Describes in detail the concept of compliance to therapeutic regimen, difference between adherence and compliance, factors which influence compliance, methods of assessing, reasons for non-compliance and strategies to improve compliance to the therapy.
Patient medication adherence, Medication adherence, Causes of medication non-adherence, Problems linked with Medication Non-adherence, Factors affecting medication adherence, Patient related factors, Social and Economic factor, Disease related factor, Health care provider related factors, Therapy related factors, pharmacist role in the medication adherence, role of pharmacist in the medication adherence, monitoring of patient medication adherence, Direct method, Indirect method
DEFINITION
BACKGROUND
METHODS OF ASSESSING COMPLIANCE.
Factors concerned with compliance.
BARRIERS TO COMPLIANCE
IMPROVEMENT OF COMPLIANCE .
NON-COMPLIANCE FACTORS.
Patient medication adherence, Medication adherence, Causes of medication non-adherence, Problems linked with Medication Non-adherence, Factors affecting medication adherence, Patient related factors, Social and Economic factor, Disease related factor, Health care provider related factors, Therapy related factors, pharmacist role in the medication adherence, role of pharmacist in the medication adherence, monitoring of patient medication adherence, Direct method, Indirect method
DEFINITION
BACKGROUND
METHODS OF ASSESSING COMPLIANCE.
Factors concerned with compliance.
BARRIERS TO COMPLIANCE
IMPROVEMENT OF COMPLIANCE .
NON-COMPLIANCE FACTORS.
Role of the pharmacist in medication safety.Subash321
Role of the pharmacist in medication safety. In this you know about the medication safety, medication error & how to prevent medication error. And the role of the pharmacists in medication safety.
Drug distribution is one of the basic service provided by the hospital pharmacy.
Drug distribution system falls in to 3 categories -
1)Ward – controlled system
2)Pharmacy controlled imprest based system
3)Pharmacy controlled patient issue system
Barriers of patient counseling in a community pharmacy and Strategies to over...MerrinJoseph1
Second Pharm -D , Patient Counseling Barriers and Strategies to overcome the barriers-pharmacist specific barriers,patient specific barrires and system based barriers and how to overcome the barriers for effective patient counseling in a community pharmacy.
Introduction to Clinical Pharmacy, Concept of clinical pharmacy, functions and
responsibilities of clinical pharmacist, Drug therapy monitoring - medication chart
review, clinical review
Role of the pharmacist in medication safety.Subash321
Role of the pharmacist in medication safety. In this you know about the medication safety, medication error & how to prevent medication error. And the role of the pharmacists in medication safety.
Drug distribution is one of the basic service provided by the hospital pharmacy.
Drug distribution system falls in to 3 categories -
1)Ward – controlled system
2)Pharmacy controlled imprest based system
3)Pharmacy controlled patient issue system
Barriers of patient counseling in a community pharmacy and Strategies to over...MerrinJoseph1
Second Pharm -D , Patient Counseling Barriers and Strategies to overcome the barriers-pharmacist specific barriers,patient specific barrires and system based barriers and how to overcome the barriers for effective patient counseling in a community pharmacy.
Introduction to Clinical Pharmacy, Concept of clinical pharmacy, functions and
responsibilities of clinical pharmacist, Drug therapy monitoring - medication chart
review, clinical review
With MiFID II just round the corner, the need to consider how to meet regulatory demands on the recording of telephone conversations and electronic communications is imminent. Here are our top 6 compliance-driven solutions to consider.
Journal of Advances in Pharmacoepidemiology and Drug SafetyOMICS International
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From Blind Side to Upside: Redesigning Our Response to Patients' Social NeedsJosinaV
Slides from masters defense presentation - Josina Vink.
Masters of Design in Strategic Foresight and Innovation, OCADU.
It has been suggested that as much as 50% of population health outcomes can be attributed to social determinants of health (SDOH), the conditions in which people live (O’Hara, 2005). Despite widespread recognition of the importance of SDOH, little has been done to support primary care in effectively responding to the social aspects of patients’ health (Bloch, Broden, & Rozmovits, 2011). Using a variety of design research methods, including interviews and observations, this study investigated why rural family physicians are unable to successfully address SDOH of low-income patients. This exploration revealed underlying cultural and systemic barriers that inhibit physicians from meeting the social needs of their patients. After understanding the gap around the social aspects of heath that exists in medicine, recently dubbed ‘health care’s blind side’ (Robert Wood Johnson Foundation, 2011), and the related design opportunity, the Community Health Accelerator (CHA) concept was developed. A CHA is a system innovation that catalyzes connections and conversations about the social side of health by leveraging the role of primary care and catalyzing community action. This concept has the potential to create significant population health improvements and long-term reductions in health care expenditures by reorganizing existing resources.
medication Adherence defined as the act of filling a new prescription for the first time.
The extent to which the patients take medications as prescribed by the prescriber.
Medication Adherence- Introduction
Definition
Causes of medication non-adherence
Pharmacist role in the medication adherence
Monitoring of patient medication adherence.
brief review on clinical pharmacy, drug information centre & patient safety program
The lecture was presented at Al-Mahmoudiya General Hospital as part of the training course for fresh appointed pharmacist at 16/5/2023 at 11 & 15/5/2023
Medication Adherence , setting up directions .. Ahmed Nouri
presenting the terminology of adherence, statistics of non-adherence and its impact, why do patients have difficulty with treatment, how to measure and how to improve the adherence, in addition to the role of the pharmacist in improving adherence.
For proper use of medication rational drug use (RDU) is raised. Requirements of rational drug use and it's different steps and roles of pharmacists are described here.
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This presentation describes the concept of Hyperconjugation in simple words, gives definition of hyperconjugation, explains why it is called as 'No bond Resonance' and gives the effects of hyperconjugation on the chemical properties of compounds: alkyl cations and their relative stability, alkyl radicals and their relative stability, alkenes and their relative stability, bond length, anomeric effect and Baker - Nathan effect.
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He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
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2. • Compliance is defined as adherence to
a prescribed therapeutic regimen
because of a perceived self-benefit and
a positive outcome.
• Noncompliance with therapy is one of
the biggest threats to successful
treatment and one of the most common
problems encountered in clinical
practice.
3. Adherence vs compliance
• Compliance suggests a process in which dutiful
patients passively follow the advice of their
physicians.
• Adherence suggests how most of the patients
actively participate in their care and decide
themselves when and whether to follow their
doctor’s advice.
4. Patient non-adherence to
medications can be attributed to
4 key reasons :
• Language barrier
• Low education level
• Poor doctor – patient interaction
• System related obstacles
5. Degree of non-compliance is
expressed as a percentage of
the deal compliance
• % compliance = (NDP-NME)*100/NDP
– NDP = number of doses prescribed
– NME = number of medication errors
– Any arbitrary value less than 90% indicates
suboptimal use of medication
6. Conditions necessary for
adherence : The patient must -
• Understand and believe the diagnosis
• Be interested in their health
• Correctly assess the impact of the
diagnosis
• Believe in the efficacy of the prescribed
treatment
7. • Know exactly how and how long to use
their medication
• Know onset of action
• Value outcome of the treatment more
than the cost
• Be ready to use the medication
8. Non-adherence is of most
concern when–
• Chronic illness
• Asymptomatic
• Progressive
• Complex regimen
• Side effects
• Patient knowledge and understanding is
limited
10. 1. Disease –
• Chronicity and severity of the disease and
presence or absence of complications
• For example, in a patient with a chronic disease
with few or no symptoms, adherence to a certain
regimen is very poor.
• Attitude towards the disease and acceptance of
the sick role
• Mental disorders and severely disabling diseases
interfere with the ability to comply
11. 2. Therapeutic regimen -
• Longer and more frequent administration –
less patient compliance
• Multiple drug therapy and complex
treatments that interfere with the daily life
• Disabling and intolerable adverse effects
• Cost of the therapy
12. 3. Interaction between patient and
healthcare professional -
• Caring, concerned and supportive
healthcare professional will increase the
patient compliance
• Good communication and counseling and
increase in patient’s understanding of the
therapy
13. 4. Socio-economic factors -
• Age extremes, lack of material resources,
interference with work schedule and lack
of family support
• Old people living alone, with limited
finances and requiring multiple drugs
15. • Many ways to evaluate – no “Gold
standard” method
• Information reported by patients – orally
or in writing – unreliable due to –
inability to remember or false reporting
to please or avoid disapproval of the
physician
16. Indirect methods -
• 1. Interrogation –
– Use of standard questionnaires to assess
compliance level and inconvenience of the
regimen, incidence of side effects and overall
level of comprehension
– Too subjective – not always reliable
17. • 2. Pill count (Residual tablet counting)
– At every visit, according to requirements, the patients
received a supply sufficient for the interval to the next
appointment plus extra tablets for a week. They were asked
to return the remaining tablets at the time of the next clinic
visit. Compliance was assessed as the percentage of pills
prescribed which were taken:
– Compliance (%)
=(Number of pills taken)/(Number of pills prescribed )x 100
=(# of tabs prescribed-#of tabs returned)/(# of tabs
prescribed)x100
18. • 3. MEMS devices –
– Medication Event Monitoring System
– Standard pill containers with microprocessors to record
timing and frequency of bottle openings
– Major limitation – opening of the bottle is recorded as
an event whether or not patient actually took the drug
– At every visit, patient had a MEMS reading, data
showed as a calendar plot with information regarding
no. of bottle openings each day and exact time when
the bottle was opened
– Compliance – assessed as ratio of no. of opening to no.
of doses prescribed
19. Direct methods -
• 1. Drug Analysis –
– Specific and sensitive methods of analysis to detect
potent agents in body fluids
– Bioavailability (F) and clearance (CL) – assumed to
remain constant, average steady state
concentration (CPSS) for a dose (D) administered at
dosage interval (T) is expressed as –
• CPSS = (FD)/(CL*T)
– Dose input rate is calculated as –
• FD/T = CPSS*CL
20. • 2. Urine markers –
– Urine marker – Riboflavin : added to dosage
regimen and its presence in the urine is noted
for more accurate assessment of compliance
22. 1. Poor standards of labeling -
• Labels – must be clear and
specific (no ambiguity)
• Instructions such as “take as
required” or “use as directed”
are not specific
• Poorly written labels with bad
handwriting – major source of
medication errors
23. 2. Inappropriate packing -
• Elderly patients – difficulty in opening container,
specially if size is too small or cap is difficult to
twist
• Blister pack – too rigid
Glass bottle – fragile
Thus difficulty in handling
24. 3. Complex Therapeutic Regimen
• Difficult to memorize and thus unintentional
noncompliance
25. 4. Nature of Medication -
• Unpleasant taste, colour or odour – noncompliance
within patients (particularly children)
• Extremely small tablets – difficult to handle or identify
Large tablets – difficult to swallow
• Occurance of irritating side effects – precipitate in
noncompliance
26. 5. Deliberate deviation -
• Some patients believe that once they begin to feel
better, treatment may be stopped
• Mental frailty – may forget to take occasional dose
• Forgetfulness – complete omission of doses or
duplication of doses : more common with socially
isolated geriatric patients
• Lack of proper physician – pharmacist – patient
rapport
29. 1. Simplification of therapeutic regimen
• Minimizing the complexity – minimum number of drugs with well
defined dosage schedule
• Use of sustained release and long acting oral preparations
• Single dose drugs (phenytoin, propranolol or antidepressants)
promote compliance by reducing adverse effects
• Fixed dose combinations for-
– Synergism (Cotrimoxazole)
– Improved efficacy ( oestrogen-progesterone contraceptives)
– Reduction in side effects ( levodopa and decarboxylase
inhibitor)
30. 2. Development of suitable
medication packing -
• Unit dose package – blister pack – encourage
degree of self monitoring – improved
compliance in intelligent and motivated
patients
• Medication box – all the different drugs to be
taken at a specific time are grouped together
in one compartment
31. 3. Supplementary labeling -
• Precautions or recommendations that enhance the
advice of the prescriber
• Based on potential clinical significance for the benefit
of patients
• Should be concise, uncomplicated and foolproof
– Description of drug action given in lay terminology
– Symbols and graphics to emphasize correct time of
administration
– ‘Daily calendar’ or ‘Tablet identification card’ bearing
details of administration schedule
32. 4. Patient counseling and education
• Pharmacist should inform, educate and counsel
patients about following items about each medication
in the dosage regimen –
– Name (trade name, generic name and common
name)
– Intended use and expected action
– Route, dosage form, dosage and administration
schedule
33. – Special directions
– Common side effects
– Techniques for self-monitoring
– Proper storage
– Drug-drug or drug-food interactions
– Prescription refill information
– Action to be taken in event of a missed dose
– Selection of OTC drugs and their use
34. • Methods for imparting patient education
depend on type and extent of advice needed :
– Verbal counseling
– Printed information
• Warning cards
• Medication instruction sheet
• Leaflets and booklets describing drugs
• Patient package inserts
– In-patient medication training programmes
– Compliance clinics
35. • Routine counseling is both undesirable and
impractical.
• Priority should be given to cases where –
– Prophylactic treatment is required in absence of
symptoms (tuberculosis)
– Drugs having low safety margin (warfarin)
– Premature withdrawal may have serious
consequences (corticosteroids)
– Long term therapy for chronic conditions (epilepsy)
36. Advisory and precautionary instructions
Instructions Examples of drugs
Do not take aspirin with this medication Warfarin
Take medication with plenty of water All sulpha drugs
Don’t drink milk while taking this
medication
Tetracycline
Take medication with milk Iodine preparations
Chill medication before taking Magnesium citrate solution
Avoid contact with skin and clothing Non staining iodine ointment
Avoid contact with teeth, use straw to
drink
Syrup of ferrous iodide
37. Avoid undue exposure to sunlight Sulphasalazine
Shake well before use Oral emulsions and suspensions
Take medication on empty stomach Penicillin, cloxacillin
Take medication half an hour before
meal
Ampicillin, erythromycin
Take with meals Reserpine, Tolbutamide
Take after meals Isoniazid, hydrocortisone
Medication may colour the urine Rifampicin
Complete the course of treatment
unless otherwise directed
Antibiotics
38. Instructions for specific dosage forms
Dosage form Instruction
Oral liquids •Shake well before use
•Use standard measuring device for
uniform dosage
•Store in cool and dark place
•Replace the cap tightly after use
•Expiry date
Capsules •To be swallowed whole without breaking
the shell
•To be swallowed with full glass of water
•Hot drinks could affect timed release
capsules
Tablets •Store in cool and dry place
•Sublingual tablets – place below the
tongue
•Chewable tablets – to be chewed, not to
be crushed or swallowed
39. Eye and ear drops •Method of inserting without touching
head
•Explain position of head while
administering eye drops
•Importance of keeping the dropper clean
and sterile
•Use may cause temporary discomfort
Injections •Watch for infiltration or oozing of
medication from injection site
•If there is localized swelling, pain or
inflammation at injection site, inform
physician
Inhalation aerosole •Check the mouth piece and actuator for
cleanliness
•Shake the inhaler vigorously before
action
•Hold you breath for few seconds, before
breathing out slowly
41. Overall rates of noncompliance
• 90% of elderly patients make some medication
errors
• 35% of elderly patients make potentially serious
medication errors
• 75% of chronic care patients prescribed drugs
either stop taking their medication at some point or
don’t take them as directed
• Only 75% of the patients who understand and
agree with the treatment are compliant
42. Health effects of
noncompliance –
– Increased morbidity
– Treatment failure
– Exacerbation of disease
– Increase in frequency of physician visit
– Increased hospitalization
– Death