This document provides information on the classification, nomenclature, and isomerism of organic compounds. It discusses how organic compounds are classified based on their structure as acyclic, cyclic, aromatic, etc. It also describes the IUPAC system for systematically naming organic compounds based on functional groups and molecular structure. Key points covered include naming conventions for alkanes, alkenes, alkyl halides, and other compound classes.
Basic concepts of organic chemistry such as structural formulas, different kinds of representation, types of isomerism, examples, alkanes, alkenes, alkynes etc.
Basic concepts of organic chemistry such as structural formulas, different kinds of representation, types of isomerism, examples, alkanes, alkenes, alkynes etc.
Classification, Nomenclature and structural isomerism of organic compound Ganesh Mote
Classification of organic compound, Nomenclature of alkane, alkene, alkyne, alcohol, alkyl halide, aldehyde, ketone, carboxylic acid and its derivatives, amines, ethers, polyfunctional groups and structural isomerism of organic compounds
Aldehydes and ketones are organic compounds which incorporate a carbonyl functional group, C=O. The carbon atom of this group has two remaining bonds that may be occupied by hydrogen or alkyl or aryl substituents. If at least one of these substituents is hydrogen, the compound is an aldehyde.
What is IUPAC naming?
In order to give compounds a name, certain rules must be followed. When naming organic compounds, the IUPAC (International Union of Pure and Applied Chemistry) nomenclature (naming scheme) is used. This is to give consistency to the names. It also enables every compound to have a unique name, which is not possible with the common names used (for example in industry). We will first look at some of the steps that need to be followed when naming a compound, and then try to apply these rules to some specific examples.
Classification, Nomenclature and structural isomerism of organic compound Ganesh Mote
Classification of organic compound, Nomenclature of alkane, alkene, alkyne, alcohol, alkyl halide, aldehyde, ketone, carboxylic acid and its derivatives, amines, ethers, polyfunctional groups and structural isomerism of organic compounds
Aldehydes and ketones are organic compounds which incorporate a carbonyl functional group, C=O. The carbon atom of this group has two remaining bonds that may be occupied by hydrogen or alkyl or aryl substituents. If at least one of these substituents is hydrogen, the compound is an aldehyde.
What is IUPAC naming?
In order to give compounds a name, certain rules must be followed. When naming organic compounds, the IUPAC (International Union of Pure and Applied Chemistry) nomenclature (naming scheme) is used. This is to give consistency to the names. It also enables every compound to have a unique name, which is not possible with the common names used (for example in industry). We will first look at some of the steps that need to be followed when naming a compound, and then try to apply these rules to some specific examples.
NOMENCLATURE OF ORGANIC COMPOUNDS BY -- KHUSH AHUJAKhushAhuja
In chemical nomenclature, the IUPAC nomenclature of organic chemistry is a method of naming organic chemical compounds as recommended[1] by the International Union of Pure and Applied Chemistry (IUPAC). It is published in the Nomenclature of Organic Chemistry (informally called the Blue Book). Ideally, every possible organic compound should have a name from which an unambiguous structural formula can be created. There is also an IUPAC nomenclature of inorganic chemistry.
To avoid long and tedious names in normal communication, the official IUPAC naming recommendations are not always followed in practice, except when it is necessary to give an unambiguous and absolute definition to a compound. IUPAC names can sometimes be simpler than older names, as with ethanol, instead of ethyl alcohol. For relatively simple molecules they can be more easily understood than non-systematic names, which must be learnt or looked over. However, the common or trivial name is often substantially shorter and clearer, and so preferred. These non-systematic names are often derived from an original source of the compound. In addition, very long names may be less clear than structural formula.
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Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
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Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
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Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
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The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
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CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
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The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
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Classification, Nomenclature of Organic Compounds.pptx
1. Classification , Nomenclature &
Isomerism of Organic Compounds
By
Dr. Nidhi Gupta
MM College of Pharmacy, MM (Deemed to be
University), Mullana, Ambala, India
2. ▶ Organic chemistry is the study of the structures,
reactions and properties of carbon-based
compounds.
▶ Note:
◦ Carbon monoxide, carbon dioxide, metal carbonates
and metal cyanides are not classified as organic
compounds.
Organic Chemistry
2
www.wewwchemistry.com
3. www.wewwchemistry.com
Why does carbon form so many
compounds?
Bonding Nature
of Carbon
Tetravalent
• Carbon forms four bonds.
• Due to strong C−C bond, it can
bond with itself to form stable
straight or branched chains, or
ring structures.
Strong C−C bonds
• C−C bonds are much stronger
than bonds between atoms of
other elements.
Bond Bond energy
/ kJ mol−1
C−C 350
Si−Si 222
N−N 160
O−O 150
Multiple bonds
• Carbon can also form
single, double or triple
bonds with itself.
• Carbon compounds can
have varying degree of
unsaturation.
6. Acyclic or open chain compounds
These compounds are also called as aliphatic compounds and
contain an open chain of carbon atoms. Further, they may be
either straight or branched chain, for example:
7. Cyclic or closed chain compounds
The compounds whose molecules contain ring structure are
called as cyclic compounds and divided into two categories;
homocyclic or carbocyclic and heterocyclic.
Carbocyclic compounds have ring made up of carbon atoms
only and further divided into two categories; alicyclic and
aromatic.
Heterocyclic compounds have one or two atoms other than
carbon in the ring.
8. Alicyclic carbocyclic compounds
Alicyclic (aliphatic cyclic) compounds contain carbon atoms
joined by single covalent bonds in the form of a ring. They
exhibit properties similar to aliphatic compounds.
Some examples are
9. Aromatic compounds
They are a special type of compounds which contain benzene and other
ring related compounds. They can also classified as monocyclic, bicyclic
and tricyclic according to they contain one, two or three aromatic rings.
Some of the examples are as follows:
10. Hetreocyclic compounds
They contain one or two atoms other than carbon atoms in the
ring. The hetreocyclic compounds containing five and six atoms
in the ring are called as five and six membered respectively.
12. Functional group
It can be defined as an atom or a group of atoms which determines the chemical
behaviour of an organic compound i.e. Chemical Properties of any organic
compound are the properties of functional group.
Each functional group gives the chemical reactions which are largely
independent of the rest of the molecule.
Examples in this case are hydroxyl group (−OH), aldehyde group (−CHO) and
carboxylic acid group (−COOH).
Classes of organic compounds
A series of compounds containing the same functional group
constitutes a class of organic compounds. For example: Following
compounds all belong to a class of compounds called as alcohols.
13. Compounds in the same class undergo similar type of chemical reactions.
Therefore, it is convenient to use a general formula for a class of
compounds. For alcohols, general formula is R-OH while for amines it is
R-NH2.
Homologous series: A group or a series of organic compounds in which
each member contains the same characteristic functional group and
differs from each other by a fixed unit form a homologous series and each
member is known as homologue of its immediate neighbor.
The members of the homologous series can be represented by a general
formula and the successive members differ from each other in the
molecular formula by a –CH2 unit. The general formula for alcohols is
CnH2n+1OH from which molecular formula of members can be calculated by
taking n = 1, 2 and 3.
All the members contain same functional group, show gradation in
physical properties & similarity in chemical properties.
14.
15.
16. Nomenclature of Organic Compounds
Common name: The name assigned to an organic compound by the
discoverer as he thought appropriate and has no structural relevance
is known as its common or trivial name.
17. Systematic name: The rationale name of an organic compound derived
from its structure is called as systematic name. Each name stands for one
compound and one structure. The systematic nomenclature has been
developed and used in modern practice is the IUPAC nomenclature. The
names assigned to the organic compounds according to this system are
known as IUPAC (International Union of Pure and Applied Chemistry)
names.
IUPAC system provides the set rules for assigning the names to all the
known organic compounds and to many more yet to be synthesized.
Open chain saturated hydrocarbons as a class are named alkanes
and with a cyclic carbon structure are named as cycloalkanes.
Straight chain hydrocarbons: The alkanes whose molecules are
made up of continuous or straight carbon chains are referred to
as Straight chain alkanes.
18. The names of such compounds are based on their chain structure, and
end with suffix ‘-ane’ and carry a prefix indicating the number of carbon
atoms present in the chain (except from CH4 to C4H10, where the prefixes
are derived from trivial names).
19. IUPAC Nomenclature of Alkyl groups
The hydrocarbon unit derived by removal of one hydrogen of an alkane, are
called alkyl groups. The IUPAC name of an alkyl group is obtained by replacing
the ending -ane of the parent alkane with -yl (alkane—ane+yl = alkyl). Thus
CH3CH3 is alkane and CH3CH2 is alkyl. The alkanes with a continuous carbon-
chain or normal carbon-chain are referred to as normal alkanes.
20. Branched alkanes: When an alkane has a shorter side-chain
attached to the continuous-chain, it is designated as a Branched
alkane. The continuous chain is called the root or parent, while
the side-chain is called the alkyl group. The carbon of the alkyl
group bonded directly to the parent chain is referred to as the
head carbon.
21.
22. ✓In the case of poly functional compounds, one of the functional group
is chosen as the principal functional group and other are treated as
substituents. The compound is then named on that basis.
The order of decreasing priority for some functional groups is:
-COOH, –SO3H, COOR, COCl, -CONH2, -CN,-HC=O, >C=O, -SH, -NH2,
>C=C<,-C≡C- , -C-C-, ROR, R-X (F, Cl, Br, I), -NO2, -R.
23. IUPAC Rules for Naming Hydrocarbons
1. Choose the correct ending: -ane, -ene, or –yne.
2. Determine the longest carbon chain. Where a double or triple
bond is present, choose the longest chain that includes this
bond. If there is a cyclic structure present, the longest chain
starts and stops within the cyclic structure.
3. Assign numbers to each C of the parent chain. For alkenes
and alkynes, the first carbon of the multiple bond should have
the smallest number. For alkanes the first branch (or first point
of difference) should have the lowest assigned number.
Carbons in a multiple bond must be numbered consecutively.
4. Attach a prefix that corresponds to the number of carbons in
the parent chain. Add cyclo- to the prefix if it is a cyclic
structure.
24. 5. Determine the correct name for each branch (“alkyl” groups
include methyl, ethyl, propyl, etc.)
5. Attach the name of the branches alphabetically, along with
their carbon position, to the front of the parent chain name.
Separate numbers from letters with hyphens (e.g. 4-ethyl-2-
methyldecane)
5. When two or more branches are identical, use prefixes (di-, tri-
tetra, etc.) (e.g. 2,4-dimethylhexane). Numbers are separated
with commas. Prefixes are ignored when determining
alphabetical order. (e.g. 2,3,5-trimethyl-4-propylheptane)
5. When identical groups are on the same carbon, repeat the
number of this carbon in the name. (e.g. 2,2-dimethylhexane)
IUPAC Rules for Naming Hydrocarbons
25. IUPAC Rules for Naming Branched Alkanes
1. Select the longest continuous carbon chain and name the branched alkane as
alkyl derivative of the parent alkane containing this chain.
2. The parent-chain carbon atoms are numbered 1, 2, 3, 4, etc., beginning with
the end nearest to the branch alkyl group. This gives the lowest number to the
carbon to which the alkyl group is attached.
3. When two or more different alkyl groups are present on the parent chain,
assign position-number to each and list them alphabetically with a hyphen in
between.
26. 4. When two or more identical groups are present, indicate this by the use of
the prefixes di, tri, tetra, etc., immediately before the alkyl group. Commas are
used to separate position numbers from each other.
5. While determining the alphabetic order, the prefixes di, tri, tetra etc., are ignored.
27. • In case the substituent on the parent chain is a complex one (containing more than 4
carbons), name it as a substituted alkyl group whose carbon chain is numbered from
the carbon attached o the main chain. The name of the complex substituent is given in
brackets to ovoid confusion with the numbers of the parent chain.
IUPAC Rules for Naming Cycloalkanes
• Cycloalkanes are saturated hydrocarbons with a ring of carbon atoms in the
molecule. Their IUPAC names are derived by prefixing cyclo to the names of
continuous-chain alkanes containing the same number of carbon atoms.
28. Substituted Cycloalkanes. These are named according to the following rule.
1. The name of the alkyl side-chain is prefixed to the name of the parent
cycloalkane.
2. When more than one side-chain is present, we number the ring beginning
with one side chain so that the next side-chain gets the lower number
possible.
3. If the alkane chain has a greater number of carbons than the ring, we
designate the ring as the substituent.
30. IUPAC Rules for Naming Alkenes
A hydrocarbon with one double bond C=C is called an alkene. The functional group
of alkenes is C=C, which is designated by the suffix ene.
1. Select the longest Continuous chain that contains both carbons of the double bond
and change the name of the corresponding alkane from ane to ene.
2. Number the parent chain beginning at the end nearer the double bond and indicate
the position of the double bond by using the number of the first carbon of the double
bond as prefix.
3. Name and indicate the position of any substituent group as for the alkanes.
4. When there are two or more double bonds in a continuous chain alkene, it is named
as Alkadiene, Alkatriene, and the locator numbers of the double bonds are prefixed.
5. In a branched alkene with several double bonds, the parent chain is the longest
continuous chain that contains the maximum number of double bonds. Thus,
31. Write the IUPAC names of following compounds
IUPAC Rules for Naming Alkyl Halides
• In the IUPAC system, alkyl halides (RX) are named as halogen substituted
alkanes (Haloalkanes). Thus the name of a halogen compound is given by
prefixing fluoro, chloro, bromo and iodo to that of the alkane. For naming
complex halogen compounds, the same IUPAC rules as for branched alkanes
are applied.
(1) The longest continuous carbon chain bearing the halogen atom is
numbered from the end nearer to the halogen and the parent alkane named.
(2) The name of the halogen substituent is prefixed to the alkane name.
32. (3) When there are two or more halogens, the appropriate prefix di-, tri-, tetra- are
used.
(4) If the halogens are different, they are named in alphabetic order.
(5) Halogen-substituted alkenes are named as Haloalkenes.