X-rays were discovered in 1895 by the German physicist Wilhelm Conrad Röntgen, who earned the Nobel Prize in Physics in 1901. Although their potential applications in medical imaging diagnosis were clear from the beginning, the implementation of the first X-ray computed tomography system was made in 1972 by Godfrey Newbold Hounsfield (Nobel prize winner in 1979 for Physiology and Medicine), who constructed the prototype of the first medical CT scanner and is considered the father of computed tomography. CT was introduced into clinical practice into 1971 with a scan of a cystic frontal lobe tumor on a patient at Atkinson Morley Hospital in Wimbledon (United Kingdom). After this, CT was immediately welcomed by the medical community and has often been referred to as the most important invention in radiological diagnosis, since the discovery of X-rays [1]. The first applications of CT in an industrial context is traced back to the first 1980´s, in the field of non destructive testing, where small number of slices of the object were visually inspected. 3D quantitative industrial CT applications appeared in the later 1990s, with simple volume and distance analysis [2]. Today, thanks to relevant improvements in both hardware and software, CT has become a powerful and widely used tool among non destructive techniques, capable of inspecting external and internal structures (without destroying them) in many industrial applications. Development of more and more stable X-ray sources and better detectors led to design of more complex CT system, providing accurate geometrical information with micrometer accuracy. CT is widely used for geometrical characterization of test objects, material composition determination, density variation inspection etc. In a relative short time, CT is capable to produce a complete three-dimensional model and tolerances of the scanned machined parts can be verified. Because of the growing interest on precision in production engineering and an increasing demand for quality control and assurance, CT is leading the field of manufacturing and coordinate metrology. With respect to traditional techniques, CT systems have indisputable advantages: internal and external geometry can be acquired without destroying the part, with a density of information much higher than common tactile and optical coordinate measuring. A key parameter for reliability of the measurement process is the establishment of measuring uncertainty. Since there are many influence parameters in CT, uncertainty contributors in CT and standards dealing with quantification of CT have not been completely established yet. The assessment of the uncertainty budget becomes a challenge for all researchers