Cocaine and amphetamines work by blocking the reuptake of neurotransmitters like dopamine, serotonin, and norepinephrine in the brain. This causes a surge of pleasure and arousal but can also lead to stimulant psychosis, paranoia, and violence with prolonged use. While initially seen as performance enhancers, these drugs are now recognized as highly addictive and dangerous due to health effects like "meth mouth" and long-term brain damage. Treatment of ADHD with stimulant drugs is common but also carries risks like insomnia, appetite loss, and potential growth delays.