This document discusses various drug delivery systems including: 1. Delayed and extended release systems which maintain therapeutic drug levels over time through enteric coating or matrix devices. 2. Site-specific systems like ocuserts for eye delivery or intrauterine devices for contraception. 3. Targeted drug carriers including liposomes, nanoparticles, and ligand-mediated systems using antibodies for diseases. 4. Rate-controlled systems that use diffusion, dissolution, or electrical currents to regulate drug release over time including transdermal patches. 5. Implantable systems for localized delivery through stents, microchips, or engineered tissues.

1. Dr.RAGHU PRASADA M S
MBBS,MD
ASSISTANT PROFESSOR
DEPT. OF PHARMACOLOGY
SSIMS & RC.

2. 1. Delayed release system
2. Extended release system
3. Site specific and receptor targeting
4. Rate controlled delivery system-Diffusion
systems –reservoir device, matrix device,
transdermal patches
5. Controlled release by stimulation
6. Target drug delivery system-nano particles
7. Colloidal drug carriers
8. Block copolymers
9. Liposomes as drug carriers
10. Ligand mediated targeting

3. 11. Resealed erythrocytes
12. Bioadhesives
13. Tissue engineered delivery systems
14. Stent implantation in angioplasty
15. Encapsulated cells
16. Refillable biohybrid artificial pancreas
17. Microchip delivery system
18. Micro fabricated micro needles
19. Powdered drug delivery

4.  Repeated intermitent dosing of a drug
 Ex. Enteric coated tablets
 Extended release system- maintainance of
therapeutic blood and tissue levels of drug

5.  Ocuserts –thin epithelial microunits
 Ex. Pilocarpine occusert-gloucoma
 Progestaserts- intrauterine
contraceptive device
 Drug encapsulated in liposomes for
intravenous infusion –Amphotericin B

6.  Inactive drug
 Levodopadopamine
 Procaine pencillin-G

7.  Targeting a drug directly to a
certain biological location
Rate controlled delivery system
 Diffusion systems –reservoir device,
 matrix device, transdermal patches
 Dissolution system-encapsulated,
matrix

8. Active ingredient is delivered across the skin for systemic distribution.
Example: transdermal scopolamine, transdermal nitroglycerine,

10.  Colloidal drug carriers
1. micro and nano
particles
2. macro molecular
complex
3. Liposomes and
niosomes
Ligand mediated
targeting
1. Vascular
compartment
2. Cellular compartment
3. Intracellular
4. Monoclonal
antibodies
5. Resealed erythrocytes

15. 1. Vascular compartment
2. Cellular compartment
3. Intracellular
4. Monoclonal antibodies
5. Resealed erythrocytes

16.  Hypoosmotic lysis
 Bioadhesives –
 mucoadhesives


17.  Nerve growth factors
 Bone tissues

18.  ImmunisationPolyclonal antibodies
 Single antigenic diterminants
 Hybridoma technology
 Murine MAbs- muromonab anti CD3
 Chimeric MAbs- rituximab -NHL
 Humanised MAbs- palivizumab

19. Micro mechanical DDS.
Example: Intanza influenza vaccine

20. Uses a tiny electrical current to promote flow of
drug (usually charged) through the skin.
Example: Dexamethasone.

21.  It is a computerized syringe which delivers
insulin into the subcutaneous tissue every few
minutes in tiny amount 24 hours a day
through a canula placed in the subcutaneous
tissue.
 Intermitenty-GnRH
 Contineously-Insulin

22. Delivers insulin subcutaneously without using needle.
Achieved by pressurizing the liquid through a small
orifice which creates high speed jet that can
penetrate the skin and underlying tissue.

23.  It is a stent placed into narrowed, diseased
peripheral or coronary arteries that slowly
release a drug to block cell proliferation hence
preventing fibrosis and re- stenosis.