Opiate drugs like opium, morphine, and heroin have been used for centuries to relieve pain but also carry high risks of addiction and dependence. While initially hailed as a treatment for pain, opiates like heroin became a major problem in the late 19th century as addiction rose. Today, prescription opiate drug abuse has increased dramatically in the US, with drugs like Oxycontin being misused. Opiates work in the brain by mimicking endorphins and reducing pain, but long term use leads to tolerance and withdrawal symptoms.