Immunization protects children from deadly diseases by making their immune systems resistant. It has saved millions of lives through vaccines for diseases like smallpox, polio, measles and more. Vaccines work by exposing the body to a weakened or dead form of the disease so the immune system can build defenses. While very safe, they come with minor side effects like soreness or fever in some cases. Maintaining high global vaccination rates keeps diseases from returning and spreading to new populations.