This document discusses different grading systems used to evaluate congenital hydronephrosis seen on ultrasound imaging. It outlines systems like the SFU grading scale and radiology grading scale but notes limitations in reliability between observers. The Onen grading system is presented as having clear terminology to classify dilation of the pelvicalyceal system and quality of renal parenchyma. The document concludes by proposing a risk stratification system for congenital hydronephrosis based on the Onen grading scale to determine need for early surgical intervention or likelihood of resolution.
10 Common Diagnostic Tests In Urology.pdfDr Ravi Gupta
Diagnostic checks are crucial in the subject of urology, imparting critical insights into patients' ailments and directing remedy plans. Urologists use lots of diagnostic methods to address an extensive variety of urinary and reproductive health troubles. These encompass both routine screenings and entire tests, which allow for the detection of a whole lot of situations including urinary tract infections, prostate cancer, kidney stones, and bladder anomalies. Familiarizing oneself with numerous diagnostic techniques and knowing their cost best empowers patients.
Importanza anestesista in oftalmologia 2013;role of the anesthesiologists in ...Claudio Melloni
Role of the anesthesiologist in ophthalmic surgery;cases,monitoring, challenges,screening of patients,complications,discussion from literature and more .dangers of Phenylephrine,accidents.
Heavy file,with documents not properly pictured,but useful for discussion.
10 Common Diagnostic Tests In Urology.pdfDr Ravi Gupta
Diagnostic checks are crucial in the subject of urology, imparting critical insights into patients' ailments and directing remedy plans. Urologists use lots of diagnostic methods to address an extensive variety of urinary and reproductive health troubles. These encompass both routine screenings and entire tests, which allow for the detection of a whole lot of situations including urinary tract infections, prostate cancer, kidney stones, and bladder anomalies. Familiarizing oneself with numerous diagnostic techniques and knowing their cost best empowers patients.
Importanza anestesista in oftalmologia 2013;role of the anesthesiologists in ...Claudio Melloni
Role of the anesthesiologist in ophthalmic surgery;cases,monitoring, challenges,screening of patients,complications,discussion from literature and more .dangers of Phenylephrine,accidents.
Heavy file,with documents not properly pictured,but useful for discussion.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
1. Different systems for grading and
risk stratification for congenital
hydronephrosis
BY/ Mohamed Elwany
2. CONGENITAL HYDRONEPHROPSIS
• Hydronephrosis refers to
dilatation of the renal
collecting system due to a
build-up of urine resulting
from drainage problems.
• Congenital hydronephrosis
occurs in up to 1%–5% of
all pregnancies
3. ULTRASOUND
• Urinary ultrasound (US) is the best
we have for the diagnosis and
follow-up of both prenatal and
post-natal hydronephrosis
• It is non-invasive, easily available,
fast, and low-cost; can be
performed directly in bedside
manner; and does not involve
radiation.
• It shows the size of kidneys,
thickness, and appearance of
parenchyma (echogenicity,
corticomedullary differentiation,
cortical cysts), severity of
hydronephrosis, ureteral dilation,
and bladder anatomy
4. Grading systems
• Correlation between prenatal and postnatal US findings
and the ultimate urological diagnosis has been
problematic, partly because of the lack of uniformity in
defining and grading urinary tract (UT) dilation
• there are several grading systems utilized.
Some are descriptive (e.g. mild-moderate-severe )
others are quantitative (e.g. numeric value of the anterior-
posterior renal pelvic diameter (APRPD)
or semi-quantitative (e.g. SFU ,European Society of
Pediatric Radiology (ESPR), Uroradiology Task Force , and
Onen grading system
6. Anterior–Posterior (AP) Diameter of Renal
Pelvis (APDRP)
• The measurement of the AP diameter of the renal pelvis
is not standardized between different
disciplines, Unfortunately, it is significantly operator
dependent.
• The renal pelvis and AP diameter is very dynamic; its
measurement changes significantly depending on
hydration, bladder filling, position (supine or prone), and
respiration
• More importantly, its measurement is very variable and
misleading due to different renal pelvic configurations (
extrarenal and intrarenal pelvis )
7. SFU Grading System
• In 1993, the Society for
Fetal Urology (SFU)
proposed a 5-point
numeric grading system
based on the postnatal
appearance of the renal
pelvis, calyces, and
renal parenchyma on
ultrasonography (USG)
images
• It is quantitative and
subjective.
8. DRAWBACKS
• It does not suggest who need surgery and who can safely
be followed non-operatively
• it is operator dependent and does not differentiate
grades 4 and 5 clearly. All grades of SFU are very variable
between operators and clinicians.
• Both SFU-1 and SFU-2a represent different degrees of
renal pelvic dilation. Therefore, it is confusing and is very
difficult to differentiate each other
• Both SFU-2b and SFU-3 represent different degrees of
calyceal dilation (major vs. minor). Therefore, it is
subjective, confusing, and very difficult to differentiate
each other .
9. Radiology Grading System
• The radiology grading system
has partially been modified from
SFU for post-natal use
• It has the same grades 1, 2, and
3 as the SFU grading system
• In addition, it includes AP
diameter for the grades 1, 2, and
3.
• This grading system divides
parenchymal loss into two
different grades, suggesting the
importance of the renal
parenchyma to determine the
severity of hydronephrosis
10. UTD Classification
• This classification
suggests the general
term “urinary tract
dilation” to indicate
ultrasound findings that
include all ureteral and
kidney dilations
• UTD has been created
retrospectively based
on reviewing,
combining, and
summarizing the
current literature .
11. DRAWBACKS
• Central and peripheral calices: It is very operator
dependent to differentiate the dilation of peripheral
(minor) calices from those of central (major) calices
due to a high discrepancy within and between raters
for interpretation of the two types of calyceal dilation
Therefore, it is subjective and confusing and is very
difficult to differentiate each other
• The wide definition of UTD-P3 fails to demonstrate
accurately the severity of hydronephrosis and thus
significant misleads from prompt treatment. It does
not suggest who need surgical treatment and who can
safely be followed non-operatively.
12. Onen Grading System
• This grading system has been developed for
both prenatal and post-natal HN
• The Onen grading system is terminologically
simple and clear. Therefore, all disciplines
including radiology, perinatology, pediatric
nephrology, and pediatric urology can easily use
not only for clinical practice but also for future
researches.
• This grading system is beneficial in determining
the possible risk of renal damage, surgical
necessity, and prognosis in infants with HN.
14. Onen Grading System
• It includes two categories of kidney findings. The first is
dilation of the pelvicalyceal system; the second which is
the most important category is the quality of the renal
parenchyma (thickness and appearance)
• This grading system divides thinning of the renal
parenchyma into two grades: medullary thinning and
cortical thinning. In addition, the appearance of the
parenchyma (echogenicity, cortical cysts,
corticomedullary differentiation) which is suggestive of
renal damage is also taken into account in this grading
system.
15. Risk stratification for congenital
hydronephrosis
• To stratify the risk of early surgical
intervention or the possibility of resolution,
attempts have been made to create a unified
grading system for urinary tract dilatation that
can be used during the prenatal or postnatal
period; however, no definitive consensus
guidelines have been established to date