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Vaccines
Immunization
Delivery systems & Antigen d.s
1
4
Contents:
Active & Passive immunization2
Formulation of vaccines3
Challenges5
What is Immunization?
Active immunization Passive immunization
1st Active immunization:
Types of Vaccines:
Live attenuated vaccines:
Inactivated or 'killed' vaccines:
Recombinant sub-unit
envelope vaccines:
Recombinant vectored vaccines:
DNA vaccines :
Toxoid vaccines:
Conjugate vaccines :
New…!!!! Edible Vaccines:
Strategy
of
production
Mode
of
Action
2ndPassive immunization:
Formulation of Vaccines:
Additives Formulation Steps
•Suspending fluids
•Preservatives & stabilizers
•Adjuvants
• Component Processing
• Aseptic Formulation
• Filtration
• Filling Prefilled Syringes
Cartridges
Freeze-Dried Vials
• Packaging and 100% Inspection
Typical Aseptic Formulation
of Vaccine
To Filling
Sterile,
Adjuvant
Suspension
Final
Formulation
Aseptic
Connections
Redundant
Sterile
Filtration
CLASS 100
Typically
Autoclaved
Pre-Sterilized
Excipients
pH Adjust
Conjugate
Manifold,
gravity fed
bags or
cans
Filtration
CLASS 10,000
Buffer
Pooling
Tank
Delivery Systems:
Parenteral Route Non-Parenteral Route
Antigen delivery systems:
Thank You 

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Vaccines Immunization Delivery Systems Formulation Challenges