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Refresher in statistics and analysis skill
A presentation meant for non-statisticians on statistics and general statistical analysis. Basically provides a short overview of the processes involved in data collection, storage, hypothesis generation and statistical analysis. It does not deal with bayesian statistics. Presented at PRODVANCE 2016 Ahmedabad
Interaction of Radiation with Matter
The document summarizes the interaction of radiation with matter. It discusses the different types of electromagnetic and particulate radiation. It then describes the four main processes radiation can undergo when interacting with matter - attenuation, absorption, scattering, and transmission. It provides details on the photoelectric effect, Compton effect, and pair production - the three primary physical interactions responsible for photon attenuation in matter.
Isocentre How to Create a Page
1. Log into Isocentre and select the desired sitegroup.
2. Click the create page button and enter a page name and title.
3. Type the page content and format text using buttons.
4. Preview the page before saving changes.
Isocentre Help Forum
This document provides instructions for using an online forum called Isocentre to get help or discuss topics. It outlines 10 steps to create a new discussion thread including providing a title, summary, and details of the issue or topic. It also explains how to reply to existing threads and ways to get updates whenever new replies are posted through email notifications or RSS feeds.
Dynamic Fractionation in Radiotherapy
This study uses a mathematical model to optimize radiation fractionation schedules by allowing fraction sizes to vary over time. The model accounts for how tumor geometry, sensitivity, and repopulation change as the tumor shrinks during treatment. Optimizing fraction sizes increased the tumor control probability from 0.7 to 0.966. The optimal schedule used larger fractions on Friday afternoons to compensate for weekend breaks, with afternoon fractions being larger than morning fractions. Fraction sizes also escalated over the course of treatment as the tumor became more sensitive and grew faster.
How to register at Isocentre
A step by step screen cast of how to register at the www.isocentre.org website
TomoTherapy
This document provides an overview of Tomotherapy, which is a technique that uses a linear accelerator mounted on a ring gantry combined with a helical CT scanner to deliver intensity-modulated radiation therapy. It discusses the Tomotherapy process, clinical applications, and concerns. The document outlines the evolution of Tomotherapy from early serial systems to the current helical Tomotherapy approach. It also describes the characteristics of the helical Tomotherapy system, including its binary MLC, cone beam delivery, megavoltage CT imaging capabilities, and dosimetric properties.
Concurrent Chemoradiation in Postoperative Setting In LAHNC. A comparision of...
A journal club presentation comparing and contrasting the EORTC and RTOG trials of concurrent chemoradiation in Head Neck Cancers in the post operative setting.
Recommended
Refresher in statistics and analysis skill
A presentation meant for non-statisticians on statistics and general statistical analysis. Basically provides a short overview of the processes involved in data collection, storage, hypothesis generation and statistical analysis. It does not deal with bayesian statistics. Presented at PRODVANCE 2016 Ahmedabad
Interaction of Radiation with Matter
The document summarizes the interaction of radiation with matter. It discusses the different types of electromagnetic and particulate radiation. It then describes the four main processes radiation can undergo when interacting with matter - attenuation, absorption, scattering, and transmission. It provides details on the photoelectric effect, Compton effect, and pair production - the three primary physical interactions responsible for photon attenuation in matter.
Isocentre How to Create a Page
1. Log into Isocentre and select the desired sitegroup.
2. Click the create page button and enter a page name and title.
3. Type the page content and format text using buttons.
4. Preview the page before saving changes.
Isocentre Help Forum
This document provides instructions for using an online forum called Isocentre to get help or discuss topics. It outlines 10 steps to create a new discussion thread including providing a title, summary, and details of the issue or topic. It also explains how to reply to existing threads and ways to get updates whenever new replies are posted through email notifications or RSS feeds.
Dynamic Fractionation in Radiotherapy
This study uses a mathematical model to optimize radiation fractionation schedules by allowing fraction sizes to vary over time. The model accounts for how tumor geometry, sensitivity, and repopulation change as the tumor shrinks during treatment. Optimizing fraction sizes increased the tumor control probability from 0.7 to 0.966. The optimal schedule used larger fractions on Friday afternoons to compensate for weekend breaks, with afternoon fractions being larger than morning fractions. Fraction sizes also escalated over the course of treatment as the tumor became more sensitive and grew faster.
How to register at Isocentre
A step by step screen cast of how to register at the www.isocentre.org website
TomoTherapy
This document provides an overview of Tomotherapy, which is a technique that uses a linear accelerator mounted on a ring gantry combined with a helical CT scanner to deliver intensity-modulated radiation therapy. It discusses the Tomotherapy process, clinical applications, and concerns. The document outlines the evolution of Tomotherapy from early serial systems to the current helical Tomotherapy approach. It also describes the characteristics of the helical Tomotherapy system, including its binary MLC, cone beam delivery, megavoltage CT imaging capabilities, and dosimetric properties.
Concurrent Chemoradiation in Postoperative Setting In LAHNC. A comparision of...
A journal club presentation comparing and contrasting the EORTC and RTOG trials of concurrent chemoradiation in Head Neck Cancers in the post operative setting.
To use or not to use the LQ model at “high” radiation doses
Examining the evidence behind the use of the linear quadratic formalism in extreme hypofractionation and high dose radiotherapy
Her2 positive metastatic breast ca
The document discusses the benefits of meditation for reducing stress and anxiety. Regular meditation practice can help calm the mind and body by lowering heart rate and blood pressure. Studies have shown that meditating for just 10-20 minutes per day can have significant positive impacts on both mental and physical health over time.
2012-michael joiner-hypofractionation
The document discusses how tumor radiobiology may impact the move toward hypofractionation in radiation therapy. It reviews evidence that the classic linear-quadratic model does not fully capture tumor response at high radiation doses, and that other factors like vascular damage and immune effects become more important. Response heterogeneity between different tumor cell populations may also help explain why survival curves appear more linear at higher doses per fraction.
Vakalis - RT for prostate cancer
This document discusses recent data on radiation therapy for prostate cancer. It begins by outlining the risk of prostate cancer development and mortality rates over time. It then examines risk stratification systems and treatment options for low, intermediate, and high risk disease. The document focuses on the benefits of dose escalation in radiation therapy, noting several studies that found higher radiation doses improved outcomes with acceptable toxicity when using newer techniques like IMRT. It also discusses hypofractionated regimens and image-guided radiation as ways to further improve the therapeutic ratio. In summary, this document reviews evidence that higher and more precisely delivered radiation doses can improve prostate cancer control while maintaining reasonable side effects.
Evolving Role of Radiation Therapy in Hodgkins Disease
1) Recent advances in radiation therapy for Hodgkin's lymphoma include reducing radiation volumes and doses based on clinical trials.
2) For early stage favorable Hodgkin's lymphoma, the standard is 2 cycles of ABVD chemotherapy followed by 20Gy involved field radiation.
3) For early stage unfavorable or poor prognosis disease, 4 cycles of ABVD plus 30Gy involved field radiation is standard based on clinical trials.
Induction chemotherapy followed by concurrent ct rt versus ct-rt in advanced ...
Induction chemotherapy followed by concurrent chemoradiation (CT-RT) has been studied as an alternative to primary CT-RT for locally advanced head and neck cancers. Meta-analyses have found induction chemotherapy provides no survival benefit compared to primary CT-RT and is associated with increased toxicity. Recent large randomized trials could not demonstrate an improvement with induction chemotherapy due to inadequate accrual and poor compliance with subsequent CT-RT. While induction chemotherapy may improve organ preservation or outcomes for select subgroups like HPV-negative cancers, current evidence indicates primary CT-RT remains the standard of care for most patients.
LDR and HDR Brachytherapy: A Primer for non radiation oncologists
A small presentation I made for a 30 minutes class comparing and contrasting LDR and HDR brachytherapy. Good for a person with non radiation oncology background to grasp the basics.
nonsquamous NSCLC
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like anxiety and depression.
radiotherapy of bone metastases,Vakalis
This document provides information on the evaluation and treatment of metastatic bone disease and spinal cord compression. It discusses:
1. Common sites of bone metastases from various primary cancers. Imaging tools to evaluate bone metastases like x-rays, bone scans, CT, PET, and MRI scans are described.
2. A multi-disciplinary treatment approach is recommended, including medical treatment, surgery, radiotherapy, radionuclides, chemotherapy, and hormonal therapy.
3. Details are provided on conventional and advanced radiation therapy techniques for treating bone metastases and spinal cord compression, including stereotactic radiosurgery. Overall pain relief rates, time to pain relief, and the benefits of combining surgery and radiation therapy are
Vakalis breast radiotherapy
The document discusses breast cancer treatment recommendations including:
- No radiation therapy is recommended for early stage DCIS or invasive breast cancer.
- A tumor bed boost is recommended for higher risk patients but large trials found no survival difference with or without a boost.
- Hypofractionated whole breast radiation has become a standard option based on trials showing no difference in survival outcomes compared to conventional fractionation.
- Several trials investigated omitting axillary lymph node dissection or radiation with favorable results for select patient groups with low tumor burden.
Hormone Resistant Prostate Cancer
Chemotherapy can be used to treat hormone-resistant prostate cancer (HRPC) to help palliate symptoms and provide a survival benefit. Docetaxel plus prednisone was established as the standard first-line treatment based on results from the TAX 327 trial showing a median overall survival of around 18 months. Several prognostic factors can help predict survival outcomes on chemotherapy. For patients who progress after first-line docetaxel treatment, metronomic cyclophosphamide with prednisone shows promise as a well-tolerated second-line option based on early clinical trials. Ongoing research continues to evaluate new agents for first- and second-line HRPC.
radiotherapy-pancreatic cancer
This document discusses pancreatic cancer and its treatment. It begins by stating that pancreatic cancer is most commonly diagnosed as locally advanced or metastatic. It then discusses the role of surgery, chemotherapy, and radiation therapy in the treatment of pancreatic cancer. It notes that the majority of surgically treated patients will have a recurrence, with a median survival of 15-20 months. The value of adjuvant and neoadjuvant therapy is debated. The document summarizes several clinical trials investigating chemotherapy and chemoradiation as adjuvant treatment after surgery. It also discusses neoadjuvant therapy and its potential advantages over adjuvant therapy. Emerging strategies discussed include induction chemotherapy followed by localized chemoradiation or second line therapy. The document concludes by describing modern radiation
Second line therapy for nsclc
This document summarizes a presentation on new perspectives on second-line therapy for non-small cell lung cancer (NSCLC). The presentation discusses current standards of care for second-line NSCLC, the unique needs of patients without targetable mutations, and emerging research findings. One study presented was the LUME-Lung 1 trial which found that the addition of the angiogenesis inhibitor nintedanib to docetaxel improved progression-free survival compared to placebo plus docetaxel in second-line NSCLC, with a significant overall survival benefit seen in the adenocarcinoma subgroup. Outstanding issues regarding biomarkers and the role of nintedanib in squamous cell carcinoma were discussed.
Spinal cord compression bhf aos study day mar 2014 final
This document provides an overview of malignant spinal cord compression (MSCC). It begins with a clinical case of a 56-year-old man initially diagnosed with back pain who is later found to have prostate cancer with MSCC. The talk then covers the anatomy of the spinal cord, definition and incidence of MSCC, typical symptoms, investigations including MRI, and treatment options like surgery, radiotherapy, and steroids. Outcomes are discussed, with the median survival being 6 months. The document concludes by outlining the key priorities for implementing NICE guidance on MSCC, including early detection and treatment of suspected cases as emergencies.
20.pet scan in oncology
PET imaging is useful for cancer diagnosis and management. It provides functional information about glucose metabolism in tumors that can help establish prognosis, guide treatment decisions, and assess response. PET using 18F-FDG has high sensitivity and specificity for detecting cancer. It has applications in staging, restaging, and monitoring treatment response for many cancer types including lung cancer, lymphoma, and head and neck cancers. PET can identify tumor involvement that may be missed by anatomical imaging alone.
Interactions of radiation_with_matter
This document discusses the interactions of various types of radiation with matter. It describes five main interactions that x-rays and gamma rays can undergo: photoelectric effect, Compton scattering, coherent scattering, pair production, and photodisintegration. It explains that the photoelectric effect and Compton scattering are most important for diagnostic and therapeutic radiology respectively. It also discusses the interactions of particulate radiation such as electrons, protons, neutrons, alpha particles, and heavy ions with matter and how they deposit energy.
mediastinal tumors investigations
This document discusses the diagnostic workup for mediastinal tumors. It begins by describing the different types of tumors that can occur in the anterior, middle, and posterior mediastinum. Signs and symptoms are non-specific but may include cough, chest pain, and weight loss. Chest x-ray is often the initial test, while CT scan provides more detail on location and tissue characteristics. MRI and nuclear imaging can further characterize masses. Tissue sampling methods include needle biopsy, mediastinoscopy, and thoracoscopy. Surgical procedures like mediastinotomy or thoracotomy may be needed in some cases. Laboratory tests help identify certain tumor types. A multidisciplinary approach is typically needed for diagnosis and treatment planning of
Firefox Speed Up
This document provides 12 tips to double the speed of the Firefox browser. The tips involve modifying configuration settings related to networking, content parsing, and page rendering to improve pipelining, reduce reflows, and display pages faster. Firefox supports Windows, Linux, and Mac operating systems as well as unofficial support for other systems. It includes features like tabbed browsing, pop-up blocking, integrated search, and privacy controls.
Reolysin
Oncolytics Biotech Inc. is a pharmaceutical company focused on developing an oncolytic virus, REOLYSIN, for the treatment of cancers. REOLYSIN contains a reovirus that selectively replicates in Ras activated tumor cells. Interim results from ongoing clinical trials show promising signs of efficacy including durable responses. Oncolytics' clinical program includes 10 active trials of REOLYSIN as a monotherapy and in combination with chemotherapy. The company has a strong intellectual property portfolio and is working to produce REOLYSIN at commercial scale.
Adjuvant radiation based on genomic risk factors emerging scenarios
Presentation on tailoring adjuvant radiotherapy for breast cancers based on Genomic risk prediction methods - a review. Presented in MVR CANCON 2018
Sample size calculation
1. Sample size calculation is an important part of ethical scientific research to avoid underpowered studies.
2. There are different approaches to sample size calculation depending on the study design and endpoints, such as comparing proportions, estimating confidence intervals, or analyzing time to event outcomes.
3. Key steps include defining the research hypothesis, primary and secondary endpoints, how and in whom the endpoints will be measured, and determining what difference is clinically meaningful to detect between study groups.
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To use or not to use the LQ model at “high” radiation doses
Examining the evidence behind the use of the linear quadratic formalism in extreme hypofractionation and high dose radiotherapy
Her2 positive metastatic breast ca
The document discusses the benefits of meditation for reducing stress and anxiety. Regular meditation practice can help calm the mind and body by lowering heart rate and blood pressure. Studies have shown that meditating for just 10-20 minutes per day can have significant positive impacts on both mental and physical health over time.
2012-michael joiner-hypofractionation
The document discusses how tumor radiobiology may impact the move toward hypofractionation in radiation therapy. It reviews evidence that the classic linear-quadratic model does not fully capture tumor response at high radiation doses, and that other factors like vascular damage and immune effects become more important. Response heterogeneity between different tumor cell populations may also help explain why survival curves appear more linear at higher doses per fraction.
Vakalis - RT for prostate cancer
This document discusses recent data on radiation therapy for prostate cancer. It begins by outlining the risk of prostate cancer development and mortality rates over time. It then examines risk stratification systems and treatment options for low, intermediate, and high risk disease. The document focuses on the benefits of dose escalation in radiation therapy, noting several studies that found higher radiation doses improved outcomes with acceptable toxicity when using newer techniques like IMRT. It also discusses hypofractionated regimens and image-guided radiation as ways to further improve the therapeutic ratio. In summary, this document reviews evidence that higher and more precisely delivered radiation doses can improve prostate cancer control while maintaining reasonable side effects.
Evolving Role of Radiation Therapy in Hodgkins Disease
1) Recent advances in radiation therapy for Hodgkin's lymphoma include reducing radiation volumes and doses based on clinical trials.
2) For early stage favorable Hodgkin's lymphoma, the standard is 2 cycles of ABVD chemotherapy followed by 20Gy involved field radiation.
3) For early stage unfavorable or poor prognosis disease, 4 cycles of ABVD plus 30Gy involved field radiation is standard based on clinical trials.
Induction chemotherapy followed by concurrent ct rt versus ct-rt in advanced ...
Induction chemotherapy followed by concurrent chemoradiation (CT-RT) has been studied as an alternative to primary CT-RT for locally advanced head and neck cancers. Meta-analyses have found induction chemotherapy provides no survival benefit compared to primary CT-RT and is associated with increased toxicity. Recent large randomized trials could not demonstrate an improvement with induction chemotherapy due to inadequate accrual and poor compliance with subsequent CT-RT. While induction chemotherapy may improve organ preservation or outcomes for select subgroups like HPV-negative cancers, current evidence indicates primary CT-RT remains the standard of care for most patients.
LDR and HDR Brachytherapy: A Primer for non radiation oncologists
A small presentation I made for a 30 minutes class comparing and contrasting LDR and HDR brachytherapy. Good for a person with non radiation oncology background to grasp the basics.
nonsquamous NSCLC
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms for those who already suffer from conditions like anxiety and depression.
radiotherapy of bone metastases,Vakalis
This document provides information on the evaluation and treatment of metastatic bone disease and spinal cord compression. It discusses:
1. Common sites of bone metastases from various primary cancers. Imaging tools to evaluate bone metastases like x-rays, bone scans, CT, PET, and MRI scans are described.
2. A multi-disciplinary treatment approach is recommended, including medical treatment, surgery, radiotherapy, radionuclides, chemotherapy, and hormonal therapy.
3. Details are provided on conventional and advanced radiation therapy techniques for treating bone metastases and spinal cord compression, including stereotactic radiosurgery. Overall pain relief rates, time to pain relief, and the benefits of combining surgery and radiation therapy are
Vakalis breast radiotherapy
The document discusses breast cancer treatment recommendations including:
- No radiation therapy is recommended for early stage DCIS or invasive breast cancer.
- A tumor bed boost is recommended for higher risk patients but large trials found no survival difference with or without a boost.
- Hypofractionated whole breast radiation has become a standard option based on trials showing no difference in survival outcomes compared to conventional fractionation.
- Several trials investigated omitting axillary lymph node dissection or radiation with favorable results for select patient groups with low tumor burden.
Hormone Resistant Prostate Cancer
Chemotherapy can be used to treat hormone-resistant prostate cancer (HRPC) to help palliate symptoms and provide a survival benefit. Docetaxel plus prednisone was established as the standard first-line treatment based on results from the TAX 327 trial showing a median overall survival of around 18 months. Several prognostic factors can help predict survival outcomes on chemotherapy. For patients who progress after first-line docetaxel treatment, metronomic cyclophosphamide with prednisone shows promise as a well-tolerated second-line option based on early clinical trials. Ongoing research continues to evaluate new agents for first- and second-line HRPC.
radiotherapy-pancreatic cancer
This document discusses pancreatic cancer and its treatment. It begins by stating that pancreatic cancer is most commonly diagnosed as locally advanced or metastatic. It then discusses the role of surgery, chemotherapy, and radiation therapy in the treatment of pancreatic cancer. It notes that the majority of surgically treated patients will have a recurrence, with a median survival of 15-20 months. The value of adjuvant and neoadjuvant therapy is debated. The document summarizes several clinical trials investigating chemotherapy and chemoradiation as adjuvant treatment after surgery. It also discusses neoadjuvant therapy and its potential advantages over adjuvant therapy. Emerging strategies discussed include induction chemotherapy followed by localized chemoradiation or second line therapy. The document concludes by describing modern radiation
Second line therapy for nsclc
This document summarizes a presentation on new perspectives on second-line therapy for non-small cell lung cancer (NSCLC). The presentation discusses current standards of care for second-line NSCLC, the unique needs of patients without targetable mutations, and emerging research findings. One study presented was the LUME-Lung 1 trial which found that the addition of the angiogenesis inhibitor nintedanib to docetaxel improved progression-free survival compared to placebo plus docetaxel in second-line NSCLC, with a significant overall survival benefit seen in the adenocarcinoma subgroup. Outstanding issues regarding biomarkers and the role of nintedanib in squamous cell carcinoma were discussed.
Spinal cord compression bhf aos study day mar 2014 final
This document provides an overview of malignant spinal cord compression (MSCC). It begins with a clinical case of a 56-year-old man initially diagnosed with back pain who is later found to have prostate cancer with MSCC. The talk then covers the anatomy of the spinal cord, definition and incidence of MSCC, typical symptoms, investigations including MRI, and treatment options like surgery, radiotherapy, and steroids. Outcomes are discussed, with the median survival being 6 months. The document concludes by outlining the key priorities for implementing NICE guidance on MSCC, including early detection and treatment of suspected cases as emergencies.
20.pet scan in oncology
PET imaging is useful for cancer diagnosis and management. It provides functional information about glucose metabolism in tumors that can help establish prognosis, guide treatment decisions, and assess response. PET using 18F-FDG has high sensitivity and specificity for detecting cancer. It has applications in staging, restaging, and monitoring treatment response for many cancer types including lung cancer, lymphoma, and head and neck cancers. PET can identify tumor involvement that may be missed by anatomical imaging alone.
Interactions of radiation_with_matter
This document discusses the interactions of various types of radiation with matter. It describes five main interactions that x-rays and gamma rays can undergo: photoelectric effect, Compton scattering, coherent scattering, pair production, and photodisintegration. It explains that the photoelectric effect and Compton scattering are most important for diagnostic and therapeutic radiology respectively. It also discusses the interactions of particulate radiation such as electrons, protons, neutrons, alpha particles, and heavy ions with matter and how they deposit energy.
mediastinal tumors investigations
This document discusses the diagnostic workup for mediastinal tumors. It begins by describing the different types of tumors that can occur in the anterior, middle, and posterior mediastinum. Signs and symptoms are non-specific but may include cough, chest pain, and weight loss. Chest x-ray is often the initial test, while CT scan provides more detail on location and tissue characteristics. MRI and nuclear imaging can further characterize masses. Tissue sampling methods include needle biopsy, mediastinoscopy, and thoracoscopy. Surgical procedures like mediastinotomy or thoracotomy may be needed in some cases. Laboratory tests help identify certain tumor types. A multidisciplinary approach is typically needed for diagnosis and treatment planning of
Firefox Speed Up
This document provides 12 tips to double the speed of the Firefox browser. The tips involve modifying configuration settings related to networking, content parsing, and page rendering to improve pipelining, reduce reflows, and display pages faster. Firefox supports Windows, Linux, and Mac operating systems as well as unofficial support for other systems. It includes features like tabbed browsing, pop-up blocking, integrated search, and privacy controls.
Reolysin
Oncolytics Biotech Inc. is a pharmaceutical company focused on developing an oncolytic virus, REOLYSIN, for the treatment of cancers. REOLYSIN contains a reovirus that selectively replicates in Ras activated tumor cells. Interim results from ongoing clinical trials show promising signs of efficacy including durable responses. Oncolytics' clinical program includes 10 active trials of REOLYSIN as a monotherapy and in combination with chemotherapy. The company has a strong intellectual property portfolio and is working to produce REOLYSIN at commercial scale.
Viewers also liked (20)
To use or not to use the LQ model at “high” radiation doses
To use or not to use the LQ model at “high” radiation doses
Evolving Role of Radiation Therapy in Hodgkins Disease
Evolving Role of Radiation Therapy in Hodgkins Disease
Induction chemotherapy followed by concurrent ct rt versus ct-rt in advanced ...
Induction chemotherapy followed by concurrent ct rt versus ct-rt in advanced ...
LDR and HDR Brachytherapy: A Primer for non radiation oncologists
LDR and HDR Brachytherapy: A Primer for non radiation oncologists
Spinal cord compression bhf aos study day mar 2014 final
Spinal cord compression bhf aos study day mar 2014 final
More from Santam Chakraborty
Adjuvant radiation based on genomic risk factors emerging scenarios
Presentation on tailoring adjuvant radiotherapy for breast cancers based on Genomic risk prediction methods - a review. Presented in MVR CANCON 2018
Sample size calculation
1. Sample size calculation is an important part of ethical scientific research to avoid underpowered studies.
2. There are different approaches to sample size calculation depending on the study design and endpoints, such as comparing proportions, estimating confidence intervals, or analyzing time to event outcomes.
3. Key steps include defining the research hypothesis, primary and secondary endpoints, how and in whom the endpoints will be measured, and determining what difference is clinically meaningful to detect between study groups.
IGRT in lung cancer
A short overview of Image Guided Radiotherapy process in Lung Cancer presented at TMC Kolkata circa 2016. Basic principles and concepts as well as examples are outlined.
Introduction to meta analysis
An introduction on how to go about a meta-analysis. Primarily designed for people with non statistical background. Heavily borrows from Cochrane Handbook of Systematic Reviews of Interventions.
Isocentre Help Forum
This document provides instructions for using an online forum called Isocentre to get help or discuss topics. It outlines 10 steps: 1) log in, 2) go to the Forum section, 3) choose an appropriate category, 4) create a new thread by clicking a button, 5) add a title, 6) short summary, 7) details using a discussion format, 8) post the thread, 9) reply to existing threads, and 10) post replies. It also describes two ways to get updates: email notifications or RSS feeds.
Isocentre Help Edit Page
This document provides instructions for editing pages within the sitegroups section of the Isocentre website. It outlines 10 steps for editing a page, including logging in, selecting the sitegroup and page to edit, making changes to content and title, previewing changes, saving updates along with a summary of edits, and modifying page tags.
Helical Tomotherapy
The document discusses helical tomotherapy, a form of radiation therapy that uses a rotating x-ray beam. It summarizes a study of 150 patients treated with tomotherapy between 2006-2007 for reasons such as complex tumor geometry or need for image guidance. Setup corrections were often needed based on pretreatment MV CT scans. Treatment times were typically under 25 minutes with minimal increases over time. Tomotherapy allows conformal dose distributions and image-guided radiation for difficult cases near critical organs.
New Techniques in Radiotherapy
A summary of recent innovations in radiation oncology focussing on the priniciples of different techniques and their application. An overview of clinical results has also been given
IMRT and 3D CRT in cervical Cancers
IMRT and 3 DCRT in cervical Cancers - Principles, Uses, Methods and Planning. A short summary of results of contemporary series are also provided.
Beam Directed Radiotherapy - methods and principles
Beam directed radiotherapy aims to deliver a homogenous tumor dose while minimizing radiation to normal tissues. It involves careful patient positioning, immobilization, tumor localization, field selection, dose calculations, and verification. Key steps include using positioning aids and molds to reproducibly position the patient, imaging such as CT to delineate the tumor volume, contouring to define external body outlines, and dose calculations and verification to ensure accurate delivery.
Beam Modification in Radiotherapy
Beam modification devices are used in radiotherapy to modify the spatial distribution of radiation within the patient. The main types of beam modification are shielding to eliminate dose to some areas, compensation to allow for irregular surfaces and tissues, wedge filtration to modify isodose curves, and flattening filters to modify the natural beam profile. Beam modification devices can alter the dose distribution due to effects of primary radiation attenuation and scattering. Common beam modification devices include shielding blocks, compensators, wedges, and multileaf collimators.
Radiation Protection
The document discusses the history and development of artificial intelligence over the past 70 years. It outlines some of the key milestones in AI research from the early work in the 1950s to modern advances in deep learning. While progress has been made, fully general artificial intelligence that can match or exceed human levels of intelligence remains an ongoing challenge that researchers continue working to achieve.
Using Styles In Bibus
Bibus is a bibliography manager software that allows users to store article information and integrate with word processors for easy citation formatting. It provides predefined citation styles that can be selected or new styles can be imported. The document outlines the steps to open Bibus, view available styles, and import a new style from the local file system to customize the citation format.
Hormonal treatment of breast cancer
This document summarizes hormonal treatment for breast cancer, including the history and mechanisms of various endocrine therapies. It discusses the timeline of developments in hormonal therapies from the late 19th century to present, covering areas like surgical oophorectomy, tamoxifen, aromatase inhibitors, and more. Key findings and mechanisms of different therapies like tamoxifen, aromatase inhibitors, and fulvestrant are summarized. The optimal use and duration of adjuvant tamoxifen therapy is discussed based on various clinical trials. The relationship between tamoxifen benefit and estrogen/progesterone receptor status is also covered.
Chemotherapy for Hodgkins disease
The document discusses the history and evolution of chemotherapy in Hodgkin's lymphoma. It describes how early single-agent chemotherapy showed limited efficacy and tolerability. The development of MOPP chemotherapy in the 1970s, using multiple non-overlapping agents, improved response rates and long-term survival to over 50%. Subsequent refinements introduced additional regimens like COPP, ABVD and others to reduce toxicity while maintaining efficacy.
Management of Gastrointestinal Lymphomas
Gastrointestinal lymphomas are the most common form of primary extra nodal lymphomas, accounting for 1-4% of all gastrointestinal tumors. They are mostly non-Hodgkin's lymphomas. MALT lymphomas have a strong association with H. pylori infection and can often be cured with H. pylori eradication therapy alone through regression of the lymphoma. Treatment of MALT lymphomas focuses on H. pylori eradication, while diffuse large B-cell lymphomas may require radiotherapy in addition to address widespread disease.
Medulloblastomas
Medulloblastomas are the most common malignant brain tumors in children. They arise in the cerebellum and can spread through the CSF pathways. Complete surgical resection followed by craniospinal irradiation is the main treatment approach. CSI provides improved local and systemic tumor control compared to other radiation techniques based on early studies. Medulloblastomas are highly radiosensitive tumors, making radiation an important part of management, though younger patients and those with residual disease or metastasis have poorer outcomes.
Management of Wilms Tumors
The document discusses the management of Wilms' tumor, a type of kidney cancer that typically affects children. It covers the history, epidemiology, pathogenesis, pathology, clinical features, workup, staging, and treatment approaches for Wilms' tumor. Treatment typically involves surgical removal of the tumor, followed by chemotherapy and sometimes radiation therapy, with the goal of eliminating both the primary tumor and any metastases in a multidisciplinary, stage-adapted approach.
Small Cell Carcinoma of Lung
The document summarizes management of small cell carcinoma of the lung. It discusses the classification, epidemiology, clinical features, investigations, staging, prognostic factors, and management including the role of radiation therapy and chemotherapy for both limited and extensive stage disease.
More from Santam Chakraborty (19)
Adjuvant radiation based on genomic risk factors emerging scenarios
Adjuvant radiation based on genomic risk factors emerging scenarios
Beam Directed Radiotherapy - methods and principles
Beam Directed Radiotherapy - methods and principles