The document discusses the history and evolution of chemotherapy in Hodgkin's lymphoma. It describes how early single-agent chemotherapy showed limited efficacy and tolerability. The development of MOPP chemotherapy in the 1970s, using multiple non-overlapping agents, improved response rates and long-term survival to over 50%. Subsequent refinements introduced additional regimens like COPP, ABVD and others to reduce toxicity while maintaining efficacy.