radiological assessment of X-linked ALD.
By Felice D'Arco Pediatric neuroradiology consultant Great Ormond Street Hospital London
Basic principles of Cell injury and AdaptationAkshayYadav176
Basic principles of Cell injury and Adaptation:
(As per new syllabus of PCI)
Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis & Alkalosis,Electrolyte imbalance.
Metal Ion Neurotoxicity-role of pro-inflammatory mediatorspriyamalik43
a good pharmaceutical target for neurodegenerative disease treatment. It has been demonstrated that the neurological system is impacted by aluminium, arsenic, cadmium, lead, manganese, mercury, nitric oxide, cobalt, copper, calcium, lithium, iron, nickel, bismuth, selenium, and zinc. The degree of the immune response in the brain required to successfully manage infections without leading to neuropathology is still unknown—heavy-metal-produced neurotoxic activity, indicating the important participation of mitochondrial dysfunction triggered cell death.As a result, performs a key anti-inflammatory role by reducing microglial activation and supporting a well-regulated immune response, which is lacking during the pathophysiology of Neurotoxicity.
Neuroradiology in multiple sclerosis
MRI in diagnosis of MS
MRI in D.D. of MS
MRI in monitoring disease progression and response to DMT
New imaging techniques
Brain MRI biomarkers for improved follow up of people with Multiple Sclerosis...Wim Van Hecke
MRI is increasingly used for the diagnosis and follow-up of people with Multiple Sclerosis (MS). However, there is a need for objective MRI biomarkers that can be used in clinical practice. This is now possible. By sending MRI data to a icometrix, reliable and objective reports of brain atrophy and lesion load can be obtained.
Neurological SystemThe nervous system is a collection of nerves .docxmayank272369
Neurological System
The nervous system is a collection of nerves and specialized cells forming a spectacular network of connections which transmit signals between different parts of the body. It controls the activities of all body organs and tissues. Structurally, it is organized into two parts: the central nervous system, comprising the brain and spinal cord, and the peripheral nervous system, which connects the central nervous system to other parts of the body.
The aging process is associated with many biological, physiological, environmental, psychological, behavioral, and physical processes. These changes often result in several complex health conditions dubbed geriatric syndromes. Most cells have a short life span and are easily regenerated and replaced by new cells in the human body. On the other hand, nerve cells are generated in vivo, have a longer life span, and are usually not replaced when they die or are destroyed.
Several changes occur in the central nervous system. Firstly, nerve cells and supporting neuroglia are gradually lost with age. On the other hand, the remaining cells function less efficiently, and there is an increased concentration of harmful materials such as free radicals and iron in the remaining brain tissue (Knight & Nigam, 2017). Secondly, there is a decrease in brain mass leading to decreased function of affected areas such as the cerebral cortex, hippocampus, and motor cortex, manifesting as impairments in higher functions, memory loss, and gait. Thirdly, the ventricles increase in size and due to the loss of cells lining the ventricles. Fourthly, there is a decrease in cerebral blood flow and diminished integrity of the blood-brain barrier over time. There is also a decline in the production of neurotransmitters. Lastly, age-related changes to the vertebrae and intervertebral discs may increase pressure on the spinal cord and its branching nerve roots. This can slow down nerve impulses' conduction along motor neurons, contributing to reduced muscular strength (Manini et al., 2013).
There is a slowed nerve conduction in the peripheral nervous system attributed to decreased axonal length, loss of mitochondria, and degeneration of peripheral neurons' myelin sheath. This may result in decreased sensation, slower reflexes, and clumsiness. On top of that, damaged neurons are not repaired efficiently in older adults, and some are not repaired at all.
The decrease in brain function with aging may impair mental function seen in neurodegenerative conditions such as delirium and dementia. Delirium is defined as an acute confusional state characterized by an acute decline in attention-focus, perception, cognition, and consciousness. In contrast, dementia is an acquired global impairment of intellect, memory, and personality but without impaired consciousness.
The two conditions are similar in that they exhibit similarities in their presentation: impaired memory and judgment, confusion, disorientation, and varia.
A brief description of different methods (in use or proposed) of radiological assessment of X-linked ALD.
By Felice D'Arco Pediatric neuroradiology consultant Great Ormond Street Hospital London
Basic principles of Cell injury and AdaptationAkshayYadav176
Basic principles of Cell injury and Adaptation:
(As per new syllabus of PCI)
Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis & Alkalosis,Electrolyte imbalance.
Similar to Nanoparticles for the Treatment of Alzheimer’s Disease_102718.pptx (20)
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
This report details the geological observations and interpretations made during a field investigation of the Kaptai Rangamati road-cut section, located in southeastern Bangladesh. The purpose of this report is to document the exposed rock units, their characteristics, and the geological structures present within the road cut.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Nutrition is the science that deals with the study of nutrients and their role in maintaining human health and well-being. It encompasses the various processes involved in the intake, absorption, and utilization of essential nutrients, such as carbohydrates, proteins, fats, vitamins, minerals, and water, by the human body.
Gliese 12 b, a temperate Earth-sized planet at 12 parsecs discovered with TES...Sérgio Sacani
We report on the discovery of Gliese 12 b, the nearest transiting temperate, Earth-sized planet found to date. Gliese 12 is a
bright (V = 12.6 mag, K = 7.8 mag) metal-poor M4V star only 12.162 ± 0.005 pc away from the Solar system with one of the
lowest stellar activity levels known for M-dwarfs. A planet candidate was detected by TESS based on only 3 transits in sectors
42, 43, and 57, with an ambiguity in the orbital period due to observational gaps. We performed follow-up transit observations
with CHEOPS and ground-based photometry with MINERVA-Australis, SPECULOOS, and Purple Mountain Observatory,
as well as further TESS observations in sector 70. We statistically validate Gliese 12 b as a planet with an orbital period of
12.76144 ± 0.00006 d and a radius of 1.0 ± 0.1 R⊕, resulting in an equilibrium temperature of ∼315 K. Gliese 12 b has excellent
future prospects for precise mass measurement, which may inform how planetary internal structure is affected by the stellar
compositional environment. Gliese 12 b also represents one of the best targets to study whether Earth-like planets orbiting cool
stars can retain their atmospheres, a crucial step to advance our understanding of habitability on Earth and across the galaxy.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
We present you a part of our Tampere University's team - FHAIVE!
Besides producing excellent science, they are in charge or coordinating this project as well Tampere University, Faculty of Medicine and Health Technology.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
2. INTRODUCTION
Alzheimer’s disease (AD) is an irreversible neurodegenerative
disorder that causes a progressive decline in cognitive function,
including memory loss, language disorders, and judgment and
comprehension impairments . (Masters et al., 2015)
The German neurologist and psychiatrist Alois Alzheimer
initially described the condition in 1907.
According to the World Alzheimer’s Disease Report 2021, there
are currently around 50 million patients with AD worldwide. This
number is expected to increase to 78 million by 2030. (Nandi et
al., 2022)
3. Hypothesis
There are three accepted hypotheses for the pathological cause of
Alzheimer’s disease
the amyloid-beta (Aβ) plaque hypothesis,
the Tau hyperphosphorylation hypothesis,
neuroinflammation (Busche and Hyman, 2020).
4. Continue…
The exact cause of AD has not yet been identified, the disease is still
incurable, and most of the above therapeutic drugs can only delay its
progression.
The blood-brain barrier (BBB) is a physical barrier that regulates how
drugs enter and exits the central nervous system (CNS).
It is another significant factor hindering the development of AD drugs
(Pardridge, 2019;).
As nanotechnology advances quickly, several nanomaterials can assist
through the BBB and successfully delivering them to brain, which is
important for developing new drugs and treating CNS diseases (Zeng
et al., 2021
5. Properties of Nanomedicine
The ideal AD nanomedicine typically possesses the following characteristics: particle
size 10–100 nm
BBB penetration
high drug loading
long action time
good drug stability
nontoxicity, biodegradability
simple fabrication process
noninvasive administration
low cost and stable storage (Jagaran and Singh, 2021).
6. Types of Nanomedicine
FIGURE Schematic
representation of the
structures of the most
commonly used
nanomedicine types for
Alzheimer’s disease: lipid
(liposomes and solid lipid),
organic (dendritic and
polymer), inorganic (metal
and non-metal inorganic) and
biomimetic (albumin).
Types of Nanomedicine
7. Metal nanoparticles
The size of metal NPs is usually between 1 and 100 nm, and they typically have a
function.nal organic molecules shell around a metal core.
pure metals, including gold, silver, copper, zinc, etc., or their oxides make up metal
oxide NPs (Jamkhande et al., 2019)
13. Reference
Masters, C. L., Bateman, R., Blennow, K., Rowe, C. C., Sperling, R. A., and
Cummings, J. L. (2015). Alzheimer's disease. Nat. Rev. Dis. Prim.
Nandi, A., Counts, N., Chen, S., Seligman, B.,Tortorice, D.,Vigo, D., et al. (2022).
Global and regional projections of the economic burden of Alzheimer's disease
and related dementias from 2019 to 2050: A value of statistical life approach.
Busche, M. A., and Hyman, B.T. (2020). Synergy between amyloid-β and tau in
Alzheimer's disease. Nat. Neurosci.
Pardridge, W. M. (2019). Blood-brain barrier and delivery of protein and gene
therapeutics to brain. Front. Aging Neurosci
Jagaran, K., and Singh, M. (2021). Nanomedicine for neurodegenerative disorders:
Focus on Alzheimer's and Parkinson's diseases. Int. J. Mol. Sci. 22