Clotting factors are chemicals that circulate in the blood and are responsible for forming blood clots. There are 13 known clotting factors that exist in both active and inactive forms and activate subsequent factors in a chain reaction called the coagulation cascade. This cascade can be triggered via the intrinsic pathway involving factors within blood or the extrinsic pathway activated by tissue outside the blood vessels. Together, the clotting factors maintain hemostasis by forming stable blood clots to stop bleeding after an injury.

1. Clotting factors and their
role
Presented by
Mr.Mayur Sharad Shitole
Tybsc zoology
TC college, Baramati

2. Clotting factor
• Groups of chemicals which are constantly circulate
in blood and responsible for formation of blood
clot.
• Usually present in inactive form.
• But becomes active when any injury takes place.
• Has a cylindrical effect with each factor activating
the next.
• Help in maintaining hemostasis.

3. Clotting factor
• Also stabilize blood clot for as long as necessary.
• There are 13 clotting factors.
• Some present in both intrinsic as well as in extrinsic
pathway
• While some are present only in one pathway that
is either in extrinsic or in intrinsic pathway.

4. List of clotting factors

5. Coagulation Cascade
• The series of reaction whereby one clotting
factor activates the next is called coagulation
cascade.
• It is also called as clotting cascade.
• These are may be triggered by the extrinsic
pathway or intrinsic pathway.

6. Extrinsic pathway
• Shorter pathway.
• Occurs rapidly.
• Name because of tissue factor(tissue
thromboplastin or factor lll), leak into blood from
cells outside(extrinsic to) blood vessel.

7. Intrinsic pathway
• More complex than extrinsic pathway.
• Occurs more slowly.
• Name because of its activaters are either in direct
contact with blood or contained within (intrinsic to)
blood.
• Outside tissue damage is not needed.

8. Pathways of clotting factor

10. Role of clotting
factors in
Mechanism of
blood clotting

12. THANKING YOU